Functions and Diseases

RBP Type Non-canonical_RBPs
Diseases Cancer
Drug N.A.
Main interacting RNAs N.A.
Moonlighting functions Metabolic enzyme
Localizations N.A.
BulkPerturb-seq N.A.

Description

Ensembl ID ENSG00000182199 Gene ID 6472 Accession 10852
Symbol SHMT2 Alias GLYA;SHMT;mSHMT;NEDCASB;HEL-S-51e Full Name serine hydroxymethyltransferase 2
Status Confidence Length 5363 bases Strand Plus strand
Position 12 : 57229573 - 57234935 RNA binding domain N.A.
Summary This gene encodes the mitochondrial form of a pyridoxal phosphate-dependent enzyme that catalyzes the reversible reaction of serine and tetrahydrofolate to glycine and 5,10-methylene tetrahydrofolate. The encoded product is primarily responsible for glycine synthesis. The activity of the encoded protein has been suggested to be the primary source of intracellular glycine. The gene which encodes the cytosolic form of this enzyme is located on chromosome 17. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]

RNA binding domains (RBDs)

Protein Domain Pfam ID E-value Domain number

RNA binding proteomes (RBPomes)

Pubmed ID Full Name Cell Author Time Doi

Literatures on RNA binding capacity

Pubmed ID Title Author Time Journal
30275950 Protein interaction and functional data indicate MTHFD2 involvement in RNA processing and translation. Costas Koufaris 2018-01-01 Cancer & metabolism
30809670 The moonlighting RNA-binding activity of cytosolic serine hydroxymethyltransferase contributes to control compartmentalization of serine metabolism. Giulia Guiducci 2019-05-07 Nucleic acids research
35992092 Targeting HOTAIRM1 ameliorates glioblastoma by disrupting mitochondrial oxidative phosphorylation and serine metabolism. Wei Han 2022-08-19 iScience
31350888 Hallmarks of ribosomopathies. R Kim Kampen 2020-02-20 Nucleic acids research

Transcripts

Name Transcript ID bp Protein Translation ID
SHMT2-201 ENST00000328923 2157 504aa ENSP00000333667
SHMT2-226 ENST00000556825 2215 86aa ENSP00000451169
SHMT2-235 ENST00000557740 569 No protein -
SHMT2-213 ENST00000554600 837 No protein -
SHMT2-204 ENST00000553324 566 No protein -
SHMT2-212 ENST00000554467 3416 No protein -
SHMT2-232 ENST00000557487 1918 494aa ENSP00000452315
SHMT2-210 ENST00000553950 584 No protein -
SHMT2-220 ENST00000555634 964 234aa ENSP00000450930
SHMT2-223 ENST00000556689 768 237aa ENSP00000452035
SHMT2-227 ENST00000557269 576 52aa ENSP00000450594
SHMT2-219 ENST00000555563 895 86aa ENSP00000451630
SHMT2-231 ENST00000557433 1904 171aa ENSP00000450610
SHMT2-202 ENST00000414700 2006 483aa ENSP00000406881
SHMT2-229 ENST00000557348 1659 65aa ENSP00000450927
SHMT2-234 ENST00000557703 542 142aa ENSP00000450452
SHMT2-206 ENST00000553529 562 147aa ENSP00000452161
SHMT2-211 ENST00000554310 579 160aa ENSP00000450893
SHMT2-228 ENST00000557302 457 No protein -
SHMT2-215 ENST00000554656 817 No protein -
SHMT2-230 ENST00000557427 569 159aa ENSP00000452045
SHMT2-205 ENST00000553474 1765 483aa ENSP00000452419
SHMT2-221 ENST00000555773 600 149aa ENSP00000451968
SHMT2-216 ENST00000554975 780 215aa ENSP00000452404
SHMT2-203 ENST00000449049 2121 483aa ENSP00000413770
SHMT2-222 ENST00000555774 2311 65aa ENSP00000451872
SHMT2-217 ENST00000555116 1885 65aa ENSP00000452339
SHMT2-207 ENST00000553837 2152 192aa ENSP00000451371
SHMT2-214 ENST00000554604 879 192aa ENSP00000452163
SHMT2-209 ENST00000553949 552 No protein -
SHMT2-224 ENST00000556737 572 147aa ENSP00000451495
SHMT2-208 ENST00000553868 941 No protein -
SHMT2-218 ENST00000555213 611 No protein -
SHMT2-233 ENST00000557529 1369 264aa ENSP00000450490
SHMT2-225 ENST00000556798 525 No protein -

Gene Model

Pathways

Pathway ID Pathway Name Source

Phenotypes

ensgID Trait pValue Pubmed ID
93310Schizophrenia1E-1126198764
97816Schizophrenia2E-1225056061

GWAS

ensgIDSNPChromosomePosition TraitPubmedIDOr or BEAT EFO ID

Protein-Protein Interaction (PPI)

Paralogs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id
ENSG00000182199homo_sapiensENSP0000031886877.225763.5611homo_sapiensENSP0000033366774.007960.9127

Orthologs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id
ENSG00000182199homo_sapiensENSP0000033366796.230295.2381nomascus_leucogenysENSNLEP0000002109491.337190.3955
ENSG00000182199homo_sapiensENSP0000033366799.603299.4048pan_paniscusENSPPAP0000002142699.603299.4048
ENSG00000182199homo_sapiensENSP0000033366799.603298.8095pongo_abeliiENSPPYP0000002557399.603298.8095
ENSG00000182199homo_sapiensENSP0000033366799.603299.4048pan_troglodytesENSPTRP0000006300499.603299.4048
ENSG00000182199homo_sapiensENSP0000033366710099.6032gorilla_gorillaENSGGOP0000000999610099.6032
ENSG00000182199homo_sapiensENSP0000033366790.476285.119ornithorhynchus_anatinusENSOANP0000004849892.494987.0183
ENSG00000182199homo_sapiensENSP0000033366793.25487.5sarcophilus_harrisiiENSSHAP0000002817572.530968.0556
ENSG00000182199homo_sapiensENSP0000033366790.674686.1111notamacropus_eugeniiENSMEUP0000001309092.697888.0325
ENSG00000182199homo_sapiensENSP0000033366797.222293.254dasypus_novemcinctusENSDNOP0000002560590.239486.5562
ENSG00000182199homo_sapiensENSP0000033366789.285785.9127erinaceus_europaeusENSEEUP0000001417993.167789.648
ENSG00000182199homo_sapiensENSP0000033366780.158776.3889echinops_telfairiENSETEP0000000365080.318176.5408
ENSG00000182199homo_sapiensENSP0000033366796.62795.6349callithrix_jacchusENSCJAP0000001391598.58397.5708
ENSG00000182199homo_sapiensENSP0000033366799.404898.8095cercocebus_atysENSCATP0000004182899.404898.8095
ENSG00000182199homo_sapiensENSP0000033366799.404898.8095macaca_fascicularisENSMFAP0000000491996.346295.7692
ENSG00000182199homo_sapiensENSP0000033366799.404898.8095macaca_mulattaENSMMUP0000004290096.346295.7692
ENSG00000182199homo_sapiensENSP0000033366799.206498.6111macaca_nemestrinaENSMNEP0000003746799.206498.6111
ENSG00000182199homo_sapiensENSP0000033366799.404898.8095papio_anubisENSPANP0000000135999.404898.8095
ENSG00000182199homo_sapiensENSP0000033366799.206498.6111mandrillus_leucophaeusENSMLEP0000001533599.206498.6111
ENSG00000182199homo_sapiensENSP0000033366790.674687.6984tursiops_truncatusENSTTRP0000001240991.035988.0478
ENSG00000182199homo_sapiensENSP0000033366797.222294.8413vulpes_vulpesENSVVUP0000002471297.029794.6535
ENSG00000182199homo_sapiensENSP0000033366796.428694.0476mus_spretusMGP_SPRETEiJ_P002631996.428694.0476
ENSG00000182199homo_sapiensENSP0000033366798.015996.2302equus_asinusENSEASP0000500996389.818288.1818
ENSG00000182199homo_sapiensENSP0000033366796.825493.0556capra_hircusENSCHIP0000000169397.211293.4263
ENSG00000182199homo_sapiensENSP0000033366797.817594.8413loxodonta_africanaENSLAFP0000000963597.817594.8413
ENSG00000182199homo_sapiensENSP0000033366797.222295.6349panthera_leoENSPLOP0000001821897.222295.6349
ENSG00000182199homo_sapiensENSP0000033366797.817596.0317ailuropoda_melanoleucaENSAMEP0000000504097.817596.0317
ENSG00000182199homo_sapiensENSP0000033366797.222293.8492bos_indicus_hybridENSBIXP0000500741197.222293.8492
ENSG00000182199homo_sapiensENSP0000033366797.023894.8413oryctolagus_cuniculusENSOCUP0000001976997.410495.2191
ENSG00000182199homo_sapiensENSP0000033366798.214396.627equus_caballusENSECAP0000007222693.220391.7137
ENSG00000182199homo_sapiensENSP0000033366797.023894.6429canis_lupus_familiarisENSCAFP0084501425197.410495.0199
ENSG00000182199homo_sapiensENSP0000033366797.222295.8333panthera_pardusENSPPRP0000002272897.222295.8333
ENSG00000182199homo_sapiensENSP0000033366796.825495.2381marmota_marmota_marmotaENSMMMP0000001437796.825495.2381
ENSG00000182199homo_sapiensENSP0000033366797.817595.2381balaenoptera_musculusENSBMSP0001001216197.817595.2381
ENSG00000182199homo_sapiensENSP0000033366797.222294.6429cavia_porcellusENSCPOP0000001155997.222294.6429
ENSG00000182199homo_sapiensENSP0000033366796.825495.2381felis_catusENSFCAP0000006000890.036988.5609
ENSG00000182199homo_sapiensENSP0000033366797.222295.4365ursus_americanusENSUAMP0000002708697.222295.4365
ENSG00000182199homo_sapiensENSP0000033366797.222293.8492bison_bison_bisonENSBBBP0000001916597.222293.8492
ENSG00000182199homo_sapiensENSP0000033366736.111133.9286monodon_monocerosENSMMNP0001500348085.849180.6604
ENSG00000182199homo_sapiensENSP0000033366797.817595.2381monodon_monocerosENSMMNP0001502884097.817595.2381
ENSG00000182199homo_sapiensENSP0000033366796.62793.6508sus_scrofaENSSSCP0000005666296.62793.6508
ENSG00000182199homo_sapiensENSP0000033366792.261990.2778microcebus_murinusENSMICP0000004049587.078785.206
ENSG00000182199homo_sapiensENSP0000033366737.301635.5159octodon_degusENSODEP0000000329992.610888.1773
ENSG00000182199homo_sapiensENSP0000033366795.436593.0556octodon_degusENSODEP0000000344395.436593.0556
ENSG00000182199homo_sapiensENSP0000033366797.222295.0397jaculus_jaculusENSJJAP0000000339297.222295.0397
ENSG00000182199homo_sapiensENSP0000033366796.825493.0556ovis_aries_rambouilletENSOARP0002000202097.211293.4263
ENSG00000182199homo_sapiensENSP0000033366797.023895.2381ursus_maritimusENSUMAP0000002621297.023895.2381
ENSG00000182199homo_sapiensENSP0000033366791.865188.8889ochotona_princepsENSOPRP0000001244392.231189.243
ENSG00000182199homo_sapiensENSP0000033366797.023893.8492delphinapterus_leucasENSDLEP0000000465596.259893.1102
ENSG00000182199homo_sapiensENSP0000033366797.023894.6429physeter_catodonENSPCTP0000502399097.023894.6429
ENSG00000182199homo_sapiensENSP0000033366796.230293.8492mus_caroliMGP_CAROLIEiJ_P002504196.230293.8492
ENSG00000182199homo_sapiensENSP0000033366796.230293.8492mus_musculusENSMUSP0000002647096.230293.8492
ENSG00000182199homo_sapiensENSP0000033366796.230293.6508dipodomys_ordiiENSDORP0000001077296.230293.6508
ENSG00000182199homo_sapiensENSP0000033366796.825495.0397mustela_putorius_furoENSMPUP0000000175496.825495.0397
ENSG00000182199homo_sapiensENSP0000033366799.007997.8175aotus_nancymaaeENSANAP0000002198199.007997.8175
ENSG00000182199homo_sapiensENSP0000033366799.007997.619saimiri_boliviensis_boliviensisENSSBOP0000002480199.007997.619
ENSG00000182199homo_sapiensENSP0000033366799.206498.4127chlorocebus_sabaeusENSCSAP0000000125199.206498.4127
ENSG00000182199homo_sapiensENSP0000033366769.444467.8571tupaia_belangeriENSTBEP0000001344369.582567.9921
ENSG00000182199homo_sapiensENSP0000033366796.825493.4524mesocricetus_auratusENSMAUP0000001488296.825493.4524
ENSG00000182199homo_sapiensENSP0000033366797.420694.6429phocoena_sinusENSPSNP0000000835497.420694.6429
ENSG00000182199homo_sapiensENSP0000033366796.825494.4444camelus_dromedariusENSCDRP0000502594996.825494.4444
ENSG00000182199homo_sapiensENSP0000033366797.222296.0317carlito_syrichtaENSTSYP0000002550997.222296.0317
ENSG00000182199homo_sapiensENSP0000033366797.222295.8333panthera_tigris_altaicaENSPTIP0000000599897.222295.8333
ENSG00000182199homo_sapiensENSP0000033366733.333327.7778rattus_norvegicusENSRNOP0000009715957.93148.2759
ENSG00000182199homo_sapiensENSP0000033366796.031793.8492rattus_norvegicusENSRNOP0000001108296.031793.8492
ENSG00000182199homo_sapiensENSP0000033366796.825494.4444prolemur_simusENSPSMP0000003365796.442794.0711
ENSG00000182199homo_sapiensENSP0000033366796.230293.0556microtus_ochrogasterENSMOCP0000000652196.230293.0556
ENSG00000182199homo_sapiensENSP0000033366743.849241.8651sorex_araneusENSSARP0000000349764.809461.8768
ENSG00000182199homo_sapiensENSP0000033366796.031792.6587peromyscus_maniculatus_bairdiiENSPEMP0000001644596.031792.6587
ENSG00000182199homo_sapiensENSP0000033366797.222293.8492bos_mutusENSBMUP0000003462197.222293.8492
ENSG00000182199homo_sapiensENSP0000033366796.230293.8492mus_spicilegusENSMSIP0000000298196.230293.8492
ENSG00000182199homo_sapiensENSP0000033366796.825493.4524cricetulus_griseus_chok1gshdENSCGRP0000101885996.825493.4524
ENSG00000182199homo_sapiensENSP0000033366797.222294.6429pteropus_vampyrusENSPVAP0000000374797.222294.6429
ENSG00000182199homo_sapiensENSP0000033366797.222295.2381myotis_lucifugusENSMLUP0000000451797.222295.2381
ENSG00000182199homo_sapiensENSP0000033366794.642990.4762vombatus_ursinusENSVURP0001003033894.642990.4762
ENSG00000182199homo_sapiensENSP0000033366797.222294.246rhinolophus_ferrumequinumENSRFEP0001001930497.222294.246
ENSG00000182199homo_sapiensENSP0000033366797.222295.2381neovison_visonENSNVIP0000000164297.222295.2381
ENSG00000182199homo_sapiensENSP0000033366797.222293.8492bos_taurusENSBTAP0000003805997.222293.8492
ENSG00000182199homo_sapiensENSP0000033366733.134931.746heterocephalus_glaber_femaleENSHGLP0000004912792.265288.3978
ENSG00000182199homo_sapiensENSP0000033366799.404898.6111rhinopithecus_bietiENSRBIP0000003995799.404898.6111
ENSG00000182199homo_sapiensENSP0000033366797.61995.2381canis_lupus_dingoENSCAFP0002003067189.617587.4317
ENSG00000182199homo_sapiensENSP0000033366797.420695.8333sciurus_vulgarisENSSVLP0000501333297.420695.8333
ENSG00000182199homo_sapiensENSP0000033366794.047689.4841phascolarctos_cinereusENSPCIP0000003290085.251881.1151
ENSG00000182199homo_sapiensENSP0000033366771.62768.8492procavia_capensisENSPCAP0000001357796.524192.7807
ENSG00000182199homo_sapiensENSP0000033366796.62794.4444nannospalax_galiliENSNGAP0000001454896.62794.4444
ENSG00000182199homo_sapiensENSP0000033366797.222293.8492bos_grunniensENSBGRP0000000854997.222293.8492
ENSG00000182199homo_sapiensENSP0000033366797.61995.8333chinchilla_lanigeraENSCLAP0000002099097.61995.8333
ENSG00000182199homo_sapiensENSP0000033366797.222293.4524cervus_hanglu_yarkandensisENSCHYP0000000316797.222293.4524
ENSG00000182199homo_sapiensENSP0000033366797.023893.254catagonus_wagneriENSCWAP0000001224597.023893.254
ENSG00000182199homo_sapiensENSP0000033366796.62794.8413ictidomys_tridecemlineatusENSSTOP0000001199696.62794.8413
ENSG00000182199homo_sapiensENSP0000033366797.023895.0397otolemur_garnettiiENSOGAP0000000165397.023895.0397
ENSG00000182199homo_sapiensENSP0000033366798.809597.4206cebus_imitatorENSCCAP0000002957998.809597.4206
ENSG00000182199homo_sapiensENSP0000033366796.825495.0397urocitellus_parryiiENSUPAP0001002106696.825495.0397
ENSG00000182199homo_sapiensENSP0000033366777.182572.4206moschus_moschiferusENSMMSP0000001738987.024681.6555
ENSG00000182199homo_sapiensENSP0000033366796.825493.4524moschus_moschiferusENSMMSP0000001823096.825493.4524
ENSG00000182199homo_sapiensENSP0000033366785.317582.9365rhinopithecus_roxellanaENSRROP0000004468384.980282.6087
ENSG00000182199homo_sapiensENSP0000033366796.230293.6508mus_pahariMGP_PahariEiJ_P008762896.230293.6508
ENSG00000182199homo_sapiensENSP0000033366797.420695.6349propithecus_coquereliENSPCOP0000002422397.420695.6349
ENSG00000182199homo_sapiensENSP0000033366771.031753.9683caenorhabditis_elegansC05D11.11b.170.611453.6489
ENSG00000182199homo_sapiensENSP0000033366773.214355.9524drosophila_melanogasterFBpp007079268.715152.514
ENSG00000182199homo_sapiensENSP0000033366779.960366.4683ciona_intestinalisENSCINP0000001367382.413168.5072
ENSG00000182199homo_sapiensENSP0000033366785.912776.3889petromyzon_marinusENSPMAP0000000679985.912776.3889
ENSG00000182199homo_sapiensENSP0000033366781.349269.6429eptatretus_burgeriENSEBUP0000000684782.995971.0526
ENSG00000182199homo_sapiensENSP0000033366787.896876.9841callorhinchus_miliiENSCMIP0000004538888.677.6
ENSG00000182199homo_sapiensENSP0000033366790.87380.3571latimeria_chalumnaeENSLACP0000002170984.501874.7232
ENSG00000182199homo_sapiensENSP0000033366788.492177.5794lepisosteus_oculatusENSLOCP0000000732388.492177.5794
ENSG00000182199homo_sapiensENSP0000033366787.575.7936clupea_harengusENSCHAP0000002544385.797774.3191
ENSG00000182199homo_sapiensENSP0000033366786.904876.1905danio_rerioENSDARP0000013234089.024478.0488
ENSG00000182199homo_sapiensENSP0000033366756.74644.6429carassius_auratusENSCARP0000001151055.212443.4363
ENSG00000182199homo_sapiensENSP0000033366787.575carassius_auratusENSCARP0000012915488.023975.4491
ENSG00000182199homo_sapiensENSP0000033366726.388924.2063carassius_auratusENSCARP0000007135481.595174.8466
ENSG00000182199homo_sapiensENSP0000033366788.888977.1825astyanax_mexicanusENSAMXP0000003929589.24377.49
ENSG00000182199homo_sapiensENSP0000033366788.293676.9841ictalurus_punctatusENSIPUP0000003558889.357477.9116
ENSG00000182199homo_sapiensENSP0000033366787.301676.3889esox_luciusENSELUP0000007191587.128776.2376
ENSG00000182199homo_sapiensENSP0000033366786.507975.3968electrophorus_electricusENSEEEP0000004567886.679975.5467
ENSG00000182199homo_sapiensENSP0000033366786.507975.5952oncorhynchus_kisutchENSOKIP0000506225783.846273.2692
ENSG00000182199homo_sapiensENSP0000033366776.190566.2698oncorhynchus_mykissENSOMYP0000002814475.590665.748
ENSG00000182199homo_sapiensENSP0000033366787.698476.7857salmo_salarENSSSAP0000004295983.553973.1569
ENSG00000182199homo_sapiensENSP0000033366757.539746.4286salmo_salarENSSSAP0000007774867.599154.5455
ENSG00000182199homo_sapiensENSP0000033366787.896876.3889salmo_truttaENSSTUP0000001976587.033475.6385
ENSG00000182199homo_sapiensENSP0000033366784.12773.4127gadus_morhuaENSGMOP0000001767683.629272.9783
ENSG00000182199homo_sapiensENSP0000033366787.698477.1825gadus_morhuaENSGMOP0000003452487.698477.1825
ENSG00000182199homo_sapiensENSP0000033366726.587323.6111fundulus_heteroclitusENSFHEP0000002184979.289970.4142
ENSG00000182199homo_sapiensENSP0000033366788.492177.381poecilia_reticulataENSPREP0000001268786.601975.7282
ENSG00000182199homo_sapiensENSP0000033366785.317575.1984poecilia_reticulataENSPREP0000000219881.132171.5094
ENSG00000182199homo_sapiensENSP0000033366788.888977.1825xiphophorus_maculatusENSXMAP0000000616389.421277.6447
ENSG00000182199homo_sapiensENSP0000033366785.714374.8016xiphophorus_maculatusENSXMAP0000001909081.355970.9981
ENSG00000182199homo_sapiensENSP0000033366784.325472.2222oryzias_latipesENSORLP0000000478980.492468.9394
ENSG00000182199homo_sapiensENSP0000033366789.087377.5794oryzias_latipesENSORLP0000000697089.620878.0439
ENSG00000182199homo_sapiensENSP0000033366787.301674.6032cyclopterus_lumpusENSCLMP0000502703986.78574.1617
ENSG00000182199homo_sapiensENSP0000033366784.523873.4127cyclopterus_lumpusENSCLMP0000500269384.356473.2673
ENSG00000182199homo_sapiensENSP0000033366777.976266.8651oreochromis_niloticusENSONIP0000007197371.715361.4963
ENSG00000182199homo_sapiensENSP0000033366787.576.9841oreochromis_niloticusENSONIP0000003098888.023977.4451
ENSG00000182199homo_sapiensENSP0000033366782.142969.4444oreochromis_niloticusENSONIP0000004697576.808964.9351
ENSG00000182199homo_sapiensENSP0000033366783.333370.6349haplochromis_burtoniENSHBUP000000264768471.2
ENSG00000182199homo_sapiensENSP0000033366776.785766.2698haplochromis_burtoniENSHBUP0000001657184.497872.9258
ENSG00000182199homo_sapiensENSP0000033366785.11973.6111haplochromis_burtoniENSHBUP0000000943285.11973.6111
ENSG00000182199homo_sapiensENSP0000033366777.579467.8571astatotilapia_callipteraENSACLP0000003207085.934175.1648
ENSG00000182199homo_sapiensENSP0000033366788.293677.5794astatotilapia_callipteraENSACLP0000002716781.056571.2204
ENSG00000182199homo_sapiensENSP0000033366784.12771.2302astatotilapia_callipteraENSACLP0000002844484.871.8
ENSG00000182199homo_sapiensENSP0000033366785.11973.8095sparus_aurataENSSAUP000100264117867.6364
ENSG00000182199homo_sapiensENSP0000033366787.896875.1984sparus_aurataENSSAUP0001005502485.686773.3075
ENSG00000182199homo_sapiensENSP0000033366784.920675.1984lates_calcariferENSLCAP0001000161185.25975.498
ENSG00000182199homo_sapiensENSP0000033366788.293676.9841lates_calcariferENSLCAP0001003519089.717778.2258
ENSG00000182199homo_sapiensENSP0000033366789.88178.9683xenopus_tropicalisENSXETP0000006986290.059679.1253
ENSG00000182199homo_sapiensENSP0000033366788.293680.3571chrysemys_picta_belliiENSCPBP0000001927392.323784.0249
ENSG00000182199homo_sapiensENSP0000033366790.277882.1429sphenodon_punctatusENSSPUP0000001822290.457382.3062
ENSG00000182199homo_sapiensENSP0000033366791.468381.1508laticauda_laticaudataENSLLTP0000000439791.832781.4741
ENSG00000182199homo_sapiensENSP0000033366791.468381.5476notechis_scutatusENSNSUP0000000722191.832781.8725
ENSG00000182199homo_sapiensENSP0000033366781.944472.619pseudonaja_textilisENSPTXP0000001296787.872377.8723
ENSG00000182199homo_sapiensENSP0000033366789.682580.754anas_platyrhynchos_platyrhynchosENSAPLP0000000342485.931677.3764
ENSG00000182199homo_sapiensENSP0000033366789.88180.754parus_majorENSPMJP0000000608090.419281.2375
ENSG00000182199homo_sapiensENSP0000033366791.269881.9444anolis_carolinensisENSACAP0000000620491.633582.2709
ENSG00000182199homo_sapiensENSP0000033366729.563528.1746neolamprologus_brichardiENSNBRP0000000492794.303889.8734
ENSG00000182199homo_sapiensENSP0000033366783.531770.4365neolamprologus_brichardiENSNBRP0000000583184.031970.8583
ENSG00000182199homo_sapiensENSP0000033366784.325473.2143neolamprologus_brichardiENSNBRP0000000275785.858674.5455
ENSG00000182199homo_sapiensENSP0000033366791.865181.3492naja_najaENSNNAP0000002489692.231181.6733
ENSG00000182199homo_sapiensENSP0000033366791.269881.5476podarcis_muralisENSPMRP0000001535291.633581.8725
ENSG00000182199homo_sapiensENSP0000033366772.61965.2778geospiza_fortisENSGFOP0000001103892.191482.8715
ENSG00000182199homo_sapiensENSP0000033366789.087379.5635taeniopygia_guttataENSTGUP0000001620078.63470.2277
ENSG00000182199homo_sapiensENSP0000033366787.698478.5714erpetoichthys_calabaricusENSECRP0000000689888.933679.6781
ENSG00000182199homo_sapiensENSP0000033366786.111174.4048kryptolebias_marmoratusENSKMAP0000001641386.282374.5527
ENSG00000182199homo_sapiensENSP0000033366788.293676.9841kryptolebias_marmoratusENSKMAP0000001718888.822477.4451
ENSG00000182199homo_sapiensENSP0000033366791.865182.7381salvator_merianaeENSSMRP0000000110892.231183.0677
ENSG00000182199homo_sapiensENSP0000033366785.11973.4127oryzias_javanicusENSOJAP0000004175181.2570.0758
ENSG00000182199homo_sapiensENSP0000033366784.325473.0159oryzias_javanicusENSOJAP0000001664779.58868.9139
ENSG00000182199homo_sapiensENSP0000033366728.968322.0238amphilophus_citrinellusENSACIP0000002066774.489856.6327
ENSG00000182199homo_sapiensENSP0000033366783.928673.4127amphilophus_citrinellusENSACIP0000003033386.858375.9754
ENSG00000182199homo_sapiensENSP0000033366785.515974.6032amphilophus_citrinellusENSACIP0000002071290.736879.1579
ENSG00000182199homo_sapiensENSP0000033366781.349269.0476dicentrarchus_labraxENSDLAP0000503765276.923165.2908
ENSG00000182199homo_sapiensENSP0000033366788.492176.5873dicentrarchus_labraxENSDLAP0000502012587.45175.6863
ENSG00000182199homo_sapiensENSP0000033366784.920674.6032amphiprion_perculaENSAPEP0000001887785.771575.3507
ENSG00000182199homo_sapiensENSP0000033366788.888977.381amphiprion_perculaENSAPEP0000001284789.779678.1563
ENSG00000182199homo_sapiensENSP0000033366788.095276.7857oryzias_sinensisENSOSIP0000004748287.058875.8824
ENSG00000182199homo_sapiensENSP0000033366780.555669.246oryzias_sinensisENSOSIP0000002973183.711371.9588
ENSG00000182199homo_sapiensENSP0000033366790.277882.3413gopherus_evgoodeiENSGEVP0000500014290.457382.505
ENSG00000182199homo_sapiensENSP0000033366735.912731.5476chelonoidis_abingdoniiENSCABP0000000609672.463.6
ENSG00000182199homo_sapiensENSP0000033366783.730273.0159seriola_dumeriliENSSDUP0000002803485.425174.4939
ENSG00000182199homo_sapiensENSP0000033366789.087377.381seriola_dumeriliENSSDUP0000002688980.178669.6429
ENSG00000182199homo_sapiensENSP0000033366784.12773.6111cottoperca_gobioENSCGOP0000001103085.140674.498
ENSG00000182199homo_sapiensENSP0000033366788.095275cottoperca_gobioENSCGOP0000002770882.835870.5224
ENSG00000182199homo_sapiensENSP0000033366776.587368.8492struthio_camelus_australisENSSCUP0000000057494.376584.8411
ENSG00000182199homo_sapiensENSP0000033366790.277880.754anser_brachyrhynchusENSABRP0000000404076.214468.1742
ENSG00000182199homo_sapiensENSP0000033366786.706474.4048gasterosteus_aculeatusENSGACP0000000850587.051874.7012
ENSG00000182199homo_sapiensENSP0000033366787.896876.5873cynoglossus_semilaevisENSCSEP0000001723288.423277.0459
ENSG00000182199homo_sapiensENSP0000033366789.484177.5794poecilia_formosaENSPFOP0000000530290.0278.0439
ENSG00000182199homo_sapiensENSP0000033366784.920675poecilia_formosaENSPFOP0000001434880.451171.0526
ENSG00000182199homo_sapiensENSP0000033366788.095276.7857myripristis_murdjanENSMMDP0000502139082.527971.9331
ENSG00000182199homo_sapiensENSP0000033366786.309575myripristis_murdjanENSMMDP0000501323486.138674.8515
ENSG00000182199homo_sapiensENSP0000033366788.888976.5873sander_luciopercaENSSLUP0000005122485.171173.384
ENSG00000182199homo_sapiensENSP0000033366785.317574.8016sander_luciopercaENSSLUP0000001651555.19948.3954
ENSG00000182199homo_sapiensENSP0000033366788.690580.5556strigops_habroptilaENSSHBP000050186577568.1208
ENSG00000182199homo_sapiensENSP0000033366783.531773.4127amphiprion_ocellarisENSAOCP0000001794087.52676.9231
ENSG00000182199homo_sapiensENSP0000033366789.087377.381amphiprion_ocellarisENSAOCP0000000272289.9878.1563
ENSG00000182199homo_sapiensENSP0000033366760.714354.5635terrapene_carolina_triunguisENSTMTP0000001552593.292783.8415
ENSG00000182199homo_sapiensENSP0000033366732.142930.3571terrapene_carolina_triunguisENSTMTP0000002641291.525486.4407
ENSG00000182199homo_sapiensENSP0000033366787.896877.1825hucho_huchoENSHHUP0000000423887.896877.1825
ENSG00000182199homo_sapiensENSP0000033366744.444437.1032hucho_huchoENSHHUP0000004429072.025760.1286
ENSG00000182199homo_sapiensENSP0000033366787.301675.5952betta_splendensENSBSLP0000005466286.78575.1479
ENSG00000182199homo_sapiensENSP0000033366788.095275.9921pygocentrus_nattereriENSPNAP0000001196188.446276.2948
ENSG00000182199homo_sapiensENSP0000033366787.698475.5952anabas_testudineusENSATEP0000006614683.553972.0227
ENSG00000182199homo_sapiensENSP0000033366783.928673.4127anabas_testudineusENSATEP0000001611585.627574.8988
ENSG00000182199homo_sapiensENSP0000033366778.37363.6905ciona_savignyiENSCSAVP0000000571680.777165.6442
ENSG00000182199homo_sapiensENSP0000033366768.452450saccharomyces_cerevisiaeYLR058C73.560853.7313
ENSG00000182199homo_sapiensENSP0000033366784.920674.2064seriola_lalandi_dorsalisENSSLDP0000003033685.25974.502
ENSG00000182199homo_sapiensENSP0000033366788.492176.9841seriola_lalandi_dorsalisENSSLDP0000000636789.02277.4451
ENSG00000182199homo_sapiensENSP0000033366788.690576.1905labrus_bergyltaENSLBEP0000001679089.221676.6467
ENSG00000182199homo_sapiensENSP0000033366785.515975labrus_bergyltaENSLBEP0000000845586.027975.4491
ENSG00000182199homo_sapiensENSP0000033366776.785767.4603pundamilia_nyerereiENSPNYP0000001877480.290570.5394
ENSG00000182199homo_sapiensENSP0000033366777.579467.8571pundamilia_nyerereiENSPNYP0000001444185.934175.1648
ENSG00000182199homo_sapiensENSP0000033366783.531770.4365pundamilia_nyerereiENSPNYP0000001771284.271
ENSG00000182199homo_sapiensENSP0000033366723.412718.6508mastacembelus_armatusENSMAMP0000003822980.272163.9456
ENSG00000182199homo_sapiensENSP0000033366788.095276.7857mastacembelus_armatusENSMAMP0000005996686.549775.4386
ENSG00000182199homo_sapiensENSP0000033366789.087376.9841stegastes_partitusENSSPAP0000002872889.620877.4451
ENSG00000182199homo_sapiensENSP0000033366785.317574.6032stegastes_partitusENSSPAP0000000373385.657474.9004
ENSG00000182199homo_sapiensENSP0000033366786.904875.1984oncorhynchus_tshawytschaENSOTSP0000500153684.719573.3075
ENSG00000182199homo_sapiensENSP0000033366784.722274.8016acanthochromis_polyacanthusENSAPOP0000001332185.475.4
ENSG00000182199homo_sapiensENSP0000033366788.690577.1825acanthochromis_polyacanthusENSAPOP0000003249289.579277.9559
ENSG00000182199homo_sapiensENSP0000033366789.88180.5556aquila_chrysaetos_chrysaetosENSACCP0002002309390.419281.0379
ENSG00000182199homo_sapiensENSP0000033366788.690577.9762nothobranchius_furzeriENSNFUP0001504754489.221678.4431
ENSG00000182199homo_sapiensENSP0000033366785.317574.6032cyprinodon_variegatusENSCVAP0000000097880.979370.8098
ENSG00000182199homo_sapiensENSP0000033366788.888977.381cyprinodon_variegatusENSCVAP0000002469989.421277.8443
ENSG00000182199homo_sapiensENSP0000033366787.576.7857denticeps_clupeoidesENSDCDP0000006052387.576.7857
ENSG00000182199homo_sapiensENSP0000033366786.111174.8016larimichthys_croceaENSLCRP0000502829886.282374.9503
ENSG00000182199homo_sapiensENSP0000033366789.682576.9841larimichthys_croceaENSLCRP0000505678879.858768.5512
ENSG00000182199homo_sapiensENSP0000033366784.523873.8095takifugu_rubripesENSTRUP0000008726576.344166.6667
ENSG00000182199homo_sapiensENSP0000033366786.507974.4048takifugu_rubripesENSTRUP0000007879382.732471.1575
ENSG00000182199homo_sapiensENSP0000033366760.317553.373ficedula_albicollisENSFALP0000000027292.682982.0122
ENSG00000182199homo_sapiensENSP0000033366788.690577.5794hippocampus_comesENSHCOP0000001740889.221678.0439
ENSG00000182199homo_sapiensENSP0000033366788.095276.3889cyprinus_carpio_carpioENSCCRP0000012623688.877
ENSG00000182199homo_sapiensENSP0000033366779.365167.8571cyprinus_carpio_carpioENSCCRP000001683095042.75
ENSG00000182199homo_sapiensENSP0000033366778.571469.0476coturnix_japonicaENSCJPP0000500463682.672272.6514
ENSG00000182199homo_sapiensENSP0000033366789.484177.5794poecilia_latipinnaENSPLAP0000002704890.0278.0439
ENSG00000182199homo_sapiensENSP0000033366784.722274.4048poecilia_latipinnaENSPLAP0000001294884.722274.4048
ENSG00000182199homo_sapiensENSP0000033366777.182566.2698sinocyclocheilus_grahamiENSSGRP0000001786268.971659.2199
ENSG00000182199homo_sapiensENSP0000033366777.182566.2698sinocyclocheilus_grahamiENSSGRP0000005371685.30773.2456
ENSG00000182199homo_sapiensENSP0000033366785.11973.6111maylandia_zebraENSMZEP0000502761084.950573.4653
ENSG00000182199homo_sapiensENSP0000033366788.095277.5794maylandia_zebraENSMZEP0000500897080.874371.2204
ENSG00000182199homo_sapiensENSP0000033366784.12771.4286maylandia_zebraENSMZEP0000500827684.872
ENSG00000182199homo_sapiensENSP0000033366784.12772.4206tetraodon_nigroviridisENSTNIP0000001496684.873
ENSG00000182199homo_sapiensENSP0000033366787.575.7936tetraodon_nigroviridisENSTNIP0000000985487.848676.0956
ENSG00000182199homo_sapiensENSP0000033366787.896876.7857paramormyrops_kingsleyaeENSPKIP0000001745087.376776.3314
ENSG00000182199homo_sapiensENSP0000033366788.492177.5794scleropages_formosusENSSFOP0001505861286.601975.9223
ENSG00000182199homo_sapiensENSP0000033366789.484180.9524leptobrachium_leishanenseENSLLEP0000001758790.927482.2581
ENSG00000182199homo_sapiensENSP0000033366786.507975scophthalmus_maximusENSSMAP0000006810186.336674.8515
ENSG00000182199homo_sapiensENSP0000033366783.928673.2143oryzias_melastigmaENSOMEP0000002478276.630466.8478
ENSG00000182199homo_sapiensENSP0000033366783.928674.0079oryzias_melastigmaENSOMEP0000003254684.674.6

Gene Ontology

Go ID Go term No. evidence Entries Species Category
GO:0000900enables mRNA regulatory element binding translation repressor activity1IBAHomo_sapiens(9606)Function
GO:0002082involved_in regulation of oxidative phosphorylation2IBA,IMPHomo_sapiens(9606)Process
GO:0003682enables chromatin binding1IDAHomo_sapiens(9606)Function
GO:0004372enables glycine hydroxymethyltransferase activity3IBA,IDA,IMPHomo_sapiens(9606)Function
GO:0005515enables protein binding1IPIHomo_sapiens(9606)Function
GO:0005634is_active_in nucleus2IBA,IDAHomo_sapiens(9606)Component
GO:0005737is_active_in cytoplasm2IBA,IDAHomo_sapiens(9606)Component
GO:0005739located_in mitochondrion1IDAHomo_sapiens(9606)Component
GO:0005743is_active_in mitochondrial inner membrane3IBA,IDA,TASHomo_sapiens(9606)Component
GO:0005759is_active_in mitochondrial matrix2IBA,IDAHomo_sapiens(9606)Component
GO:0005829is_active_in cytosol1IBAHomo_sapiens(9606)Component
GO:0006544involved_in glycine metabolic process2IDA,IMPHomo_sapiens(9606)Process
GO:0006563involved_in L-serine metabolic process2IDA,IMPHomo_sapiens(9606)Process
GO:0006565involved_in L-serine catabolic process1IBAHomo_sapiens(9606)Process
GO:0006730involved_in one-carbon metabolic process2IDA,IMPHomo_sapiens(9606)Process
GO:0008270enables zinc ion binding1IBAHomo_sapiens(9606)Function
GO:0009113involved_in purine nucleobase biosynthetic process1IBAHomo_sapiens(9606)Process
GO:0015630located_in microtubule cytoskeleton1IDAHomo_sapiens(9606)Component
GO:0017148involved_in negative regulation of translation1IEAHomo_sapiens(9606)Process
GO:0019264involved_in glycine biosynthetic process from serine1IBAHomo_sapiens(9606)Process
GO:0030170enables pyridoxal phosphate binding2IBA,IDAHomo_sapiens(9606)Function
GO:0034340involved_in response to type I interferon2IBA,IDAHomo_sapiens(9606)Process
GO:0035999involved_in tetrahydrofolate interconversion2IBA,IEAHomo_sapiens(9606)Process
GO:0042645located_in mitochondrial nucleoid1IDAHomo_sapiens(9606)Component
GO:0042803enables protein homodimerization activity1IBAHomo_sapiens(9606)Function
GO:0046653involved_in tetrahydrofolate metabolic process1IDAHomo_sapiens(9606)Process
GO:0046655involved_in folic acid metabolic process1IBAHomo_sapiens(9606)Process
GO:0048027enables mRNA 5-UTR binding1IBAHomo_sapiens(9606)Function
GO:0051262involved_in protein tetramerization1IDAHomo_sapiens(9606)Process
GO:0051289involved_in protein homotetramerization2IBA,IDAHomo_sapiens(9606)Process
GO:0070062located_in extracellular exosome1HDAHomo_sapiens(9606)Component
GO:0070129involved_in regulation of mitochondrial translation1IMPHomo_sapiens(9606)Process
GO:0070536involved_in protein K63-linked deubiquitination1IMPHomo_sapiens(9606)Process
GO:0070552part_of BRISC complex2IBA,IDAHomo_sapiens(9606)Component
GO:0070905enables serine binding1IBAHomo_sapiens(9606)Function
GO:1903715involved_in regulation of aerobic respiration1IMPHomo_sapiens(9606)Process

Expression