Functions and Diseases

RBP Type Non-canonical_RBPs
Diseases Cancer
Drug Drug
Main interacting RNAs ncRNA
Moonlighting functions Transmemebrane
Localizations N.A.
BulkPerturb-seq N.A.

Description

Ensembl ID ENSG00000196664 Gene ID 51284 Accession 15631
Symbol TLR7 Alias IMD74;SLEB17;TLR7-like Full Name toll like receptor 7
Status Confidence Length 23290 bases Strand Plus strand
Position X : 12867072 - 12890361 RNA binding domain N.A.
Summary The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. The human TLR family comprises 11 members. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. For the recognition of structural components in foreign microorganisms, the various TLRs exhibit different patterns of expression as well; in this way for example, TLR-3, -7, and -8 are essential in the recognition of single-stranded RNA viruses. TLR7 senses single-stranded RNA oligonucleotides containing guanosine- and uridine-rich sequences from RNA viruses, a recognition occuring in the endosomes of plasmacytoid dendritic cells and B cells. This gene is predominantly expressed in lung, placenta, and spleen, and is phylogenetically related and lies in close proximity to another family member, TLR8, on chromosome X. [provided by RefSeq, Aug 2020]

RNA binding domains (RBDs)

Protein Domain Pfam ID E-value Domain number

RNA binding proteomes (RBPomes)

Pubmed ID Full Name Cell Author Time Doi

Literatures on RNA binding capacity

Pubmed ID Title Author Time Journal
34868046 Anti-TLR7 Antibody Protects Against Lupus Nephritis in NZBWF1 Mice by Targeting B Cells and Patrolling Monocytes. Yusuke Murakami 2021-01-01 Frontiers in immunology
26683146 Endosomal Toll-like receptors in clinically overt and silent autoimmunity. M Robert Clancy 2016-01-01 Immunological reviews
27329272 CD4 T cell epitope specificity determines follicular versus non-follicular helper differentiation in the polyclonal response to influenza infection or vaccination. G A Zackery Knowlden 2016-06-22 Scientific reports
29500721 Innate Immune Signaling and Alcohol Use Disorders. G Leon Coleman 2018-01-01 Handbook of experimental pharmacology
29439290 Review: Cell Death, Nucleic Acids, and Immunity: Inflammation Beyond the Grave. B Keith Elkon 2018-06-01 Arthritis & rheumatology (Hoboken, N.J.)
37513775 The Potential of Probiotics as Ingestible Adjuvants and Immune Modulators for Antiviral Immunity and Management of SARS-CoV-2 Infection and COVID-19. Sophie Tomkinson 2023-07-11 Pathogens (Basel, Switzerland)
21389263 Neutrophils activate plasmacytoid dendritic cells by releasing self-DNA-peptide complexes in systemic lupus erythematosus. Roberto Lande 2011-03-09 Science translational medicine
19633559 Innate immunity and inflammation in systemic sclerosis. Robert Lafyatis 2009-11-01 Current opinion in rheumatology
19592080 Toll-like receptor 7 and 9 defects in common variable immunodeficiency. E Joyce Yu 2009-08-01 The Journal of allergy and clinical immunology
34393859 SIGIRR and TNFAIP3 Are Differentially Expressed in Both PBMC and TNF-α Secreting Cells of Patients With Major Depressive Disorder. Chin-Chuen Lin 2021-01-01 Frontiers in psychiatry
23151919 Therapeutic applications of nucleic acids and their analogues in Toll-like receptor signaling. Vijayakumar Gosu 2012-11-14 Molecules (Basel, Switzerland)
26302811 Innate and Adaptive Immune Responses in Chronic HCV Infection. B Lynn Dustin 2017-01-01 Current drug targets
28471483 Bone Marrow-Derived Mesenchymal Stem Cells From Patients With Systemic Lupus Erythematosus Have a Senescence-Associated Secretory Phenotype Mediated by a Mitochondrial Antiviral Signaling Protein-Interferon-β Feedback Loop. Lin Gao 2017-08-01 Arthritis & rheumatology (Hoboken, N.J.)
24740301 Interleukin-7 and Toll-like receptor 7 induce synergistic B cell and T cell activation. Angela Bikker 2014-01-01 PloS one
21389264 Netting neutrophils are major inducers of type I IFN production in pediatric systemic lupus erythematosus. S Gina Garcia-Romo 2011-03-09 Science translational medicine
25010440 Advances in understanding the role of type I interferons in systemic lupus erythematosus. K Mary Crow 2014-09-01 Current opinion in rheumatology
26442097 Polymorphisms in Toll-like receptor genes are associated with vitiligo. Tanel Traks 2015-01-01 Frontiers in genetics
35456913 STAT1 and Its Crucial Role in the Control of Viral Infections. Manlio Tolomeo 2022-04-07 International journal of molecular sciences
26545385 Human TLR8 senses UR/URR motifs in bacterial and mitochondrial RNA. Anne Krüger 2015-12-01 EMBO reports
28604502 Association of HIV-1 Gag-Specific IgG Antibodies With Natural Control of HIV-1 Infection in Individuals Not Carrying HLA-B*57: 01 Is Only Observed in Viremic Controllers. Christian M Tjiam 2017-11-01 Journal of acquired immune deficiency syndromes (1999)
27412723 An efficient method for gene silencing in human primary plasmacytoid dendritic cells: silencing of the TLR7/IRF-7 pathway as a proof of concept. Nikaïa Smith 2016-07-14 Scientific reports
29181003 The Human-Associated Archaeon Methanosphaera stadtmanae Is Recognized through Its RNA and Induces TLR8-Dependent NLRP3 Inflammasome Activation. Tim Vierbuchen 2017-01-01 Frontiers in immunology
19006693 IRAK-4- and MyD88-dependent pathways are essential for the removal of developing autoreactive B cells in humans. Isabelle Isnardi 2008-11-14 Immunity
16330816 Immune stimulation mediated by autoantigen binding sites within small nuclear RNAs involves Toll-like receptors 7 and 8. Jörg Vollmer 2005-12-05 The Journal of experimental medicine

Transcripts

Name Transcript ID bp Protein Translation ID
TLR7-201 ENST00000380659 5003 1049aa ENSP00000370034
TLR7-202 ENST00000484204 299 No protein -

Gene Model

Pathways

Pathway ID Pathway Name Source

Phenotypes

ensgID Trait pValue Pubmed ID

GWAS

ensgIDSNPChromosomePosition TraitPubmedIDOr or BEAT EFO ID

Protein-Protein Interaction (PPI)

Paralogs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id
ENSG00000196664homo_sapiensENSP0000030686428.974717.682homo_sapiensENSP0000037003418.589111.3441
ENSG00000196664homo_sapiensENSP0000021553939.504125.6198homo_sapiensENSP0000037003422.783614.776
ENSG00000196664homo_sapiensENSP0000036308939.213323.0036homo_sapiensENSP0000037003431.363218.3985
ENSG00000196664homo_sapiensENSP0000034424238.548821.542homo_sapiensENSP0000037003416.20599.05624
ENSG00000196664homo_sapiensENSP0000021803259.942442.3631homo_sapiensENSP0000037003459.485242.04
ENSG00000196664homo_sapiensENSP0000029159238.132323.3463homo_sapiensENSP000003700349.342235.71973
ENSG00000196664homo_sapiensENSP0000036715738.181821.8182homo_sapiensENSP0000037003410.00955.71973
ENSG00000196664homo_sapiensENSP0000037988038.223921.6216homo_sapiensENSP000003700349.437565.33842
ENSG00000196664homo_sapiensENSP0000032862534.971118.9306homo_sapiensENSP0000037003423.069612.4881
ENSG00000196664homo_sapiensENSP0000030892536.744819.3588homo_sapiensENSP0000037003428.40814.9666
ENSG00000196664homo_sapiensENSP0000029679541.371724.8894homo_sapiensENSP0000037003435.65321.449
ENSG00000196664homo_sapiensENSP0000049635539.743622.6107homo_sapiensENSP0000037003432.507118.4938
ENSG00000196664homo_sapiensENSP0000033266835.127522.6629homo_sapiensENSP0000037003411.82087.62631
ENSG00000196664homo_sapiensENSP0000029838632.758618.435homo_sapiensENSP0000037003423.546213.2507
ENSG00000196664homo_sapiensENSP0000049442538.137822.3214homo_sapiensENSP0000037003428.503316.6826
ENSG00000196664homo_sapiensENSP0000026006137.764423.565homo_sapiensENSP0000037003423.832214.8713
ENSG00000196664homo_sapiensENSP0000035493238.040720.6107homo_sapiensENSP0000037003428.503315.4433
ENSG00000196664homo_sapiensENSP0000036118531.090915.8182homo_sapiensENSP0000037003416.30128.29361
ENSG00000196664homo_sapiensENSP0000030324832.628817.8336homo_sapiensENSP0000037003423.546212.8694
ENSG00000196664homo_sapiensENSP0000029463511.70816.49559homo_sapiensENSP0000037003413.9187.72164
ENSG00000196664homo_sapiensENSP0000042471835.929619.3467homo_sapiensENSP0000037003427.264114.6806
ENSG00000196664homo_sapiensENSP0000025644739.183122.3903homo_sapiensENSP0000037003424.690214.1087

Orthologs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id
ENSG00000196664homo_sapiensENSP0000037003499.42898.5701nomascus_leucogenysENSNLEP0000001110499.42898.5701
ENSG00000196664homo_sapiensENSP0000037003499.71499.6187pan_paniscusENSPPAP0000000957299.71499.6187
ENSG00000196664homo_sapiensENSP0000037003499.42898.9514pongo_abeliiENSPPYP0000003839999.42898.9514
ENSG00000196664homo_sapiensENSP0000037003499.523499.428pan_troglodytesENSPTRP0000004749499.523499.428
ENSG00000196664homo_sapiensENSP0000037003499.71499.428gorilla_gorillaENSGGOP0000002062499.71499.428
ENSG00000196664homo_sapiensENSP0000037003484.270770.0667ornithorhynchus_anatinusENSOANP0000000415578.647765.3915
ENSG00000196664homo_sapiensENSP0000037003483.508172.6406sarcophilus_harrisiiENSSHAP0000003831583.428672.5714
ENSG00000196664homo_sapiensENSP0000037003484.175473.0219notamacropus_eugeniiENSMEUP0000001382983.935472.8137
ENSG00000196664homo_sapiensENSP0000037003477.69371.4967dasypus_novemcinctusENSDNOP0000001981389.955882.7815
ENSG00000196664homo_sapiensENSP0000037003483.222175.8818erinaceus_europaeusENSEEUP0000000292483.460876.0994
ENSG00000196664homo_sapiensENSP0000037003486.65478.837echinops_telfairiENSETEP0000000420886.65478.837
ENSG00000196664homo_sapiensENSP0000037003496.663593.9943callithrix_jacchusENSCJAP0000000712896.663593.9943
ENSG00000196664homo_sapiensENSP0000037003498.856197.8074cercocebus_atysENSCATP0000004281598.856197.8074
ENSG00000196664homo_sapiensENSP0000037003498.951497.9028macaca_fascicularisENSMFAP0000005627598.951497.9028
ENSG00000196664homo_sapiensENSP0000037003498.951497.9028macaca_mulattaENSMMUP0000001871998.951497.9028
ENSG00000196664homo_sapiensENSP0000037003498.951497.9028macaca_nemestrinaENSMNEP0000002740598.951497.9028
ENSG00000196664homo_sapiensENSP0000037003498.951497.9028papio_anubisENSPANP0000000876198.951497.9028
ENSG00000196664homo_sapiensENSP0000037003498.760797.7121mandrillus_leucophaeusENSMLEP0000003399998.760797.7121
ENSG00000196664homo_sapiensENSP0000037003492.75586.1773tursiops_truncatusENSTTRP0000000302592.666786.0952
ENSG00000196664homo_sapiensENSP0000037003492.46985.4147vulpes_vulpesENSVVUP0000002624686.529979.9286
ENSG00000196664homo_sapiensENSP0000037003489.323280.8389mus_spretusMGP_SPRETEiJ_P009716289.238180.7619
ENSG00000196664homo_sapiensENSP0000037003492.373786.2726equus_asinusENSEASP0000506036991.935585.8634
ENSG00000196664homo_sapiensENSP0000037003492.087786.368capra_hircusENSCHIP0000002344391.650985.9583
ENSG00000196664homo_sapiensENSP0000037003490.657884.1754loxodonta_africanaENSLAFP0000002869491.442384.9038
ENSG00000196664homo_sapiensENSP0000037003492.46986.1773panthera_leoENSPLOP0000002927392.38186.0952
ENSG00000196664homo_sapiensENSP0000037003492.850385.796ailuropoda_melanoleucaENSAMEP0000002083292.761985.7143
ENSG00000196664homo_sapiensENSP0000037003491.706486.368bos_indicus_hybridENSBIXP0000502963591.271385.9583
ENSG00000196664homo_sapiensENSP0000037003492.373786.2726equus_caballusENSECAP0000006430192.373786.2726
ENSG00000196664homo_sapiensENSP0000037003492.46985.51canis_lupus_familiarisENSCAFP0084503916686.529980.0178
ENSG00000196664homo_sapiensENSP0000037003492.46986.082panthera_pardusENSPPRP0000002179892.38186
ENSG00000196664homo_sapiensENSP0000037003491.801784.8427marmota_marmota_marmotaENSMMMP0000000477491.977185.0048
ENSG00000196664homo_sapiensENSP0000037003492.659786.368balaenoptera_musculusENSBMSP0001002612792.571486.2857
ENSG00000196664homo_sapiensENSP0000037003490.467183.3174cavia_porcellusENSCPOP0000002881890.467183.3174
ENSG00000196664homo_sapiensENSP0000037003492.373786.2726felis_catusENSFCAP0000003967490.476284.5005
ENSG00000196664homo_sapiensENSP0000037003492.564385.51ursus_americanusENSUAMP0000003516091.690384.7026
ENSG00000196664homo_sapiensENSP0000037003457.864654.9094bison_bison_bisonENSBBBP0000000260357.864654.9094
ENSG00000196664homo_sapiensENSP0000037003492.564385.9867monodon_monocerosENSMMNP0001502144492.476285.9048
ENSG00000196664homo_sapiensENSP0000037003492.659785.0334sus_scrofaENSSSCP0000001289892.220184.63
ENSG00000196664homo_sapiensENSP0000037003493.04187.7026microcebus_murinusENSMICP0000004899892.952487.619
ENSG00000196664homo_sapiensENSP0000037003490.371882.8408octodon_degusENSODEP0000000482290.371882.8408
ENSG00000196664homo_sapiensENSP0000037003491.515783.0315jaculus_jaculusENSJJAP0000002038791.428682.9524
ENSG00000196664homo_sapiensENSP0000037003492.659785.51ursus_maritimusENSUMAP0000000680592.571485.4286
ENSG00000196664homo_sapiensENSP0000037003467.969561.1058ochotona_princepsENSOPRP0000001551968.229761.3397
ENSG00000196664homo_sapiensENSP0000037003492.373785.796delphinapterus_leucasENSDLEP0000002761391.935585.389
ENSG00000196664homo_sapiensENSP0000037003492.945786.1773physeter_catodonENSPCTP0000502107091.377784.7235
ENSG00000196664homo_sapiensENSP0000037003489.418581.7922mus_caroliMGP_CAROLIEiJ_P009339289.333381.7143
ENSG00000196664homo_sapiensENSP0000037003489.227880.7436mus_musculusENSMUSP0000010778789.142980.6667
ENSG00000196664homo_sapiensENSP0000037003489.609280.8389dipodomys_ordiiENSDORP0000002664289.523880.7619
ENSG00000196664homo_sapiensENSP0000037003491.89783.9847mustela_putorius_furoENSMPUP0000000253489.01281.3481
ENSG00000196664homo_sapiensENSP0000037003496.663594.4709aotus_nancymaaeENSANAP0000002657596.663594.4709
ENSG00000196664homo_sapiensENSP0000037003496.377594.2803saimiri_boliviensis_boliviensisENSSBOP0000000310596.377594.2803
ENSG00000196664homo_sapiensENSP0000037003465.776961.1058vicugna_pacosENSVPAP0000000030165.902661.2225
ENSG00000196664homo_sapiensENSP0000037003498.760797.6168chlorocebus_sabaeusENSCSAP0000001902898.760797.6168
ENSG00000196664homo_sapiensENSP0000037003488.751279.7903mesocricetus_auratusENSMAUP0000001940188.666779.7143
ENSG00000196664homo_sapiensENSP0000037003492.46986.082phocoena_sinusENSPSNP0000002172692.38186
ENSG00000196664homo_sapiensENSP0000037003491.801785.0334camelus_dromedariusENSCDRP0000501458985.070778.7986
ENSG00000196664homo_sapiensENSP0000037003493.803688.4652carlito_syrichtaENSTSYP0000001941493.714388.381
ENSG00000196664homo_sapiensENSP0000037003492.373785.8913panthera_tigris_altaicaENSPTIP0000001998392.285785.8095
ENSG00000196664homo_sapiensENSP0000037003488.751280.5529rattus_norvegicusENSRNOP0000009464987.172379.1199
ENSG00000196664homo_sapiensENSP0000037003493.708387.8932prolemur_simusENSPSMP0000003741893.61987.8095
ENSG00000196664homo_sapiensENSP0000037003488.179279.3136microtus_ochrogasterENSMOCP0000001110588.095279.2381
ENSG00000196664homo_sapiensENSP0000037003489.513880.1716peromyscus_maniculatus_bairdiiENSPEMP0000000092389.428680.0952
ENSG00000196664homo_sapiensENSP0000037003491.706486.368bos_mutusENSBMUP0000001953491.271385.9583
ENSG00000196664homo_sapiensENSP0000037003488.941879.7903cricetulus_griseus_chok1gshdENSCGRP0000101582188.857179.7143
ENSG00000196664homo_sapiensENSP0000037003491.611186.082pteropus_vampyrusENSPVAP0000000890691.611186.082
ENSG00000196664homo_sapiensENSP0000037003491.515784.1754myotis_lucifugusENSMLUP0000001934291.603184.2557
ENSG00000196664homo_sapiensENSP0000037003484.556773.3079vombatus_ursinusENSVURP0001002926882.974771.9364
ENSG00000196664homo_sapiensENSP0000037003492.850387.2259rhinolophus_ferrumequinumENSRFEP0001002517692.850387.2259
ENSG00000196664homo_sapiensENSP0000037003491.515783.6034neovison_visonENSNVIP0000002553391.778283.8432
ENSG00000196664homo_sapiensENSP0000037003491.706486.368bos_taurusENSBTAP0000007179291.271385.9583
ENSG00000196664homo_sapiensENSP0000037003492.087785.0334heterocephalus_glaber_femaleENSHGLP0000000096492.087785.0334
ENSG00000196664homo_sapiensENSP0000037003499.237498.0934rhinopithecus_bietiENSRBIP0000000485499.237498.0934
ENSG00000196664homo_sapiensENSP0000037003492.46985.51canis_lupus_dingoENSCAFP0002000325891.509484.6226
ENSG00000196664homo_sapiensENSP0000037003492.18386.654sciurus_vulgarisENSSVLP0000502715092.359186.8195
ENSG00000196664homo_sapiensENSP0000037003483.698873.0219phascolarctos_cinereusENSPCIP0000004074882.132871.6558
ENSG00000196664homo_sapiensENSP0000037003439.275535.653procavia_capensisENSPCAP0000000902471.652265.0435
ENSG00000196664homo_sapiensENSP0000037003489.323280.9342nannospalax_galiliENSNGAP0000002383689.238180.8571
ENSG00000196664homo_sapiensENSP0000037003491.611186.2726bos_grunniensENSBGRP0000003058991.176585.8634
ENSG00000196664homo_sapiensENSP0000037003491.325184.0801chinchilla_lanigeraENSCLAP0000000045991.325184.0801
ENSG00000196664homo_sapiensENSP0000037003492.087786.368cervus_hanglu_yarkandensisENSCHYP000000359549286.2857
ENSG00000196664homo_sapiensENSP0000037003492.373785.4147catagonus_wagneriENSCWAP0000002379392.285785.3333
ENSG00000196664homo_sapiensENSP0000037003491.706484.8427ictidomys_tridecemlineatusENSSTOP0000002007891.184884.3602
ENSG00000196664homo_sapiensENSP0000037003491.992485.51otolemur_garnettiiENSOGAP0000001440292.080285.5916
ENSG00000196664homo_sapiensENSP0000037003496.568294.1849cebus_imitatorENSCCAP0000001170896.568294.1849
ENSG00000196664homo_sapiensENSP0000037003491.801784.8427urocitellus_parryiiENSUPAP0001000282991.977185.0048
ENSG00000196664homo_sapiensENSP0000037003491.992486.1773moschus_moschiferusENSMMSP0000001576791.904886.0952
ENSG00000196664homo_sapiensENSP0000037003499.332798.1888rhinopithecus_roxellanaENSRROP0000000417599.332798.1888
ENSG00000196664homo_sapiensENSP0000037003489.227881.3155mus_pahariMGP_PahariEiJ_P009099389.142981.2381
ENSG00000196664homo_sapiensENSP0000037003451.286933.1745petromyzon_marinusENSPMAP0000000688756.87136.7865
ENSG00000196664homo_sapiensENSP0000037003456.053439.2755petromyzon_marinusENSPMAP0000000254755.211338.6854
ENSG00000196664homo_sapiensENSP0000037003445.662531.9352eptatretus_burgeriENSEBUP0000000357957.850240.4589
ENSG00000196664homo_sapiensENSP0000037003473.403257.0067callorhinchus_miliiENSCMIP0000002185973.967357.4448
ENSG00000196664homo_sapiensENSP0000037003476.358460.3432latimeria_chalumnaeENSLACP0000000115875.56659.717
ENSG00000196664homo_sapiensENSP0000037003475.405260.3432latimeria_chalumnaeENSLACP0000000475876.573161.2778
ENSG00000196664homo_sapiensENSP0000037003473.403257.8646lepisosteus_oculatusENSLOCP0000001219772.916757.4811
ENSG00000196664homo_sapiensENSP0000037003467.302252.0496clupea_harengusENSCHAP0000006109169.556653.7931
ENSG00000196664homo_sapiensENSP0000037003472.259355.3861danio_rerioENSDARP0000010567172.535955.5981
ENSG00000196664homo_sapiensENSP0000037003472.16456.7207carassius_auratusENSCARP0000000532272.16456.7207
ENSG00000196664homo_sapiensENSP0000037003472.831357.102carassius_auratusENSCARP0000005980272.417156.7773
ENSG00000196664homo_sapiensENSP0000037003473.212656.4347astyanax_mexicanusENSAMXP0000002676572.589855.9546
ENSG00000196664homo_sapiensENSP0000037003471.496755.1001esox_luciusENSELUP0000006731671.0954.7867
ENSG00000196664homo_sapiensENSP0000037003470.543455.1954electrophorus_electricusENSEEEP0000002682571.77556.1591
ENSG00000196664homo_sapiensENSP0000037003473.403256.6254oncorhynchus_kisutchENSOKIP0000501759172.710156.0907
ENSG00000196664homo_sapiensENSP0000037003473.212656.1487oncorhynchus_mykissENSOMYP0000006094973.212656.1487
ENSG00000196664homo_sapiensENSP0000037003473.498656.53salmo_salarENSSSAP0000003577272.530655.7855
ENSG00000196664homo_sapiensENSP0000037003473.498656.53salmo_truttaENSSTUP0000003198972.530655.7855
ENSG00000196664homo_sapiensENSP0000037003472.640655.5767gadus_morhuaENSGMOP0000003296871.886855
ENSG00000196664homo_sapiensENSP0000037003472.259355.4814gadus_morhuaENSGMOP0000002401671.44254.8539
ENSG00000196664homo_sapiensENSP0000037003471.59255.3861fundulus_heteroclitusENSFHEP0000003386671.184855.0711
ENSG00000196664homo_sapiensENSP0000037003472.16455.1954poecilia_reticulataENSPREP0000000262471.958255.038
ENSG00000196664homo_sapiensENSP0000037003471.87855.2908xiphophorus_maculatusENSXMAP0000000443671.741255.1855
ENSG00000196664homo_sapiensENSP0000037003472.259356.6254oryzias_latipesENSORLP0000003113371.984856.4103
ENSG00000196664homo_sapiensENSP0000037003473.784656.816cyclopterus_lumpusENSCLMP0000503212673.434556.5465
ENSG00000196664homo_sapiensENSP0000037003473.784656.816oreochromis_niloticusENSONIP0000002598173.504356.6002
ENSG00000196664homo_sapiensENSP0000037003473.689256.7207haplochromis_burtoniENSHBUP0000003481472.378355.7116
ENSG00000196664homo_sapiensENSP0000037003473.593956.7207astatotilapia_callipteraENSACLP0000000979272.284655.7116
ENSG00000196664homo_sapiensENSP0000037003471.973354.5281sparus_aurataENSSAUP0001003684269.972253.012
ENSG00000196664homo_sapiensENSP0000037003473.498657.102lates_calcariferENSLCAP0001001335373.63957.2111
ENSG00000196664homo_sapiensENSP0000037003444.423335.081lates_calcariferENSLCAP0001004950672.698957.4103
ENSG00000196664homo_sapiensENSP0000037003476.358460.7245xenopus_tropicalisENSXETP0000001172575.996260.4364
ENSG00000196664homo_sapiensENSP0000037003482.173568.5415chrysemys_picta_belliiENSCPBP0000001726781.397567.8942
ENSG00000196664homo_sapiensENSP0000037003481.124966.5396crocodylus_porosusENSCPRP0000500886279.162864.9302
ENSG00000196664homo_sapiensENSP0000037003470.066755.1954laticauda_laticaudataENSLLTP0000000364272.129556.8204
ENSG00000196664homo_sapiensENSP0000037003469.399454.4328notechis_scutatusENSNSUP0000001082871.724156.2562
ENSG00000196664homo_sapiensENSP0000037003469.780754.7188pseudonaja_textilisENSPTXP0000000786970.79355.5126
ENSG00000196664homo_sapiensENSP0000037003479.12365.3956anas_platyrhynchos_platyrhynchosENSAPLP0000000363076.216762.9936
ENSG00000196664homo_sapiensENSP0000037003478.360363.775gallus_gallusENSGALP0001000261577.620463.1728
ENSG00000196664homo_sapiensENSP0000037003478.360363.9657meleagris_gallopavoENSMGAP0000001558078.5164.0879
ENSG00000196664homo_sapiensENSP0000037003478.932365.205serinus_canariaENSSCAP0000001850779.083165.3295
ENSG00000196664homo_sapiensENSP0000037003476.835163.2984serinus_canariaENSSCAP0000001851280.666.4
ENSG00000196664homo_sapiensENSP0000037003479.504365.0143parus_majorENSPMJP0000001519276.513862.5688
ENSG00000196664homo_sapiensENSP0000037003415.157312.2021parus_majorENSPMJP0000001519179.899564.3216
ENSG00000196664homo_sapiensENSP0000037003474.737857.2927anolis_carolinensisENSACAP0000000154474.242456.9129
ENSG00000196664homo_sapiensENSP0000037003473.879957.102neolamprologus_brichardiENSNBRP0000001131773.599256.8851
ENSG00000196664homo_sapiensENSP0000037003466.158252.0496naja_najaENSNNAP0000001151570.744155.6575
ENSG00000196664homo_sapiensENSP0000037003473.689257.2927podarcis_muralisENSPMRP0000001112274.68658.0676
ENSG00000196664homo_sapiensENSP0000037003478.169764.4423geospiza_fortisENSGFOP0000000554379.303765.3772
ENSG00000196664homo_sapiensENSP0000037003478.646364.8236geospiza_fortisENSGFOP0000002021979.250765.3218
ENSG00000196664homo_sapiensENSP0000037003422.592918.5891geospiza_fortisENSGFOP0000002022280.33966.1017
ENSG00000196664homo_sapiensENSP0000037003478.741764.8236geospiza_fortisENSGFOP0000002021678.892164.9475
ENSG00000196664homo_sapiensENSP0000037003478.932364.7283taeniopygia_guttataENSTGUP0000003215479.083164.852
ENSG00000196664homo_sapiensENSP0000037003473.021955.1001erpetoichthys_calabaricusENSECRP0000001731072.332454.5798
ENSG00000196664homo_sapiensENSP0000037003472.259356.6254kryptolebias_marmoratusENSKMAP0000002368671.173755.7746
ENSG00000196664homo_sapiensENSP0000037003470.924755.4814salvator_merianaeENSSMRP0000002935371.196255.6938
ENSG00000196664homo_sapiensENSP0000037003472.831356.244oryzias_javanicusENSOJAP0000002672472.554656.0304
ENSG00000196664homo_sapiensENSP0000037003473.307956.0534amphilophus_citrinellusENSACIP0000001084772.89155.7346
ENSG00000196664homo_sapiensENSP0000037003473.879957.8646dicentrarchus_labraxENSDLAP0000506049873.599257.6448
ENSG00000196664homo_sapiensENSP0000037003473.212655.8627amphiprion_perculaENSAPEP0000003391572.934555.6505
ENSG00000196664homo_sapiensENSP0000037003472.640656.7207oryzias_sinensisENSOSIP0000002593672.364756.5052
ENSG00000196664homo_sapiensENSP0000037003481.124967.8742pelodiscus_sinensisENSPSIP0000000041081.047667.8095
ENSG00000196664homo_sapiensENSP0000037003482.078268.3508gopherus_evgoodeiENSGEVP000050088278268.2857
ENSG00000196664homo_sapiensENSP0000037003476.739864.633chelonoidis_abingdoniiENSCABP0000001548581.892268.9725
ENSG00000196664homo_sapiensENSP0000037003473.021956.244seriola_dumeriliENSSDUP0000000434972.813756.0836
ENSG00000196664homo_sapiensENSP0000037003473.689256.3394cottoperca_gobioENSCGOP0000005021573.270156.019
ENSG00000196664homo_sapiensENSP0000037003479.790365.3956struthio_camelus_australisENSSCUP0000002226875.473461.8575
ENSG00000196664homo_sapiensENSP0000037003479.218365.1096anser_brachyrhynchusENSABRP0000001190478.17564.2521
ENSG00000196664homo_sapiensENSP0000037003472.926655.7674gasterosteus_aculeatusENSGACP0000000525973.416556.142
ENSG00000196664homo_sapiensENSP0000037003472.831354.9094cynoglossus_semilaevisENSCSEP0000001565172.143554.3909
ENSG00000196664homo_sapiensENSP0000037003472.354655.3861poecilia_formosaENSPFOP0000002572971.603854.8113
ENSG00000196664homo_sapiensENSP0000037003473.593957.1973sander_luciopercaENSSLUP0000000060973.175456.872
ENSG00000196664homo_sapiensENSP0000037003479.790365.1096strigops_habroptilaENSSHBP0000502283679.942765.234
ENSG00000196664homo_sapiensENSP0000037003473.498656.1487amphiprion_ocellarisENSAOCP0000001288973.219455.9354
ENSG00000196664homo_sapiensENSP0000037003477.311765.205terrapene_carolina_triunguisENSTMTP0000001904682.168269.3009
ENSG00000196664homo_sapiensENSP0000037003477.407165.3003terrapene_carolina_triunguisENSTMTP0000000332982.269569.4022
ENSG00000196664homo_sapiensENSP0000037003473.212656.244hucho_huchoENSHHUP0000004103572.248455.5033
ENSG00000196664homo_sapiensENSP0000037003472.735956.7207betta_splendensENSBSLP0000004098072.597556.6128
ENSG00000196664homo_sapiensENSP0000037003473.212656.816pygocentrus_nattereriENSPNAP0000002547671.775755.7009
ENSG00000196664homo_sapiensENSP0000037003474.165956.9113anabas_testudineusENSATEP0000001932773.884156.6952
ENSG00000196664homo_sapiensENSP0000037003473.403256.4347seriola_lalandi_dorsalisENSSLDP0000000113073.193956.2738
ENSG00000196664homo_sapiensENSP0000037003473.498655.5767labrus_bergyltaENSLBEP0000002693273.219455.3656
ENSG00000196664homo_sapiensENSP0000037003473.689256.9113pundamilia_nyerereiENSPNYP0000001530973.409356.6952
ENSG00000196664homo_sapiensENSP0000037003473.498656.0534mastacembelus_armatusENSMAMP0000001986873.219455.8405
ENSG00000196664homo_sapiensENSP0000037003472.640655.5767stegastes_partitusENSSPAP0000001049872.364755.3656
ENSG00000196664homo_sapiensENSP0000037003473.403256.6254oncorhynchus_tshawytschaENSOTSP0000506093572.710156.0907
ENSG00000196664homo_sapiensENSP0000037003473.403256.6254oncorhynchus_tshawytschaENSOTSP0000506842872.710156.0907
ENSG00000196664homo_sapiensENSP0000037003473.117355.7674acanthochromis_polyacanthusENSAPOP0000003341872.839555.5556
ENSG00000196664homo_sapiensENSP0000037003476.739862.8217aquila_chrysaetos_chrysaetosENSACCP0002001364080.904566.2312
ENSG00000196664homo_sapiensENSP0000037003472.640657.102nothobranchius_furzeriENSNFUP0001501922371.954756.5628
ENSG00000196664homo_sapiensENSP0000037003471.782755.1954cyprinodon_variegatusENSCVAP0000002721872.334355.6196
ENSG00000196664homo_sapiensENSP0000037003471.973354.8141denticeps_clupeoidesENSDCDP0000003441371.631954.5541
ENSG00000196664homo_sapiensENSP0000037003473.403254.8141larimichthys_croceaENSLCRP0000502593473.124454.6059
ENSG00000196664homo_sapiensENSP0000037003472.735955.3861takifugu_rubripesENSTRUP0000002008272.874955.4919
ENSG00000196664homo_sapiensENSP0000037003414.20411.9161ficedula_albicollisENSFALP0000002013265.929255.3097
ENSG00000196664homo_sapiensENSP0000037003414.299311.5348ficedula_albicollisENSFALP0000003277367.567654.5045
ENSG00000196664homo_sapiensENSP0000037003478.646364.061ficedula_albicollisENSFALP0000000466178.796664.1834
ENSG00000196664homo_sapiensENSP0000037003471.687353.8608hippocampus_comesENSHCOP0000000279470.943453.3019
ENSG00000196664homo_sapiensENSP0000037003472.640657.2927cyprinus_carpio_carpioENSCCRP0000000503272.640657.2927
ENSG00000196664homo_sapiensENSP0000037003478.455765.0143coturnix_japonicaENSCJPP0000502291678.605565.1385
ENSG00000196664homo_sapiensENSP0000037003472.259355.3861poecilia_latipinnaENSPLAP0000001815372.053255.2281
ENSG00000196664homo_sapiensENSP0000037003472.4557.1973sinocyclocheilus_grahamiENSSGRP0000010214772.4557.1973
ENSG00000196664homo_sapiensENSP0000037003472.926657.4833sinocyclocheilus_grahamiENSSGRP0000007186072.787857.3739
ENSG00000196664homo_sapiensENSP0000037003472.831355.6721tetraodon_nigroviridisENSTNIP0000001696772.900855.7252
ENSG00000196664homo_sapiensENSP0000037003473.498656.6254paramormyrops_kingsleyaeENSPKIP0000003111472.942356.1968
ENSG00000196664homo_sapiensENSP0000037003472.4556.6254scleropages_formosusENSSFOP0001500485671.765856.0907
ENSG00000196664homo_sapiensENSP0000037003474.070558.3413leptobrachium_leishanenseENSLLEP0000000576173.929658.2303
ENSG00000196664homo_sapiensENSP0000037003466.825548.7131scophthalmus_maximusENSSMAP0000006879345.578733.225
ENSG00000196664homo_sapiensENSP0000037003472.640656.6254oryzias_melastigmaENSOMEP0000000576372.364756.4103

Gene Ontology

Go ID Go term No. evidence Entries Species Category
GO:0000139located_in Golgi membrane1TASHomo_sapiens(9606)Component
GO:0001932involved_in regulation of protein phosphorylation1IEAHomo_sapiens(9606)Process
GO:0002224involved_in toll-like receptor signaling pathway1IBAHomo_sapiens(9606)Process
GO:0003725enables double-stranded RNA binding1IDAHomo_sapiens(9606)Function
GO:0003727enables single-stranded RNA binding2IMP,ISSHomo_sapiens(9606)Function
GO:0005515enables protein binding1IPIHomo_sapiens(9606)Function
GO:0005737located_in cytoplasm1IDAHomo_sapiens(9606)Component
GO:0005764located_in lysosome1ISSHomo_sapiens(9606)Component
GO:0005768located_in endosome1ISSHomo_sapiens(9606)Component
GO:0005783located_in endoplasmic reticulum1ISSHomo_sapiens(9606)Component
GO:0005789located_in endoplasmic reticulum membrane1TASHomo_sapiens(9606)Component
GO:0005886is_active_in plasma membrane2IBA,IDAHomo_sapiens(9606)Component
GO:0006954involved_in inflammatory response1IEAHomo_sapiens(9606)Process
GO:0007249involved_in I-kappaB kinase/NF-kappaB signaling2IBA,IMPHomo_sapiens(9606)Process
GO:0007252involved_in I-kappaB phosphorylation1IDAHomo_sapiens(9606)Process
GO:0007254involved_in JNK cascade1IEAHomo_sapiens(9606)Process
GO:0010008located_in endosome membrane1TASHomo_sapiens(9606)Component
GO:0032009located_in early phagosome1ISSHomo_sapiens(9606)Component
GO:0032722involved_in positive regulation of chemokine production1IDAHomo_sapiens(9606)Process
GO:0032727involved_in positive regulation of interferon-alpha production1IDAHomo_sapiens(9606)Process
GO:0032728involved_in positive regulation of interferon-beta production1IDAHomo_sapiens(9606)Process
GO:0032729involved_in positive regulation of type II interferon production1IDAHomo_sapiens(9606)Process
GO:0032755involved_in positive regulation of interleukin-6 production1IBAHomo_sapiens(9606)Process
GO:0032757involved_in positive regulation of interleukin-8 production2IDA,IMPHomo_sapiens(9606)Process
GO:0034154involved_in toll-like receptor 7 signaling pathway1IBAHomo_sapiens(9606)Process
GO:0035197enables siRNA binding1ISSHomo_sapiens(9606)Function
GO:0036020located_in endolysosome membrane1TASHomo_sapiens(9606)Component
GO:0038187enables pattern recognition receptor activity1IBAHomo_sapiens(9606)Function
GO:0043235part_of receptor complex1IDAHomo_sapiens(9606)Component
GO:0045087involved_in innate immune response1IMPHomo_sapiens(9606)Process
GO:0045944involved_in positive regulation of transcription by RNA polymerase II1IEAHomo_sapiens(9606)Process
GO:0050729involved_in positive regulation of inflammatory response1ICHomo_sapiens(9606)Process
GO:0051607involved_in defense response to virus3IBA,IEP,IMPHomo_sapiens(9606)Process
GO:0060907involved_in positive regulation of macrophage cytokine production1IEAHomo_sapiens(9606)Process
GO:0070305involved_in response to cGMP1IMPHomo_sapiens(9606)Process
GO:0071260involved_in cellular response to mechanical stimulus1IEPHomo_sapiens(9606)Process
GO:0098586involved_in cellular response to virus1IEAHomo_sapiens(9606)Process
GO:1901224involved_in positive regulation of NIK/NF-kappaB signaling1IDAHomo_sapiens(9606)Process

Expression