Ensembl ID ENSG00000196396 Gene ID 5770 Accession 9642
Gene Symbol PTPN1 Alias PTP1B Full Name protein tyrosine phosphatase non-receptor type 1
Position 20 : 50510321 - 50585241 Length 74921 bases Strand Plus strand
Status Confidence Main interacting RNAsN.A.RBP type Non-canonical_RBPs
Summary The protein encoded by this gene is the founding member of the protein tyrosine phosphatase (PTP) family, which was isolated and identified based on its enzymatic activity and amino acid sequence. PTPs catalyze the hydrolysis of the phosphate monoesters specifically on tyrosine residues. Members of the PTP family share a highly conserved catalytic motif, which is essential for the catalytic activity. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP has been shown to act as a negative regulator of insulin signaling by dephosphorylating the phosphotryosine residues of insulin receptor kinase. This PTP was also reported to dephosphorylate epidermal growth factor receptor kinase, as well as JAK2 and TYK2 kinases, which implicated the role of this PTP in cell growth control, and cell response to interferon stimulation. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2013]

ENSG00000196396 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000196396 PTPN1 0.50 2.20e-12 KIRC
ENSG00000196396 PTPN1 0.90 1.55e-25 BRCA
ENSG00000196396 PTPN1 -0.7 7.38e-29 LUSC
ENSG00000196396 PTPN1 0.91 2.34e-15 KIRP
ENSG00000196396 PTPN1 -1.0 2.03e-43 LUAD
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000196396 PTPN1 tumor 10023672
ENSG00000196396 PTPN1 tumors 10815905
ENSG00000196396 PTPN1 cancer 10816386
ENSG00000196396 PTPN1 breast cancer 11007774
ENSG00000196396 PTPN1 cancer 12028501
ENSG00000196396 PTPN1 tumors 12417041
ENSG00000196396 PTPN1 cancer 12554649
ENSG00000196396 PTPN1 tumors 12883693
ENSG00000196396 PTPN1 stomach cancer 12907755
ENSG00000196396 PTPN1 tumor 14766979
ENSG00000196396 PTPN1 tumors 15044856
ENSG00000196396 PTPN1 gastric cancer 15701848
ENSG00000196396 PTPN1 ovarian cancers 15880741
ENSG00000196396 PTPN1 cancer 16198645
ENSG00000196396 PTPN1 cancer 16209522
ENSG00000196396 PTPN1 tumors 16267035
ENSG00000196396 PTPN1 prostate cancer 16652382
ENSG00000196396 PTPN1 cancer 16919785
ENSG00000196396 PTPN1 Cancer 17035054
ENSG00000196396 PTPN1 cancer 17039461
ENSG00000196396 PTPN1 tumors 17143621
ENSG00000196396 PTPN1 breast cancer 17259984
ENSG00000196396 PTPN1 cancer 17279797
ENSG00000196396 PTPN1 breast cancer 17347513
ENSG00000196396 PTPN1 breast cancer 17349579
ENSG00000196396 PTPN1 cancer 17563729
ENSG00000196396 PTPN1 colon cancer 17974954
ENSG00000196396 PTPN1 cancer 18067579
ENSG00000196396 PTPN1 breast cancer 18183590
ENSG00000196396 PTPN1 cancer 18236007
ENSG00000196396 PTPN1 tumor 18259840
ENSG00000196396 PTPN1 breast cancer 18317580
ENSG00000196396 PTPN1 breast cancer 18332219
ENSG00000196396 PTPN1 cancer 18387954
ENSG00000196396 PTPN1 cancer 19012396
ENSG00000196396 PTPN1 cancer 19091943
ENSG00000196396 PTPN1 cancer 19288492
ENSG00000196396 PTPN1 tumor 19370169
ENSG00000196396 PTPN1 HNSCC 19430297
ENSG00000196396 PTPN1 breast cancer 19435911
ENSG00000196396 PTPN1 tumor 19609293
ENSG00000196396 PTPN1 tumors 19635455
ENSG00000196396 PTPN1 cancer 19782770
ENSG00000196396 PTPN1 breast cancer 19836230
ENSG00000196396 PTPN1 tumor 19936768
ENSG00000196396 PTPN1 cancer 20000419
ENSG00000196396 PTPN1 cancer 20011591
ENSG00000196396 PTPN1 breast cancer 20059965
ENSG00000196396 PTPN1 breast cancer 20381358
ENSG00000196396 PTPN1 gastric cancer 20388125
ENSG00000196396 PTPN1 tumor 20428235
ENSG00000196396 PTPN1 tumor 20504764
ENSG00000196396 PTPN1 breast cancer 20572251
ENSG00000196396 PTPN1 tumor 20707194
ENSG00000196396 PTPN1 tumors 20842227
ENSG00000196396 PTPN1 breast cancer 20952588
ENSG00000196396 PTPN1 tumor 21119599
ENSG00000196396 PTPN1 tumor 21135139
ENSG00000196396 PTPN1 cancer 21426149
ENSG00000196396 PTPN1 gastric cancer 21442314
ENSG00000196396 PTPN1 breast cancer 21630024
ENSG00000196396 PTPN1 tumor 21849469
ENSG00000196396 PTPN1 cancer 22133022
ENSG00000196396 PTPN1 cancer 22203966
ENSG00000196396 PTPN1 prostate cancer 22282656
ENSG00000196396 PTPN1 cancer 22308688
ENSG00000196396 PTPN1 tumor 22450318
ENSG00000196396 PTPN1 cancer 22477519
ENSG00000196396 PTPN1 ovarian cancer 22582758
ENSG00000196396 PTPN1 cancer 22741586
ENSG00000196396 PTPN1 tumor 22789536
ENSG00000196396 PTPN1 colon tumor 22822354
ENSG00000196396 PTPN1 breast cancer 22962253
ENSG00000196396 PTPN1 tumor 22962263
ENSG00000196396 PTPN1 breast cancer 23022281
ENSG00000196396 PTPN1 breast cancer 23036105
ENSG00000196396 PTPN1 cancer 23085163
ENSG00000196396 PTPN1 cancer 23121648
ENSG00000196396 PTPN1 cancer 23126191
ENSG00000196396 PTPN1 cancer 23139594
ENSG00000196396 PTPN1 breast cancer 23242616
ENSG00000196396 PTPN1 cancer 23274914
ENSG00000196396 PTPN1 Breast Cancer 23275709
ENSG00000196396 PTPN1 colorectal cancer 23280316
ENSG00000196396 PTPN1 tumour 23348582
ENSG00000196396 PTPN1 breast cancer 23358729
ENSG00000196396 PTPN1 tumors 23580575
ENSG00000196396 PTPN1 tumor 23814025
ENSG00000196396 PTPN1 ovarian cancer 23814047
ENSG00000196396 PTPN1 cancer 23879520
ENSG00000196396 PTPN1 colorectal cancer 23990346
ENSG00000196396 PTPN1 cancer 23994026
ENSG00000196396 PTPN1 cancer 24047800
ENSG00000196396 PTPN1 Pancreatic cancer 24123012
ENSG00000196396 PTPN1 cancer 24366088
ENSG00000196396 PTPN1 cancer 24387659
ENSG00000196396 PTPN1 cancer 24391355
ENSG00000196396 PTPN1 non-small-cell lung cancer 24417921
ENSG00000196396 PTPN1 colon cancer 24465712
ENSG00000196396 PTPN1 lymphoid cancers 24706663
ENSG00000196396 PTPN1 tumor 24715221
ENSG00000196396 PTPN1 cancer 24719298
ENSG00000196396 PTPN1 tumor 24809452
ENSG00000196396 PTPN1 breast cancer 24815008
ENSG00000196396 PTPN1 tumor 24845231
ENSG00000196396 PTPN1 breast cancer 24913037
ENSG00000196396 PTPN1 tumour 25130259
ENSG00000196396 PTPN1 cancer 25137153
ENSG00000196396 PTPN1 breast cancer 25220640
ENSG00000196396 PTPN1 tumor 25263441
ENSG00000196396 PTPN1 cancer 25364621
ENSG00000196396 PTPN1 gastric cancer 25590580
ENSG00000196396 PTPN1 non-small cell lung cancer 25617799
ENSG00000196396 PTPN1 cancer 25805211
ENSG00000196396 PTPN1 cancers 25894283
ENSG00000196396 PTPN1 cancer 26075871
ENSG00000196396 PTPN1 cancer 26091075
ENSG00000196396 PTPN1 tumor 26260902
ENSG00000196396 PTPN1 tumor 26337385
ENSG00000196396 PTPN1 breast cancer 26388336
ENSG00000196396 PTPN1 cancer 26396684
ENSG00000196396 PTPN1 cancer 26461422
ENSG00000196396 PTPN1 DLBCL 26654227
ENSG00000196396 PTPN1 cancer 26711144
ENSG00000196396 PTPN1 tumor 26755347
ENSG00000196396 PTPN1 tumor 26840794
ENSG00000196396 PTPN1 cancer 26841168
ENSG00000196396 PTPN1 ovarian cancer 26861122
ENSG00000196396 PTPN1 cancers 26865097
ENSG00000196396 PTPN1 colorectal cancer 26942883
ENSG00000196396 PTPN1 tumor 27013923
ENSG00000196396 PTPN1 Prostate Cancers 27020859
ENSG00000196396 PTPN1 colon cancer 27095436
ENSG00000196396 PTPN1 tumor 27308433
ENSG00000196396 PTPN1 tumour 27323329
ENSG00000196396 PTPN1 breast cancer 27465552
ENSG00000196396 PTPN1 breast cancer 27548130
ENSG00000196396 PTPN1 DLBCL 27600067
ENSG00000196396 PTPN1 tumor 27752061
ENSG00000196396 PTPN1 tumor 27824079
ENSG00000196396 PTPN1 Breast Cancer 27840578
ENSG00000196396 PTPN1 Thyroid Tumors 27855221
ENSG00000196396 PTPN1 cancer 27890939
ENSG00000196396 PTPN1 tumor 28038441
ENSG00000196396 PTPN1 tumor 28082443
ENSG00000196396 PTPN1 cancer 28140583
ENSG00000196396 PTPN1 cancer 28212750
ENSG00000196396 PTPN1 cancer 28318895
ENSG00000196396 PTPN1 breast cancer 28378571
ENSG00000196396 PTPN1 cancer 28492548
ENSG00000196396 PTPN1 Breast Cancer 28551626
ENSG00000196396 PTPN1 cancer 28569147
ENSG00000196396 PTPN1 cancers 28656243
ENSG00000196396 PTPN1 breast cancer 28662582
ENSG00000196396 PTPN1 tumor 28680757
ENSG00000196396 PTPN1 tumor 28807715
ENSG00000196396 PTPN1 cancer 28834433
ENSG00000196396 PTPN1 Breast Cancer 28870898
ENSG00000196396 PTPN1 breast cancer 28933366
ENSG00000196396 PTPN1 tumor 28994534
ENSG00000196396 PTPN1 tumor 29122767
ENSG00000196396 PTPN1 cancer 29186763
ENSG00000196396 PTPN1 cancer 29196128
ENSG00000196396 PTPN1 cancer 29216799
ENSG00000196396 PTPN1 cancers 29235148
ENSG00000196396 PTPN1 cancer 29257069
ENSG00000196396 PTPN1 tumor 29385181
ENSG00000196396 PTPN1 cancer 29441120
ENSG00000196396 PTPN1 cancer 29525218
ENSG00000196396 PTPN1 cancer 29533213
ENSG00000196396 PTPN1 tumor 29558404
ENSG00000196396 PTPN1 cancer 29608303
ENSG00000196396 PTPN1 tumor 29652789
ENSG00000196396 PTPN1 cancer 29705509
ENSG00000196396 PTPN1 tumor 29743567
ENSG00000196396 PTPN1 colon cancer 29743988
ENSG00000196396 PTPN1 ovarian cancer 29920310
ENSG00000196396 PTPN1 ovarian cancer 29928877
ENSG00000196396 PTPN1 benign tumors 30001383
ENSG00000196396 PTPN1 cancer 30160205
ENSG00000196396 PTPN1 tumour 30223019
ENSG00000196396 PTPN1 breast cancer 30247891
ENSG00000196396 PTPN1 breast cancer 30258080
ENSG00000196396 PTPN1 breast cancer 30360441
ENSG00000196396 PTPN1 breast cancer 30548198
ENSG00000196396 PTPN1 breast cancers 30558204
ENSG00000196396 PTPN1 breast cancer 30584278
ENSG00000196396 PTPN1 cancer 30704618
ENSG00000196396 PTPN1 cancer 30711953
ENSG00000196396 PTPN1 breast cancer 30805963
ENSG00000196396 PTPN1 cancer 31041978
ENSG00000196396 PTPN1 tumor 31048362
ENSG00000196396 PTPN1 cancer 31173266
ENSG00000196396 PTPN1 cancer 31261776
ENSG00000196396 PTPN1 lung cancer 31262859
ENSG00000196396 PTPN1 DLBCL 31331250
ENSG00000196396 PTPN1 cancer, liver 31339082
ENSG00000196396 PTPN1 breast cancer 31419504
ENSG00000196396 PTPN1 cancer 31438997
ENSG00000196396 PTPN1 Gastric Cancer 31441000
ENSG00000196396 PTPN1 Cancer 31446553
ENSG00000196396 PTPN1 Cancer 31484460
ENSG00000196396 PTPN1 cancer 31491569
ENSG00000196396 PTPN1 cancer 31494471
ENSG00000196396 PTPN1 tumor 31527306
ENSG00000196396 PTPN1 Breast Cancer 31652764
ENSG00000196396 PTPN1 tumor 31695578
ENSG00000196396 PTPN1 pancreatic cancer 31745071
ENSG00000196396 PTPN1 tumor 31803360
ENSG00000196396 PTPN1 cancer 31808495
ENSG00000196396 PTPN1 tumor 31837707
ENSG00000196396 PTPN1 breast cancer 31960729
ENSG00000196396 PTPN1 breast cancer 7905928
ENSG00000196396 PTPN1 tumor 7949181
ENSG00000196396 PTPN1 tumors 8097963
ENSG00000196396 PTPN1 tumors 8166206
ENSG00000196396 PTPN1 ovarian cancer 8626139
ENSG00000196396 PTPN1 tumors 8640675
ENSG00000196396 PTPN1 tumors 8758909
ENSG00000196396 PTPN1 tumors 9404849
ENSG00000196396 PTPN1 tumors 9826659
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000196396 PTPN1 MESO 0.0075 high
ENSG00000196396 PTPN1 SARC 0.023 high
ENSG00000196396 PTPN1 UCEC 0.0068 high
ENSG00000196396 PTPN1 THCA 0.0064 high
ENSG00000196396 PTPN1 LUSC 0.015 high
ENSG00000196396 PTPN1 HNSC 0.038 high
ENSG00000196396 PTPN1 THYM 0.0031 high
ENSG00000196396 PTPN1 ESCA 0.033 low
ENSG00000196396 PTPN1 OV 0.006 high
ENSG00000196396 PTPN1 KIRC 0.00024 high
ENSG00000196396 PTPN1 TGCT 0.0036 low
ENSG00000196396 PTPN1 BLCA 0.022 high
ENSG00000196396 PTPN1 SKCM 0.0057 low
ENSG00000196396 PTPN1 CESC 0.05 low
ENSG00000196396 PTPN1 LIHC 0.0047 high
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000196396 PTPN1 LAML Del 0.831320 0.032876 0.745788 0.020942
ENSG00000196396 PTPN1 LUAD Amp 0.609174 0.113938 0.431748 0.432171
ENSG00000196396 PTPN1 READ Amp 1.357261 0.158982 1.295250 0.890909
ENSG00000196396 PTPN1 COAD Amp 5.362373 0.146421 1.198023 0.725055
ENSG00000196396 PTPN1 BRCA Amp 15.654363 0.314792 0.684627 0.484259
ENSG00000196396 PTPN1 STAD Amp 4.100836 0.218921 0.724184 0.659864
ENSG00000196396 PTPN1 PRAD Amp 0.696352 0.045379 0.389016 0.079268
ENSG00000196396 PTPN1 UCEC Amp 1.221251 0.116303 0.639862 0.272727
ENSG00000196396 PTPN1 OV Amp 0.928341 0.336745 0.825943 0.652850