RBPWorld - a comprehensive database of RNA Binding Proteins

Functions and Diseases

RBP Type	Non-canonical_RBPs
Diseases	Cancer
Drug	Drug
Main interacting RNAs	diverse
Moonlighting functions	N.A.
Localizations	N.A.
BulkPerturb-seq	N.A.

Description

Ensembl ID	ENSG00000198056	Gene ID	5557	Accession	9369
Symbol	PRIM1	Alias	p49;PDIL	Full Name	DNA primase subunit 1
Status	Confidence	Length	21937 bases	Strand	Minus strand
Position	12 : 56730438 - 56752374	RNA binding domain	N.A.
Summary	The replication of DNA in eukaryotic cells is carried out by a complex chromosomal replication apparatus, in which DNA polymerase alpha and primase are two key enzymatic components. Primase, which is a heterodimer of a small subunit and a large subunit, synthesizes small RNA primers for the Okazaki fragments made during discontinuous DNA replication. The protein encoded by this gene is the small, 49 kDa primase subunit. [provided by RefSeq, Jul 2008]

Protein	Domain	Pfam ID	E-value	Domain number
No data available in table

RNA binding proteomes (RBPomes)

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Pubmed ID	Full Name	Cell	Author	Time	Doi
30824702	PtexRIC_PMID30824702_293T_human	293T	Erika C Urdaneta	2019 Mar 1	doi: 10.1038/s41467-019-08942-3
33693821	PP.enrichment.RIC_PMID33693821_Hela_human	Hela	Zheng Zhang	2021 Jun 21	doi: 10.1093/nar/gkab156
37421941	RIC_PMID37421941_Hydra10_human		Wenhao Jin	2023 Jul 20	doi: 10.1016/j.molcel.2023.06.019.?Epub 2023 Jul 7

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Literatures on RNA binding capacity

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Pubmed ID	Title	Author	Time	Journal
21965548	Four genetic loci influencing electrocardiographic indices of left ventricular hypertrophy.	Sonia Shah	2011-12-01	Circulation. Cardiovascular genetics
22187447	What can genetic studies of left ventricular mass tell us?	Christopher Newton-Cheh	2011-12-01	Circulation. Cardiovascular genetics
35830881	Structures of the human CST-Polα-primase complex bound to telomere templates.	Qixiang He	2022-08-01	Nature

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Transcripts

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Name	Transcript ID	bp	Protein	Translation ID
PRIM1-201	ENST00000338193	1423	420aa	ENSP00000350491
PRIM1-202	ENST00000546761	381	No protein	-
PRIM1-203	ENST00000548173	590	No protein	-
PRIM1-204	ENST00000549549	456	152aa	ENSP00000449806
PRIM1-205	ENST00000550224	1206	No protein	-
PRIM1-206	ENST00000550770	1008	327aa	ENSP00000450185
PRIM1-207	ENST00000552408	566	No protein	-
PRIM1-208	ENST00000552590	1459	185aa	ENSP00000448178
PRIM1-209	ENST00000672280	1875	459aa	ENSP00000500157
PRIM1-210	ENST00000706566	1726	420aa	ENSP00000516451

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Gene Model

Click here to download ENSG00000198056's gene model file

Phenotypes

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ensgID	Trait	pValue	Pubmed ID
91039	Menopause	2E-19	22267201

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ensgID	SNP	Chromosome	Position	Trait	PubmedID	Or or BEAT	EFO ID
No data available in table

Protein-Protein Interaction (PPI)

Click here to download ENSG00000198056's PPI file

Orthologs

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Ensembl ID	Source				Target
Ensembl ID	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id
ENSG00000198056	homo_sapiens	ENSP00000350491	90.9524	90	nomascus_leucogenys	ENSNLEP00000021168	99.2208	98.1818
ENSG00000198056	homo_sapiens	ENSP00000350491	100	100	pan_paniscus	ENSPPAP00000023172	100	100
ENSG00000198056	homo_sapiens	ENSP00000350491	99.7619	99.2857	pongo_abelii	ENSPPYP00000033509	91.2854	90.8497
ENSG00000198056	homo_sapiens	ENSP00000350491	100	100	pan_troglodytes	ENSPTRP00000041095	100	100
ENSG00000198056	homo_sapiens	ENSP00000350491	99.7619	99.5238	gorilla_gorilla	ENSGGOP00000013245	99.7619	99.5238
ENSG00000198056	homo_sapiens	ENSP00000350491	82.619	70.2381	ornithorhynchus_anatinus	ENSOANP00000012906	83.4135	70.9135
ENSG00000198056	homo_sapiens	ENSP00000350491	93.3333	85.4762	sarcophilus_harrisii	ENSSHAP00000003614	93.1116	85.2732
ENSG00000198056	homo_sapiens	ENSP00000350491	58.5714	53.3333	notamacropus_eugenii	ENSMEUP00000013054	59.2771	53.9759
ENSG00000198056	homo_sapiens	ENSP00000350491	51.9048	50.2381	choloepus_hoffmanni	ENSCHOP00000005892	74.4027	72.0136
ENSG00000198056	homo_sapiens	ENSP00000350491	95.4762	90.9524	dasypus_novemcinctus	ENSDNOP00000001250	95.7041	91.1694

Showing 1 to 10 of 213 entries

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Gene Ontology

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Go ID	Go term	No. evidence	Entries	Species	Category
GO:0003896	enables DNA primase activity	3	IBA,IDA,ISS	Homo_sapiens(9606)	Function
GO:0005658	part_of alpha DNA polymerase:primase complex	3	IBA,IDA,IPI	Homo_sapiens(9606)	Component
GO:0006269	involved_in DNA replication, synthesis of RNA primer	2	IBA,IDA	Homo_sapiens(9606)	Process
GO:0000287	enables magnesium ion binding	1	IDA	Homo_sapiens(9606)	Function
GO:0005515	enables protein binding	1	IPI	Homo_sapiens(9606)	Function
GO:0005654	located_in nucleoplasm	1	TAS	Homo_sapiens(9606)	Component
GO:0006270	involved_in DNA replication initiation	1	IDA	Homo_sapiens(9606)	Process
GO:0008270	enables zinc ion binding	1	IDA	Homo_sapiens(9606)	Function
GO:0016020	located_in membrane	1	HDA	Homo_sapiens(9606)	Component
GO:0032553	enables ribonucleotide binding	1	IDA	Homo_sapiens(9606)	Function

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Welcome to

RBP World!

Functions and Diseases

Description

RNA binding domains (RBDs)

RNA binding proteomes (RBPomes)

Literatures on RNA binding capacity

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

Protein-Protein Interaction (PPI)

Paralogs

Orthologs

Gene Ontology

Expression