Functions and Diseases

RBP Type Canonical_RBPs
Diseases Cancer Disease
Drug N.A.
Main interacting RNAs mRNA
Moonlighting functions N.A.
Localizations P-bodyNucleoli
BulkPerturb-seq N.A.

Description

Ensembl ID ENSG00000183258 Gene ID 51428 Accession 18674
Symbol DDX41 Alias ABS;MPLPF Full Name DEAD-box helicase 41
Status Confidence Length 5385 bases Strand Minus strand
Position 5 : 177511577 - 177516961 RNA binding domain DEAD
Summary DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure, such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of the DEAD box protein family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. The protein encoded by this gene is a member of the DEAD box protein family and interacts with several spliceosomal proteins. In addition, the encoded protein may recognize the bacterial second messengers cyclic di-GMP and cyclic di-AMP, resulting in the induction of genes involved in the innate immune response. [provided by RefSeq, Jan 2017]

RNA binding domains (RBDs)

RNA binding proteomes (RBPomes)

Literatures on RNA binding capacity

Transcripts

Phenotypes

Protein-Protein Interaction (PPI)

Paralogs

Orthologs

Gene Ontology

Expression