Ensembl ID ENSG00000196664 Gene ID 51284 Accession 15631
Gene Symbol TLR7 Alias IMD74;SLEB17;TLR7-like Full Name toll like receptor 7
Position X : 12867072 - 12890361 Length 23290 bases Strand Plus strand
Status Confidence Main interacting RNAsncRNARBP type Non-canonical_RBPs
Summary The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. The human TLR family comprises 11 members. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. For the recognition of structural components in foreign microorganisms, the various TLRs exhibit different patterns of expression as well; in this way for example, TLR-3, -7, and -8 are essential in the recognition of single-stranded RNA viruses. TLR7 senses single-stranded RNA oligonucleotides containing guanosine- and uridine-rich sequences from RNA viruses, a recognition occuring in the endosomes of plasmacytoid dendritic cells and B cells. This gene is predominantly expressed in lung, placenta, and spleen, and is phylogenetically related and lies in close proximity to another family member, TLR8, on chromosome X. [provided by RefSeq, Aug 2020]

ENSG00000196664 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000196664 TLR7 2.06 4.21e-42 KIRC
ENSG00000196664 TLR7 -1.7 2.74e-17 COAD
ENSG00000196664 TLR7 -1.8 1.41e-20 LUSC
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000196664 TLR7 cancers 12527213
ENSG00000196664 TLR7 tumor 15072849
ENSG00000196664 TLR7 tumor 15943496
ENSG00000196664 TLR7 cancer 16365416
ENSG00000196664 TLR7 tumor 17114492
ENSG00000196664 TLR7 HNSCC 17201162
ENSG00000196664 TLR7 tumor 17218388
ENSG00000196664 TLR7 cancers 17308125
ENSG00000196664 TLR7 tumor 17312119
ENSG00000196664 TLR7 cancer 17476348
ENSG00000196664 TLR7 cancer 17535975
ENSG00000196664 TLR7 cancer 17660481
ENSG00000196664 TLR7 tumor 17698636
ENSG00000196664 TLR7 cancer 17804388
ENSG00000196664 TLR7 tumor 17922128
ENSG00000196664 TLR7 tumor 17935622
ENSG00000196664 TLR7 cancer 18056192
ENSG00000196664 TLR7 cancer 18176600
ENSG00000196664 TLR7 tumour 18397197
ENSG00000196664 TLR7 tumor 18439103
ENSG00000196664 TLR7 tumors 18463538
ENSG00000196664 TLR7 cancer 18566444
ENSG00000196664 TLR7 cancer 18701762
ENSG00000196664 TLR7 tumour 18765427
ENSG00000196664 TLR7 cancer 18791716
ENSG00000196664 TLR7 tumors 18794336
ENSG00000196664 TLR7 head and neck cancer 18949362
ENSG00000196664 TLR7 tumor 18989354
ENSG00000196664 TLR7 cancers 19093959
ENSG00000196664 TLR7 skin cancer 19096763
ENSG00000196664 TLR7 tumor 19308683
ENSG00000196664 TLR7 skin cancer 19355914
ENSG00000196664 TLR7 tumors 19380767
ENSG00000196664 TLR7 cancers 19426145
ENSG00000196664 TLR7 acute myeloid leukemia (AML) 19449004
ENSG00000196664 TLR7 skin cancers 19516264
ENSG00000196664 TLR7 tumor 19620771
ENSG00000196664 TLR7 tumor 19685283
ENSG00000196664 TLR7 tumors 19812695
ENSG00000196664 TLR7 Cancer 19848448
ENSG00000196664 TLR7 tumor 19887600
ENSG00000196664 TLR7 tumor 20065291
ENSG00000196664 TLR7 tumour 20067543
ENSG00000196664 TLR7 tumor 20237413
ENSG00000196664 TLR7 tumor 20332325
ENSG00000196664 TLR7 bladder cancer 20337728
ENSG00000196664 TLR7 cancer 20380038
ENSG00000196664 TLR7 tumor 20426849
ENSG00000196664 TLR7 lung tumor 20512556
ENSG00000196664 TLR7 tumor 20515950
ENSG00000196664 TLR7 cancer 20519933
ENSG00000196664 TLR7 tumor 20540112
ENSG00000196664 TLR7 tumor 20543857
ENSG00000196664 TLR7 Tumour 20658750
ENSG00000196664 TLR7 tumour 20728343
ENSG00000196664 TLR7 cervix cancers 20820775
ENSG00000196664 TLR7 cancer 20832362
ENSG00000196664 TLR7 tumour 20840632
ENSG00000196664 TLR7 tumor 20919443
ENSG00000196664 TLR7 tumor 21030882
ENSG00000196664 TLR7 cancer 21060729
ENSG00000196664 TLR7 tumor 21150709
ENSG00000196664 TLR7 tumor 21271351
ENSG00000196664 TLR7 tumors 21402711
ENSG00000196664 TLR7 tumors 21423261
ENSG00000196664 TLR7 cervical cancer 21527067
ENSG00000196664 TLR7 cancer 21697281
ENSG00000196664 TLR7 cancer 21748646
ENSG00000196664 TLR7 precancerous skin lesions 21765012
ENSG00000196664 TLR7 tumors 21869824
ENSG00000196664 TLR7 tumor 21990957
ENSG00000196664 TLR7 skin cancers 22116053
ENSG00000196664 TLR7 tumor 22251703
ENSG00000196664 TLR7 Tumors 22481916
ENSG00000196664 TLR7 oral cancer 22577802
ENSG00000196664 TLR7 cancer 22578090
ENSG00000196664 TLR7 tumour 22586164
ENSG00000196664 TLR7 tumor 22718118
ENSG00000196664 TLR7 tumor 22720240
ENSG00000196664 TLR7 cancer 22720251
ENSG00000196664 TLR7 tumour 22730373
ENSG00000196664 TLR7 cancer 22733292
ENSG00000196664 TLR7 tumor 22737605
ENSG00000196664 TLR7 tumor 22753494
ENSG00000196664 TLR7 breast cancer 22767669
ENSG00000196664 TLR7 tumors 22927956
ENSG00000196664 TLR7 tumors 22934262
ENSG00000196664 TLR7 tumor 22934264
ENSG00000196664 TLR7 pancreatic cancer 23023703
ENSG00000196664 TLR7 breast cancer 23048078
ENSG00000196664 TLR7 tumor 23086756
ENSG00000196664 TLR7 tumour 23136362
ENSG00000196664 TLR7 cancer 23151919
ENSG00000196664 TLR7 cervical tumors 23221735
ENSG00000196664 TLR7 cancer 23222301
ENSG00000196664 TLR7 tumors 23264929
ENSG00000196664 TLR7 tumor 23318200
ENSG00000196664 TLR7 breast cancer 23389942
ENSG00000196664 TLR7 tumour 23396449
ENSG00000196664 TLR7 tumor 23402811
ENSG00000196664 TLR7 tumor 23451142
ENSG00000196664 TLR7 pancreatic cancer 23483804
ENSG00000196664 TLR7 tumor 23519132
ENSG00000196664 TLR7 tumors 23521528
ENSG00000196664 TLR7 tumour 23551576
ENSG00000196664 TLR7 prostate cancer 23588478
ENSG00000196664 TLR7 cancer 23593527
ENSG00000196664 TLR7 cancer 23702041
ENSG00000196664 TLR7 Tumor 23722543
ENSG00000196664 TLR7 prostate cancer 23790156
ENSG00000196664 TLR7 tumor 23839094
ENSG00000196664 TLR7 dermal tumors 23867290
ENSG00000196664 TLR7 bladder cancer 23979666
ENSG00000196664 TLR7 tumour 23995793
ENSG00000196664 TLR7 cancers 24012797
ENSG00000196664 TLR7 pancreatic cancer 24058792
ENSG00000196664 TLR7 cervical cancer 24347177
ENSG00000196664 TLR7 cancer 24375473
ENSG00000196664 TLR7 tumor 24390981
ENSG00000196664 TLR7 breast cancer 24404422
ENSG00000196664 TLR7 tumors 24573220
ENSG00000196664 TLR7 cancer 24616506
ENSG00000196664 TLR7 tumor 24658058
ENSG00000196664 TLR7 tumour 24684292
ENSG00000196664 TLR7 tumor 24743316
ENSG00000196664 TLR7 cancer 24782650
ENSG00000196664 TLR7 tumor 24954733
ENSG00000196664 TLR7 tumor 24955288
ENSG00000196664 TLR7 tumors 24982761
ENSG00000196664 TLR7 tumour 24990399
ENSG00000196664 TLR7 non-small cell lung cancer 25074614
ENSG00000196664 TLR7 cancer 25083332
ENSG00000196664 TLR7 DLBCL 25112836
ENSG00000196664 TLR7 tumor 25132835
ENSG00000196664 TLR7 tumor 25135627
ENSG00000196664 TLR7 metastatic cancer 25252955
ENSG00000196664 TLR7 AML 25283842
ENSG00000196664 TLR7 cancer 25322876
ENSG00000196664 TLR7 DLBCLs 25391967
ENSG00000196664 TLR7 tumor 25411122
ENSG00000196664 TLR7 gastric cancer 25413058
ENSG00000196664 TLR7 cancer 25428647
ENSG00000196664 TLR7 tumor 25518732
ENSG00000196664 TLR7 skin cancer 25524580
ENSG00000196664 TLR7 tumor 25547486
ENSG00000196664 TLR7 tumor 25567751
ENSG00000196664 TLR7 tumor 25593198
ENSG00000196664 TLR7 tumor 25609199
ENSG00000196664 TLR7 Tumour 25692288
ENSG00000196664 TLR7 cancer 25766763
ENSG00000196664 TLR7 tumor 25825448
ENSG00000196664 TLR7 tumour 25828894
ENSG00000196664 TLR7 tumours 25887995
ENSG00000196664 TLR7 lung cancer 25949912
ENSG00000196664 TLR7 tumor 25990580
ENSG00000196664 TLR7 cancer 26007168
ENSG00000196664 TLR7 tumors 26042126
ENSG00000196664 TLR7 breast cancer 26043701
ENSG00000196664 TLR7 tumor 26091797
ENSG00000196664 TLR7 pancreatic cancer 26134824
ENSG00000196664 TLR7 pancreatic cancer 26155170
ENSG00000196664 TLR7 tumors 26166013
ENSG00000196664 TLR7 pancreatic cancer 26172047
ENSG00000196664 TLR7 gastric cancer 26185376
ENSG00000196664 TLR7 cancer 26228277
ENSG00000196664 TLR7 pancreatic cancer 26238718
ENSG00000196664 TLR7 tumor 26288465
ENSG00000196664 TLR7 cancer 26381186
ENSG00000196664 TLR7 tumor 26433159
ENSG00000196664 TLR7 cancer 26438211
ENSG00000196664 TLR7 cancer 26675675
ENSG00000196664 TLR7 tumor 26718332
ENSG00000196664 TLR7 pancreatic cancer 26718740
ENSG00000196664 TLR7 cancer 26770023
ENSG00000196664 TLR7 skin cancer 26775629
ENSG00000196664 TLR7 tumor 26959743
ENSG00000196664 TLR7 cancer 27047954
ENSG00000196664 TLR7 tumor 27057445
ENSG00000196664 TLR7 hepatic cancer 27123047
ENSG00000196664 TLR7 tumor 27141361
ENSG00000196664 TLR7 precancerous skin lesions 27318760
ENSG00000196664 TLR7 tumor 27336891
ENSG00000196664 TLR7 gastric cancer 27347192
ENSG00000196664 TLR7 breast cancer 27363264
ENSG00000196664 TLR7 Liver Tumor 27456065
ENSG00000196664 TLR7 esophageal cancer 27467941
ENSG00000196664 TLR7 cancer 27522582
ENSG00000196664 TLR7 liver cancer 27588480
ENSG00000196664 TLR7 cancer 27622045
ENSG00000196664 TLR7 cancers of the skin 27692612
ENSG00000196664 TLR7 tumor 27872698
ENSG00000196664 TLR7 tumor 27890931
ENSG00000196664 TLR7 tumour 27902922
ENSG00000196664 TLR7 tumour 27936237
ENSG00000196664 TLR7 tumor 27941651
ENSG00000196664 TLR7 cancer 27999739
ENSG00000196664 TLR7 tumors 27999742
ENSG00000196664 TLR7 tumor 28000738
ENSG00000196664 TLR7 cancer 28036266
ENSG00000196664 TLR7 tumor 28052019
ENSG00000196664 TLR7 cancer 28153581
ENSG00000196664 TLR7 tumors 28196735
ENSG00000196664 TLR7 tumors 28197384
ENSG00000196664 TLR7 cancer 28212561
ENSG00000196664 TLR7 cancer 28234357
ENSG00000196664 TLR7 breast cancer 28432455
ENSG00000196664 TLR7 tumor 28439064
ENSG00000196664 TLR7 tumor 28450804
ENSG00000196664 TLR7 metastatic colorectal cancer 28569041
ENSG00000196664 TLR7 tumor 28588009
ENSG00000196664 TLR7 cancer 28601430
ENSG00000196664 TLR7 tumor 28620298
ENSG00000196664 TLR7 cervical cancer 28626766
ENSG00000196664 TLR7 Tumors 28637878
ENSG00000196664 TLR7 tumor 28666747
ENSG00000196664 TLR7 Malignant Epithelial Tumors 28857981
ENSG00000196664 TLR7 ovarian cancer 28901470
ENSG00000196664 TLR7 tumors 28919783
ENSG00000196664 TLR7 cancer 28928743
ENSG00000196664 TLR7 tumor 28931759
ENSG00000196664 TLR7 cancer 28971564
ENSG00000196664 TLR7 tumor 29098928
ENSG00000196664 TLR7 tumor 29123526
ENSG00000196664 TLR7 cancer 29157965
ENSG00000196664 TLR7 tumor 29158790
ENSG00000196664 TLR7 tumors 29170511
ENSG00000196664 TLR7 AML 29181334
ENSG00000196664 TLR7 tumor 29190881
ENSG00000196664 TLR7 cancer 29190907
ENSG00000196664 TLR7 cancer 29238879
ENSG00000196664 TLR7 lung cancer 29435270
ENSG00000196664 TLR7 cancer 29462934
ENSG00000196664 TLR7 cancer 29482062
ENSG00000196664 TLR7 tumor 29553135
ENSG00000196664 TLR7 tumor 29563317
ENSG00000196664 TLR7 tumor 29568358
ENSG00000196664 TLR7 pancreatic cancer 29620272
ENSG00000196664 TLR7 cancers 29632539
ENSG00000196664 TLR7 cancer 29656235
ENSG00000196664 TLR7 tumor 29662615
ENSG00000196664 TLR7 tumours 29667229
ENSG00000196664 TLR7 tumors 29708510
ENSG00000196664 TLR7 Gastric cancer 29739434
ENSG00000196664 TLR7 tumor 29762000
ENSG00000196664 TLR7 cancer 29854832
ENSG00000196664 TLR7 tumor 29892301
ENSG00000196664 TLR7 cancer 29964062
ENSG00000196664 TLR7 metastatic cancer 29967183
ENSG00000196664 TLR7 cancer 30018715
ENSG00000196664 TLR7 Tumor 30021725
ENSG00000196664 TLR7 tumor 30049538
ENSG00000196664 TLR7 cancer 30069688
ENSG00000196664 TLR7 cancers 30104878
ENSG00000196664 TLR7 cancer 30140783
ENSG00000196664 TLR7 tumor 30175192
ENSG00000196664 TLR7 tumor 30181782
ENSG00000196664 TLR7 tumor 30201735
ENSG00000196664 TLR7 Cancer 30209066
ENSG00000196664 TLR7 tumor 30276880
ENSG00000196664 TLR7 tumors 30328949
ENSG00000196664 TLR7 tumour 30345161
ENSG00000196664 TLR7 tumor 30349530
ENSG00000196664 TLR7 tumor 30351939
ENSG00000196664 TLR7 tumors 30388137
ENSG00000196664 TLR7 tumor 30400835
ENSG00000196664 TLR7 cancer 30403212
ENSG00000196664 TLR7 tumor 30415018
ENSG00000196664 TLR7 cancer 30429335
ENSG00000196664 TLR7 cancer 30450098
ENSG00000196664 TLR7 tumors 30508377
ENSG00000196664 TLR7 cancer 30546943
ENSG00000196664 TLR7 Cancer 30610006
ENSG00000196664 TLR7 ovarian cancer 30610800
ENSG00000196664 TLR7 breast cancer 30623789
ENSG00000196664 TLR7 cancer 30653899
ENSG00000196664 TLR7 cancer 30736860
ENSG00000196664 TLR7 cancer 30779113
ENSG00000196664 TLR7 tumor 30794027
ENSG00000196664 TLR7 gastric cancer 30863783
ENSG00000196664 TLR7 tumor 30926058
ENSG00000196664 TLR7 tumor 30937265
ENSG00000196664 TLR7 tumor 30976817
ENSG00000196664 TLR7 tumor 30979057
ENSG00000196664 TLR7 cancer 30981947
ENSG00000196664 TLR7 tumor 30987228
ENSG00000196664 TLR7 tumour 31015631
ENSG00000196664 TLR7 tumor 31083581
ENSG00000196664 TLR7 tumor 31093508
ENSG00000196664 TLR7 cancers 31111189
ENSG00000196664 TLR7 tumor 31143525
ENSG00000196664 TLR7 breast cancer 31154723
ENSG00000196664 TLR7 tumor 31161238
ENSG00000196664 TLR7 cancers 31173789
ENSG00000196664 TLR7 HNSCC 31178219
ENSG00000196664 TLR7 Tumour 31202966
ENSG00000196664 TLR7 tumour 31238894
ENSG00000196664 TLR7 tumor 31240216
ENSG00000196664 TLR7 tumors 31314777
ENSG00000196664 TLR7 AML 31336716
ENSG00000196664 TLR7 cancer 31397948
ENSG00000196664 TLR7 Pancreatic Cancer 31409607
ENSG00000196664 TLR7 gastric cancer 31467388
ENSG00000196664 TLR7 cancers 31480568
ENSG00000196664 TLR7 tumor 31507609
ENSG00000196664 TLR7 tumor 31511088
ENSG00000196664 TLR7 Tumor 31589013
ENSG00000196664 TLR7 tumors 31599020
ENSG00000196664 TLR7 tumor 31615993
ENSG00000196664 TLR7 tumor 31619293
ENSG00000196664 TLR7 colorectal cancer 31629935
ENSG00000196664 TLR7 cancer 31695691
ENSG00000196664 TLR7 tumors 31695804
ENSG00000196664 TLR7 nonmelanoma skin cancer 31702822
ENSG00000196664 TLR7 colon cancer 31741755
ENSG00000196664 TLR7 cancer 31784317
ENSG00000196664 TLR7 breast cancer 31789409
ENSG00000196664 TLR7 cancer 31864800
ENSG00000196664 TLR7 Cancer 31879528
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000196664 TLR7 MESO 0.025 low
ENSG00000196664 TLR7 STAD 0.026 high
ENSG00000196664 TLR7 UVM 0.0027 high
ENSG00000196664 TLR7 UCEC 0.048 high
ENSG00000196664 TLR7 THCA 0.00087 low
ENSG00000196664 TLR7 ACC 0.018 low
ENSG00000196664 TLR7 LGG 0.00064 high
ENSG00000196664 TLR7 HNSC 0.011 low
ENSG00000196664 TLR7 READ 0.042 low
ENSG00000196664 TLR7 KIRP 0.00063 low
ENSG00000196664 TLR7 PCPG 0.0082 low
ENSG00000196664 TLR7 THYM 0.00041 low
ENSG00000196664 TLR7 COAD 0.041 low
ENSG00000196664 TLR7 OV 0.033 high
ENSG00000196664 TLR7 DLBC 0.0059 high
ENSG00000196664 TLR7 KIRC 0.018 low
ENSG00000196664 TLR7 PRAD 0.045 low
ENSG00000196664 TLR7 TGCT 0.00081 low
ENSG00000196664 TLR7 BLCA 0.016 low
ENSG00000196664 TLR7 LAML 0.0025 high
ENSG00000196664 TLR7 CESC 0.0031 low
ENSG00000196664 TLR7 LIHC 0.046 high
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency