Ensembl ID ENSG00000177954 Gene ID 6232 Accession 10416
Gene Symbol RPS27 Alias S27;MPS1;eS27;DBA17;MPS-1 Full Name ribosomal protein S27
Position 1 : 153990762 - 153992155 Length 1394 bases Strand Plus strand
Status Confidence Main interacting RNAsrRNARBP type Canonical_RBPs
Summary Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of four RNA species and approximately 80 structurally distinct proteins. This gene encodes a member of the S27e family of ribosomal proteins and component of the 40S subunit. The encoded protein contains a C4-type zinc finger domain that can bind to zinc and may bind to nucleic acid. Mutations in this gene have been identified in numerous melanoma patients and in at least one patient with Diamond-Blackfan anemia (DBA). Elevated expression of this gene has been observed in various human cancers. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2018]

ENSG00000177954 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000177954 RPS27 0.70 7.22e-21 KIRC
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000177954 RPS27 tumors 10697607
ENSG00000177954 RPS27 tumor 11425264
ENSG00000177954 RPS27 breast cancer 12175529
ENSG00000177954 RPS27 HNSCC 14732777
ENSG00000177954 RPS27 HNSCC 15598348
ENSG00000177954 RPS27 gastric cancer 16299651
ENSG00000177954 RPS27 gastric cancer 16388747
ENSG00000177954 RPS27 gastric cancer 16914586
ENSG00000177954 RPS27 cancer 18400081
ENSG00000177954 RPS27 tumor 19642098
ENSG00000177954 RPS27 cancer 21170087
ENSG00000177954 RPS27 gastric cancer 21796632
ENSG00000177954 RPS27 cancer 21889435
ENSG00000177954 RPS27 cancer 22798506
ENSG00000177954 RPS27 cancer 23613646
ENSG00000177954 RPS27 gastric cancer 23803695
ENSG00000177954 RPS27 cancers 27336610
ENSG00000177954 RPS27 cancer 28147343
ENSG00000177954 RPS27 tumors 28380042
ENSG00000177954 RPS27 tumors 28820908
ENSG00000177954 RPS27 GBM 30210815
ENSG00000177954 RPS27 breast cancer 31394662
ENSG00000177954 RPS27 breast cancer 31394666
ENSG00000177954 RPS27 tumor 31506433
ENSG00000177954 RPS27 cancer 31663663
ENSG00000177954 RPS27 tumor 8407955
ENSG00000177954 RPS27 tumor 9179190
ENSG00000177954 RPS27 colon cancer 9216656
ENSG00000177954 RPS27 tumor 9404850
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000177954 RPS27 UVM 0.0025 low
ENSG00000177954 RPS27 PAAD 0.029 high
ENSG00000177954 RPS27 UCEC 0.044 low
ENSG00000177954 RPS27 ACC 0.0011 high
ENSG00000177954 RPS27 LGG 0.0028 low
ENSG00000177954 RPS27 LUSC 0.005 low
ENSG00000177954 RPS27 KICH 0.00027 high
ENSG00000177954 RPS27 BRCA 0.0011 low
ENSG00000177954 RPS27 OV 0.027 low
ENSG00000177954 RPS27 DLBC 0.0028 low
ENSG00000177954 RPS27 GBM 0.014 low
ENSG00000177954 RPS27 SKCM 0.015 low
ENSG00000177954 RPS27 LIHC 0.041 high
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000177954 RPS27 CHOL Amp 1.106022 0.534678 1.013955 0.638889
ENSG00000177954 RPS27 LUSC Amp 3.550030 0.274973 0.549511 0.528942
ENSG00000177954 RPS27 LUAD Amp 19.737899 0.392457 0.603003 0.742248
ENSG00000177954 RPS27 CESC Amp 2.712063 0.201679 0.621250 0.532203
ENSG00000177954 RPS27 READ Amp 1.132342 0.147656 0.622107 0.278788
ENSG00000177954 RPS27 UCS Amp 1.060248 0.553918 0.746190 0.696429
ENSG00000177954 RPS27 SARC Amp 4.744677 0.445044 0.732581 0.392996
ENSG00000177954 RPS27 SKCM Amp 4.467139 0.229123 0.698985 0.555858
ENSG00000177954 RPS27 LIHC Amp 18.855525 0.410633 0.905254 0.751351
ENSG00000177954 RPS27 PCPG Amp 3.268801 0.113313 0.695367 0.172840
ENSG00000177954 RPS27 TGCT Amp 0.658729 0.114210 0.441408 0.460000
ENSG00000177954 RPS27 DLBC Amp 1.306895 0.247389 0.653875 0.250000
ENSG00000177954 RPS27 BLCA Amp 10.376974 0.396737 0.593566 0.470588
ENSG00000177954 RPS27 STAD Amp 3.313829 0.201272 0.482908 0.367347
ENSG00000177954 RPS27 PRAD Amp 2.373950 0.068516 0.587345 0.083333
ENSG00000177954 RPS27 UCEC Amp 8.599927 0.229814 0.870776 0.443414