RBP Type	Canonical_RBPs
Diseases	Cancer Disease
Drug	N.A.
Main interacting RNAs	snRNA
Moonlighting functions	N.A.
Localizations	Stress granucleP-body
BulkPerturb-seq	N.A.

Ensembl ID	ENSG00000175324	Gene ID	27257	Accession	20472
Symbol	LSM1	Alias	CASM;YJL124C	Full Name	LSM1 homolog, mRNA degradation associated
Status	Confidence	Length	13340 bases	Strand	Minus strand
Position	8 : 38163335 - 38176674	RNA binding domain	LSM
Summary	This gene encodes a member of the LSm family of RNA-binding proteins. LSm proteins form stable heteromers that bind specifically to the 3'-terminal oligo(U) tract of U6 snRNA and may play a role in pre-mRNA splicing by mediating U4/U6 snRNP formation. Increased expression of this gene may play a role in cellular transformation and the progression of several malignancies including lung cancer, mesothelioma and breast cancer. Alternatively spliced transcript variants have been observed for this gene, and a pseudogene of this gene is located on the short arm of chromosome 9. [provided by RefSeq, Nov 2011]