Functions and Diseases

RBP Type Canonical_RBPs
Diseases CancerSARS-COV-OC43FlavivirusesHIVRVSARS-COV-2SINVDengue
Drug N.A.
Main interacting RNAs mRNA
Moonlighting functions N.A.
Localizations P-body
BulkPerturb-seq DataSet_01_196 DataSet_01_321

Description

Ensembl ID ENSG00000179950 Gene ID 22827 Accession 17042
Symbol PUF60 Alias FIR;VRJS;RoBPI;SIAHBP1 Full Name poly(U) binding splicing factor 60
Status Confidence Length 14366 bases Strand Minus strand
Position 8 : 143816344 - 143830709 RNA binding domain RRM_1
Summary This gene encodes a nucleic acid-binding protein that plays a role in a variety of nuclear processes, including pre-mRNA splicing and transcriptional regulation. The encoded protein forms a complex with the far upstream DNA element (FUSE) and FUSE-binding protein at the myelocytomatosis oncogene (MYC) promoter. This complex represses MYC transcription through the core-TFIIH basal transcription factor. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2012]

RNA binding domains (RBDs)

Protein Domain Pfam ID E-value Domain number
ENSP00000322016 RRM_1 PF00076 5.2e-42 1
ENSP00000322016 RRM_1 PF00076 5.2e-42 2
ENSP00000431960 RRM_1 PF00076 5.9e-42 1
ENSP00000431960 RRM_1 PF00076 5.9e-42 2
ENSP00000402953 RRM_1 PF00076 6.1e-42 1
ENSP00000402953 RRM_1 PF00076 6.1e-42 2
ENSP00000515498 RRM_1 PF00076 6.1e-42 1
ENSP00000515498 RRM_1 PF00076 6.1e-42 2
ENSP00000515500 RRM_1 PF00076 6.1e-42 1
ENSP00000515500 RRM_1 PF00076 6.1e-42 2
ENSP00000515501 RRM_1 PF00076 6.1e-42 1
ENSP00000515501 RRM_1 PF00076 6.1e-42 2
ENSP00000395417 RRM_1 PF00076 6.8e-42 1
ENSP00000395417 RRM_1 PF00076 6.8e-42 2
ENSP00000322036 RRM_1 PF00076 6.8e-42 1
ENSP00000322036 RRM_1 PF00076 6.8e-42 2
ENSP00000432610 RRM_1 PF00076 7.1e-42 1
ENSP00000432610 RRM_1 PF00076 7.1e-42 2
ENSP00000434359 RRM_1 PF00076 7.8e-42 1
ENSP00000434359 RRM_1 PF00076 7.8e-42 2
ENSP00000515511 RRM_1 PF00076 7.8e-42 1
ENSP00000515511 RRM_1 PF00076 7.8e-42 2
ENSP00000436131 RRM_1 PF00076 8.2e-42 1
ENSP00000436131 RRM_1 PF00076 8.2e-42 2
ENSP00000515502 RRM_1 PF00076 9.9e-42 1
ENSP00000515502 RRM_1 PF00076 9.9e-42 2
ENSP00000515503 RRM_1 PF00076 9.9e-42 1
ENSP00000515503 RRM_1 PF00076 9.9e-42 2
ENSP00000433403 RRM_1 PF00076 1e-41 1
ENSP00000433403 RRM_1 PF00076 1e-41 2
ENSP00000515499 RRM_1 PF00076 1e-41 1
ENSP00000515499 RRM_1 PF00076 1e-41 2
ENSP00000432091 RRM_1 PF00076 1.2e-34 1
ENSP00000432091 RRM_1 PF00076 1.2e-34 2
ENSP00000434863 RRM_1 PF00076 3.6e-18 1
ENSP00000437309 RRM_1 PF00076 7.9e-18 1

RNA binding proteomes (RBPomes)

Pubmed ID Full Name Cell Author Time Doi

Literatures on RNA binding capacity

Pubmed ID Title Author Time Journal
32219041 Identification of key gene modules and hub genes of human mantle cell lymphoma by coexpression network analysis. Dongmei Guo 2020-01-01 PeerJ
28327570 PUF60 variants cause a syndrome of ID, short stature, microcephaly, coloboma, craniofacial, cardiac, renal and spinal features. J Karen Low 2017-05-01 European journal of human genetics : EJHG
32664474 Cancer-Associated Substitutions in RNA Recognition Motifs of PUF60 and U2AF65 Reveal Residues Required for Correct Folding and 3' Splice-Site Selection. Jana Kralovicova 2020-07-11 Cancers
17579712 Control of pre-mRNA splicing by the general splicing factors PUF60 and U2AF(65). L Michelle Hastings 2007-06-20 PloS one
17537823 Proteomic analysis of in vivo-assembled pre-mRNA splicing complexes expands the catalog of participating factors. G Yen-I Chen 2007-01-01 Nucleic acids research
33117697 PUF60/AURKA Axis Contributes to Tumor Progression and Malignant Phenotypes in Bladder Cancer. Qian Long 2020-01-01 Frontiers in oncology
26253095 PUF60: a prominent new target of the autoimmune response in dermatomyositis and Sjögren's syndrome. F David Fiorentino 2016-06-01 Annals of the rheumatic diseases
29788428 PUF60-activated exons uncover altered 3' splice-site selection by germline missense mutations in a single RRM. Jana Královicová 2018-07-06 Nucleic acids research
28993636 Involvement of PUF60 in Transcriptional and Post-transcriptional Regulation of Hepatitis B Virus Pregenomic RNA Expression. Suofeng Sun 2017-10-09 Scientific reports
33550394 Restriction of an intron size en route to endothermy. Jana Královičová 2021-03-18 Nucleic acids research
35453681 Integrated In Silico Analyses Identify PUF60 and SF3A3 as New Spliceosome-Related Breast Cancer RNA-Binding Proteins. M Jennyfer García-Cárdenas 2022-03-22 Biology
33253191 Unraveling the mechanism of recognition of the 3' splice site of the adenovirus major late promoter intron by the alternative splicing factor PUF60. T Hsin-Hao Hsiao 2020-01-01 PloS one

Transcripts

Name Transcript ID bp Protein Translation ID
PUF60-208 ENST00000526683 1868 559aa ENSP00000434359
PUF60-203 ENST00000453551 1842 516aa ENSP00000402953
PUF60-201 ENST00000313352 1804 499aa ENSP00000322016
PUF60-204 ENST00000456095 1736 530aa ENSP00000395417
PUF60-202 ENST00000349157 1821 542aa ENSP00000322036
PUF60-222 ENST00000703744 2519 No protein -
PUF60-206 ENST00000526151 3854 No protein -
PUF60-224 ENST00000703846 1837 516aa ENSP00000515498
PUF60-223 ENST00000703803 2056 No protein -
PUF60-225 ENST00000703847 2140 596aa ENSP00000515499
PUF60-216 ENST00000531951 1947 516aa ENSP00000515500
PUF60-226 ENST00000703848 1812 No protein -
PUF60-227 ENST00000703849 1942 516aa ENSP00000515501
PUF60-218 ENST00000532127 2015 129aa ENSP00000515484
PUF60-220 ENST00000533162 1936 596aa ENSP00000433403
PUF60-221 ENST00000533362 2053 584aa ENSP00000515502
PUF60-211 ENST00000527744 1795 558aa ENSP00000436131
PUF60-228 ENST00000703850 1952 584aa ENSP00000515503
PUF60-209 ENST00000527197 1559 513aa ENSP00000431960
PUF60-207 ENST00000526459 1661 541aa ENSP00000432610
PUF60-232 ENST00000703866 2527 559aa ENSP00000515511
PUF60-205 ENST00000524570 2363 No protein -
PUF60-219 ENST00000532884 819 273aa ENSP00000432091
PUF60-229 ENST00000703851 1112 No protein -
PUF60-230 ENST00000703852 921 36aa ENSP00000515504
PUF60-212 ENST00000528320 922 No protein -
PUF60-214 ENST00000529999 867 263aa ENSP00000434863
PUF60-213 ENST00000528999 431 No protein -
PUF60-215 ENST00000531897 785 247aa ENSP00000437309
PUF60-231 ENST00000703853 549 No protein -
PUF60-210 ENST00000527584 547 No protein -
PUF60-217 ENST00000531995 631 No protein -

Gene Model

Pathways

Pathway ID Pathway Name Source

Phenotypes

ensgID Trait pValue Pubmed ID

GWAS

ensgIDSNPChromosomePosition TraitPubmedIDOr or BEAT EFO ID

Protein-Protein Interaction (PPI)

Paralogs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id
ENSG00000179950homo_sapiensENSP0000028607024.472612.0253homo_sapiensENSP0000043435920.751310.1968
ENSG00000179950homo_sapiensENSP0000029490441.871922.9064homo_sapiensENSP0000043435930.411416.6369
ENSG00000179950homo_sapiensENSP0000031300726.886814.7799homo_sapiensENSP0000043435930.590316.8157
ENSG00000179950homo_sapiensENSP0000028158926.14913.9461homo_sapiensENSP0000043435929.51715.7424
ENSG00000179950homo_sapiensENSP0000035216238.964624.5232homo_sapiensENSP0000043435925.581416.1002
ENSG00000179950homo_sapiensENSP0000030440523.696711.6904homo_sapiensENSP0000043435926.833613.2379
ENSG00000179950homo_sapiensENSP0000035863523.75612.0385homo_sapiensENSP0000043435926.475813.4168
ENSG00000179950homo_sapiensENSP0000030801230.366515.9686homo_sapiensENSP0000043435920.751310.9123
ENSG00000179950homo_sapiensENSP0000038526942.63825.4601homo_sapiensENSP0000043435924.865814.8479
ENSG00000179950homo_sapiensENSP0000026203141.76921.6216homo_sapiensENSP0000043435930.411415.7424
ENSG00000179950homo_sapiensENSP0000038622626.046513.9535homo_sapiensENSP0000043435920.035810.7335
ENSG00000179950homo_sapiensENSP0000027162829.481116.7453homo_sapiensENSP0000043435922.361412.7013
ENSG00000179950homo_sapiensENSP0000031174716.14357.32436homo_sapiensENSP0000043435919.32028.76565
ENSG00000179950homo_sapiensENSP0000034853834.309621.3389homo_sapiensENSP0000043435914.66919.12344
ENSG00000179950homo_sapiensENSP0000036088939.617523.4973homo_sapiensENSP0000043435925.939215.3846
ENSG00000179950homo_sapiensENSP0000036834136.440722.8814homo_sapiensENSP0000043435915.38469.66011
ENSG00000179950homo_sapiensENSP0000038047940.3923.9554homo_sapiensENSP0000043435925.939215.3846
ENSG00000179950homo_sapiensENSP0000046323331.081115.4054homo_sapiensENSP0000043435920.572510.1968
ENSG00000179950homo_sapiensENSP0000036194925.30313.7879homo_sapiensENSP0000043435929.874816.2791
ENSG00000179950homo_sapiensENSP0000037327738.215120.8238homo_sapiensENSP0000043435929.874816.2791
ENSG00000179950homo_sapiensENSP0000024018524.396112.8019homo_sapiensENSP0000043435918.0689.48122
ENSG00000179950homo_sapiensENSP0000021707325.52513.7318homo_sapiensENSP0000043435928.264815.2057
ENSG00000179950homo_sapiensENSP000003626213015homo_sapiensENSP0000043435910.73355.36673
ENSG00000179950homo_sapiensENSP000003626183015homo_sapiensENSP0000043435910.73355.36673

Orthologs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id
ENSG00000179950homo_sapiensENSP00000434359100100nomascus_leucogenysENSNLEP00000044735100100
ENSG00000179950homo_sapiensENSP00000434359100100pan_paniscusENSPPAP00000013761100100
ENSG00000179950homo_sapiensENSP0000043435998.211198.0322pongo_abeliiENSPPYP0000003541592.268992.1008
ENSG00000179950homo_sapiensENSP0000043435998.211197.6744pan_troglodytesENSPTRP0000006388598.211197.6744
ENSG00000179950homo_sapiensENSP0000043435910099.8211pan_troglodytesENSPTRP0000007004810099.8211
ENSG00000179950homo_sapiensENSP00000434359100100gorilla_gorillaENSGGOP00000044696100100
ENSG00000179950homo_sapiensENSP0000043435989.624388.3721sarcophilus_harrisiiENSSHAP0000000767696.346295
ENSG00000179950homo_sapiensENSP0000043435958.318457.9606notamacropus_eugeniiENSMEUP0000000828063.547863.1579
ENSG00000179950homo_sapiensENSP0000043435982.647680.6798dasypus_novemcinctusENSDNOP0000002599689.534987.4031
ENSG00000179950homo_sapiensENSP0000043435996.7896.78callithrix_jacchusENSCJAP0000009383169.537369.5373
ENSG00000179950homo_sapiensENSP00000434359100100cercocebus_atysENSCATP00000023896100100
ENSG00000179950homo_sapiensENSP00000434359100100macaca_fascicularisENSMFAP00000023680100100
ENSG00000179950homo_sapiensENSP0000043435999.284499.2844macaca_mulattaENSMMUP0000003187294.709994.7099
ENSG00000179950homo_sapiensENSP00000434359100100macaca_nemestrinaENSMNEP00000014054100100
ENSG00000179950homo_sapiensENSP00000434359100100papio_anubisENSPANP00000031743100100
ENSG00000179950homo_sapiensENSP0000043435992.307792.3077mandrillus_leucophaeusENSMLEP00000031643100100
ENSG00000179950homo_sapiensENSP0000043435991.413291.0555tursiops_truncatusENSTTRP0000001619999.223398.835
ENSG00000179950homo_sapiensENSP0000043435997.495597.4955vulpes_vulpesENSVVUP0000003086298.021698.0216
ENSG00000179950homo_sapiensENSP0000043435999.105598.7478mus_spretusMGP_SPRETEiJ_P004038198.22797.8723
ENSG00000179950homo_sapiensENSP0000043435998.926798.9267equus_asinusENSEASP0000501391670.988470.9884
ENSG00000179950homo_sapiensENSP0000043435997.853397.1377capra_hircusENSCHIP0000000119191.01590.3494
ENSG00000179950homo_sapiensENSP0000043435996.243395.3488loxodonta_africanaENSLAFP0000001785296.762695.8633
ENSG00000179950homo_sapiensENSP0000043435999.284499.1055panthera_leoENSPLOP0000000003998.404398.227
ENSG00000179950homo_sapiensENSP0000043435967.084165.8318ailuropoda_melanoleucaENSAMEP0000000676189.928188.2494
ENSG00000179950homo_sapiensENSP0000043435996.064495.8855bos_indicus_hybridENSBIXP0000500077392.26892.0962
ENSG00000179950homo_sapiensENSP0000043435998.211197.8533equus_caballusENSECAP0000002225298.211197.8533
ENSG00000179950homo_sapiensENSP0000043435997.495597.4955canis_lupus_familiarisENSCAFP0084500780697.147997.1479
ENSG00000179950homo_sapiensENSP0000043435999.463399.2844panthera_pardusENSPPRP0000000841698.581698.4043
ENSG00000179950homo_sapiensENSP0000043435998.747898.5689marmota_marmota_marmotaENSMMMP0000000731399.102398.9228
ENSG00000179950homo_sapiensENSP0000043435999.463399.2844balaenoptera_musculusENSBMSP0001002670398.581698.4043
ENSG00000179950homo_sapiensENSP0000043435993.559993.0233cavia_porcellusENSCPOP0000001316793.392992.8571
ENSG00000179950homo_sapiensENSP0000043435999.463399.2844felis_catusENSFCAP0000000097385.015384.8624
ENSG00000179950homo_sapiensENSP0000043435998.926798.9267ursus_americanusENSUAMP0000003265399.103999.1039
ENSG00000179950homo_sapiensENSP0000043435996.958996.4222monodelphis_domesticaENSMODP0000004532594.755294.2308
ENSG00000179950homo_sapiensENSP0000043435996.064495.8855bison_bison_bisonENSBBBP0000001367598.532198.3486
ENSG00000179950homo_sapiensENSP0000043435999.105599.1055monodon_monocerosENSMMNP0001502463898.576598.5765
ENSG00000179950homo_sapiensENSP0000043435991.234390.3399sus_scrofaENSSSCP0000006599185.427184.5896
ENSG00000179950homo_sapiensENSP0000043435990.518890.161microcebus_murinusENSMICP0000001958890.196189.8396
ENSG00000179950homo_sapiensENSP0000043435970.304165.653octodon_degusENSODEP0000002104882.217676.7782
ENSG00000179950homo_sapiensENSP0000043435973.524173.5241octodon_degusENSODEP0000001901798.325498.3254
ENSG00000179950homo_sapiensENSP0000043435998.747898.5689jaculus_jaculusENSJJAP0000000118198.220698.0427
ENSG00000179950homo_sapiensENSP0000043435998.747898.5689ovis_aries_rambouilletENSOARP0002001257298.924798.7455
ENSG00000179950homo_sapiensENSP0000043435993.38192.6655ursus_maritimusENSUMAP0000000030694.736894.0109
ENSG00000179950homo_sapiensENSP0000043435966.547465.4741ochotona_princepsENSOPRP0000000198172.23371.068
ENSG00000179950homo_sapiensENSP0000043435994.812293.9177delphinapterus_leucasENSDLEP0000002385794.982194.086
ENSG00000179950homo_sapiensENSP0000043435987.119984.9732physeter_catodonENSPCTP0000501725788.224686.0507
ENSG00000179950homo_sapiensENSP0000043435999.105598.7478mus_caroliMGP_CAROLIEiJ_P003857498.22797.8723
ENSG00000179950homo_sapiensENSP0000043435999.105598.7478mus_musculusENSMUSP0000009809698.22797.8723
ENSG00000179950homo_sapiensENSP0000043435997.316697.1377dipodomys_ordiiENSDORP0000000429497.666197.4865
ENSG00000179950homo_sapiensENSP0000043435998.032296.9589mustela_putorius_furoENSMPUP0000000807896.991195.9292
ENSG00000179950homo_sapiensENSP0000043435994.991194.2755aotus_nancymaaeENSANAP0000000267085.783585.1373
ENSG00000179950homo_sapiensENSP0000043435994.991194.2755saimiri_boliviensis_boliviensisENSSBOP0000002113895.675794.955
ENSG00000179950homo_sapiensENSP0000043435992.307792.3077chlorocebus_sabaeusENSCSAP00000005138100100
ENSG00000179950homo_sapiensENSP0000043435951.162850.805tupaia_belangeriENSTBEP0000000238395.652294.9833
ENSG00000179950homo_sapiensENSP0000043435952.41550.0894tupaia_belangeriENSTBEP0000000163787.98884.0841
ENSG00000179950homo_sapiensENSP0000043435973.524171.9141mesocricetus_auratusENSMAUP0000002055287.446885.5319
ENSG00000179950homo_sapiensENSP0000043435971.198671.1986mesocricetus_auratusENSMAUP0000001454197.54997.549
ENSG00000179950homo_sapiensENSP0000043435998.568998.39phocoena_sinusENSPSNP0000002756998.392998.2143
ENSG00000179950homo_sapiensENSP0000043435995.885595.7066camelus_dromedariusENSCDRP0000501238892.894392.721
ENSG00000179950homo_sapiensENSP0000043435999.463399.2844carlito_syrichtaENSTSYP0000002054998.581698.4043
ENSG00000179950homo_sapiensENSP0000043435994.454493.9177panthera_tigris_altaicaENSPTIP0000000848075.862175.431
ENSG00000179950homo_sapiensENSP0000043435998.926798.5689rattus_norvegicusENSRNOP0000009681890.212189.8858
ENSG00000179950homo_sapiensENSP0000043435992.307789.8032prolemur_simusENSPSMP0000003712190.526388.0702
ENSG00000179950homo_sapiensENSP0000043435999.105598.9267microtus_ochrogasterENSMOCP0000002142398.22798.0496
ENSG00000179950homo_sapiensENSP0000043435999.105598.9267peromyscus_maniculatus_bairdiiENSPEMP0000000668298.22798.0496
ENSG00000179950homo_sapiensENSP0000043435991.413291.2343bos_mutusENSBMUP0000001647897.705597.5143
ENSG00000179950homo_sapiensENSP0000043435999.105598.7478mus_spicilegusENSMSIP0000002666098.22797.8723
ENSG00000179950homo_sapiensENSP0000043435998.926798.7478cricetulus_griseus_chok1gshdENSCGRP0000101739898.049697.8723
ENSG00000179950homo_sapiensENSP0000043435970.840870.6619pteropus_vampyrusENSPVAP0000001525776.744276.5504
ENSG00000179950homo_sapiensENSP0000043435997.137796.4222myotis_lucifugusENSMLUP0000000022197.486596.7684
ENSG00000179950homo_sapiensENSP0000043435989.445486.7621myotis_lucifugusENSMLUP0000001185597.465994.5419
ENSG00000179950homo_sapiensENSP0000043435997.853397.6744vombatus_ursinusENSVURP0001003254598.91598.7342
ENSG00000179950homo_sapiensENSP0000043435998.926798.7478rhinolophus_ferrumequinumENSRFEP0001002701198.7598.5714
ENSG00000179950homo_sapiensENSP0000043435991.949991.5921neovison_visonENSNVIP0000001101099.612499.2248
ENSG00000179950homo_sapiensENSP0000043435999.105598.9267bos_taurusENSBTAP0000006112498.576598.3986
ENSG00000179950homo_sapiensENSP0000043435998.3997.8533heterocephalus_glaber_femaleENSHGLP0000003633391.059690.5629
ENSG00000179950homo_sapiensENSP00000434359100100rhinopithecus_bietiENSRBIP00000022801100100
ENSG00000179950homo_sapiensENSP0000043435998.926798.9267canis_lupus_dingoENSCAFP0002002381798.7598.75
ENSG00000179950homo_sapiensENSP0000043435998.926798.7478sciurus_vulgarisENSSVLP0000503142699.103998.9247
ENSG00000179950homo_sapiensENSP0000043435997.853397.6744phascolarctos_cinereusENSPCIP0000002713398.91598.7342
ENSG00000179950homo_sapiensENSP0000043435974.239774.0608procavia_capensisENSPCAP0000001384199.520499.2806
ENSG00000179950homo_sapiensENSP0000043435999.284499.1055nannospalax_galiliENSNGAP0000000093498.404398.227
ENSG00000179950homo_sapiensENSP0000043435993.202192.8444bos_grunniensENSBGRP0000001151490.294689.948
ENSG00000179950homo_sapiensENSP0000043435999.642299.4633chinchilla_lanigeraENSCLAP0000001325698.758998.5816
ENSG00000179950homo_sapiensENSP0000043435998.926798.7478cervus_hanglu_yarkandensisENSCHYP0000002207798.57498.3957
ENSG00000179950homo_sapiensENSP0000043435998.926798.39catagonus_wagneriENSCWAP0000001233599.103998.5663
ENSG00000179950homo_sapiensENSP0000043435998.926798.7478ictidomys_tridecemlineatusENSSTOP0000002173799.103998.9247
ENSG00000179950homo_sapiensENSP0000043435997.853397.3166otolemur_garnettiiENSOGAP0000000559297.853397.3166
ENSG00000179950homo_sapiensENSP0000043435999.642299.4633cebus_imitatorENSCCAP0000000156498.934398.7567
ENSG00000179950homo_sapiensENSP0000043435998.926798.7478urocitellus_parryiiENSUPAP0001002986799.103998.9247
ENSG00000179950homo_sapiensENSP0000043435998.568998.39moschus_moschiferusENSMMSP0000002612798.392998.2143
ENSG00000179950homo_sapiensENSP00000434359100100rhinopithecus_roxellanaENSRROP00000009912100100
ENSG00000179950homo_sapiensENSP0000043435999.105598.7478mus_pahariMGP_PahariEiJ_P004194698.22797.8723
ENSG00000179950homo_sapiensENSP0000043435993.38192.8444propithecus_coquereliENSPCOP0000003052687.583987.0805
ENSG00000179950homo_sapiensENSP0000043435959.570742.7549caenorhabditis_elegansY47G6A.20b.144.459331.9092
ENSG00000179950homo_sapiensENSP0000043435963.148551.3417drosophila_melanogasterFBpp007259355.41645.0549
ENSG00000179950homo_sapiensENSP0000043435944.364933.4526ciona_intestinalisENSCINP0000002527168.319651.5152
ENSG00000179950homo_sapiensENSP0000043435959.391844.3649ciona_intestinalisENSCINP0000001720067.206550.2024
ENSG00000179950homo_sapiensENSP0000043435926.654725.4025petromyzon_marinusENSPMAP0000001086291.975387.6543
ENSG00000179950homo_sapiensENSP0000043435976.565365.8318eptatretus_burgeriENSEBUP0000002320263.501554.5994
ENSG00000179950homo_sapiensENSP0000043435972.987562.4329eptatretus_burgeriENSEBUP0000000845276.404565.3558
ENSG00000179950homo_sapiensENSP0000043435986.046581.932callorhinchus_miliiENSCMIP0000000533087.295883.1216
ENSG00000179950homo_sapiensENSP0000043435962.25459.5707latimeria_chalumnaeENSLACP0000000615195.08290.9836
ENSG00000179950homo_sapiensENSP0000043435987.835484.2576lepisosteus_oculatusENSLOCP0000001238393.168989.3738
ENSG00000179950homo_sapiensENSP0000043435983.54276.9231clupea_harengusENSCHAP0000001041086.003779.1897
ENSG00000179950homo_sapiensENSP0000043435983.184377.102clupea_harengusENSCHAP0000004108885.321179.0826
ENSG00000179950homo_sapiensENSP0000043435979.427672.4508danio_rerioENSDARP0000015395685.384677.8846
ENSG00000179950homo_sapiensENSP0000043435985.509881.3953danio_rerioENSDARP0000012131792.100287.6686
ENSG00000179950homo_sapiensENSP0000043435986.404381.3953carassius_auratusENSCARP0000008917985.185280.2469
ENSG00000179950homo_sapiensENSP0000043435979.427673.1664carassius_auratusENSCARP0000000317085.220778.5029
ENSG00000179950homo_sapiensENSP0000043435985.152180.1431carassius_auratusENSCARP0000003573386.545581.4545
ENSG00000179950homo_sapiensENSP0000043435976.744270.1252carassius_auratusENSCARP0000001983978.715671.9266
ENSG00000179950homo_sapiensENSP0000043435978.533173.1664carassius_auratusENSCARP0000001898884.91379.1103
ENSG00000179950homo_sapiensENSP0000043435981.216574.9553astyanax_mexicanusENSAMXP0000005243072.6467.04
ENSG00000179950homo_sapiensENSP0000043435977.638672.093astyanax_mexicanusENSAMXP0000005214384.765678.7109
ENSG00000179950homo_sapiensENSP0000043435978.533172.6297ictalurus_punctatusENSIPUP0000000670884.099677.7778
ENSG00000179950homo_sapiensENSP0000043435983.54278.3542ictalurus_punctatusENSIPUP0000000347687.126981.7164
ENSG00000179950homo_sapiensENSP0000043435984.078779.6064esox_luciusENSELUP0000006551087.523382.8678
ENSG00000179950homo_sapiensENSP0000043435984.257677.9964esox_luciusENSELUP0000000545684.560178.2765
ENSG00000179950homo_sapiensENSP0000043435984.615479.9642electrophorus_electricusENSEEEP0000003353587.269482.4723
ENSG00000179950homo_sapiensENSP0000043435974.418668.3363electrophorus_electricusENSEEEP0000000680179.693573.1801
ENSG00000179950homo_sapiensENSP0000043435984.078776.9231oncorhynchus_kisutchENSOKIP0000509104983.77976.6488
ENSG00000179950homo_sapiensENSP0000043435983.54276.7442oncorhynchus_kisutchENSOKIP0000500622284.144177.2973
ENSG00000179950homo_sapiensENSP0000043435978.890974.2397oncorhynchus_mykissENSOMYP0000000934879.746875.0452
ENSG00000179950homo_sapiensENSP0000043435983.899877.102oncorhynchus_mykissENSOMYP0000002984583.008976.2832
ENSG00000179950homo_sapiensENSP0000043435983.899877.102oncorhynchus_mykissENSOMYP0000009806483.15676.4184
ENSG00000179950homo_sapiensENSP0000043435983.54276.7442salmo_salarENSSSAP0000009329184.144177.2973
ENSG00000179950homo_sapiensENSP0000043435983.720978.712salmo_salarENSSSAP0000014140583.422578.4314
ENSG00000179950homo_sapiensENSP0000043435983.720976.9231salmo_salarENSSSAP0000007069781.2574.6528
ENSG00000179950homo_sapiensENSP0000043435983.720976.7442salmo_truttaENSSTUP0000006555681.675474.8691
ENSG00000179950homo_sapiensENSP0000043435980.500973.703salmo_truttaENSSTUP0000003965478.12571.5278
ENSG00000179950homo_sapiensENSP0000043435984.436579.2487gadus_morhuaENSGMOP0000004185886.924581.5838
ENSG00000179950homo_sapiensENSP0000043435984.436579.0698fundulus_heteroclitusENSFHEP0000003311789.733884.0304
ENSG00000179950homo_sapiensENSP0000043435984.436579.0698poecilia_reticulataENSPREP0000000824787.407481.8519
ENSG00000179950homo_sapiensENSP0000043435984.436579.0698xiphophorus_maculatusENSXMAP0000000186085.507280.0725
ENSG00000179950homo_sapiensENSP0000043435984.257678.712oryzias_latipesENSORLP0000001536589.543783.6502
ENSG00000179950homo_sapiensENSP0000043435984.794379.2487cyclopterus_lumpusENSCLMP0000502820787.777882.037
ENSG00000179950homo_sapiensENSP0000043435984.794378.5331oreochromis_niloticusENSONIP0000006028487.615581.146
ENSG00000179950homo_sapiensENSP0000043435984.794378.5331haplochromis_burtoniENSHBUP0000003018287.132480.6985
ENSG00000179950homo_sapiensENSP0000043435984.257678.3542astatotilapia_callipteraENSACLP0000000668091.812985.3801
ENSG00000179950homo_sapiensENSP0000043435985.152178.8909sparus_aurataENSSAUP0001005620386.545580.1818
ENSG00000179950homo_sapiensENSP0000043435984.973279.0698lates_calcariferENSLCAP0001002905087.96381.8519
ENSG00000179950homo_sapiensENSP0000043435992.307791.5921chrysemys_picta_belliiENSCPBP0000000710997.175196.4218
ENSG00000179950homo_sapiensENSP0000043435954.919552.9517sphenodon_punctatusENSSPUP0000001750688.472685.3026
ENSG00000179950homo_sapiensENSP0000043435992.307791.4132crocodylus_porosusENSCPRP0000502022397.175196.2335
ENSG00000179950homo_sapiensENSP0000043435992.307790.6977laticauda_laticaudataENSLLTP0000002474295.202993.5424
ENSG00000179950homo_sapiensENSP0000043435985.152184.6154notechis_scutatusENSNSUP0000001012797.54196.9262
ENSG00000179950homo_sapiensENSP0000043435991.77190.3399pseudonaja_textilisENSPTXP0000002637794.475193.0018
ENSG00000179950homo_sapiensENSP0000043435989.087787.2987anas_platyrhynchos_platyrhynchosENSAPLP0000002764891.881990.0369
ENSG00000179950homo_sapiensENSP0000043435990.518888.7299gallus_gallusENSGALP0001001152683.360881.7133
ENSG00000179950homo_sapiensENSP0000043435989.803288.0143meleagris_gallopavoENSMGAP0000001820687.304385.5652
ENSG00000179950homo_sapiensENSP0000043435991.234390.6977serinus_canariaENSSCAP0000000000998.837298.2558
ENSG00000179950homo_sapiensENSP0000043435966.010761.3596parus_majorENSPMJP0000001798550.204146.6667
ENSG00000179950homo_sapiensENSP0000043435992.486690.8766anolis_carolinensisENSACAP0000000162095.563893.9002
ENSG00000179950homo_sapiensENSP0000043435971.198666.0107neolamprologus_brichardiENSNBRP0000001698986.521780.2174
ENSG00000179950homo_sapiensENSP0000043435992.307790.8766naja_najaENSNNAP0000001557195.027693.5543
ENSG00000179950homo_sapiensENSP0000043435992.307791.0555podarcis_muralisENSPMRP0000001521596.629295.3184
ENSG00000179950homo_sapiensENSP0000043435956.350654.3828geospiza_fortisENSGFOP0000001529787.743784.6797
ENSG00000179950homo_sapiensENSP0000043435991.949991.2343taeniopygia_guttataENSTGUP0000003024597.164596.4083
ENSG00000179950homo_sapiensENSP0000043435988.55187.8354taeniopygia_guttataENSTGUP0000002972697.826197.0356
ENSG00000179950homo_sapiensENSP0000043435987.656584.9732erpetoichthys_calabaricusENSECRP0000001677894.412391.5222
ENSG00000179950homo_sapiensENSP0000043435984.078778.8909kryptolebias_marmoratusENSKMAP0000002257091.617985.9649
ENSG00000179950homo_sapiensENSP0000043435992.307790.6977salvator_merianaeENSSMRP0000001502095.910894.2379
ENSG00000179950homo_sapiensENSP0000043435983.899878.712oryzias_javanicusENSOJAP0000001442886.531481.1808
ENSG00000179950homo_sapiensENSP0000043435984.257678.3542amphilophus_citrinellusENSACIP0000002802591.812985.3801
ENSG00000179950homo_sapiensENSP0000043435985.330979.0698dicentrarchus_labraxENSDLAP0000502404088.170181.7006
ENSG00000179950homo_sapiensENSP0000043435980.143174.2397amphiprion_perculaENSAPEP0000001672890.140883.501
ENSG00000179950homo_sapiensENSP0000043435980.858772.9875oryzias_sinensisENSOSIP0000003283783.394875.2768
ENSG00000179950homo_sapiensENSP0000043435992.486691.5921pelodiscus_sinensisENSPSIP0000000501098.102597.1537
ENSG00000179950homo_sapiensENSP0000043435993.738892.4866gopherus_evgoodeiENSGEVP0000500357294.414493.1532
ENSG00000179950homo_sapiensENSP0000043435993.738892.4866chelonoidis_abingdoniiENSCABP0000003091094.414493.1532
ENSG00000179950homo_sapiensENSP0000043435984.615479.0698seriola_dumeriliENSSDUP0000001403489.077283.2392
ENSG00000179950homo_sapiensENSP0000043435984.257678.8909cottoperca_gobioENSCGOP0000005010889.373883.6812
ENSG00000179950homo_sapiensENSP0000043435991.413290.8766struthio_camelus_australisENSSCUP0000000612399.03198.4496
ENSG00000179950homo_sapiensENSP0000043435992.486691.5921anser_brachyrhynchusENSABRP0000000345094.862493.945
ENSG00000179950homo_sapiensENSP0000043435976.207567.4419gasterosteus_aculeatusENSGACP0000000622480.834971.537
ENSG00000179950homo_sapiensENSP0000043435985.509879.0698cynoglossus_semilaevisENSCSEP0000003106785.20578.7879
ENSG00000179950homo_sapiensENSP0000043435984.436579.0698poecilia_formosaENSPFOP0000001933385.507280.0725
ENSG00000179950homo_sapiensENSP0000043435981.753175.8497myripristis_murdjanENSMMDP0000503986183.699677.6557
ENSG00000179950homo_sapiensENSP0000043435984.615478.8909sander_luciopercaENSSLUP0000001798287.592681.6667
ENSG00000179950homo_sapiensENSP0000043435992.307791.5921strigops_habroptilaENSSHBP0000500126597.175196.4218
ENSG00000179950homo_sapiensENSP0000043435985.152179.2487amphiprion_ocellarisENSAOCP0000002095390.494384.2205
ENSG00000179950homo_sapiensENSP0000043435993.738892.4866terrapene_carolina_triunguisENSTMTP0000002595794.414493.1532
ENSG00000179950homo_sapiensENSP0000043435983.720976.9231hucho_huchoENSHHUP0000005050884.782677.8986
ENSG00000179950homo_sapiensENSP0000043435975.313170.483hucho_huchoENSHHUP0000006162887.708382.0833
ENSG00000179950homo_sapiensENSP0000043435983.363276.5653hucho_huchoENSHHUP0000005711183.96477.1171
ENSG00000179950homo_sapiensENSP0000043435984.615479.2487betta_splendensENSBSLP0000003244788.081982.4953
ENSG00000179950homo_sapiensENSP0000043435976.028671.0197pygocentrus_nattereriENSPNAP0000001353178.996373.7918
ENSG00000179950homo_sapiensENSP0000043435982.468777.9964pygocentrus_nattereriENSPNAP0000003216691.287186.3366
ENSG00000179950homo_sapiensENSP0000043435984.973279.2487anabas_testudineusENSATEP0000005501685.585679.8198
ENSG00000179950homo_sapiensENSP0000043435957.42442.7549ciona_savignyiENSCSAVP0000000799171.017752.8761
ENSG00000179950homo_sapiensENSP0000043435958.497346.6905ciona_savignyiENSCSAVP0000000235961.121548.785
ENSG00000179950homo_sapiensENSP0000043435984.973279.0698seriola_lalandi_dorsalisENSSLDP0000003133087.800481.7006
ENSG00000179950homo_sapiensENSP0000043435984.257677.2809labrus_bergyltaENSLBEP0000001635580.238573.5946
ENSG00000179950homo_sapiensENSP0000043435984.257678.3542pundamilia_nyerereiENSPNYP0000000330291.812985.3801
ENSG00000179950homo_sapiensENSP0000043435984.615478.8909mastacembelus_armatusENSMAMP0000001537585.379179.6029
ENSG00000179950homo_sapiensENSP0000043435984.794379.2487stegastes_partitusENSSPAP0000001611787.777882.037
ENSG00000179950homo_sapiensENSP0000043435983.54276.7442oncorhynchus_tshawytschaENSOTSP0000501948483.096176.3345
ENSG00000179950homo_sapiensENSP0000043435983.899876.7442oncorhynchus_tshawytschaENSOTSP0000505522582.71675.6614
ENSG00000179950homo_sapiensENSP0000043435982.826577.4597oncorhynchus_tshawytschaENSOTSP0000504370184.02978.5844
ENSG00000179950homo_sapiensENSP0000043435985.330979.4276acanthochromis_polyacanthusENSAPOP0000000050890.684484.4106
ENSG00000179950homo_sapiensENSP0000043435992.307791.5921aquila_chrysaetos_chrysaetosENSACCP0002000263597.175196.4218
ENSG00000179950homo_sapiensENSP0000043435984.973279.4276nothobranchius_furzeriENSNFUP0001502891883.479878.0316
ENSG00000179950homo_sapiensENSP0000043435983.899878.8909cyprinodon_variegatusENSCVAP0000002495591.42385.9649
ENSG00000179950homo_sapiensENSP0000043435985.152180.6798denticeps_clupeoidesENSDCDP0000001765186.07681.5552
ENSG00000179950homo_sapiensENSP0000043435982.647677.6386denticeps_clupeoidesENSDCDP0000001258682.577.5
ENSG00000179950homo_sapiensENSP0000043435984.615478.8909larimichthys_croceaENSLCRP0000504347683.716878.0531
ENSG00000179950homo_sapiensENSP0000043435984.257678.1753takifugu_rubripesENSTRUP0000001301385.480979.3103
ENSG00000179950homo_sapiensENSP0000043435978.890977.2809ficedula_albicollisENSFALP0000000119095.248493.3045
ENSG00000179950homo_sapiensENSP0000043435984.078778.3542hippocampus_comesENSHCOP0000002542488.01582.0225
ENSG00000179950homo_sapiensENSP0000043435980.143173.5241cyprinus_carpio_carpioENSCCRP0000001983183.271476.3941
ENSG00000179950homo_sapiensENSP0000043435985.688780.8587cyprinus_carpio_carpioENSCCRP0000001104387.090982.1818
ENSG00000179950homo_sapiensENSP0000043435974.955367.0841cyprinus_carpio_carpioENSCCRP0000001941481.835973.2422
ENSG00000179950homo_sapiensENSP0000043435986.225481.0376cyprinus_carpio_carpioENSCCRP0000009590487.636482.3636
ENSG00000179950homo_sapiensENSP0000043435971.019765.653coturnix_japonicaENSCJPP0000501360574.484168.8555
ENSG00000179950homo_sapiensENSP0000043435983.899878.8909poecilia_latipinnaENSPLAP0000002449291.42385.9649
ENSG00000179950homo_sapiensENSP0000043435985.867680.8587sinocyclocheilus_grahamiENSSGRP0000003276986.330981.295
ENSG00000179950homo_sapiensENSP0000043435978.533172.8086sinocyclocheilus_grahamiENSSGRP0000000845479.673373.8657
ENSG00000179950homo_sapiensENSP0000043435975.849771.9141sinocyclocheilus_grahamiENSSGRP0000005985889.640684.9894
ENSG00000179950homo_sapiensENSP0000043435984.257678.3542maylandia_zebraENSMZEP0000502479691.812985.3801
ENSG00000179950homo_sapiensENSP0000043435984.436578.3542tetraodon_nigroviridisENSTNIP0000001667590.769284.2308
ENSG00000179950homo_sapiensENSP0000043435984.078779.7853paramormyrops_kingsleyaeENSPKIP0000001895687.850583.3645
ENSG00000179950homo_sapiensENSP0000043435985.688782.2898paramormyrops_kingsleyaeENSPKIP0000003191191.238187.619
ENSG00000179950homo_sapiensENSP0000043435986.94182.6476scleropages_formosusENSSFOP0001503019887.884383.5443
ENSG00000179950homo_sapiensENSP0000043435982.468778.1753scleropages_formosusENSSFOP0001504383989.341184.6899
ENSG00000179950homo_sapiensENSP0000043435984.257682.8265leptobrachium_leishanenseENSLLEP0000003127383.510682.0922
ENSG00000179950homo_sapiensENSP0000043435984.794379.0698scophthalmus_maximusENSSMAP0000004015887.615581.7006
ENSG00000179950homo_sapiensENSP0000043435983.899878.712oryzias_melastigmaENSOMEP0000002218187.337181.9367

Gene Ontology

Go ID Go term No. evidence Entries Species Category
GO:0000380involved_in alternative mRNA splicing, via spliceosome1IBAHomo_sapiens(9606)Process
GO:0000381involved_in regulation of alternative mRNA splicing, via spliceosome1IBAHomo_sapiens(9606)Process
GO:0003677enables DNA binding1IEAHomo_sapiens(9606)Function
GO:0003723enables RNA binding1HDAHomo_sapiens(9606)Function
GO:0005515enables protein binding1IPIHomo_sapiens(9606)Function
GO:0005654located_in nucleoplasm2IDA,TASHomo_sapiens(9606)Component
GO:0006376involved_in mRNA splice site recognition1IBAHomo_sapiens(9606)Process
GO:0006915involved_in apoptotic process1IEAHomo_sapiens(9606)Process
GO:0030054located_in cell junction1IDAHomo_sapiens(9606)Component
GO:0042802enables identical protein binding1IPIHomo_sapiens(9606)Function
GO:0045296enables cadherin binding1HDAHomo_sapiens(9606)Function
GO:1990904part_of ribonucleoprotein complex1IEAHomo_sapiens(9606)Component

Expression