Functions and Diseases

RBP Type Non-canonical_RBPs
Diseases N.A.
Drug Drug
Main interacting RNAs N.A.
Moonlighting functions Kinase
Localizations N.A.
BulkPerturb-seq

Description

Ensembl ID ENSG00000178999 Gene ID 9212 Accession 11390
Symbol AURKB Alias AIK2;AIM1;ARK2;AurB;IPL1;STK5;AIM-1;ARK-2;STK-1;STK12;PPP1R48;aurkb-sv1;aurkb-sv2 Full Name aurora kinase B
Status Confidence Length 5852 bases Strand Minus strand
Position 17 : 8204733 - 8210584 RNA binding domain N.A.
Summary This gene encodes a member of the aurora kinase subfamily of serine/threonine kinases. The genes encoding the other two members of this subfamily are located on chromosomes 19 and 20. These kinases participate in the regulation of alignment and segregation of chromosomes during mitosis and meiosis through association with microtubules. A pseudogene of this gene is located on chromosome 8. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2015]

RNA binding domains (RBDs)

Protein Domain Pfam ID E-value Domain number

RNA binding proteomes (RBPomes)

Pubmed ID Full Name Cell Author Time Doi

Literatures on RNA binding capacity

Pubmed ID Title Author Time Journal
19704020 AURKB-mediated effects on chromatin regulate binding versus release of XIST RNA to the inactive chromosome. L Lisa Hall 2009-08-24 The Journal of cell biology
21447818 XIST RNA and architecture of the inactive X chromosome: implications for the repeat genome. L L Hall 2010-01-01 Cold Spring Harbor symposia on quantitative biology
33127860 PAR-TERRA is the main contributor to telomeric repeat-containing RNA transcripts in normal and cancer mouse cells. Nikenza Viceconte 2021-01-01 RNA (New York, N.Y.)

Transcripts

Name Transcript ID bp Protein Translation ID
AURKB-201 ENST00000316199 1254 345aa ENSP00000313950
AURKB-214 ENST00000585124 1243 344aa ENSP00000463999
AURKB-202 ENST00000534871 1167 303aa ENSP00000443869
AURKB-213 ENST00000584972 739 242aa ENSP00000462858
AURKB-204 ENST00000578549 939 312aa ENSP00000462207
AURKB-207 ENST00000580998 746 123aa ENSP00000461981
AURKB-205 ENST00000578753 467 No protein -
AURKB-203 ENST00000577833 867 230aa ENSP00000463636
AURKB-208 ENST00000581511 742 228aa ENSP00000462930
AURKB-206 ENST00000580390 740 No protein -
AURKB-212 ENST00000584561 1010 No protein -
AURKB-209 ENST00000582368 771 172aa ENSP00000464031
AURKB-211 ENST00000583915 397 69aa ENSP00000462027
AURKB-210 ENST00000583124 323 No protein -

Gene Model

Pathways

Pathway ID Pathway Name Source

Phenotypes

ensgID Trait pValue Pubmed ID

GWAS

ensgIDSNPChromosomePosition TraitPubmedIDOr or BEAT EFO ID

Protein-Protein Interaction (PPI)

Paralogs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id

Orthologs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id

Gene Ontology

Go ID Go term No. evidence Entries Species Category
GO:0000122involved_in negative regulation of transcription by RNA polymerase II1IDAHomo_sapiens(9606)Process
GO:0000278involved_in mitotic cell cycle1NASHomo_sapiens(9606)Process
GO:0000281involved_in mitotic cytokinesis1NASHomo_sapiens(9606)Process
GO:0000776is_active_in kinetochore3IBA,IDAHomo_sapiens(9606)Component
GO:0000779located_in condensed chromosome, centromeric region1IDAHomo_sapiens(9606)Component
GO:0001934involved_in positive regulation of protein phosphorylation1NASHomo_sapiens(9606)Process
GO:0002903involved_in negative regulation of B cell apoptotic process1IDAHomo_sapiens(9606)Process
GO:0004674enables protein serine/threonine kinase activity4EXP,IDA,TASHomo_sapiens(9606)Function
GO:0004712enables protein serine/threonine/tyrosine kinase activity1TASHomo_sapiens(9606)Function
GO:0005515enables protein binding1IPIHomo_sapiens(9606)Function
GO:0005524enables ATP binding1IEAHomo_sapiens(9606)Function
GO:0005634located_in nucleus1IDAHomo_sapiens(9606)Component
GO:0005654located_in nucleoplasm2IDA,TASHomo_sapiens(9606)Component
GO:0005819located_in spindle1TASHomo_sapiens(9606)Component
GO:0005829located_in cytosol1TASHomo_sapiens(9606)Component
GO:0005876is_active_in spindle microtubule1IBAHomo_sapiens(9606)Component
GO:0006338involved_in chromatin remodeling1IEAHomo_sapiens(9606)Process
GO:0006468involved_in protein phosphorylation2IDA,NASHomo_sapiens(9606)Process
GO:0007051involved_in spindle organization1IMPHomo_sapiens(9606)Process
GO:0007052involved_in mitotic spindle organization2IBA,NASHomo_sapiens(9606)Process
GO:0008608involved_in attachment of spindle microtubules to kinetochore1TASHomo_sapiens(9606)Process
GO:0009838involved_in abscission1ISSHomo_sapiens(9606)Process
GO:0010369located_in chromocenter1IEAHomo_sapiens(9606)Component
GO:0015630located_in microtubule cytoskeleton1IDAHomo_sapiens(9606)Component
GO:0016570involved_in histone modification1TASHomo_sapiens(9606)Process
GO:0019900enables kinase binding1IPIHomo_sapiens(9606)Function
GO:0030496located_in midbody2IDA,TASHomo_sapiens(9606)Component
GO:0031616is_active_in spindle pole centrosome1IBAHomo_sapiens(9606)Component
GO:0032091involved_in negative regulation of protein binding1IDAHomo_sapiens(9606)Process
GO:0032133part_of chromosome passenger complex3IBA,IPI,TASHomo_sapiens(9606)Component
GO:0032212involved_in positive regulation of telomere maintenance via telomerase1IMPHomo_sapiens(9606)Process
GO:0032465involved_in regulation of cytokinesis1IBAHomo_sapiens(9606)Process
GO:0032466involved_in negative regulation of cytokinesis1ISSHomo_sapiens(9606)Process
GO:0032467involved_in positive regulation of cytokinesis2IMP,TASHomo_sapiens(9606)Process
GO:0034501involved_in protein localization to kinetochore1IMPHomo_sapiens(9606)Process
GO:0034644involved_in cellular response to UV1IDAHomo_sapiens(9606)Process
GO:0036089involved_in cleavage furrow formation1IDAHomo_sapiens(9606)Process
GO:0043687involved_in post-translational protein modification1ISSHomo_sapiens(9606)Process
GO:0044022enables histone H3S28 kinase activity1IEAHomo_sapiens(9606)Function
GO:0044839involved_in cell cycle G2/M phase transition1IDAHomo_sapiens(9606)Process
GO:0044878involved_in mitotic cytokinesis checkpoint signaling1ISSHomo_sapiens(9606)Process
GO:0045824involved_in negative regulation of innate immune response1IDAHomo_sapiens(9606)Process
GO:0046777involved_in protein autophosphorylation1TASHomo_sapiens(9606)Process
GO:0051233is_active_in spindle midzone1IBAHomo_sapiens(9606)Component
GO:0051256involved_in mitotic spindle midzone assembly3IMP,NAS,TASHomo_sapiens(9606)Process
GO:0051973involved_in positive regulation of telomerase activity1IMPHomo_sapiens(9606)Process
GO:0051983involved_in regulation of chromosome segregation1TASHomo_sapiens(9606)Process
GO:0062033involved_in positive regulation of mitotic sister chromatid segregation1IDAHomo_sapiens(9606)Process
GO:0090267involved_in positive regulation of mitotic cell cycle spindle assembly checkpoint1NASHomo_sapiens(9606)Process
GO:0097431located_in mitotic spindle pole1IEAHomo_sapiens(9606)Component
GO:0106310enables protein serine kinase activity1IEAHomo_sapiens(9606)Function
GO:1901796involved_in regulation of signal transduction by p53 class mediator1TASHomo_sapiens(9606)Process
GO:1901970involved_in positive regulation of mitotic sister chromatid separation1NASHomo_sapiens(9606)Process
GO:1902425involved_in positive regulation of attachment of mitotic spindle microtubules to kinetochore1NASHomo_sapiens(9606)Process
GO:1903490involved_in positive regulation of mitotic cytokinesis1NASHomo_sapiens(9606)Process
GO:1904355involved_in positive regulation of telomere capping1IMPHomo_sapiens(9606)Process
GO:1905116involved_in positive regulation of lateral attachment of mitotic spindle microtubules to kinetochore1IDAHomo_sapiens(9606)Process
GO:1990023located_in mitotic spindle midzone1IEAHomo_sapiens(9606)Component

Expression