RBP Type
Canonical_RBPs
Diseases
SARS-COV-2 Dengue Zika
Drug
Main interacting RNAs
rRNA
Moonlighting functions
Metabolic enzyme
Localizations
Nucleoli
BulkPerturb-seq
N.A.
Ensembl ID ENSG00000177954 Gene ID
6232 Accession
10416
Symbol
RPS27
Alias
S27;MPS1;eS27;DBA17;MPS-1
Full Name
ribosomal protein S27
Status
Confidence
Length
1394 bases
Strand
Plus strand
Position
1 : 153990762 - 153992155
RNA binding domain
Ribosomal_S27e
Summary
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of four RNA species and approximately 80 structurally distinct proteins. This gene encodes a member of the S27e family of ribosomal proteins and component of the 40S subunit. The encoded protein contains a C4-type zinc finger domain that can bind to zinc and may bind to nucleic acid. Mutations in this gene have been identified in numerous melanoma patients and in at least one patient with Diamond-Blackfan anemia (DBA). Elevated expression of this gene has been observed in various human cancers. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2018]
RNA binding domains (RBDs)
Protein
Domain
Pfam ID
E-value
Domain number
ENSP00000499044
Ribosomal_S27e
PF01667 8.2e-30
1
RNA binding proteomes (RBPomes)
Pubmed ID
Full Name
Cell
Author
Time
Doi
Literatures on RNA binding capacity
Pubmed ID
Title
Author
Time
Journal
Name
Transcript ID
bp
Protein
Translation ID
RPS27-201
ENST00000392558
625
No protein
-
RPS27-205
ENST00000651669
352
84aa
ENSP00000499044
RPS27-203
ENST00000493224
573
No protein
-
RPS27-204
ENST00000643794
467
81aa
ENSP00000495765
RPS27-202
ENST00000477151
496
No protein
-
Pathway ID
Pathway Name
Source
ensgID
Trait
pValue
Pubmed ID
ensgID SNP Chromosome Position
Trait PubmedID Or or BEAT
EFO ID
Protein-Protein Interaction (PPI)
Ensembl ID
Source
Target
Species
Protein ID
Perc_pos
Perc_id
Species
Protein ID
Perc_pos
Perc_id
ENSG00000177954 homo_sapiens ENSP00000331019 98.8095 96.4286 homo_sapiens ENSP00000499044 98.8095 96.4286
Ensembl ID
Source
Target
Species
Protein ID
Perc_pos
Perc_id
Species
Protein ID
Perc_pos
Perc_id
ENSG00000177954 homo_sapiens ENSP00000499044 100 100 pan_paniscus ENSPPAP00000038655 100 100 ENSG00000177954 homo_sapiens ENSP00000499044 100 100 pongo_abelii ENSPPYP00000000924 100 100 ENSG00000177954 homo_sapiens ENSP00000499044 97.619 96.4286 pan_troglodytes ENSPTRP00000077042 97.619 96.4286 ENSG00000177954 homo_sapiens ENSP00000499044 97.619 96.4286 gorilla_gorilla ENSGGOP00000025257 97.619 96.4286 ENSG00000177954 homo_sapiens ENSP00000499044 100 98.8095 gorilla_gorilla ENSGGOP00000021741 100 98.8095 ENSG00000177954 homo_sapiens ENSP00000499044 100 100 notamacropus_eugenii ENSMEUP00000006515 100 100 ENSG00000177954 homo_sapiens ENSP00000499044 100 100 choloepus_hoffmanni ENSCHOP00000008462 100 100 ENSG00000177954 homo_sapiens ENSP00000499044 88.0952 88.0952 echinops_telfairi ENSETEP00000014088 100 100 ENSG00000177954 homo_sapiens ENSP00000499044 97.619 97.619 callithrix_jacchus ENSCJAP00000010716 98.7952 98.7952 ENSG00000177954 homo_sapiens ENSP00000499044 98.8095 98.8095 callithrix_jacchus ENSCJAP00000085750 98.8095 98.8095 ENSG00000177954 homo_sapiens ENSP00000499044 98.8095 97.619 callithrix_jacchus ENSCJAP00000086318 98.8095 97.619 ENSG00000177954 homo_sapiens ENSP00000499044 95.2381 94.0476 cercocebus_atys ENSCATP00000007996 95.2381 94.0476 ENSG00000177954 homo_sapiens ENSP00000499044 92.8571 92.8571 macaca_fascicularis ENSMFAP00000011155 82.9787 82.9787 ENSG00000177954 homo_sapiens ENSP00000499044 100 100 macaca_mulatta ENSMMUP00000023976 100 100 ENSG00000177954 homo_sapiens ENSP00000499044 100 100 macaca_nemestrina ENSMNEP00000010076 100 100 ENSG00000177954 homo_sapiens ENSP00000499044 100 100 papio_anubis ENSPANP00000022744 100 100 ENSG00000177954 homo_sapiens ENSP00000499044 91.6667 91.6667 vulpes_vulpes ENSVVUP00000001130 78.5714 78.5714 ENSG00000177954 homo_sapiens ENSP00000499044 90.4762 90.4762 equus_asinus ENSEASP00005037140 87.3563 87.3563 ENSG00000177954 homo_sapiens ENSP00000499044 100 100 capra_hircus ENSCHIP00000006649 100 100 ENSG00000177954 homo_sapiens ENSP00000499044 96.4286 95.2381 bos_indicus_hybrid ENSBIXP00005038409 96.4286 95.2381 ENSG00000177954 homo_sapiens ENSP00000499044 100 100 oryctolagus_cuniculus ENSOCUP00000022234 100 100 ENSG00000177954 homo_sapiens ENSP00000499044 88.0952 85.7143 canis_lupus_familiaris ENSCAFP00845014002 94.8718 92.3077 ENSG00000177954 homo_sapiens ENSP00000499044 95.2381 95.2381 balaenoptera_musculus ENSBMSP00010016445 97.561 97.561 ENSG00000177954 homo_sapiens ENSP00000499044 100 100 felis_catus ENSFCAP00000026404 100 100 ENSG00000177954 homo_sapiens ENSP00000499044 76.1905 75 ursus_americanus ENSUAMP00000003653 77.1084 75.9036 ENSG00000177954 homo_sapiens ENSP00000499044 100 100 monodelphis_domestica ENSMODP00000021571 100 100 ENSG00000177954 homo_sapiens ENSP00000499044 96.4286 95.2381 bison_bison_bison ENSBBBP00000014409 89.011 87.9121 ENSG00000177954 homo_sapiens ENSP00000499044 84.5238 83.3333 bison_bison_bison ENSBBBP00000001400 91.0256 89.7436 ENSG00000177954 homo_sapiens ENSP00000499044 95.2381 94.0476 monodon_monoceros ENSMMNP00015015731 86.0215 84.9462 ENSG00000177954 homo_sapiens ENSP00000499044 100 100 sus_scrofa ENSSSCP00000058333 100 100 ENSG00000177954 homo_sapiens ENSP00000499044 95.2381 95.2381 microcebus_murinus ENSMICP00000025845 96.3855 96.3855 ENSG00000177954 homo_sapiens ENSP00000499044 100 100 octodon_degus ENSODEP00000027017 100 100 ENSG00000177954 homo_sapiens ENSP00000499044 86.9048 86.9048 ovis_aries_rambouillet ENSOARP00020026937 91.25 91.25 ENSG00000177954 homo_sapiens ENSP00000499044 76.1905 75 ursus_maritimus ENSUMAP00000011354 77.1084 75.9036 ENSG00000177954 homo_sapiens ENSP00000499044 100 100 ochotona_princeps ENSOPRP00000009807 100 100 ENSG00000177954 homo_sapiens ENSP00000499044 92.8571 92.8571 delphinapterus_leucas ENSDLEP00000001331 93.9759 93.9759 ENSG00000177954 homo_sapiens ENSP00000499044 95.2381 94.0476 delphinapterus_leucas ENSDLEP00000022630 96.3855 95.1807 ENSG00000177954 homo_sapiens ENSP00000499044 86.9048 86.9048 physeter_catodon ENSPCTP00005009354 84.8837 84.8837 ENSG00000177954 homo_sapiens ENSP00000499044 100 100 mus_caroli MGP_CAROLIEiJ_P0058795 100 100 ENSG00000177954 homo_sapiens ENSP00000499044 100 100 mus_musculus ENSMUSP00000060523 100 100 ENSG00000177954 homo_sapiens ENSP00000499044 97.619 97.619 aotus_nancymaae ENSANAP00000004164 97.619 97.619 ENSG00000177954 homo_sapiens ENSP00000499044 98.8095 98.8095 saimiri_boliviensis_boliviensis ENSSBOP00000005173 98.8095 98.8095 ENSG00000177954 homo_sapiens ENSP00000499044 98.8095 98.8095 saimiri_boliviensis_boliviensis ENSSBOP00000004242 98.8095 98.8095 ENSG00000177954 homo_sapiens ENSP00000499044 98.8095 96.4286 chlorocebus_sabaeus ENSCSAP00000017352 98.8095 96.4286 ENSG00000177954 homo_sapiens ENSP00000499044 90.4762 90.4762 tupaia_belangeri ENSTBEP00000012147 92.6829 92.6829 ENSG00000177954 homo_sapiens ENSP00000499044 100 100 mesocricetus_auratus ENSMAUP00000019749 100 100 ENSG00000177954 homo_sapiens ENSP00000499044 100 100 phocoena_sinus ENSPSNP00000002814 100 100 ENSG00000177954 homo_sapiens ENSP00000499044 83.3333 79.7619 camelus_dromedarius ENSCDRP00005030344 90.9091 87.013 ENSG00000177954 homo_sapiens ENSP00000499044 98.8095 96.4286 carlito_syrichta ENSTSYP00000020153 98.8095 96.4286 ENSG00000177954 homo_sapiens ENSP00000499044 86.9048 85.7143 panthera_tigris_altaica ENSPTIP00000026161 83.908 82.7586 ENSG00000177954 homo_sapiens ENSP00000499044 90.4762 90.4762 rattus_norvegicus ENSRNOP00000097240 84.4444 84.4444 ENSG00000177954 homo_sapiens ENSP00000499044 100 98.8095 prolemur_simus ENSPSMP00000030728 84 83 ENSG00000177954 homo_sapiens ENSP00000499044 97.619 97.619 sorex_araneus ENSSARP00000008017 100 100 ENSG00000177954 homo_sapiens ENSP00000499044 96.4286 94.0476 peromyscus_maniculatus_bairdii ENSPEMP00000032638 96.4286 94.0476 ENSG00000177954 homo_sapiens ENSP00000499044 94.0476 92.8571 bos_mutus ENSBMUP00000000385 74.5283 73.5849 ENSG00000177954 homo_sapiens ENSP00000499044 94.0476 92.8571 mus_spicilegus ENSMSIP00000009439 94.0476 92.8571 ENSG00000177954 homo_sapiens ENSP00000499044 84.5238 84.5238 mus_spicilegus ENSMSIP00000011522 93.4211 93.4211 ENSG00000177954 homo_sapiens ENSP00000499044 90.4762 90.4762 cricetulus_griseus_chok1gshd ENSCGRP00001000483 80.8511 80.8511 ENSG00000177954 homo_sapiens ENSP00000499044 100 100 myotis_lucifugus ENSMLUP00000017201 100 100 ENSG00000177954 homo_sapiens ENSP00000499044 100 100 myotis_lucifugus ENSMLUP00000015671 100 100 ENSG00000177954 homo_sapiens ENSP00000499044 84.5238 82.1429 vombatus_ursinus ENSVURP00010016581 82.5581 80.2326 ENSG00000177954 homo_sapiens ENSP00000499044 97.619 96.4286 rhinolophus_ferrumequinum ENSRFEP00010009498 85.4167 84.375 ENSG00000177954 homo_sapiens ENSP00000499044 96.4286 95.2381 bos_taurus ENSBTAP00000052370 96.4286 95.2381 ENSG00000177954 homo_sapiens ENSP00000499044 90.4762 90.4762 heterocephalus_glaber_female ENSHGLP00000039345 84.4444 84.4444 ENSG00000177954 homo_sapiens ENSP00000499044 100 100 rhinopithecus_bieti ENSRBIP00000002884 100 100 ENSG00000177954 homo_sapiens ENSP00000499044 100 100 rhinopithecus_bieti ENSRBIP00000011025 100 100 ENSG00000177954 homo_sapiens ENSP00000499044 92.8571 89.2857 canis_lupus_dingo ENSCAFP00020011477 61.4173 59.0551 ENSG00000177954 homo_sapiens ENSP00000499044 88.0952 85.7143 canis_lupus_dingo ENSCAFP00020016637 94.8718 92.3077 ENSG00000177954 homo_sapiens ENSP00000499044 90.4762 90.4762 sciurus_vulgaris ENSSVLP00005014756 80 80 ENSG00000177954 homo_sapiens ENSP00000499044 89.2857 86.9048 phascolarctos_cinereus ENSPCIP00000010001 82.4176 80.2198 ENSG00000177954 homo_sapiens ENSP00000499044 94.0476 92.8571 bos_grunniens ENSBGRP00000010954 82.2917 81.25 ENSG00000177954 homo_sapiens ENSP00000499044 100 100 chinchilla_lanigera ENSCLAP00000009832 100 100 ENSG00000177954 homo_sapiens ENSP00000499044 90.4762 90.4762 cervus_hanglu_yarkandensis ENSCHYP00000003370 90.4762 90.4762 ENSG00000177954 homo_sapiens ENSP00000499044 90.4762 90.4762 catagonus_wagneri ENSCWAP00000009202 92.6829 92.6829 ENSG00000177954 homo_sapiens ENSP00000499044 90.4762 90.4762 catagonus_wagneri ENSCWAP00000012619 93.8272 93.8272 ENSG00000177954 homo_sapiens ENSP00000499044 100 98.8095 ictidomys_tridecemlineatus ENSSTOP00000028646 100 98.8095 ENSG00000177954 homo_sapiens ENSP00000499044 100 97.619 otolemur_garnettii ENSOGAP00000020518 100 97.619 ENSG00000177954 homo_sapiens ENSP00000499044 100 100 urocitellus_parryii ENSUPAP00010019060 100 100 ENSG00000177954 homo_sapiens ENSP00000499044 86.9048 84.5238 moschus_moschiferus ENSMMSP00000020042 86.9048 84.5238 ENSG00000177954 homo_sapiens ENSP00000499044 100 98.8095 rhinopithecus_roxellana ENSRROP00000006863 100 98.8095 ENSG00000177954 homo_sapiens ENSP00000499044 100 100 mus_pahari MGP_PahariEiJ_P0069755 100 100 ENSG00000177954 homo_sapiens ENSP00000499044 58.3333 53.5714 eptatretus_burgeri ENSEBUP00000007814 68.0556 62.5 ENSG00000177954 homo_sapiens ENSP00000499044 100 100 latimeria_chalumnae ENSLACP00000008947 100 100 ENSG00000177954 homo_sapiens ENSP00000499044 100 98.8095 lepisosteus_oculatus ENSLOCP00000008094 82.3529 81.3726 ENSG00000177954 homo_sapiens ENSP00000499044 88.0952 85.7143 esox_lucius ENSELUP00000059320 87.0588 84.7059 ENSG00000177954 homo_sapiens ENSP00000499044 100 100 crocodylus_porosus ENSCPRP00005003341 84 84 ENSG00000177954 homo_sapiens ENSP00000499044 100 100 laticauda_laticaudata ENSLLTP00000001704 100 100 ENSG00000177954 homo_sapiens ENSP00000499044 98.8095 98.8095 notechis_scutatus ENSNSUP00000019901 78.3019 78.3019 ENSG00000177954 homo_sapiens ENSP00000499044 90.4762 90.4762 gallus_gallus ENSGALP00010040596 47.7987 47.7987 ENSG00000177954 homo_sapiens ENSP00000499044 97.619 97.619 meleagris_gallopavo ENSMGAP00000028148 100 100 ENSG00000177954 homo_sapiens ENSP00000499044 97.619 97.619 anolis_carolinensis ENSACAP00000011367 100 100 ENSG00000177954 homo_sapiens ENSP00000499044 97.619 97.619 naja_naja ENSNNAP00000006329 100 100 ENSG00000177954 homo_sapiens ENSP00000499044 97.619 97.619 podarcis_muralis ENSPMRP00000022742 100 100 ENSG00000177954 homo_sapiens ENSP00000499044 97.619 97.619 geospiza_fortis ENSGFOP00000012650 100 100 ENSG00000177954 homo_sapiens ENSP00000499044 100 100 taeniopygia_guttata ENSTGUP00000024702 100 100 ENSG00000177954 homo_sapiens ENSP00000499044 100 100 erpetoichthys_calabaricus ENSECRP00000013372 67.7419 67.7419 ENSG00000177954 homo_sapiens ENSP00000499044 98.8095 98.8095 salvator_merianae ENSSMRP00000001008 61.0294 61.0294 ENSG00000177954 homo_sapiens ENSP00000499044 97.619 97.619 pelodiscus_sinensis ENSPSIP00000019138 100 100 ENSG00000177954 homo_sapiens ENSP00000499044 100 100 chelonoidis_abingdonii ENSCABP00000004686 100 100 ENSG00000177954 homo_sapiens ENSP00000499044 55.9524 55.9524 struthio_camelus_australis ENSSCUP00000010931 88.6792 88.6792 ENSG00000177954 homo_sapiens ENSP00000499044 85.7143 85.7143 anser_brachyrhynchus ENSABRP00000004937 70.5882 70.5882 ENSG00000177954 homo_sapiens ENSP00000499044 100 100 gasterosteus_aculeatus ENSGACP00000004388 100 100 ENSG00000177954 homo_sapiens ENSP00000499044 100 100 strigops_habroptila ENSSHBP00005020252 100 100 ENSG00000177954 homo_sapiens ENSP00000499044 100 100 terrapene_carolina_triunguis ENSTMTP00000021539 100 100 ENSG00000177954 homo_sapiens ENSP00000499044 98.8095 96.4286 ciona_savignyi ENSCSAVP00000008994 98.8095 96.4286 ENSG00000177954 homo_sapiens ENSP00000499044 100 100 aquila_chrysaetos_chrysaetos ENSACCP00020004420 100 100 ENSG00000177954 homo_sapiens ENSP00000499044 94.0476 88.0952 denticeps_clupeoides ENSDCDP00000055154 72.4771 67.8899 ENSG00000177954 homo_sapiens ENSP00000499044 97.619 97.619 ficedula_albicollis ENSFALP00000018263 100 100 ENSG00000177954 homo_sapiens ENSP00000499044 83.3333 79.7619 cyprinus_carpio_carpio ENSCCRP00000160099 88.6076 84.8101 ENSG00000177954 homo_sapiens ENSP00000499044 94.0476 88.0952 scleropages_formosus ENSSFOP00015053299 64.2276 60.1626 ENSG00000177954 homo_sapiens ENSP00000499044 89.2857 88.0952 leptobrachium_leishanense ENSLLEP00000029984 96.1538 94.8718
Go ID
Go term
No. evidence
Entries
Species
Category
GO:0000028 involved_in ribosomal small subunit assembly 1 IBA Homo_sapiens(9606) Process GO:0002181 involved_in cytoplasmic translation 1 IC Homo_sapiens(9606) Process GO:0003677 enables DNA binding 1 NAS Homo_sapiens(9606) Function GO:0003723 enables RNA binding 2 HDA,IBA Homo_sapiens(9606) Function GO:0003735 enables structural constituent of ribosome 2 IBA,IDA Homo_sapiens(9606) Function GO:0005515 enables protein binding 1 IPI Homo_sapiens(9606) Function GO:0005634 located_in nucleus 1 IDA Homo_sapiens(9606) Component GO:0005654 located_in nucleoplasm 1 TAS Homo_sapiens(9606) Component GO:0005730 located_in nucleolus 1 IEA Homo_sapiens(9606) Component GO:0005829 located_in cytosol 1 TAS Homo_sapiens(9606) Component GO:0005840 located_in ribosome 1 NAS Homo_sapiens(9606) Component GO:0006364 involved_in rRNA processing 1 IMP Homo_sapiens(9606) Process GO:0006412 involved_in translation 2 IC,NAS Homo_sapiens(9606) Process GO:0008270 enables zinc ion binding 1 NAS Homo_sapiens(9606) Function GO:0014069 is_active_in postsynaptic density 2 EXP,IDA Homo_sapiens(9606) Component GO:0022626 located_in cytosolic ribosome 1 IDA Homo_sapiens(9606) Component GO:0022627 part_of cytosolic small ribosomal subunit 3 HDA,IBA,IDA Homo_sapiens(9606) Component GO:0032040 part_of small-subunit processome 1 IDA Homo_sapiens(9606) Component GO:0042274 involved_in ribosomal small subunit biogenesis 1 IDA Homo_sapiens(9606) Process
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