Ensembl ID ENSG00000179950 Gene ID 22827 Accession 17042
Gene Symbol PUF60 Alias FIR;VRJS;RoBPI;SIAHBP1 Full Name poly(U) binding splicing factor 60
Position 8 : 143816344 - 143830709 Length 14366 bases Strand Minus strand
Status Confidence Main interacting RNAsmRNARBP type Canonical_RBPs
Summary This gene encodes a nucleic acid-binding protein that plays a role in a variety of nuclear processes, including pre-mRNA splicing and transcriptional regulation. The encoded protein forms a complex with the far upstream DNA element (FUSE) and FUSE-binding protein at the myelocytomatosis oncogene (MYC) promoter. This complex represses MYC transcription through the core-TFIIH basal transcription factor. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2012]

ENSG00000179950 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000179950 PUF60 0.86 1.03e-30 BRCA
ENSG00000179950 PUF60 0.85 8.00e-29 LUSC
ENSG00000179950 PUF60 0.90 3.43e-15 LIHC
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000179950 PUF60 tumor 16452196
ENSG00000179950 PUF60 cancer 19273283
ENSG00000179950 PUF60 cancer 20077813
ENSG00000179950 PUF60 ovarian cancer 20386695
ENSG00000179950 PUF60 tumor 21245665
ENSG00000179950 PUF60 cancer 21435101
ENSG00000179950 PUF60 colorectal cancer 23594796
ENSG00000179950 PUF60 cancer 24764668
ENSG00000179950 PUF60 tumor 26100984
ENSG00000179950 PUF60 tumor 26360582
ENSG00000179950 PUF60 gastric cancer 26497854
ENSG00000179950 PUF60 colon cancer 27756887
ENSG00000179950 PUF60 cancer 29606096
ENSG00000179950 PUF60 esophageal cancers 29796163
ENSG00000179950 PUF60 breast cancer 30697074
ENSG00000179950 PUF60 cancer 30980774
ENSG00000179950 PUF60 tumor 31817495
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000179950 PUF60 STAD 0.047 low
ENSG00000179950 PUF60 UVM 0.013 high
ENSG00000179950 PUF60 THCA 0.018 low
ENSG00000179950 PUF60 LUSC 0.015 high
ENSG00000179950 PUF60 HNSC 0.034 high
ENSG00000179950 PUF60 READ 0.033 low
ENSG00000179950 PUF60 KIRP 0.00015 high
ENSG00000179950 PUF60 LUAD 0.0014 high
ENSG00000179950 PUF60 PCPG 0.042 high
ENSG00000179950 PUF60 BRCA 0.00069 high
ENSG00000179950 PUF60 UCS 0.037 high
ENSG00000179950 PUF60 OV 0.012 low
ENSG00000179950 PUF60 DLBC 0.015 low
ENSG00000179950 PUF60 KIRC 0.0072 high
ENSG00000179950 PUF60 PRAD 0.0046 low
ENSG00000179950 PUF60 BLCA 0.037 high
ENSG00000179950 PUF60 LAML 0.023 high
ENSG00000179950 PUF60 GBM 0.033 low
ENSG00000179950 PUF60 SKCM 0.0052 high
ENSG00000179950 PUF60 LIHC 0.014 high
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000179950 PUF60 LUSC Amp 7.784518 0.359942 0.580716 0.658683
ENSG00000179950 PUF60 LUAD Amp 6.207216 0.222454 0.623214 0.569767
ENSG00000179950 PUF60 LGG Amp 10.971340 0.160031 0.701236 0.177388
ENSG00000179950 PUF60 LGG Del 1.685039 0.049384 0.554899 0.052632
ENSG00000179950 PUF60 CESC Amp 2.979236 0.211316 0.634779 0.406780
ENSG00000179950 PUF60 READ Amp 3.595480 0.253176 0.831380 0.624242
ENSG00000179950 PUF60 COAD Amp 5.805710 0.153305 0.773983 0.556541
ENSG00000179950 PUF60 PAAD Amp 2.279447 0.134298 0.435665 0.353261
ENSG00000179950 PUF60 ESCA Amp 5.180642 0.483424 0.713960 0.668478
ENSG00000179950 PUF60 SKCM Amp 4.353501 0.226150 0.772184 0.523161
ENSG00000179950 PUF60 HNSC Amp 9.977552 0.277564 0.610609 0.718391
ENSG00000179950 PUF60 LIHC Amp 17.372652 0.388155 1.175858 0.597297
ENSG00000179950 PUF60 DLBC Amp 1.416472 0.258396 0.609102 0.291667
ENSG00000179950 PUF60 BLCA Amp 2.688094 0.230258 0.581016 0.588235
ENSG00000179950 PUF60 BRCA Amp 31.243178 0.429882 1.001511 0.570370
ENSG00000179950 PUF60 STAD Amp 3.573414 0.207122 0.583909 0.634921
ENSG00000179950 PUF60 PRAD Amp 1.261535 0.053984 0.694419 0.274390
ENSG00000179950 PUF60 UCEC Amp 1.470785 0.121943 0.738530 0.333952
ENSG00000179950 PUF60 UVM Amp 11.732583 0.660526 1.518657 0.762500
ENSG00000179950 PUF60 OV Amp 103.216232 1.520017 1.229702 0.756477