Ensembl ID ENSG00000183258 Gene ID 51428 Accession 18674
Gene Symbol DDX41 Alias ABS;MPLPF Full Name DEAD-box helicase 41
Position 5 : 177511577 - 177516961 Length 5385 bases Strand Minus strand
Status Confidence Main interacting RNAsmRNARBP type Canonical_RBPs
Summary DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure, such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of the DEAD box protein family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. The protein encoded by this gene is a member of the DEAD box protein family and interacts with several spliceosomal proteins. In addition, the encoded protein may recognize the bacterial second messengers cyclic di-GMP and cyclic di-AMP, resulting in the induction of genes involved in the innate immune response. [provided by RefSeq, Jan 2017]

ENSG00000183258 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000183258 DDX41 1.03 4.92e-46 KIRC
ENSG00000183258 DDX41 0.69 1.56e-46 BRCA
ENSG00000183258 DDX41 0.56 2.41e-12 KIRP
ENSG00000183258 DDX41 0.66 6.57e-20 LIHC
ENSG00000183258 DDX41 0.85 7.25e-18 UCEC
ENSG00000183258 DDX41 0.59 5.35e-19 LUAD
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000183258 DDX41 tumours 12075003
ENSG00000183258 DDX41 breast cancer 19356240
ENSG00000183258 DDX41 cancer 20069054
ENSG00000183258 DDX41 prostate cancer 20160681
ENSG00000183258 DDX41 breast cancer 2211609
ENSG00000183258 DDX41 AML 22237025
ENSG00000183258 DDX41 tumor 2254668
ENSG00000183258 DDX41 papillary thyroid cancer 23050789
ENSG00000183258 DDX41 tumor 23318396
ENSG00000183258 DDX41 cancer 23509463
ENSG00000183258 DDX41 tumor 25920683
ENSG00000183258 DDX41 Cancer 25965566
ENSG00000183258 DDX41 AML 26693794
ENSG00000183258 DDX41 acute myeloid leukemia (AML) 26712909
ENSG00000183258 DDX41 cancer 26925418
ENSG00000183258 DDX41 cancer 26934647
ENSG00000183258 DDX41 cancers 27036224
ENSG00000183258 DDX41 tumor 27174803
ENSG00000183258 DDX41 acute myeloid leukemia (AML) 27210295
ENSG00000183258 DDX41 Familial AML 27248996
ENSG00000183258 DDX41 AML 27502187
ENSG00000183258 DDX41 colon cancer 28293423
ENSG00000183258 DDX41 tumors 28547672
ENSG00000183258 DDX41 AML 28642594
ENSG00000183258 DDX41 AML 28955657
ENSG00000183258 DDX41 tumor 29670473
ENSG00000183258 DDX41 tumor 29871919
ENSG00000183258 DDX41 tumor 29930723
ENSG00000183258 DDX41 cancer 30144193
ENSG00000183258 DDX41 Cancer 30791739
ENSG00000183258 DDX41 cancer 30909662
ENSG00000183258 DDX41 cancer 30963592
ENSG00000183258 DDX41 cancer 31240215
ENSG00000183258 DDX41 AMLs 31484648
ENSG00000183258 DDX41 endometrial cancer 31521546
ENSG00000183258 DDX41 cancer 31523712
ENSG00000183258 DDX41 tumor 31779709
ENSG00000183258 DDX41 breast cancer 3383282
ENSG00000183258 DDX41 tumors 9926915
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000183258 DDX41 STAD 0.019 high
ENSG00000183258 DDX41 UVM 0.015 high
ENSG00000183258 DDX41 PAAD 0.026 low
ENSG00000183258 DDX41 THCA 0.037 high
ENSG00000183258 DDX41 ACC 0.025 high
ENSG00000183258 DDX41 LGG 0.018 low
ENSG00000183258 DDX41 HNSC 0.013 high
ENSG00000183258 DDX41 LUAD 0.0086 high
ENSG00000183258 DDX41 BRCA 0.03 high
ENSG00000183258 DDX41 COAD 0.032 low
ENSG00000183258 DDX41 DLBC 0.041 low
ENSG00000183258 DDX41 KIRC 0.001 high
ENSG00000183258 DDX41 PRAD 0.044 low
ENSG00000183258 DDX41 GBM 0.027 high
ENSG00000183258 DDX41 SKCM 0.00031 high
ENSG00000183258 DDX41 LIHC 0.00033 high
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000183258 DDX41 LGG Del 4.095460 0.068800 0.419539 0.111111
ENSG00000183258 DDX41 KIRP Amp 0.969852 0.061208 0.634107 0.125000
ENSG00000183258 DDX41 ACC Amp 1.739466 0.455962 1.265817 0.688889
ENSG00000183258 DDX41 SKCM Del 2.011377 0.086730 0.481580 0.299728
ENSG00000183258 DDX41 HNSC Del 0.946984 0.057244 0.388249 0.379310
ENSG00000183258 DDX41 LIHC Amp 1.990663 0.146109 0.560398 0.356757
ENSG00000183258 DDX41 BLCA Del 2.426385 0.104285 0.403817 0.485294
ENSG00000183258 DDX41 KIRC Amp 59.407579 0.327773 0.552815 0.626894