Ensembl ID ENSG00000181222 Gene ID 5430 Accession 9187
Gene Symbol POLR2A Alias RPB1;RPO2;POLR2;POLRA;RPBh1;RPOL2;NEDHIB;RpIILS;hsRPB1;hRPB220 Full Name RNA polymerase II subunit A
Position 17 : 7484366 - 7514179 Length 29814 bases Strand Plus strand
Status Confidence Main interacting RNAsmRNARBP type Canonical_RBPs
Summary This gene encodes the largest subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. The product of this gene contains a carboxy terminal domain composed of heptapeptide repeats that are essential for polymerase activity. These repeats contain serine and threonine residues that are phosphorylated in actively transcribing RNA polymerase. In addition, this subunit, in combination with several other polymerase subunits, forms the DNA binding domain of the polymerase, a groove in which the DNA template is transcribed into RNA. [provided by RefSeq, Jul 2008]

ENSG00000181222 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000181222 POLR2A tumors 10344733
ENSG00000181222 POLR2A tumor 11929820
ENSG00000181222 POLR2A tumor 12560491
ENSG00000181222 POLR2A cancer 16396619
ENSG00000181222 POLR2A cancer 19165236
ENSG00000181222 POLR2A Lung cancer 21102586
ENSG00000181222 POLR2A breast cancer 21731475
ENSG00000181222 POLR2A Tumour 21806841
ENSG00000181222 POLR2A tumor 22089348
ENSG00000181222 POLR2A gastric cancer 22350505
ENSG00000181222 POLR2A Tumor 23638030
ENSG00000181222 POLR2A DLBCL 23678368
ENSG00000181222 POLR2A tumour 25901683
ENSG00000181222 POLR2A Colorectal cancer 25985938
ENSG00000181222 POLR2A cancer 26376693
ENSG00000181222 POLR2A tumor 26893365
ENSG00000181222 POLR2A tumors 27548314
ENSG00000181222 POLR2A lung tumor 27900369
ENSG00000181222 POLR2A cancer 28027311
ENSG00000181222 POLR2A tumours 28195122
ENSG00000181222 POLR2A tumor 28302141
ENSG00000181222 POLR2A cancer 28355574
ENSG00000181222 POLR2A tumor 28558830
ENSG00000181222 POLR2A cancers 28767039
ENSG00000181222 POLR2A tumour 29212158
ENSG00000181222 POLR2A tumors 29222441
ENSG00000181222 POLR2A cancers 29445088
ENSG00000181222 POLR2A colorectal cancer 30349055
ENSG00000181222 POLR2A ovarian cancer 30428638
ENSG00000181222 POLR2A tumour 30549251
ENSG00000181222 POLR2A tumours 30804480
ENSG00000181222 POLR2A tumors 30936423
ENSG00000181222 POLR2A colorectal cancer 31123282
ENSG00000181222 POLR2A breast cancer 31262335
ENSG00000181222 POLR2A tumor 31398954
ENSG00000181222 POLR2A tumour 31443700
ENSG00000181222 POLR2A AML 31574286
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000181222 POLR2A SARC 0.016 high
ENSG00000181222 POLR2A UVM 0.027 high
ENSG00000181222 POLR2A ACC 0.0095 high
ENSG00000181222 POLR2A LGG 0.0034 low
ENSG00000181222 POLR2A READ 0.034 low
ENSG00000181222 POLR2A PRAD 0.0099 low
ENSG00000181222 POLR2A TGCT 0.022 high
ENSG00000181222 POLR2A BLCA 0.014 high
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000181222 POLR2A SARC Del 16.077265 0.370292 0.597318 0.447471
ENSG00000181222 POLR2A GBM Del 2.954422 0.076180 0.489530 0.161179
ENSG00000181222 POLR2A LIHC Del 8.827238 0.156545 0.662372 0.602703
ENSG00000181222 POLR2A BRCA Del 1.824238 0.073279 0.489991 0.605556
ENSG00000181222 POLR2A PRAD Del 28.776815 0.244697 0.555232 0.321138