RBPWorld - a comprehensive database of RNA Binding Proteins

Functions and Diseases

RBP Type	Canonical_RBPs
Diseases	CancerSARS-COV-2Dengue
Drug	N.A.
Main interacting RNAs	snRNA
Moonlighting functions	N.A.
Localizations	N.A.
BulkPerturb-seq	N.A.

Description

Ensembl ID	ENSG00000182004	Gene ID	6635	Accession	11161
Symbol	SNRPE	Alias	SME;Sm-E;HYPT11;snRNP-E	Full Name	small nuclear ribonucleoprotein polypeptide E
Status	Confidence	Length	9554 bases	Strand	Plus strand
Position	1 : 203861599 - 203871152	RNA binding domain	LSM
Summary	The protein encoded by this gene is a core component of U small nuclear ribonucleoproteins, which are key components of the pre-mRNA processing spliceosome. The encoded protein plays a role in the 3' end processing of histone transcripts. This protein is one of the targets in the autoimmune disease systemic lupus erythematosus, and mutations in this gene have been associated with hypotrichosis. Several pseudogenes of this gene have been identified. [provided by RefSeq, Jun 2016]

RNA binding domains (RBDs)

Search:

Protein	Domain	Pfam ID	E-value	Domain number
ENSP00000356176	LSM	PF01423	1.1e-14	1
ENSP00000400591	LSM	PF01423	5e-17	1

Showing 1 to 2 of 2 entries

RNA binding proteomes (RBPomes)

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Pubmed ID	Full Name	Cell	Author	Time	Doi
25173706	Pclap_PMID25173706_Hs_HEK293	HEK293	Katharina Kramer	2014 Oct;11	doi: 10.1038/nmeth.3092.?Epub 2014 Aug 31
29636419	CARIC_PMID29636419_Hs_CARIC		Rongbing Huang	2018 Apr 24	doi: 10.1073/pnas.1718406115
30352994	eRIC_PMID30352994_Hs_JURKAT.2018	JURKAT	Joel I Perez-Perri	2018 Oct 23	doi: 10.1038/s41467-018-06557-8
30799147	cRIC_PMID30799147_Hs_HEK293.cRIC.SINV	HEK293	Manuel Garcia-Moreno	2019 Apr 4	doi: 10.1016/j.molcel.2019.01.017.?Epub 2019 Feb 21
30799147	cRIC_PMID30799147._Hs_HEK293	HEK293	Manuel Garcia-Moreno	2019 Apr 4	doi: 10.1016/j.molcel.2019.01.017.?Epub 2019 Feb 21
30824702	PtexRIC_PMID30824702_293T_human	293T	Erika C Urdaneta	2019 Mar 1	doi: 10.1038/s41467-019-08942-3
31076284	R.Deep_PMID_31076284_Hs		Maiwen Caudron-Herger	2019 Jul 11	doi: 10.1016/j.molcel.2019.04.018.?Epub 2019 May 7
33235359	RIC_PMID33235359_humanRIC.superset.2021		Fatima Gebauer	2021 Mar	doi: 10.1038/s41576-020-00302-y
35451177	PhotoCAX.MS_PMID35451177_293T_human	293T	Huixin Luo	2022 Jul 4	doi: 10.1002/anie.202202008

Showing 1 to 9 of 9 entries

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Literatures on RNA binding capacity

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Pubmed ID	Title	Author	Time	Journal
23246290	Mutations in SNRPE, which encodes a core protein of the spliceosome, cause autosomal-dominant hypotrichosis simplex.	M Sandra Pasternack	2013-01-10	American journal of human genetics

Showing 1 to 1 of 1 entries

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Transcripts

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Name	Transcript ID	bp	Protein	Translation ID
SNRPE-201	ENST00000367208	355	52aa	ENSP00000356176
SNRPE-202	ENST00000414487	1560	92aa	ENSP00000400591
SNRPE-203	ENST00000469451	248	No protein	-
SNRPE-204	ENST00000470492	478	No protein	-
SNRPE-205	ENST00000475035	532	No protein	-
SNRPE-206	ENST00000483099	967	No protein	-

Showing 1 to 6 of 6 entries

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Gene Model

Click here to download ENSG00000182004's gene model file

ensgID	Trait	pValue	Pubmed ID
No data available in table

ensgID	SNP	Chromosome	Position	Trait	PubmedID	Or or BEAT	EFO ID
No data available in table

Protein-Protein Interaction (PPI)

Click here to download ENSG00000182004's PPI file

Orthologs

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Ensembl ID	Source				Target
Ensembl ID	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id
ENSG00000182004	homo_sapiens	ENSP00000400591	100	100	pan_paniscus	ENSPPAP00000036605	100	100
ENSG00000182004	homo_sapiens	ENSP00000400591	100	100	pan_troglodytes	ENSPTRP00000061816	100	100
ENSG00000182004	homo_sapiens	ENSP00000400591	100	100	gorilla_gorilla	ENSGGOP00000047776	100	100
ENSG00000182004	homo_sapiens	ENSP00000400591	100	98.913	ornithorhynchus_anatinus	ENSOANP00000004915	53.4884	52.907
ENSG00000182004	homo_sapiens	ENSP00000400591	100	100	sarcophilus_harrisii	ENSSHAP00000023120	100	100
ENSG00000182004	homo_sapiens	ENSP00000400591	100	100	dasypus_novemcinctus	ENSDNOP00000003464	100	100
ENSG00000182004	homo_sapiens	ENSP00000400591	100	100	echinops_telfairi	ENSETEP00000011375	100	100
ENSG00000182004	homo_sapiens	ENSP00000400591	100	100	callithrix_jacchus	ENSCJAP00000065787	100	100
ENSG00000182004	homo_sapiens	ENSP00000400591	100	100	macaca_mulatta	ENSMMUP00000067146	63.4483	63.4483
ENSG00000182004	homo_sapiens	ENSP00000400591	100	100	macaca_nemestrina	ENSMNEP00000021646	100	100

Showing 1 to 10 of 161 entries

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Gene Ontology

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Go ID	Go term	No. evidence	Entries	Species	Category
GO:0005685	part_of U1 snRNP	4	IBA,IDA,IPI,NAS	Homo_sapiens(9606)	Component
GO:0000398	involved_in mRNA splicing, via spliceosome	3	IC,IDA,NAS	Homo_sapiens(9606)	Process
GO:0005687	part_of U4 snRNP	3	IBA,IDA,NAS	Homo_sapiens(9606)	Component
GO:0046540	part_of U4/U6 x U5 tri-snRNP complex	3	IBA,IDA,IPI	Homo_sapiens(9606)	Component
GO:0000387	involved_in spliceosomal snRNP assembly	2	IBA,IDA	Homo_sapiens(9606)	Process
GO:0005634	located_in nucleus	2	IDA,NAS	Homo_sapiens(9606)	Component
GO:0005681	part_of spliceosomal complex	2	IPI,NAS	Homo_sapiens(9606)	Component
GO:0005682	part_of U5 snRNP	2	IBA,NAS	Homo_sapiens(9606)	Component
GO:0005686	part_of U2 snRNP	2	IBA,NAS	Homo_sapiens(9606)	Component
GO:0005829	located_in cytosol	2	IDA,TAS	Homo_sapiens(9606)	Component

Showing 1 to 10 of 27 entries

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Welcome to

RBP World!

Functions and Diseases

Description

RNA binding domains (RBDs)

RNA binding proteomes (RBPomes)

Literatures on RNA binding capacity

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

Protein-Protein Interaction (PPI)

Paralogs

Orthologs

Gene Ontology

Expression