Functions and Diseases

RBP Type Non-canonical_RBPs
Diseases CancerSARS-COV-2
Drug N.A.
Main interacting RNAs N.A.
Moonlighting functions Transmemebrane
Localizations N.A.
BulkPerturb-seq N.A.

Description

Ensembl ID ENSG00000196396 Gene ID 5770 Accession 9642
Symbol PTPN1 Alias PTP1B Full Name protein tyrosine phosphatase non-receptor type 1
Status Confidence Length 74921 bases Strand Plus strand
Position 20 : 50510321 - 50585241 RNA binding domain N.A.
Summary The protein encoded by this gene is the founding member of the protein tyrosine phosphatase (PTP) family, which was isolated and identified based on its enzymatic activity and amino acid sequence. PTPs catalyze the hydrolysis of the phosphate monoesters specifically on tyrosine residues. Members of the PTP family share a highly conserved catalytic motif, which is essential for the catalytic activity. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP has been shown to act as a negative regulator of insulin signaling by dephosphorylating the phosphotryosine residues of insulin receptor kinase. This PTP was also reported to dephosphorylate epidermal growth factor receptor kinase, as well as JAK2 and TYK2 kinases, which implicated the role of this PTP in cell growth control, and cell response to interferon stimulation. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2013]

RNA binding domains (RBDs)

Protein Domain Pfam ID E-value Domain number

RNA binding proteomes (RBPomes)

Pubmed ID Full Name Cell Author Time Doi

Literatures on RNA binding capacity

Pubmed ID Title Author Time Journal

Transcripts

Name Transcript ID bp Protein Translation ID
PTPN1-202 ENST00000541713 3469 362aa ENSP00000437732
PTPN1-201 ENST00000371621 3979 435aa ENSP00000360683

Gene Model

Pathways

Pathway ID Pathway Name Source

Phenotypes

ensgID Trait pValue Pubmed ID
43869Platelet Function Tests7.7715610E-015-

GWAS

ensgIDSNPChromosomePosition TraitPubmedIDOr or BEAT EFO ID

Protein-Protein Interaction (PPI)

Paralogs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id
ENSG00000196396homo_sapiensENSP000003770478.552925.09719homo_sapiensENSP0000036068345.517227.1264
ENSG00000196396homo_sapiensENSP0000036345929.761920homo_sapiensENSP0000036068328.735619.3103
ENSG00000196396homo_sapiensENSP000004072495.754533.82294homo_sapiensENSP0000036068332.873621.8391
ENSG00000196396homo_sapiensENSP0000035592312.72118.00337homo_sapiensENSP0000036068334.712621.8391
ENSG00000196396homo_sapiensENSP0000035720914.02788.05556homo_sapiensENSP0000036068346.436826.6667
ENSG00000196396homo_sapiensENSP0000031185772.530156.3855homo_sapiensENSP0000036068369.195453.7931
ENSG00000196396homo_sapiensENSP0000048273224.283317.5379homo_sapiensENSP0000036068333.103423.908
ENSG00000196396homo_sapiensENSP0000024859419.743612.5641homo_sapiensENSP0000036068335.402322.5287
ENSG00000196396homo_sapiensENSP0000035134225.132713.9823homo_sapiensENSP0000036068332.643718.1609
ENSG00000196396homo_sapiensENSP0000045241412.43618.00681homo_sapiensENSP0000036068333.563221.6092
ENSG00000196396homo_sapiensENSP0000026370817.926611.987homo_sapiensENSP0000036068338.160925.5172
ENSG00000196396homo_sapiensENSP0000046332513.92498.12287homo_sapiensENSP0000036068346.896627.3563
ENSG00000196396homo_sapiensENSP0000028117112.82898.38816homo_sapiensENSP0000036068335.862123.4483
ENSG00000196396homo_sapiensENSP0000034094429.51118.0438homo_sapiensENSP0000036068340.229924.5977
ENSG00000196396homo_sapiensENSP0000041135514.85458.3461homo_sapiensENSP0000036068344.597725.0575
ENSG00000196396homo_sapiensENSP0000017575630.434820.2174homo_sapiensENSP0000036068332.183921.3793
ENSG00000196396homo_sapiensENSP000002546672715.8571homo_sapiensENSP0000036068343.448325.5172
ENSG00000196396homo_sapiensENSP0000036552813.27358.96861homo_sapiensENSP0000036068334.02322.9885
ENSG00000196396homo_sapiensENSP000003349287.53954.87585homo_sapiensENSP0000036068338.390824.8276
ENSG00000196396homo_sapiensENSP0000026556210.08565.86797homo_sapiensENSP0000036068337.93122.069
ENSG00000196396homo_sapiensENSP0000036366717.743711.8291homo_sapiensENSP0000036068337.241424.8276
ENSG00000196396homo_sapiensENSP0000035283319.08312.6394homo_sapiensENSP0000036068335.402323.4483
ENSG00000196396homo_sapiensENSP0000050943636.111124.1667homo_sapiensENSP0000036068329.885120
ENSG00000196396homo_sapiensENSP0000037406913.99019.55665homo_sapiensENSP0000036068332.643722.2989
ENSG00000196396homo_sapiensENSP0000029571814.504610.0102homo_sapiensENSP0000036068332.643722.5287
ENSG00000196396homo_sapiensENSP0000036228314.57328.11936homo_sapiensENSP0000036068348.275926.8966
ENSG00000196396homo_sapiensENSP0000028322822.0713.6986homo_sapiensENSP0000036068333.333320.6897
ENSG00000196396homo_sapiensENSP0000036288413.23127.66017homo_sapiensENSP0000036068343.678225.2874
ENSG00000196396homo_sapiensENSP0000035303010.90727.18406homo_sapiensENSP0000036068347.816131.4943
ENSG00000196396homo_sapiensENSP0000040001012.34116.88108homo_sapiensENSP0000036068337.93121.1494
ENSG00000196396homo_sapiensENSP0000026296310.98566.82752homo_sapiensENSP0000036068349.195430.5747
ENSG00000196396homo_sapiensENSP0000037059311.03566.90377homo_sapiensENSP0000036068348.505730.3448
ENSG00000196396homo_sapiensENSP0000041811214.25618.3045homo_sapiensENSP0000036068347.356327.5862
ENSG00000196396homo_sapiensENSP0000038278723.690813.8404homo_sapiensENSP0000036068343.678225.5172
ENSG00000196396homo_sapiensENSP0000032601027.39517.479homo_sapiensENSP0000036068337.471323.908

Orthologs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id
ENSG00000196396homo_sapiensENSP000003606838077.4713nomascus_leucogenysENSNLEP0000004242485.925983.2099
ENSG00000196396homo_sapiensENSP00000360683100100pan_paniscusENSPPAP00000008568100100
ENSG00000196396homo_sapiensENSP0000036068399.540298.6207pongo_abeliiENSPPYP0000001243399.540298.6207
ENSG00000196396homo_sapiensENSP00000360683100100pan_troglodytesENSPTRP00000043532100100
ENSG00000196396homo_sapiensENSP0000036068399.770199.5402gorilla_gorillaENSGGOP0000000688599.770199.5402
ENSG00000196396homo_sapiensENSP0000036068386.896680.6897ornithorhynchus_anatinusENSOANP0000001382586.104879.9544
ENSG00000196396homo_sapiensENSP0000036068386.896682.2989sarcophilus_harrisiiENSSHAP0000004598188.111983.4499
ENSG00000196396homo_sapiensENSP0000036068393.103487.5862choloepus_hoffmanniENSCHOP0000000057093.31887.788
ENSG00000196396homo_sapiensENSP0000036068383.678277.7011dasypus_novemcinctusENSDNOP0000002797784.259378.2407
ENSG00000196396homo_sapiensENSP0000036068353.103448.7356erinaceus_europaeusENSEEUP000000110115550.4762
ENSG00000196396homo_sapiensENSP0000036068358.160953.1034echinops_telfairiENSETEP0000001169758.294953.2258
ENSG00000196396homo_sapiensENSP0000036068397.93195.1724callithrix_jacchusENSCJAP0000000090997.93195.1724
ENSG00000196396homo_sapiensENSP0000036068394.712690.3448callithrix_jacchusENSCJAP0000007640994.712690.3448
ENSG00000196396homo_sapiensENSP0000036068399.080597.7011cercocebus_atysENSCATP0000003507099.080597.7011
ENSG00000196396homo_sapiensENSP0000036068399.080597.7011macaca_fascicularisENSMFAP0000004690099.080597.7011
ENSG00000196396homo_sapiensENSP0000036068399.080597.7011macaca_mulattaENSMMUP0000001034999.080597.7011
ENSG00000196396homo_sapiensENSP0000036068398.850697.4713macaca_nemestrinaENSMNEP0000002776098.850697.4713
ENSG00000196396homo_sapiensENSP0000036068399.080597.7011papio_anubisENSPANP0000001461099.080597.7011
ENSG00000196396homo_sapiensENSP0000036068399.080597.7011mandrillus_leucophaeusENSMLEP0000000617499.080597.7011
ENSG00000196396homo_sapiensENSP0000036068393.333388.5057tursiops_truncatusENSTTRP0000001353294.859889.9533
ENSG00000196396homo_sapiensENSP0000036068393.333388.9655vulpes_vulpesENSVVUP0000003072295.08290.6323
ENSG00000196396homo_sapiensENSP0000036068390.114982.5287mus_spretusMGP_SPRETEiJ_P005851990.740783.1019
ENSG00000196396homo_sapiensENSP0000036068390.804683.6782equus_asinusENSEASP0000505467880.612274.2857
ENSG00000196396homo_sapiensENSP0000036068392.873687.5862capra_hircusENSCHIP0000001941995.28389.8585
ENSG00000196396homo_sapiensENSP0000036068384.137974.9425loxodonta_africanaENSLAFP0000002669088.405878.744
ENSG00000196396homo_sapiensENSP0000036068394.252989.4253panthera_leoENSPLOP0000000414496.018791.1007
ENSG00000196396homo_sapiensENSP0000036068392.643789.1954ailuropoda_melanoleucaENSAMEP0000003161588.571485.2747
ENSG00000196396homo_sapiensENSP0000036068390.344884.3678bos_indicus_hybridENSBIXP0000501650191.608485.5478
ENSG00000196396homo_sapiensENSP0000036068389.655284.1379oryctolagus_cuniculusENSOCUP0000000744078.787973.9394
ENSG00000196396homo_sapiensENSP0000036068392.643787.1264equus_caballusENSECAP0000006226384.663979.6218
ENSG00000196396homo_sapiensENSP0000036068377.93172.1839canis_lupus_familiarisENSCAFP0084503631586.259579.8982
ENSG00000196396homo_sapiensENSP0000036068394.482889.4253panthera_pardusENSPPRP0000000466996.252991.1007
ENSG00000196396homo_sapiensENSP0000036068336.09234.023marmota_marmota_marmotaENSMMMP0000002696988.202283.1461
ENSG00000196396homo_sapiensENSP0000036068382.988577.4713marmota_marmota_marmotaENSMMMP0000000860084.941279.2941
ENSG00000196396homo_sapiensENSP0000036068392.643788.046balaenoptera_musculusENSBMSP0001002566895.047290.3302
ENSG00000196396homo_sapiensENSP0000036068392.873686.4368cavia_porcellusENSCPOP0000002241293.518587.037
ENSG00000196396homo_sapiensENSP0000036068394.482889.8851felis_catusENSFCAP0000000364096.252991.5691
ENSG00000196396homo_sapiensENSP0000036068391.264487.3563ursus_americanusENSUAMP0000002726693.632189.6226
ENSG00000196396homo_sapiensENSP0000036068380.229976.5517monodelphis_domesticaENSMODP0000002041789.258385.1662
ENSG00000196396homo_sapiensENSP0000036068389.195484.1379bison_bison_bisonENSBBBP0000000170095.09889.7059
ENSG00000196396homo_sapiensENSP0000036068393.333388.5057monodon_monocerosENSMMNP0001500157894.859889.9533
ENSG00000196396homo_sapiensENSP0000036068393.103488.7356sus_scrofaENSSSCP0000005358595.518991.0377
ENSG00000196396homo_sapiensENSP0000036068395.632291.4943microcebus_murinusENSMICP0000004574877.611974.2537
ENSG00000196396homo_sapiensENSP0000036068393.793186.4368octodon_degusENSODEP0000001222594.009286.6359
ENSG00000196396homo_sapiensENSP0000036068391.034586.2069jaculus_jaculusENSJJAP0000002369092.523487.6168
ENSG00000196396homo_sapiensENSP0000036068394.02388.5057ovis_aries_rambouilletENSOARP0002001421795.33889.7436
ENSG00000196396homo_sapiensENSP0000036068391.494387.5862ursus_maritimusENSUMAP0000003393293.867989.8585
ENSG00000196396homo_sapiensENSP0000036068390.114985.5172ochotona_princepsENSOPRP0000000094193.333388.5714
ENSG00000196396homo_sapiensENSP0000036068392.413887.8161delphinapterus_leucasENSDLEP0000000275794.811390.0943
ENSG00000196396homo_sapiensENSP0000036068393.103488.5057physeter_catodonENSPCTP0000500751794.626289.9533
ENSG00000196396homo_sapiensENSP0000036068390.114982.5287mus_caroliMGP_CAROLIEiJ_P005634690.740783.1019
ENSG00000196396homo_sapiensENSP0000036068390.344882.7586mus_musculusENSMUSP0000002905390.972283.3333
ENSG00000196396homo_sapiensENSP0000036068390.574785.5172dipodomys_ordiiENSDORP0000002474990.36785.3211
ENSG00000196396homo_sapiensENSP0000036068392.643788.9655mustela_putorius_furoENSMPUP0000001744195.047291.2736
ENSG00000196396homo_sapiensENSP0000036068393.333390.1149aotus_nancymaaeENSANAP0000004193094.859891.5888
ENSG00000196396homo_sapiensENSP0000036068397.701195.4023aotus_nancymaaeENSANAP0000002576297.701195.4023
ENSG00000196396homo_sapiensENSP0000036068398.160996.092saimiri_boliviensis_boliviensisENSSBOP0000000868098.160996.092
ENSG00000196396homo_sapiensENSP0000036068391.724186.6667saimiri_boliviensis_boliviensisENSSBOP0000000777993.224388.0841
ENSG00000196396homo_sapiensENSP0000036068387.816183.4483vicugna_pacosENSVPAP0000000698195.590.75
ENSG00000196396homo_sapiensENSP0000036068399.080597.4713chlorocebus_sabaeusENSCSAP0000001120699.080597.4713
ENSG00000196396homo_sapiensENSP0000036068362.06957.0115tupaia_belangeriENSTBEP0000000171263.529458.3529
ENSG00000196396homo_sapiensENSP0000036068391.264484.8276mesocricetus_auratusENSMAUP0000000865291.898185.4167
ENSG00000196396homo_sapiensENSP0000036068393.103488.5057phocoena_sinusENSPSNP0000002917792.045587.5
ENSG00000196396homo_sapiensENSP0000036068394.252989.8851camelus_dromedariusENSCDRP0000502131995.794491.3551
ENSG00000196396homo_sapiensENSP0000036068390.344884.8276carlito_syrichtaENSTSYP0000000097290.55385.023
ENSG00000196396homo_sapiensENSP0000036068389.655284.8276panthera_tigris_altaicaENSPTIP0000001069491.334986.4169
ENSG00000196396homo_sapiensENSP0000036068390.804684.5977rattus_norvegicusENSRNOP0000001430991.435285.1852
ENSG00000196396homo_sapiensENSP0000036068397.241493.1034prolemur_simusENSPSMP0000001805597.018392.8899
ENSG00000196396homo_sapiensENSP0000036068391.034584.3678microtus_ochrogasterENSMOCP0000000208191.666784.9537
ENSG00000196396homo_sapiensENSP0000036068387.356380sorex_araneusENSSARP0000001062294.059486.1386
ENSG00000196396homo_sapiensENSP0000036068390.804685.7471peromyscus_maniculatus_bairdiiENSPEMP0000001249591.435286.3426
ENSG00000196396homo_sapiensENSP0000036068394.02388.2759bos_mutusENSBMUP0000001529195.33889.5105
ENSG00000196396homo_sapiensENSP0000036068390.344882.7586mus_spicilegusENSMSIP0000003769590.972283.3333
ENSG00000196396homo_sapiensENSP0000036068391.264485.2874cricetulus_griseus_chok1gshdENSCGRP0000101035691.898185.8796
ENSG00000196396homo_sapiensENSP0000036068394.482888.9655pteropus_vampyrusENSPVAP0000001530596.478990.8451
ENSG00000196396homo_sapiensENSP0000036068388.275984.1379myotis_lucifugusENSMLUP0000001309795.285490.8189
ENSG00000196396homo_sapiensENSP0000036068388.505783.2184vombatus_ursinusENSVURP0001002463891.016585.5792
ENSG00000196396homo_sapiensENSP0000036068392.873687.1264rhinolophus_ferrumequinumENSRFEP0001002022595.28389.3868
ENSG00000196396homo_sapiensENSP0000036068394.02390.3448neovison_visonENSNVIP0000000936795.784592.0375
ENSG00000196396homo_sapiensENSP0000036068393.103487.5862bos_taurusENSBTAP0000000867895.294189.6471
ENSG00000196396homo_sapiensENSP0000036068393.563286.8966heterocephalus_glaber_femaleENSHGLP0000005655594.21387.5
ENSG00000196396homo_sapiensENSP0000036068398.850697.0115rhinopithecus_bietiENSRBIP0000000225898.850697.0115
ENSG00000196396homo_sapiensENSP0000036068392.183988.046canis_lupus_dingoENSCAFP0002002213294.575590.3302
ENSG00000196396homo_sapiensENSP0000036068393.563287.3563sciurus_vulgarisENSSVLP0000500016993.13586.9565
ENSG00000196396homo_sapiensENSP0000036068388.04683.2184phascolarctos_cinereusENSPCIP0000001037789.48684.5794
ENSG00000196396homo_sapiensENSP0000036068374.712670.5747procavia_capensisENSPCAP0000000446776.650972.4057
ENSG00000196396homo_sapiensENSP0000036068392.643787.3563nannospalax_galiliENSNGAP0000000687692.219786.9565
ENSG00000196396homo_sapiensENSP0000036068393.103487.3563bos_grunniensENSBGRP0000000676695.294189.4118
ENSG00000196396homo_sapiensENSP0000036068394.712687.8161chinchilla_lanigeraENSCLAP0000000825495.370488.4259
ENSG00000196396homo_sapiensENSP0000036068391.95486.6667cervus_hanglu_yarkandensisENSCHYP0000001526894.117688.7059
ENSG00000196396homo_sapiensENSP0000036068393.793190.1149catagonus_wagneriENSCWAP0000000701995.550491.8033
ENSG00000196396homo_sapiensENSP0000036068388.275983.4483ictidomys_tridecemlineatusENSSTOP0000002014992.978287.8935
ENSG00000196396homo_sapiensENSP0000036068386.666778.8506ictidomys_tridecemlineatusENSSTOP0000001881587.06779.2148
ENSG00000196396homo_sapiensENSP0000036068391.724186.6667otolemur_garnettiiENSOGAP0000000490496.844791.5049
ENSG00000196396homo_sapiensENSP0000036068361.609259.3103cebus_imitatorENSCCAP0000001139296.402992.8058
ENSG00000196396homo_sapiensENSP0000036068370.114965.2874urocitellus_parryiiENSUPAP0001001251089.442883.2845
ENSG00000196396homo_sapiensENSP0000036068393.103488.046urocitellus_parryiiENSUPAP0001000040582.991878.4836
ENSG00000196396homo_sapiensENSP0000036068393.333388.046moschus_moschiferusENSMMSP0000000055294.638789.2774
ENSG00000196396homo_sapiensENSP0000036068397.701195.6322rhinopithecus_roxellanaENSRROP0000003773791.397989.4624
ENSG00000196396homo_sapiensENSP0000036068390.344882.5287mus_pahariMGP_PahariEiJ_P006732790.972283.1019
ENSG00000196396homo_sapiensENSP0000036068396.09292.1839propithecus_coquereliENSPCOP0000000908696.09292.1839
ENSG00000196396homo_sapiensENSP0000036068351.494338.8506eptatretus_burgeriENSEBUP0000001400755.172441.6256
ENSG00000196396homo_sapiensENSP0000036068379.080568.7356callorhinchus_miliiENSCMIP0000003192373.978564.3011
ENSG00000196396homo_sapiensENSP0000036068384.137975.8621latimeria_chalumnaeENSLACP0000000442883.371375.1708
ENSG00000196396homo_sapiensENSP0000036068377.701167.3563lepisosteus_oculatusENSLOCP0000000268176.470666.2896
ENSG00000196396homo_sapiensENSP0000036068371.95462.9885clupea_harengusENSCHAP0000005596371.136462.2727
ENSG00000196396homo_sapiensENSP0000036068357.701151.0345danio_rerioENSDARP0000006269271.714363.4286
ENSG00000196396homo_sapiensENSP0000036068373.793162.9885carassius_auratusENSCARP0000011737067.43757.563
ENSG00000196396homo_sapiensENSP0000036068374.482863.6782carassius_auratusENSCARP0000003185367.557.7083
ENSG00000196396homo_sapiensENSP0000036068374.712663.6782carassius_auratusENSCARP0000002801576.112464.8712
ENSG00000196396homo_sapiensENSP0000036068369.195460.6897astyanax_mexicanusENSAMXP0000005176337.06932.5123
ENSG00000196396homo_sapiensENSP0000036068374.482863.908ictalurus_punctatusENSIPUP0000000813073.804163.3257
ENSG00000196396homo_sapiensENSP0000036068374.252963.2184esox_luciusENSELUP0000004251070.217459.7826
ENSG00000196396homo_sapiensENSP0000036068372.413863.2184electrophorus_electricusENSEEEP0000000413472.247763.0734
ENSG00000196396homo_sapiensENSP0000036068373.563263.2184oncorhynchus_kisutchENSOKIP0000503197371.748961.6592
ENSG00000196396homo_sapiensENSP0000036068372.413863.4483oncorhynchus_kisutchENSOKIP0000508260571.75462.8702
ENSG00000196396homo_sapiensENSP0000036068373.103462.7586oncorhynchus_mykissENSOMYP0000010727367.088657.5949
ENSG00000196396homo_sapiensENSP0000036068373.103463.908oncorhynchus_mykissENSOMYP0000001154272.108863.0385
ENSG00000196396homo_sapiensENSP0000036068373.563263.2184salmo_salarENSSSAP0000014618672.072161.9369
ENSG00000196396homo_sapiensENSP0000036068373.333364.1379salmo_salarENSSSAP0000003942772.335663.2653
ENSG00000196396homo_sapiensENSP0000036068373.333362.9885salmo_truttaENSSTUP0000002470471.205461.1607
ENSG00000196396homo_sapiensENSP0000036068371.034561.3793salmo_truttaENSSTUP0000002267769.594660.1351
ENSG00000196396homo_sapiensENSP0000036068369.195458.8506gadus_morhuaENSGMOP0000002101569.837659.3968
ENSG00000196396homo_sapiensENSP0000036068374.252962.9885fundulus_heteroclitusENSFHEP0000000469373.91362.7002
ENSG00000196396homo_sapiensENSP0000036068374.252962.9885poecilia_reticulataENSPREP0000000169174.768563.4259
ENSG00000196396homo_sapiensENSP0000036068373.793162.2989xiphophorus_maculatusENSXMAP0000001158176.066464.218
ENSG00000196396homo_sapiensENSP0000036068373.793164.1379oryzias_latipesENSORLP0000001883674.305664.5833
ENSG00000196396homo_sapiensENSP0000036068373.563263.2184cyclopterus_lumpusENSCLMP0000500577473.563263.2184
ENSG00000196396homo_sapiensENSP0000036068372.873662.9885oreochromis_niloticusENSONIP0000002112074.764264.6226
ENSG00000196396homo_sapiensENSP0000036068362.758653.1034haplochromis_burtoniENSHBUP0000002851570.725459.8446
ENSG00000196396homo_sapiensENSP0000036068375.402364.1379sparus_aurataENSSAUP0001000983275.402364.1379
ENSG00000196396homo_sapiensENSP0000036068375.402364.8276lates_calcariferENSLCAP0001003529175.402364.8276
ENSG00000196396homo_sapiensENSP0000036068382.298972.1839xenopus_tropicalisENSXETP0000007725082.67972.5173
ENSG00000196396homo_sapiensENSP0000036068386.896679.7701chrysemys_picta_belliiENSCPBP0000002173581.641574.946
ENSG00000196396homo_sapiensENSP0000036068385.057577.2414sphenodon_punctatusENSSPUP0000002359685.057577.2414
ENSG00000196396homo_sapiensENSP0000036068385.057579.0805crocodylus_porosusENSCPRP0000500646179.913674.2981
ENSG00000196396homo_sapiensENSP0000036068357.011550.5747laticauda_laticaudataENSLLTP0000002187077.74368.9655
ENSG00000196396homo_sapiensENSP0000036068381.839173.5632notechis_scutatusENSNSUP0000001960782.983774.5921
ENSG00000196396homo_sapiensENSP0000036068382.06973.7931pseudonaja_textilisENSPTXP0000000301283.216874.8252
ENSG00000196396homo_sapiensENSP0000036068382.758675.1724anas_platyrhynchos_platyrhynchosENSAPLP0000000822382.568875
ENSG00000196396homo_sapiensENSP0000036068385.747177.931gallus_gallusENSGALP0001002039177.225770.1863
ENSG00000196396homo_sapiensENSP0000036068382.298975.4023meleagris_gallopavoENSMGAP0000003401069.649863.8132
ENSG00000196396homo_sapiensENSP0000036068378.850673.3333serinus_canariaENSSCAP0000002165184.275278.3784
ENSG00000196396homo_sapiensENSP0000036068382.06974.7126parus_majorENSPMJP0000001188681.321274.0319
ENSG00000196396homo_sapiensENSP0000036068368.275961.1494anolis_carolinensisENSACAP0000000370782.960974.3017
ENSG00000196396homo_sapiensENSP0000036068372.873662.7586neolamprologus_brichardiENSNBRP0000000933474.764264.3868
ENSG00000196396homo_sapiensENSP0000036068381.839173.7931naja_najaENSNNAP0000000649182.983774.8252
ENSG00000196396homo_sapiensENSP0000036068384.137977.2414podarcis_muralisENSPMRP0000001580456.13551.5337
ENSG00000196396homo_sapiensENSP000003606838074.7126geospiza_fortisENSGFOP0000000239483.855478.3133
ENSG00000196396homo_sapiensENSP0000036068385.057577.931taeniopygia_guttataENSTGUP0000000896185.648178.4722
ENSG00000196396homo_sapiensENSP0000036068385.057577.931taeniopygia_guttataENSTGUP0000001425985.648178.4722
ENSG00000196396homo_sapiensENSP0000036068374.482863.2184erpetoichthys_calabaricusENSECRP0000001710574.141962.9291
ENSG00000196396homo_sapiensENSP0000036068374.942564.1379kryptolebias_marmoratusENSKMAP0000002430274.942564.1379
ENSG00000196396homo_sapiensENSP0000036068381.839174.9425salvator_merianaeENSSMRP0000000750684.160877.0686
ENSG00000196396homo_sapiensENSP0000036068371.724162.069oryzias_javanicusENSOJAP000000002737867.5
ENSG00000196396homo_sapiensENSP0000036068367.586258.6207amphilophus_citrinellusENSACIP0000001608672.952963.2754
ENSG00000196396homo_sapiensENSP0000036068373.333363.4483dicentrarchus_labraxENSDLAP0000504513975.058864.9412
ENSG00000196396homo_sapiensENSP0000036068374.252964.3678amphiprion_perculaENSAPEP0000003163674.082664.2202
ENSG00000196396homo_sapiensENSP0000036068373.563264.3678oryzias_sinensisENSOSIP0000004783775.471766.0377
ENSG00000196396homo_sapiensENSP0000036068370.114964.8276pelodiscus_sinensisENSPSIP0000001859284.958278.5515
ENSG00000196396homo_sapiensENSP0000036068386.436879.7701gopherus_evgoodeiENSGEVP0000500701480.686774.4635
ENSG00000196396homo_sapiensENSP0000036068386.436879.5402chelonoidis_abingdoniiENSCABP0000002273281.385374.8918
ENSG00000196396homo_sapiensENSP0000036068374.482863.908seriola_dumeriliENSSDUP0000000196974.141963.6156
ENSG00000196396homo_sapiensENSP0000036068382.06975.6322struthio_camelus_australisENSSCUP0000002451174.842868.9727
ENSG00000196396homo_sapiensENSP0000036068385.97777.931anser_brachyrhynchusENSABRP0000002522285.97777.931
ENSG00000196396homo_sapiensENSP0000036068369.425360gasterosteus_aculeatusENSGACP0000001564669.907460.4167
ENSG00000196396homo_sapiensENSP0000036068353.793147.5862cynoglossus_semilaevisENSCSEP0000003358171.779163.4969
ENSG00000196396homo_sapiensENSP0000036068374.252963.6782poecilia_formosaENSPFOP0000000741374.94264.2691
ENSG00000196396homo_sapiensENSP0000036068374.482864.5977myripristis_murdjanENSMMDP0000502452674.826864.8961
ENSG00000196396homo_sapiensENSP0000036068374.482864.3678sander_luciopercaENSSLUP0000004027575.878265.5738
ENSG00000196396homo_sapiensENSP0000036068385.97778.8506strigops_habroptilaENSSHBP0000500786385.97778.8506
ENSG00000196396homo_sapiensENSP0000036068374.02364.1379amphiprion_ocellarisENSAOCP0000001668073.853263.9908
ENSG00000196396homo_sapiensENSP0000036068386.896679.7701terrapene_carolina_triunguisENSTMTP0000000259981.641574.946
ENSG00000196396homo_sapiensENSP0000036068373.333364.1379hucho_huchoENSHHUP0000005012572.335663.2653
ENSG00000196396homo_sapiensENSP0000036068373.563262.9885hucho_huchoENSHHUP0000001538972.562462.1315
ENSG00000196396homo_sapiensENSP0000036068373.563264.5977betta_splendensENSBSLP0000005157872.727363.8636
ENSG00000196396homo_sapiensENSP0000036068373.333364.3678pygocentrus_nattereriENSPNAP0000003125167.016858.8235
ENSG00000196396homo_sapiensENSP0000036068373.563264.5977anabas_testudineusENSATEP0000003488373.563264.5977
ENSG00000196396homo_sapiensENSP0000036068374.482863.908seriola_lalandi_dorsalisENSSLDP0000001702374.141963.6156
ENSG00000196396homo_sapiensENSP0000036068371.494361.6092labrus_bergyltaENSLBEP0000001971867.31658.0087
ENSG00000196396homo_sapiensENSP0000036068372.873662.5287pundamilia_nyerereiENSPNYP0000001740374.764264.1509
ENSG00000196396homo_sapiensENSP0000036068373.793163.2184mastacembelus_armatusENSMAMP0000000164772.460562.0767
ENSG00000196396homo_sapiensENSP0000036068374.02363.4483stegastes_partitusENSSPAP0000001867573.51663.0137
ENSG00000196396homo_sapiensENSP0000036068373.333363.2184oncorhynchus_tshawytschaENSOTSP0000502261471.524761.6592
ENSG00000196396homo_sapiensENSP0000036068372.643763.4483oncorhynchus_tshawytschaENSOTSP0000505204671.981862.8702
ENSG00000196396homo_sapiensENSP0000036068374.02363.6782acanthochromis_polyacanthusENSAPOP0000000237074.193663.8249
ENSG00000196396homo_sapiensENSP0000036068386.206978.3908aquila_chrysaetos_chrysaetosENSACCP0002001371979.787272.5532
ENSG00000196396homo_sapiensENSP0000036068372.183962.9885nothobranchius_furzeriENSNFUP0001503223068.112859.436
ENSG00000196396homo_sapiensENSP0000036068373.793163.4483cyprinodon_variegatusENSCVAP0000003158273.963163.5945
ENSG00000196396homo_sapiensENSP0000036068373.793164.1379denticeps_clupeoidesENSDCDP0000004560765.778757.1721
ENSG00000196396homo_sapiensENSP0000036068375.172463.908larimichthys_croceaENSLCRP0000500681474.487563.3257
ENSG00000196396homo_sapiensENSP0000036068373.793164.8276takifugu_rubripesENSTRUP0000005283972.954564.0909
ENSG00000196396homo_sapiensENSP0000036068381.609274.4828ficedula_albicollisENSFALP0000003000382.558175.3488
ENSG00000196396homo_sapiensENSP0000036068367.816156.7816hippocampus_comesENSHCOP0000002240272.660160.8374
ENSG00000196396homo_sapiensENSP0000036068373.103462.5287cyprinus_carpio_carpioENSCCRP0000001805569.736859.6491
ENSG00000196396homo_sapiensENSP0000036068374.942563.908cyprinus_carpio_carpioENSCCRP0000012698367.916757.9167
ENSG00000196396homo_sapiensENSP0000036068385.517277.931coturnix_japonicaENSCJPP0000500809880.519573.3766
ENSG00000196396homo_sapiensENSP0000036068374.252963.4483poecilia_latipinnaENSPLAP0000002180074.94264.0371
ENSG00000196396homo_sapiensENSP0000036068374.482863.6782sinocyclocheilus_grahamiENSSGRP0000009632774.826863.9723
ENSG00000196396homo_sapiensENSP0000036068374.482864.1379sinocyclocheilus_grahamiENSSGRP0000002311174.654464.2857
ENSG00000196396homo_sapiensENSP0000036068372.873662.7586maylandia_zebraENSMZEP0000503537474.764264.3868
ENSG00000196396homo_sapiensENSP0000036068372.643762.2989tetraodon_nigroviridisENSTNIP0000001544573.488463.0233
ENSG00000196396homo_sapiensENSP0000036068372.413861.1494paramormyrops_kingsleyaeENSPKIP0000001803870.155959.2428
ENSG00000196396homo_sapiensENSP0000036068370.574759.0805paramormyrops_kingsleyaeENSPKIP0000002313473.269761.3365
ENSG00000196396homo_sapiensENSP0000036068371.724160.2299scleropages_formosusENSSFOP000150030536554.5833
ENSG00000196396homo_sapiensENSP0000036068373.793163.4483scleropages_formosusENSSFOP0001503318071.812161.745
ENSG00000196396homo_sapiensENSP0000036068379.310370.5747leptobrachium_leishanenseENSLLEP0000004626077.528168.9888
ENSG00000196396homo_sapiensENSP0000036068372.413861.1494scophthalmus_maximusENSSMAP0000006915246.255539.0602
ENSG00000196396homo_sapiensENSP0000036068373.563264.1379oryzias_melastigmaENSOMEP0000000178174.941565.3396

Gene Ontology

Go ID Go term No. evidence Entries Species Category
GO:0003723enables RNA binding1HDAHomo_sapiens(9606)Function
GO:0004725enables protein tyrosine phosphatase activity2IDA,TASHomo_sapiens(9606)Function
GO:0004726enables non-membrane spanning protein tyrosine phosphatase activity1IBAHomo_sapiens(9606)Function
GO:0005158enables insulin receptor binding1IEAHomo_sapiens(9606)Function
GO:0005515enables protein binding1IPIHomo_sapiens(9606)Function
GO:0005737is_active_in cytoplasm2IBA,ISSHomo_sapiens(9606)Component
GO:0005759located_in mitochondrial matrix1IEAHomo_sapiens(9606)Component
GO:0005769is_active_in early endosome3IBA,IDA,ISSHomo_sapiens(9606)Component
GO:0005783is_active_in endoplasmic reticulum2IBA,IDAHomo_sapiens(9606)Component
GO:0005829located_in cytosol1TASHomo_sapiens(9606)Component
GO:0005886colocalizes_with plasma membrane1IDAHomo_sapiens(9606)Component
GO:0006470involved_in protein dephosphorylation1IMPHomo_sapiens(9606)Process
GO:0008270enables zinc ion binding1IDAHomo_sapiens(9606)Function
GO:0008286involved_in insulin receptor signaling pathway1IEAHomo_sapiens(9606)Process
GO:0009966involved_in regulation of signal transduction1IMPHomo_sapiens(9606)Process
GO:0009968involved_in negative regulation of signal transduction1TASHomo_sapiens(9606)Process
GO:0019899enables enzyme binding1IPIHomo_sapiens(9606)Function
GO:0019901enables protein kinase binding2IBA,IPIHomo_sapiens(9606)Function
GO:0030036involved_in actin cytoskeleton organization1IMPHomo_sapiens(9606)Process
GO:0030061located_in mitochondrial crista1IEAHomo_sapiens(9606)Component
GO:0030100involved_in regulation of endocytosis1IDAHomo_sapiens(9606)Process
GO:0030948involved_in negative regulation of vascular endothelial growth factor receptor signaling pathway1ISSHomo_sapiens(9606)Process
GO:0030968involved_in endoplasmic reticulum unfolded protein response1IDAHomo_sapiens(9606)Process
GO:0030971enables receptor tyrosine kinase binding1IPIHomo_sapiens(9606)Function
GO:0031904located_in endosome lumen1IEAHomo_sapiens(9606)Component
GO:0032991part_of protein-containing complex1IDAHomo_sapiens(9606)Component
GO:0033157involved_in regulation of intracellular protein transport1IMPHomo_sapiens(9606)Process
GO:0034620involved_in cellular response to unfolded protein1TASHomo_sapiens(9606)Process
GO:0035335involved_in peptidyl-tyrosine dephosphorylation3IBA,IDA,IMPHomo_sapiens(9606)Process
GO:0035791involved_in platelet-derived growth factor receptor-beta signaling pathway1IMPHomo_sapiens(9606)Process
GO:0036498involved_in IRE1-mediated unfolded protein response1ISSHomo_sapiens(9606)Process
GO:0038020involved_in insulin receptor recycling1IEAHomo_sapiens(9606)Process
GO:0043407involved_in negative regulation of MAP kinase activity1IMPHomo_sapiens(9606)Process
GO:0043507acts_upstream_of positive regulation of JUN kinase activity1ISSHomo_sapiens(9606)Process
GO:0045296enables cadherin binding1HDAHomo_sapiens(9606)Function
GO:0046627involved_in negative regulation of insulin receptor signaling pathway1NASHomo_sapiens(9606)Process
GO:0046875enables ephrin receptor binding1IPIHomo_sapiens(9606)Function
GO:0051721enables protein phosphatase 2A binding1IEAHomo_sapiens(9606)Function
GO:0060338involved_in regulation of type I interferon-mediated signaling pathway1TASHomo_sapiens(9606)Process
GO:0060397involved_in growth hormone receptor signaling pathway via JAK-STAT1TASHomo_sapiens(9606)Process
GO:0061098involved_in positive regulation of protein tyrosine kinase activity1IDAHomo_sapiens(9606)Process
GO:0070373involved_in negative regulation of ERK1 and ERK2 cascade2IBA,ISSHomo_sapiens(9606)Process
GO:0097443located_in sorting endosome1ISSHomo_sapiens(9606)Component
GO:0098554located_in cytoplasmic side of endoplasmic reticulum membrane1IDAHomo_sapiens(9606)Component
GO:1902202involved_in regulation of hepatocyte growth factor receptor signaling pathway1IMPHomo_sapiens(9606)Process
GO:1902236involved_in negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway1ISSHomo_sapiens(9606)Process
GO:1903896involved_in positive regulation of IRE1-mediated unfolded protein response1TASHomo_sapiens(9606)Process
GO:1903898involved_in negative regulation of PERK-mediated unfolded protein response2IBA,IDAHomo_sapiens(9606)Process
GO:1990264involved_in peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity1ISSHomo_sapiens(9606)Process
GO:2000646involved_in positive regulation of receptor catabolic process1IMPHomo_sapiens(9606)Process

Expression