Ensembl ID ENSG00000175324 Gene ID 27257 Accession 20472
Gene Symbol LSM1 Alias CASM;YJL124C Full Name LSM1 homolog, mRNA degradation associated
Position 8 : 38163335 - 38176674 Length 13340 bases Strand Minus strand
Status Confidence Main interacting RNAssnRNARBP type Canonical_RBPs
Summary This gene encodes a member of the LSm family of RNA-binding proteins. LSm proteins form stable heteromers that bind specifically to the 3'-terminal oligo(U) tract of U6 snRNA and may play a role in pre-mRNA splicing by mediating U4/U6 snRNP formation. Increased expression of this gene may play a role in cellular transformation and the progression of several malignancies including lung cancer, mesothelioma and breast cancer. Alternatively spliced transcript variants have been observed for this gene, and a pseudogene of this gene is located on the short arm of chromosome 9. [provided by RefSeq, Nov 2011]

ENSG00000175324 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000175324 LSM1 -0.4 1.40e-14 KIRC
ENSG00000175324 LSM1 0.99 4.05e-25 BRCA
ENSG00000175324 LSM1 1.13 4.32e-16 LUSC
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000175324 LSM1 pancreatic cancer 10923016
ENSG00000175324 LSM1 pancreatic tumors 11490361
ENSG00000175324 LSM1 tumors 12110768
ENSG00000175324 LSM1 pancreatic cancer 12894573
ENSG00000175324 LSM1 cancer 16024624
ENSG00000175324 LSM1 cancer 18218995
ENSG00000175324 LSM1 pancreatic cancer 26751936
ENSG00000175324 LSM1 pancreatic tumor 9230209
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000175324 LSM1 MESO 0.00063 high
ENSG00000175324 LSM1 PAAD 0.013 high
ENSG00000175324 LSM1 UCEC 0.014 low
ENSG00000175324 LSM1 ACC 0.017 high
ENSG00000175324 LSM1 LUSC 0.0032 low
ENSG00000175324 LSM1 BRCA 0.0076 high
ENSG00000175324 LSM1 ESCA 0.027 low
ENSG00000175324 LSM1 OV 0.037 low
ENSG00000175324 LSM1 DLBC 0.033 high
ENSG00000175324 LSM1 KIRC 0.00033 high
ENSG00000175324 LSM1 PRAD 0.046 low
ENSG00000175324 LSM1 LAML 0.0053 high
ENSG00000175324 LSM1 GBM 0.045 high
ENSG00000175324 LSM1 LIHC 0.00085 high
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000175324 LSM1 LUSC Amp 52.190898 0.913155 1.145625 0.445110
ENSG00000175324 LSM1 LUAD Amp 2.854107 0.166567 0.617117 0.261628
ENSG00000175324 LSM1 COAD Amp 5.515171 0.148842 0.667532 0.332594
ENSG00000175324 LSM1 UCS Amp 1.608114 0.635693 1.072457 0.464286
ENSG00000175324 LSM1 PAAD Amp 0.940145 0.090105 0.381943 0.173913
ENSG00000175324 LSM1 ESCA Amp 2.189397 0.347782 0.693686 0.402174
ENSG00000175324 LSM1 HNSC Amp 14.217315 0.332733 0.788585 0.300766
ENSG00000175324 LSM1 BLCA Amp 9.697009 0.384273 0.862564 0.299020
ENSG00000175324 LSM1 BRCA Amp 81.849239 0.725522 1.385788 0.376852
ENSG00000175324 LSM1 PRAD Amp 3.149366 0.079024 0.688035 0.140244
ENSG00000175324 LSM1 PRAD Del 0.952009 0.075477 0.572054 0.335366
ENSG00000175324 LSM1 UCEC Amp 1.542272 0.123419 0.825839 0.226345
ENSG00000175324 LSM1 UCEC Del 1.782987 0.061062 0.614610 0.137291