Ensembl ID ENSG00000182199 Gene ID 6472 Accession 10852
Gene Symbol SHMT2 Alias GLYA;SHMT;mSHMT;NEDCASB;HEL-S-51e Full Name serine hydroxymethyltransferase 2
Position 12 : 57229573 - 57234935 Length 5363 bases Strand Plus strand
Status Confidence Main interacting RNAsN.A.RBP type Non-canonical_RBPs
Summary This gene encodes the mitochondrial form of a pyridoxal phosphate-dependent enzyme that catalyzes the reversible reaction of serine and tetrahydrofolate to glycine and 5,10-methylene tetrahydrofolate. The encoded product is primarily responsible for glycine synthesis. The activity of the encoded protein has been suggested to be the primary source of intracellular glycine. The gene which encodes the cytosolic form of this enzyme is located on chromosome 17. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]

ENSG00000182199 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000182199 SHMT2 1.93 6.22e-111 KIRC
ENSG00000182199 SHMT2 1.33 1.23e-17 BLCA
ENSG00000182199 SHMT2 0.95 3.52e-45 BRCA
ENSG00000182199 SHMT2 1.47 5.75e-36 COAD
ENSG00000182199 SHMT2 1.44 1.35e-13 READ
ENSG00000182199 SHMT2 1.99 1.98e-107 LUSC
ENSG00000182199 SHMT2 0.78 1.91e-20 PRAD
ENSG00000182199 SHMT2 1.91 1.61e-11 GBM
ENSG00000182199 SHMT2 1.46 1.51e-32 UCEC
ENSG00000182199 SHMT2 -1.5 3.62e-11 CHOL
ENSG00000182199 SHMT2 1.47 6.64e-40 LUAD
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000182199 SHMT2 cancer 24755469
ENSG00000182199 SHMT2 tumor 25186948
ENSG00000182199 SHMT2 cancers 25243088
ENSG00000182199 SHMT2 lung cancer 25412303
ENSG00000182199 SHMT2 breast cancer 25436979
ENSG00000182199 SHMT2 cancer 25476909
ENSG00000182199 SHMT2 GBM 25855294
ENSG00000182199 SHMT2 cancers 25870517
ENSG00000182199 SHMT2 breast cancer 25999742
ENSG00000182199 SHMT2 tumours 26482881
ENSG00000182199 SHMT2 breast cancer 26646448
ENSG00000182199 SHMT2 lung cancer 26717037
ENSG00000182199 SHMT2 cancer 26824641
ENSG00000182199 SHMT2 cancer 26900062
ENSG00000182199 SHMT2 cancer 26942765
ENSG00000182199 SHMT2 tumors 27277675
ENSG00000182199 SHMT2 cancer 27325891
ENSG00000182199 SHMT2 cancer 27386546
ENSG00000182199 SHMT2 cancer 27391339
ENSG00000182199 SHMT2 cancer 27530298
ENSG00000182199 SHMT2 tumor 27589771
ENSG00000182199 SHMT2 cancer 27635066
ENSG00000182199 SHMT2 cancer 27666119
ENSG00000182199 SHMT2 colorectal tumor 27878282
ENSG00000182199 SHMT2 cancer 28040803
ENSG00000182199 SHMT2 tumour 28107674
ENSG00000182199 SHMT2 prostate cancer 28120266
ENSG00000182199 SHMT2 cancer 28177894
ENSG00000182199 SHMT2 cancer 28259896
ENSG00000182199 SHMT2 cancer 28472819
ENSG00000182199 SHMT2 GBM 28491867
ENSG00000182199 SHMT2 cancer 28649560
ENSG00000182199 SHMT2 tumor 28794642
ENSG00000182199 SHMT2 breast cancer 29020998
ENSG00000182199 SHMT2 cancer 29073064
ENSG00000182199 SHMT2 Cancer 29180469
ENSG00000182199 SHMT2 cancers 29321536
ENSG00000182199 SHMT2 cancer 29342092
ENSG00000182199 SHMT2 tumor 29344121
ENSG00000182199 SHMT2 cancer 29390138
ENSG00000182199 SHMT2 tumors 29873416
ENSG00000182199 SHMT2 cancer 29991441
ENSG00000182199 SHMT2 tumor 30197878
ENSG00000182199 SHMT2 tumor 30228815
ENSG00000182199 SHMT2 cancer 30367038
ENSG00000182199 SHMT2 cancer 30582043
ENSG00000182199 SHMT2 tumor 30755591
ENSG00000182199 SHMT2 lung cancer 30809670
ENSG00000182199 SHMT2 tumor 30857125
ENSG00000182199 SHMT2 cancers 31127856
ENSG00000182199 SHMT2 colon cancer 31167694
ENSG00000182199 SHMT2 breast cancer 31211507
ENSG00000182199 SHMT2 cancer 31253574
ENSG00000182199 SHMT2 pancreatic cancer 31289137
ENSG00000182199 SHMT2 tumor 31379360
ENSG00000182199 SHMT2 cancer 31442042
ENSG00000182199 SHMT2 prostate cancer 31500219
ENSG00000182199 SHMT2 cancers 31581160
ENSG00000182199 SHMT2 tumour 31690790
ENSG00000182199 SHMT2 gastrointestinal tumors 31773687
ENSG00000182199 SHMT2 breast cancer 31894856
ENSG00000182199 SHMT2 breast cancers 31941752
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000182199 SHMT2 MESO 0.00083 high
ENSG00000182199 SHMT2 SARC 0.0027 high
ENSG00000182199 SHMT2 CHOL 0.033 high
ENSG00000182199 SHMT2 PAAD 0.045 high
ENSG00000182199 SHMT2 UCEC 0.045 high
ENSG00000182199 SHMT2 LGG 0.00081 low
ENSG00000182199 SHMT2 HNSC 0.03 high
ENSG00000182199 SHMT2 READ 0.025 high
ENSG00000182199 SHMT2 KIRP 0.0085 high
ENSG00000182199 SHMT2 KICH 0.0013 high
ENSG00000182199 SHMT2 LUAD 0.011 high
ENSG00000182199 SHMT2 PCPG 0.0093 low
ENSG00000182199 SHMT2 THYM 0.042 low
ENSG00000182199 SHMT2 BRCA 0.00011 high
ENSG00000182199 SHMT2 ESCA 0.041 high
ENSG00000182199 SHMT2 OV 0.022 low
ENSG00000182199 SHMT2 KIRC 0.016 high
ENSG00000182199 SHMT2 PRAD 0.019 high
ENSG00000182199 SHMT2 BLCA 0.045 high
ENSG00000182199 SHMT2 LAML 0.035 high
ENSG00000182199 SHMT2 SKCM 0.0045 high
ENSG00000182199 SHMT2 CESC 0.021 high
ENSG00000182199 SHMT2 LIHC 0.011 high
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000182199 SHMT2 LGG Amp 2.284176 0.067128 0.860840 0.038986
ENSG00000182199 SHMT2 SKCM Amp 1.330751 0.141193 0.665876 0.133515
ENSG00000182199 SHMT2 PCPG Amp 0.652641 0.069342 0.628522 0.098765
ENSG00000182199 SHMT2 STAD Amp 0.788729 0.133619 0.495709 0.222222