RBP Type	Canonical_RBPs
Diseases	CancerFlavivirusesDengue
Drug	Drug
Main interacting RNAs	mRNA
Moonlighting functions	N.A.
Localizations	N.A.
BulkPerturb-seq	N.A.

Ensembl ID	ENSG00000181222	Gene ID	5430	Accession	9187
Symbol	POLR2A	Alias	RPB1;RPO2;POLR2;POLRA;RPBh1;RPOL2;NEDHIB;RpIILS;hsRPB1;hRPB220	Full Name	RNA polymerase II subunit A
Status	Confidence	Length	29814 bases	Strand	Plus strand
Position	17 : 7484366 - 7514179	RNA binding domain	RNA_pol_Rpb1_4 , RNA_pol_Rpb1_1 , RNA_pol_Rpb1_5 , RNA_pol_Rpb1_2 , RNA_pol_Rpb1_3 , RNA_pol_Rpb1_R , RNA_pol_Rpb1_6 , RNA_pol_Rpb1_7
Summary	This gene encodes the largest subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. The product of this gene contains a carboxy terminal domain composed of heptapeptide repeats that are essential for polymerase activity. These repeats contain serine and threonine residues that are phosphorylated in actively transcribing RNA polymerase. In addition, this subunit, in combination with several other polymerase subunits, forms the DNA binding domain of the polymerase, a groove in which the DNA template is transcribed into RNA. [provided by RefSeq, Jul 2008]