Functions and Diseases

RBP Type Canonical_RBPs
Diseases Cancer
Drug N.A.
Main interacting RNAs tRNA
Moonlighting functions N.A.
Localizations N.A.
BulkPerturb-seq N.A.

Description

Ensembl ID ENSG00000183665 Gene ID 55039 Accession 26091
Symbol TRMT12 Alias TYW2;TRM12 Full Name tRNA methyltransferase 12 homolog
Status Confidence Length 2207 bases Strand Plus strand
Position 8 : 124450820 - 124453026 RNA binding domain Met_10
Summary Wybutosine (yW) is a hypermodified guanosine at the 3-prime position adjacent to the anticodon of phenylalanine tRNA that stabilizes codon-anticodon interactions during decoding on the ribosome. TRMT12 is the human homolog of a yeast gene essential for yW synthesis (Noma and Suzuki, 2006).[supplied by OMIM, Mar 2008]

RNA binding domains (RBDs)

Protein Domain Pfam ID E-value Domain number
ENSP00000329858 Met_10 PF02475 1.6e-29 1

RNA binding proteomes (RBPomes)

Pubmed ID Full Name Cell Author Time Doi

Literatures on RNA binding capacity

Pubmed ID Title Author Time Journal

Transcripts

Name Transcript ID bp Protein Translation ID
TRMT12-201 ENST00000328599 2207 448aa ENSP00000329858
TRMT12-202 ENST00000521443 562 No protein -
TRMT12-203 ENST00000522518 822 150aa ENSP00000429771

Pathways

Pathway ID Pathway Name Source

Phenotypes

ensgID Trait pValue Pubmed ID

GWAS

ensgIDSNPChromosomePosition TraitPubmedIDOr or BEAT EFO ID

Protein-Protein Interaction (PPI)

Paralogs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id
ENSG00000183665homo_sapiensENSP0000026124929.273115.3242homo_sapiensENSP0000032985833.258917.4107
ENSG00000183665homo_sapiensENSP0000035990430.88813.8996homo_sapiensENSP0000032985817.85718.03571

Orthologs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id
ENSG00000183665homo_sapiensENSP0000032985899.553698.4375pongo_abeliiENSPPYP0000002116799.553698.4375
ENSG00000183665homo_sapiensENSP0000032985875.223265.1786ornithorhynchus_anatinusENSOANP0000001583276.244366.0633
ENSG00000183665homo_sapiensENSP000003298587565.1786sarcophilus_harrisiiENSSHAP0000000380070.736861.4737
ENSG00000183665homo_sapiensENSP0000032985885.937579.0179erinaceus_europaeusENSEEUP0000000438786.516979.5506
ENSG00000183665homo_sapiensENSP0000032985882.812576.3393echinops_telfairiENSETEP0000000761882.997876.5101
ENSG00000183665homo_sapiensENSP0000032985895.758993.5268callithrix_jacchusENSCJAP0000004083095.758993.5268
ENSG00000183665homo_sapiensENSP0000032985896.87595.9821macaca_fascicularisENSMFAP0000005537897.528196.6292
ENSG00000183665homo_sapiensENSP0000032985896.87595.9821macaca_mulattaENSMMUP0000003194697.528196.6292
ENSG00000183665homo_sapiensENSP0000032985897.098296.4286papio_anubisENSPANP0000004983397.752897.0787
ENSG00000183665homo_sapiensENSP0000032985889.732183.2589vulpes_vulpesENSVVUP0000002294590.134583.6323
ENSG00000183665homo_sapiensENSP0000032985885.491178.3482mus_spretusMGP_SPRETEiJ_P004007285.874478.6996
ENSG00000183665homo_sapiensENSP0000032985887.723283.0357capra_hircusENSCHIP0000001625189.72684.9315
ENSG00000183665homo_sapiensENSP0000032985888.839384.5982loxodonta_africanaENSLAFP0000001046590.660686.3326
ENSG00000183665homo_sapiensENSP0000032985891.294688.1696panthera_leoENSPLOP0000000449980.039177.2994
ENSG00000183665homo_sapiensENSP0000032985890.178685.9375ailuropoda_melanoleucaENSAMEP0000002065792.027387.6993
ENSG00000183665homo_sapiensENSP0000032985888.616183.7054bos_indicus_hybridENSBIXP0000504402785.930781.1688
ENSG00000183665homo_sapiensENSP0000032985878.12572.5446oryctolagus_cuniculusENSOCUP0000001682989.285782.9082
ENSG00000183665homo_sapiensENSP0000032985887.723281.9196cavia_porcellusENSCPOP0000002123088.91483.0317
ENSG00000183665homo_sapiensENSP0000032985888.392983.9286ursus_americanusENSUAMP0000000224090.825786.2385
ENSG00000183665homo_sapiensENSP0000032985875.446465.625monodelphis_domesticaENSMODP0000002673973.960664.3326
ENSG00000183665homo_sapiensENSP0000032985873.660765.625monodelphis_domesticaENSMODP0000001478069.620362.0253
ENSG00000183665homo_sapiensENSP0000032985887.946482.5893bison_bison_bisonENSBBBP0000002471588.143282.774
ENSG00000183665homo_sapiensENSP0000032985886.830480.8036octodon_degusENSODEP0000002564988.610582.4601
ENSG00000183665homo_sapiensENSP0000032985888.392983.7054ovis_aries_rambouilletENSOARP0002001579090.617985.8124
ENSG00000183665homo_sapiensENSP0000032985878.348270.7589ochotona_princepsENSOPRP0000000737678.699671.0762
ENSG00000183665homo_sapiensENSP0000032985885.937579.0179mus_caroliMGP_CAROLIEiJ_P003828186.322979.3722
ENSG00000183665homo_sapiensENSP0000032985885.491178.5714mus_musculusENSMUSP0000004783185.874478.9238
ENSG00000183665homo_sapiensENSP0000032985890.62586.1607mustela_putorius_furoENSMPUP0000001902791.031486.5471
ENSG00000183665homo_sapiensENSP0000032985890.62585.7143vicugna_pacosENSVPAP0000000605091.23686.2921
ENSG00000183665homo_sapiensENSP0000032985897.321496.2054chlorocebus_sabaeusENSCSAP0000001814897.321496.2054
ENSG00000183665homo_sapiensENSP0000032985890.401885.2679phocoena_sinusENSPSNP0000001796092.255187.0159
ENSG00000183665homo_sapiensENSP0000032985879.241174.5536camelus_dromedariusENSCDRP0000500604188.528783.2918
ENSG00000183665homo_sapiensENSP0000032985886.607180.3571rattus_norvegicusENSRNOP0000001187488.787282.3799
ENSG00000183665homo_sapiensENSP0000032985885.937577.2321peromyscus_maniculatus_bairdiiENSPEMP0000003338487.699378.8155
ENSG00000183665homo_sapiensENSP0000032985888.392983.2589bos_mutusENSBMUP0000003271485.714380.7359
ENSG00000183665homo_sapiensENSP0000032985885.267977.6786mus_spicilegusENSMSIP0000001799885.650278.0269
ENSG00000183665homo_sapiensENSP0000032985872.544660.2679cricetulus_griseus_chok1gshdENSCGRP0000101379477.014263.981
ENSG00000183665homo_sapiensENSP0000032985890.178684.5982pteropus_vampyrusENSPVAP0000000862890.786585.1685
ENSG00000183665homo_sapiensENSP0000032985888.169682.5893myotis_lucifugusENSMLUP0000000341789.977284.2825
ENSG00000183665homo_sapiensENSP0000032985875.223266.7411vombatus_ursinusENSVURP0001000493876.244367.6471
ENSG00000183665homo_sapiensENSP0000032985890.62585.9375neovison_visonENSNVIP0000000222392.482987.6993
ENSG00000183665homo_sapiensENSP0000032985888.839383.4821bos_taurusENSBTAP0000002718686.147280.9524
ENSG00000183665homo_sapiensENSP0000032985888.392983.2589heterocephalus_glaber_femaleENSHGLP0000005603190.20584.9658
ENSG00000183665homo_sapiensENSP0000032985889.955485.2679canis_lupus_dingoENSCAFP0002000802991.799587.0159
ENSG00000183665homo_sapiensENSP0000032985890.62586.1607sciurus_vulgarisENSSVLP0000501484892.482987.9271
ENSG00000183665homo_sapiensENSP0000032985876.116166.5179phascolarctos_cinereusENSPCIP0000000361372.245863.1356
ENSG00000183665homo_sapiensENSP0000032985887.053681.4732procavia_capensisENSPCAP0000000050987.443981.8386
ENSG00000183665homo_sapiensENSP0000032985885.937579.4643nannospalax_galiliENSNGAP0000001279087.899581.2785
ENSG00000183665homo_sapiensENSP0000032985888.169683.0357bos_grunniensENSBGRP0000002207082.983278.1513
ENSG00000183665homo_sapiensENSP0000032985889.732184.5982cervus_hanglu_yarkandensisENSCHYP0000003995687.772982.7511
ENSG00000183665homo_sapiensENSP0000032985887.946482.8125catagonus_wagneriENSCWAP0000002286590.993185.6813
ENSG00000183665homo_sapiensENSP0000032985888.839384.375ictidomys_tridecemlineatusENSSTOP0000003156590.249485.7143
ENSG00000183665homo_sapiensENSP0000032985889.955483.2589otolemur_garnettiiENSOGAP0000001419591.799584.9658
ENSG00000183665homo_sapiensENSP0000032985889.062584.8214urocitellus_parryiiENSUPAP0001001104091.513887.156
ENSG00000183665homo_sapiensENSP0000032985889.508984.1518moschus_moschiferusENSMMSP0000002294786.796581.6017
ENSG00000183665homo_sapiensENSP0000032985886.607178.3482mus_pahariMGP_PahariEiJ_P004165486.995578.6996
ENSG00000183665homo_sapiensENSP0000032985840.848225.2232caenorhabditis_elegansF40F9.10.139.782624.5652
ENSG00000183665homo_sapiensENSP0000032985843.973231.0268ciona_intestinalisENSCINP0000003535465.886346.4883
ENSG00000183665homo_sapiensENSP0000032985864.732149.5536callorhinchus_miliiENSCMIP0000000744870.388453.8835
ENSG00000183665homo_sapiensENSP0000032985868.7554.2411latimeria_chalumnaeENSLACP0000001801168.7554.2411
ENSG00000183665homo_sapiensENSP0000032985862.723251.1161lepisosteus_oculatusENSLOCP0000001881068.704255.9902
ENSG00000183665homo_sapiensENSP0000032985862.053647.3214clupea_harengusENSCHAP0000002073166.033350.3563
ENSG00000183665homo_sapiensENSP0000032985859.37545.5357danio_rerioENSDARP0000007934965.196150
ENSG00000183665homo_sapiensENSP0000032985858.482144.6429carassius_auratusENSCARP0000010716265.664250.1253
ENSG00000183665homo_sapiensENSP0000032985863.616148.4375astyanax_mexicanusENSAMXP0000003427967.535551.4218
ENSG00000183665homo_sapiensENSP0000032985859.821446.2054ictalurus_punctatusENSIPUP0000002660260.633546.8326
ENSG00000183665homo_sapiensENSP0000032985857.812544.1964esox_luciusENSELUP0000005222263.170748.2927
ENSG00000183665homo_sapiensENSP0000032985857.142943.75esox_luciusENSELUP0000006450566.493550.9091
ENSG00000183665homo_sapiensENSP0000032985860.714345.9821electrophorus_electricusENSEEEP0000003554664.916549.1647
ENSG00000183665homo_sapiensENSP0000032985842.857133.7054salmo_salarENSSSAP0000008519664.864951.0135
ENSG00000183665homo_sapiensENSP0000032985851.116138.8393fundulus_heteroclitusENSFHEP0000001570862.228347.2826
ENSG00000183665homo_sapiensENSP0000032985856.473243.75poecilia_reticulataENSPREP0000001721163.2549
ENSG00000183665homo_sapiensENSP0000032985858.258944.8661xiphophorus_maculatusENSXMAP0000003757565.087350.1247
ENSG00000183665homo_sapiensENSP0000032985857.812546.2054oryzias_latipesENSORLP0000000157465.40452.2727
ENSG00000183665homo_sapiensENSP0000032985851.339340.625cyclopterus_lumpusENSCLMP0000500637765.340951.7045
ENSG00000183665homo_sapiensENSP0000032985858.258945.7589oreochromis_niloticusENSONIP0000000327463.814250.1222
ENSG00000183665homo_sapiensENSP0000032985858.258945.3125haplochromis_burtoniENSHBUP0000001455165.087350.6234
ENSG00000183665homo_sapiensENSP0000032985858.482145.3125astatotilapia_callipteraENSACLP0000000141365.336750.6234
ENSG00000183665homo_sapiensENSP0000032985858.705445.0893sparus_aurataENSSAUP0001003327264.938349.8765
ENSG00000183665homo_sapiensENSP0000032985841.294631.0268lates_calcariferENSLCAP0001003471261.258346.0265
ENSG00000183665homo_sapiensENSP0000032985867.187552.4554xenopus_tropicalisENSXETP0000002122973.774557.598
ENSG00000183665homo_sapiensENSP000003298587562.2768chrysemys_picta_belliiENSCPBP0000001985473.52361.0503
ENSG00000183665homo_sapiensENSP0000032985872.991159.1518sphenodon_punctatusENSSPUP0000000701272.185458.4989
ENSG00000183665homo_sapiensENSP0000032985871.205459.5982crocodylus_porosusENSCPRP0000501386471.524759.8655
ENSG00000183665homo_sapiensENSP0000032985869.642956.0268laticauda_laticaudataENSLLTP0000001814170.588256.7873
ENSG00000183665homo_sapiensENSP0000032985871.87557.1429notechis_scutatusENSNSUP0000000370871.396956.7627
ENSG00000183665homo_sapiensENSP0000032985871.651856.9196pseudonaja_textilisENSPTXP0000002760271.175256.541
ENSG00000183665homo_sapiensENSP0000032985862.276851.5625gallus_gallusENSGALP0001002340552.74143.6673
ENSG00000183665homo_sapiensENSP0000032985866.517954.6875meleagris_gallopavoENSMGAP0000000395669.463957.1096
ENSG00000183665homo_sapiensENSP0000032985857.589348.4375serinus_canariaENSSCAP0000000418063.861453.7129
ENSG00000183665homo_sapiensENSP0000032985868.080454.0179parus_majorENSPMJP0000000100451.782741.0866
ENSG00000183665homo_sapiensENSP0000032985857.812545.0893neolamprologus_brichardiENSNBRP0000002823465.569651.1392
ENSG00000183665homo_sapiensENSP0000032985870.312556.6964podarcis_muralisENSPMRP0000002962471.106157.3363
ENSG00000183665homo_sapiensENSP0000032985867.633953.3482taeniopygia_guttataENSTGUP0000003545147.867337.7567
ENSG00000183665homo_sapiensENSP0000032985864.732150erpetoichthys_calabaricusENSECRP0000001873266.2151.1416
ENSG00000183665homo_sapiensENSP0000032985858.705445.9821kryptolebias_marmoratusENSKMAP0000000113768.134753.3679
ENSG00000183665homo_sapiensENSP0000032985870.982156.4732salvator_merianaeENSSMRP0000001700872.272757.5
ENSG00000183665homo_sapiensENSP0000032985858.482144.8661oryzias_javanicusENSOJAP0000002843566.497551.0152
ENSG00000183665homo_sapiensENSP0000032985856.696443.75amphilophus_citrinellusENSACIP0000001667267.195851.8519
ENSG00000183665homo_sapiensENSP0000032985858.482145.5357amphiprion_perculaENSAPEP0000000883766.497551.7766
ENSG00000183665homo_sapiensENSP0000032985856.919645.3125oryzias_sinensisENSOSIP0000004613764.885551.6539
ENSG00000183665homo_sapiensENSP0000032985846.205440.4018pelodiscus_sinensisENSPSIP0000000365276.383866.7897
ENSG00000183665homo_sapiensENSP0000032985874.107162.2768gopherus_evgoodeiENSGEVP0000501966174.774862.8378
ENSG00000183665homo_sapiensENSP0000032985858.482146.6518seriola_dumeriliENSSDUP0000000845965.336752.1197
ENSG00000183665homo_sapiensENSP0000032985858.705445.5357cottoperca_gobioENSCGOP0000004096660.73947.1132
ENSG00000183665homo_sapiensENSP0000032985873.883959.5982struthio_camelus_australisENSSCUP0000002223670.726557.0513
ENSG00000183665homo_sapiensENSP0000032985863.392950.8929anser_brachyrhynchusENSABRP0000001322066.355153.271
ENSG00000183665homo_sapiensENSP0000032985856.026845.0893gasterosteus_aculeatusENSGACP0000002292268.021754.7425
ENSG00000183665homo_sapiensENSP0000032985861.607144.6429cynoglossus_semilaevisENSCSEP0000000410464.48646.729
ENSG00000183665homo_sapiensENSP0000032985858.035744.1964poecilia_formosaENSPFOP0000001700964.516149.1315
ENSG00000183665homo_sapiensENSP0000032985860.044647.0982myripristis_murdjanENSMMDP0000504168666.419852.0988
ENSG00000183665homo_sapiensENSP0000032985859.37546.2054sander_luciopercaENSSLUP0000005221065.841651.2376
ENSG00000183665homo_sapiensENSP0000032985868.080454.2411strigops_habroptilaENSSHBP0000502452848.956739.0048
ENSG00000183665homo_sapiensENSP0000032985858.482145.3125amphiprion_ocellarisENSAOCP0000001572566.497551.5228
ENSG00000183665homo_sapiensENSP0000032985875.223262.0536terrapene_carolina_triunguisENSTMTP0000002237273.741860.8315
ENSG00000183665homo_sapiensENSP0000032985859.151847.3214betta_splendensENSBSLP0000004767065.432152.3457
ENSG00000183665homo_sapiensENSP0000032985862.053646.875pygocentrus_nattereriENSPNAP0000001319366.033349.8812
ENSG00000183665homo_sapiensENSP0000032985860.044646.2054anabas_testudineusENSATEP0000002642866.419851.1111
ENSG00000183665homo_sapiensENSP0000032985845.758934.375ciona_savignyiENSCSAVP0000000073870.934353.2872
ENSG00000183665homo_sapiensENSP0000032985838.169620.3125saccharomyces_cerevisiaeYML005W37.01319.697
ENSG00000183665homo_sapiensENSP0000032985859.151846.875seriola_lalandi_dorsalisENSSLDP0000003258265.432151.8519
ENSG00000183665homo_sapiensENSP0000032985854.910742.4107labrus_bergyltaENSLBEP0000003850663.239148.8432
ENSG00000183665homo_sapiensENSP0000032985835.714328.3482labrus_bergyltaENSLBEP0000002276665.040651.626
ENSG00000183665homo_sapiensENSP0000032985856.026843.9732pundamilia_nyerereiENSPNYP0000001409166.402152.1164
ENSG00000183665homo_sapiensENSP0000032985858.928646.6518mastacembelus_armatusENSMAMP0000003013365.024651.4778
ENSG00000183665homo_sapiensENSP0000032985858.482145.0893stegastes_partitusENSSPAP0000001241963.28548.7923
ENSG00000183665homo_sapiensENSP0000032985859.37545.9821acanthochromis_polyacanthusENSAPOP0000000967066.334251.3716
ENSG00000183665homo_sapiensENSP0000032985869.642956.25aquila_chrysaetos_chrysaetosENSACCP0002002412573.584959.434
ENSG00000183665homo_sapiensENSP0000032985859.37547.0982nothobranchius_furzeriENSNFUP0001500222466.834253.0151
ENSG00000183665homo_sapiensENSP0000032985860.491147.0982cyprinodon_variegatusENSCVAP0000002273167.7552.75
ENSG00000183665homo_sapiensENSP0000032985860.714346.2054denticeps_clupeoidesENSDCDP0000003301867.160551.1111
ENSG00000183665homo_sapiensENSP0000032985858.928645.9821larimichthys_croceaENSLCRP0000500939965.185250.8642
ENSG00000183665homo_sapiensENSP0000032985856.919645.7589takifugu_rubripesENSTRUP0000002916958.219246.8037
ENSG00000183665homo_sapiensENSP0000032985857.812546.6518ficedula_albicollisENSFALP0000001847751.084841.2229
ENSG00000183665homo_sapiensENSP0000032985857.589344.4196hippocampus_comesENSHCOP0000000366265.816350.7653
ENSG00000183665homo_sapiensENSP0000032985842.857130.5804cyprinus_carpio_carpioENSCCRP0000009377060.567843.2177
ENSG00000183665homo_sapiensENSP0000032985859.151845.0893cyprinus_carpio_carpioENSCCRP0000013550964.320449.0291
ENSG00000183665homo_sapiensENSP0000032985865.848254.6875coturnix_japonicaENSCJPP0000502033268.764657.1096
ENSG00000183665homo_sapiensENSP0000032985857.366144.1964poecilia_latipinnaENSPLAP0000001642464.2549.5
ENSG00000183665homo_sapiensENSP0000032985858.035744.4196sinocyclocheilus_grahamiENSSGRP0000003992363.106848.301
ENSG00000183665homo_sapiensENSP0000032985854.241140.625sinocyclocheilus_grahamiENSSGRP0000004169062.790747.0284
ENSG00000183665homo_sapiensENSP0000032985858.258945.3125maylandia_zebraENSMZEP0000500970665.087350.6234
ENSG00000183665homo_sapiensENSP0000032985857.366145.5357tetraodon_nigroviridisENSTNIP0000001997962.682949.7561
ENSG00000183665homo_sapiensENSP0000032985861.830450.6696paramormyrops_kingsleyaeENSPKIP0000001951568.395156.0494
ENSG00000183665homo_sapiensENSP0000032985862.723247.3214scleropages_formosusENSSFOP0001500936567.386150.8393
ENSG00000183665homo_sapiensENSP0000032985869.196452.9018leptobrachium_leishanenseENSLLEP0000002311173.809556.4286
ENSG00000183665homo_sapiensENSP0000032985858.482145.5357scophthalmus_maximusENSSMAP0000002163565.829151.2563
ENSG00000183665homo_sapiensENSP0000032985859.598245.5357oryzias_melastigmaENSOMEP0000003081266.583550.8728

Gene Ontology

Go ID Go term No. evidence Entries Species Category
GO:0005515enables protein binding1IPIHomo_sapiens(9606)Function
GO:0005737is_active_in cytoplasm1IBAHomo_sapiens(9606)Component
GO:0008175enables tRNA methyltransferase activity1IBAHomo_sapiens(9606)Function
GO:0030488involved_in tRNA methylation1IBAHomo_sapiens(9606)Process
GO:0031591involved_in wybutosine biosynthetic process1IBAHomo_sapiens(9606)Process
GO:0102522enables tRNA 4-demethylwyosine alpha-amino-alpha-carboxypropyltransferase activity1IEAHomo_sapiens(9606)Function

Expression