Functions and Diseases

RBP Type Canonical_RBPs
Diseases CancerFlavivirusesDengue
Drug N.A.
Main interacting RNAs mRNA
Moonlighting functions Transmemebrane
Localizations Stress granucle
BulkPerturb-seq N.A.

Description

Ensembl ID ENSG00000174953 Gene ID 170506 Accession 14410
Symbol DHX36 Alias G4R1;RHAU;DDX36;MLEL1 Full Name DEAH-box helicase 36
Status Confidence Length 51942 bases Strand Minus strand
Position 3 : 154272546 - 154324487 RNA binding domain DEAD , HA2 , OB_NTP_bind
Summary This gene is a member of the DEAH-box family of RNA-dependent NTPases which are named after the conserved amino acid sequence Asp-Glu-Ala-His in motif II. The protein encoded by this gene has been shown to enhance the deadenylation and decay of mRNAs with 3'-UTR AU-rich elements (ARE-mRNA). The protein has also been shown to resolve into single strands the highly stable tetramolecular DNA configuration (G4) that can form spontaneously in guanine-rich regions of DNA. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

RNA binding domains (RBDs)

Protein Domain Pfam ID E-value Domain number
ENSP00000419862 DEAD PF00270 2.2e-13 1
ENSP00000419862 HA2 PF04408 3.7e-19 2
ENSP00000309296 DEAD PF00270 3.5e-13 1
ENSP00000309296 HA2 PF04408 6.3e-18 2
ENSP00000309296 OB_NTP_bind PF07717 2.2e-15 3
ENSP00000330113 DEAD PF00270 3.6e-13 1
ENSP00000330113 HA2 PF04408 4.7e-19 2
ENSP00000330113 OB_NTP_bind PF07717 2.2e-15 3
ENSP00000417078 DEAD PF00270 3.7e-13 1
ENSP00000417078 HA2 PF04408 4.9e-19 2
ENSP00000417078 OB_NTP_bind PF07717 2.3e-15 3
ENSP00000418756 HA2 PF04408 9.3e-18 1
ENSP00000419761 HA2 PF04408 4.9e-16 1

RNA binding proteomes (RBPomes)

Pubmed ID Full Name Cell Author Time Doi

Literatures on RNA binding capacity

Pubmed ID Title Author Time Journal
36762421 Post-transcriptional polyadenylation site cleavage maintains 3'-end processing upon DNA damage. Rym Sfaxi 2023-04-03 The EMBO journal
30828720 The p53 mRNA: an integral part of the cellular stress response. Lucia Haronikova 2019-04-23 Nucleic acids research
33586621 miRNA: local guardians of presynaptic function in plasticity and disease. J Brandon Woods 2021-07-01 RNA biology
33807183 Long, Noncoding RNA Dysregulation in Glioblastoma. A Patrick DeSouza 2021-03-31 Cancers
21149580 The 5' guanosine tracts of human telomerase RNA are recognized by the G-quadruplex binding domain of the RNA helicase DHX36 and function to increase RNA accumulation. N Alec Sexton 2011-02-01 Molecular and cellular biology
24651521 DHX36 enhances RIG-I signaling by facilitating PKR-mediated antiviral stress granule formation. Ji-Seung Yoo 2014-03-01 PLoS pathogens
34680108 Coordination of RNA Processing Regulation by Signal Transduction Pathways. Veronica Ruta 2021-10-07 Biomolecules
27540585 DEAH-RHA helicase•Znf cofactor systems in kinetoplastid RNA editing and evolutionarily distant RNA processes. Jorge Cruz-Reyes 2016-01-01 RNA & disease (Houston, Tex.)
33255335 An Updated Focus on Quadruplex Structures as Potential Therapeutic Targets in Cancer. Victoria Sanchez-Martin 2020-11-24 International journal of molecular sciences
29250441 On Characterizing the Interactions between Proteins and Guanine Quadruplex Structures of Nucleic Acids. S K Ewan McRae 2017-01-01 Journal of nucleic acids
31160600 DHX36 prevents the accumulation of translationally inactive mRNAs with G4-structures in untranslated regions. Markus Sauer 2019-06-03 Nature communications
34174288 The RNA helicase DHX36-G4R1 modulates C9orf72 GGGGCC hexanucleotide repeat-associated translation. Yi-Ju Tseng 2021-08-01 The Journal of biological chemistry
25653156 Insights into the mechanism of a G-quadruplex-unwinding DEAH-box helicase. C Michael Chen 2015-02-27 Nucleic acids research
32461552 hnRNP H/F drive RNA G-quadruplex-mediated translation linked to genomic instability and therapy resistance in glioblastoma. Pauline Herviou 2020-05-27 Nature communications

Transcripts

Name Transcript ID bp Protein Translation ID
DHX36-213 ENST00000496811 6723 1008aa ENSP00000417078
DHX36-201 ENST00000308361 3487 979aa ENSP00000309296
DHX36-212 ENST00000495598 719 No protein -
DHX36-202 ENST00000329463 2985 994aa ENSP00000330113
DHX36-207 ENST00000477549 644 No protein -
DHX36-208 ENST00000479934 530 119aa ENSP00000418756
DHX36-210 ENST00000481941 2612 797aa ENSP00000419862
DHX36-203 ENST00000460695 2306 No protein -
DHX36-206 ENST00000469977 562 187aa ENSP00000419761
DHX36-209 ENST00000481332 452 No protein -
DHX36-204 ENST00000460875 478 No protein -
DHX36-205 ENST00000462464 641 No protein -
DHX36-211 ENST00000491011 833 No protein -

Gene Model

Pathways

Pathway ID Pathway Name Source

Phenotypes

ensgID Trait pValue Pubmed ID

GWAS

ensgIDSNPChromosomePosition TraitPubmedIDOr or BEAT EFO ID

Protein-Protein Interaction (PPI)

Paralogs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id
ENSG00000174953homo_sapiensENSP0000026848231.703317.8484homo_sapiensENSP0000041707838.591321.7262
ENSG00000174953homo_sapiensENSP0000025163639.079625.42homo_sapiensENSP0000041707853.075434.5238
ENSG00000174953homo_sapiensENSP0000033190734.383221.5223homo_sapiensENSP0000041707838.988124.4048
ENSG00000174953homo_sapiensENSP0000035652041.102426.6142homo_sapiensENSP0000041707851.785733.5317
ENSG00000174953homo_sapiensENSP0000028469042.934122.2073homo_sapiensENSP0000041707831.646816.369
ENSG00000174953homo_sapiensENSP0000022529644.837327.157homo_sapiensENSP0000041707831.448419.0476
ENSG00000174953homo_sapiensENSP0000024781523.367110.8556homo_sapiensENSP0000041707825.198411.7063
ENSG00000174953homo_sapiensENSP0000038462140.167422.8731homo_sapiensENSP0000041707828.571416.2698
ENSG00000174953homo_sapiensENSP0000025201149.644429.0185homo_sapiensENSP0000041707834.62320.2381
ENSG00000174953homo_sapiensENSP0000031113531.806418.7554homo_sapiensENSP0000041707836.507921.5278
ENSG00000174953homo_sapiensENSP0000040511140.620528.355homo_sapiensENSP0000041707855.853238.9881
ENSG00000174953homo_sapiensENSP0000036562536.503422.6705homo_sapiensENSP0000041707837.698423.4127
ENSG00000174953homo_sapiensENSP0000025124145.442928.2413homo_sapiensENSP0000041707835.11921.8254
ENSG00000174953homo_sapiensENSP0000016186333.356621.8881homo_sapiensENSP0000041707847.321431.0516
ENSG00000174953homo_sapiensENSP0000033674146.666728.9308homo_sapiensENSP0000041707836.805622.8175
ENSG00000174953homo_sapiensENSP0000040562037.604723.8693homo_sapiensENSP0000041707844.543728.2738
ENSG00000174953homo_sapiensENSP0000026241531.967219.5902homo_sapiensENSP0000041707838.690523.7103
ENSG00000174953homo_sapiensENSP0000038730328.871217.2938homo_sapiensENSP0000041707839.583323.7103
ENSG00000174953homo_sapiensENSP00000486184100100homo_sapiensENSP0000041707821.428621.4286

Orthologs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id
ENSG00000174953homo_sapiensENSP0000041707899.50498.9087nomascus_leucogenysENSNLEP0000000447999.602899.007
ENSG00000174953homo_sapiensENSP0000041707899.702499.6032pan_paniscusENSPPAP0000000488099.603699.5045
ENSG00000174953homo_sapiensENSP0000041707899.603299.2064pongo_abeliiENSPPYP0000001590299.405999.0099
ENSG00000174953homo_sapiensENSP0000041707899.702499.6032pan_troglodytesENSPTRP0000002676799.702499.6032
ENSG00000174953homo_sapiensENSP0000041707899.900899.504gorilla_gorillaENSGGOP0000002869799.900899.504
ENSG00000174953homo_sapiensENSP0000041707891.765985.119ornithorhynchus_anatinusENSOANP0000001126289.980583.463
ENSG00000174953homo_sapiensENSP0000041707893.353287.5sarcophilus_harrisiiENSSHAP0000001918893.353287.5
ENSG00000174953homo_sapiensENSP0000041707866.964359.7222notamacropus_eugeniiENSMEUP0000000139671.504263.7712
ENSG00000174953homo_sapiensENSP0000041707885.019881.0516choloepus_hoffmanniENSCHOP0000000207292.748988.4199
ENSG00000174953homo_sapiensENSP0000041707886.111179.2659dasypus_novemcinctusENSDNOP0000000130385.349178.5644
ENSG00000174953homo_sapiensENSP0000041707890.178686.7064erinaceus_europaeusENSEEUP0000000956790.268186.7924
ENSG00000174953homo_sapiensENSP0000041707883.63178.9683echinops_telfairiENSETEP0000000738985.151580.404
ENSG00000174953homo_sapiensENSP0000041707898.809597.0238callithrix_jacchusENSCJAP0000000174698.613996.8317
ENSG00000174953homo_sapiensENSP0000041707899.702499.2064cercocebus_atysENSCATP0000002851399.406598.912
ENSG00000174953homo_sapiensENSP0000041707899.702499.2064macaca_fascicularisENSMFAP0000001845999.702499.2064
ENSG00000174953homo_sapiensENSP0000041707899.702499.2064macaca_mulattaENSMMUP0000001489499.702499.2064
ENSG00000174953homo_sapiensENSP0000041707899.603299.1071macaca_nemestrinaENSMNEP0000003299599.603299.1071
ENSG00000174953homo_sapiensENSP0000041707899.702499.2064papio_anubisENSPANP0000000805299.702499.2064
ENSG00000174953homo_sapiensENSP0000041707899.702499.2064mandrillus_leucophaeusENSMLEP0000001730099.702499.2064
ENSG00000174953homo_sapiensENSP0000041707897.321494.0476tursiops_truncatusENSTTRP0000001600696.936893.6759
ENSG00000174953homo_sapiensENSP0000041707897.61994.1468vulpes_vulpesENSVVUP0000003391897.813194.334
ENSG00000174953homo_sapiensENSP0000041707895.833391.8651mus_spretusMGP_SPRETEiJ_P006014296.503592.5075
ENSG00000174953homo_sapiensENSP0000041707895.634991.8651equus_asinusENSEASP0000503037093.683289.9903
ENSG00000174953homo_sapiensENSP0000041707897.321493.4524capra_hircusENSCHIP0000001780197.128793.2673
ENSG00000174953homo_sapiensENSP0000041707895.138990.1786loxodonta_africanaENSLAFP0000001285395.804290.8092
ENSG00000174953homo_sapiensENSP0000041707897.916794.6429panthera_leoENSPLOP0000001323597.433494.1757
ENSG00000174953homo_sapiensENSP0000041707897.916794.7421ailuropoda_melanoleucaENSAMEP0000001235197.819694.6482
ENSG00000174953homo_sapiensENSP0000041707897.321493.4524bos_indicus_hybridENSBIXP0000503018297.128793.2673
ENSG00000174953homo_sapiensENSP0000041707894.940591.5675oryctolagus_cuniculusENSOCUP0000004341565.190762.8747
ENSG00000174953homo_sapiensENSP0000041707895.337391.6667equus_caballusENSECAP0000002268493.391689.7959
ENSG00000174953homo_sapiensENSP0000041707894.642991.2698canis_lupus_familiarisENSCAFP0084502858196.266492.8355
ENSG00000174953homo_sapiensENSP0000041707897.817594.5436panthera_pardusENSPPRP0000000776697.720594.45
ENSG00000174953homo_sapiensENSP0000041707814.980214.881marmota_marmota_marmotaENSMMMP0000001758098.692898.0392
ENSG00000174953homo_sapiensENSP0000041707897.420694.0476balaenoptera_musculusENSBMSP0001000293397.227793.8614
ENSG00000174953homo_sapiensENSP0000041707887.698484.4246cavia_porcellusENSCPOP0000000695596.506692.9039
ENSG00000174953homo_sapiensENSP0000041707898.115195.0397felis_catusENSFCAP0000004675697.727394.664
ENSG00000174953homo_sapiensENSP0000041707892.757989.6825ursus_americanusENSUAMP0000002165196.991793.7759
ENSG00000174953homo_sapiensENSP0000041707893.353287.3016monodelphis_domesticaENSMODP0000005803093.260787.2151
ENSG00000174953homo_sapiensENSP0000041707897.420693.5516bison_bison_bisonENSBBBP0000002140397.227793.3663
ENSG00000174953homo_sapiensENSP0000041707897.420694.246monodon_monocerosENSMMNP0001500416496.844293.6884
ENSG00000174953homo_sapiensENSP0000041707897.420693.8492sus_scrofaENSSSCP0000002683897.035693.4783
ENSG00000174953homo_sapiensENSP0000041707897.817595.7341microcebus_murinusENSMICP0000005154497.817595.7341
ENSG00000174953homo_sapiensENSP0000041707896.031792.6587octodon_degusENSODEP0000000118696.606893.2136
ENSG00000174953homo_sapiensENSP0000041707894.642990.873jaculus_jaculusENSJJAP0000001121095.975992.1529
ENSG00000174953homo_sapiensENSP0000041707897.321493.4524ovis_aries_rambouilletENSOARP0002000361397.128793.2673
ENSG00000174953homo_sapiensENSP0000041707898.115195.1389ursus_maritimusENSUMAP0000001619697.823994.8566
ENSG00000174953homo_sapiensENSP0000041707870.039766.6667ochotona_princepsENSOPRP0000000016171.026267.6056
ENSG00000174953homo_sapiensENSP0000041707897.420694.246delphinapterus_leucasENSDLEP0000000477296.274593.1373
ENSG00000174953homo_sapiensENSP0000041707897.718394.3452physeter_catodonENSPCTP0000500005997.428394.0653
ENSG00000174953homo_sapiensENSP0000041707895.734191.9643mus_caroliMGP_CAROLIEiJ_P005784096.592.7
ENSG00000174953homo_sapiensENSP0000041707895.833391.9643mus_musculusENSMUSP0000002933696.503592.6074
ENSG00000174953homo_sapiensENSP0000041707891.865186.9048dipodomys_ordiiENSDORP0000002721594.393589.2966
ENSG00000174953homo_sapiensENSP0000041707898.214394.8413mustela_putorius_furoENSMPUP0000000269497.729594.3731
ENSG00000174953homo_sapiensENSP0000041707892.956491.0714aotus_nancymaaeENSANAP0000000533697.604295.625
ENSG00000174953homo_sapiensENSP0000041707898.908796.9246saimiri_boliviensis_boliviensisENSSBOP0000001593298.615296.637
ENSG00000174953homo_sapiensENSP0000041707895.039791.5675vicugna_pacosENSVPAP0000000375994.757791.2957
ENSG00000174953homo_sapiensENSP0000041707899.404898.6111chlorocebus_sabaeusENSCSAP0000000814899.503598.709
ENSG00000174953homo_sapiensENSP0000041707893.551690.9722tupaia_belangeriENSTBEP0000001173393.924391.3347
ENSG00000174953homo_sapiensENSP0000041707895.238191.5675mesocricetus_auratusENSMAUP0000000015896.096192.3924
ENSG00000174953homo_sapiensENSP0000041707897.519894.246phocoena_sinusENSPSNP0000002440996.942893.6884
ENSG00000174953homo_sapiensENSP0000041707897.817594.4444camelus_dromedariusENSCDRP0000500016797.430894.0711
ENSG00000174953homo_sapiensENSP0000041707896.62793.5516carlito_syrichtaENSTSYP0000002428096.915493.8308
ENSG00000174953homo_sapiensENSP0000041707894.841391.8651panthera_tigris_altaicaENSPTIP0000002131397.55194.4898
ENSG00000174953homo_sapiensENSP0000041707895.734191.6667rattus_norvegicusENSRNOP0000001982496.592.4
ENSG00000174953homo_sapiensENSP0000041707897.023894.9405prolemur_simusENSPSMP0000000433597.120295.0348
ENSG00000174953homo_sapiensENSP0000041707896.13192.3611microtus_ochrogasterENSMOCP0000000696696.513992.7291
ENSG00000174953homo_sapiensENSP0000041707861.904858.8294sorex_araneusENSSARP0000000584277.323473.482
ENSG00000174953homo_sapiensENSP0000041707895.535792.0635peromyscus_maniculatus_bairdiiENSPEMP0000000833996.203892.7073
ENSG00000174953homo_sapiensENSP0000041707897.321493.4524bos_mutusENSBMUP0000000407697.514993.6382
ENSG00000174953homo_sapiensENSP0000041707895.734191.9643mus_spicilegusENSMSIP0000003517796.403692.6074
ENSG00000174953homo_sapiensENSP0000041707895.932592.0635cricetulus_griseus_chok1gshdENSCGRP0000101228996.314792.4303
ENSG00000174953homo_sapiensENSP0000041707880.654877.7778pteropus_vampyrusENSPVAP0000000799586.122983.0508
ENSG00000174953homo_sapiensENSP0000041707896.527892.8571myotis_lucifugusENSMLUP0000000211496.815993.1343
ENSG00000174953homo_sapiensENSP0000041707888.492181.746vombatus_ursinusENSVURP0001002256693.79686.6456
ENSG00000174953homo_sapiensENSP0000041707897.222293.254rhinolophus_ferrumequinumENSRFEP0001000808797.125993.1615
ENSG00000174953homo_sapiensENSP0000041707898.214395.0397neovison_visonENSNVIP0000001601897.729594.5706
ENSG00000174953homo_sapiensENSP0000041707897.420693.5516bos_taurusENSBTAP0000000808297.227793.3663
ENSG00000174953homo_sapiensENSP0000041707895.039791.1706heterocephalus_glaber_femaleENSHGLP0000002441894.013790.1865
ENSG00000174953homo_sapiensENSP0000041707895.238194.246rhinopithecus_bietiENSRBIP0000004282498.867197.8373
ENSG00000174953homo_sapiensENSP0000041707897.023893.4524canis_lupus_dingoENSCAFP0002000657796.544992.9911
ENSG00000174953homo_sapiensENSP0000041707896.924694.7421sciurus_vulgarisENSSVLP0000500871797.795.5
ENSG00000174953homo_sapiensENSP0000041707892.261985.4167phascolarctos_cinereusENSPCIP0000000007592.537385.6716
ENSG00000174953homo_sapiensENSP0000041707896.230292.4603nannospalax_galiliENSNGAP0000001387996.039692.2772
ENSG00000174953homo_sapiensENSP0000041707897.321493.4524bos_grunniensENSBGRP0000001787897.128793.2673
ENSG00000174953homo_sapiensENSP0000041707896.527893.254chinchilla_lanigeraENSCLAP0000000508397.202893.9061
ENSG00000174953homo_sapiensENSP0000041707897.321493.4524cervus_hanglu_yarkandensisENSCHYP0000001138796.650292.8079
ENSG00000174953homo_sapiensENSP0000041707897.321494.246catagonus_wagneriENSCWAP0000002562897.032693.9664
ENSG00000174953homo_sapiensENSP0000041707896.825494.8413ictidomys_tridecemlineatusENSSTOP0000000352097.695.6
ENSG00000174953homo_sapiensENSP0000041707895.734192.0635otolemur_garnettiiENSOGAP0000001008096.693492.986
ENSG00000174953homo_sapiensENSP0000041707897.61995.8333cebus_imitatorENSCCAP0000003465698.301796.5035
ENSG00000174953homo_sapiensENSP0000041707896.726294.6429urocitellus_parryiiENSUPAP0001000840397.595.4
ENSG00000174953homo_sapiensENSP0000041707897.023893.254moschus_moschiferusENSMMSP0000002007896.640392.8854
ENSG00000174953homo_sapiensENSP0000041707899.603298.8095rhinopithecus_roxellanaENSRROP0000002546199.603298.8095
ENSG00000174953homo_sapiensENSP0000041707896.031792.0635mus_pahariMGP_PahariEiJ_P006880396.606892.6148
ENSG00000174953homo_sapiensENSP0000041707860.714356.8452propithecus_coquereliENSPCOP0000000392985.236879.805
ENSG00000174953homo_sapiensENSP0000041707882.936579.4643propithecus_coquereliENSPCOP0000003124391.566387.7327
ENSG00000174953homo_sapiensENSP0000041707855.158736.8056drosophila_melanogasterFBpp030714659.023439.3843
ENSG00000174953homo_sapiensENSP0000041707840.87332.3413ciona_intestinalisENSCINP0000000408177.153661.0487
ENSG00000174953homo_sapiensENSP0000041707846.329439.2857petromyzon_marinusENSPMAP0000000445982.218369.7183
ENSG00000174953homo_sapiensENSP0000041707860.11950.0992eptatretus_burgeriENSEBUP0000000780579.423366.1861
ENSG00000174953homo_sapiensENSP0000041707878.075467.8571callorhinchus_miliiENSCMIP0000001054083.368672.4576
ENSG00000174953homo_sapiensENSP0000041707884.325473.9087latimeria_chalumnaeENSLACP0000001841484.915174.4256
ENSG00000174953homo_sapiensENSP0000041707881.349271.627lepisosteus_oculatusENSLOCP0000000250180.47170.8538
ENSG00000174953homo_sapiensENSP0000041707881.051669.6429clupea_harengusENSCHAP0000004949679.785268.5547
ENSG00000174953homo_sapiensENSP0000041707878.37365.873danio_rerioENSDARP0000013951176.181364.0309
ENSG00000174953homo_sapiensENSP0000041707880.75468.75carassius_auratusENSCARP0000000774679.803967.9412
ENSG00000174953homo_sapiensENSP0000041707874.603264.2857astyanax_mexicanusENSAMXP0000001807282.728371.2871
ENSG00000174953homo_sapiensENSP0000041707871.527860.6151ictalurus_punctatusENSIPUP0000001599978.284566.3409
ENSG00000174953homo_sapiensENSP0000041707880.456467.8571esox_luciusENSELUP0000000853377.238165.1429
ENSG00000174953homo_sapiensENSP0000041707877.083365.873electrophorus_electricusENSEEEP0000002511477.622466.3337
ENSG00000174953homo_sapiensENSP0000041707878.769866.8651oncorhynchus_kisutchENSOKIP0000508894963.826454.1801
ENSG00000174953homo_sapiensENSP0000041707881.448469.0476oncorhynchus_mykissENSOMYP0000011137176.159664.564
ENSG00000174953homo_sapiensENSP0000041707881.547668.8492salmo_salarENSSSAP0000008134177.328365.2869
ENSG00000174953homo_sapiensENSP0000041707881.448468.9484salmo_truttaENSSTUP0000002102077.161765.3195
ENSG00000174953homo_sapiensENSP0000041707880.853266.8651gadus_morhuaENSGMOP0000005932770.869658.6087
ENSG00000174953homo_sapiensENSP0000041707873.214359.2262fundulus_heteroclitusENSFHEP0000001601172.852958.9339
ENSG00000174953homo_sapiensENSP0000041707880.654867.2619poecilia_reticulataENSPREP0000000417776.915864.1438
ENSG00000174953homo_sapiensENSP0000041707879.563566.5675xiphophorus_maculatusENSXMAP0000000151875.305263.0047
ENSG00000174953homo_sapiensENSP0000041707879.265966.4683oryzias_latipesENSORLP0000003062976.095263.8095
ENSG00000174953homo_sapiensENSP0000041707872.420661.1111cyclopterus_lumpusENSCLMP0000500323675.413263.6364
ENSG00000174953homo_sapiensENSP0000041707881.150868.4524oreochromis_niloticusENSONIP0000000446476.879764.8496
ENSG00000174953homo_sapiensENSP0000041707881.051668.254haplochromis_burtoniENSHBUP0000003022576.857964.7225
ENSG00000174953homo_sapiensENSP0000041707880.75468.0556astatotilapia_callipteraENSACLP0000002095176.503864.4737
ENSG00000174953homo_sapiensENSP0000041707880.75467.6587sparus_aurataENSSAUP0001002171775.650663.3829
ENSG00000174953homo_sapiensENSP0000041707881.547668.4524lates_calcariferENSLCAP0001000574376.181663.9481
ENSG00000174953homo_sapiensENSP0000041707884.325471.0317xenopus_tropicalisENSXETP0000006687458.945949.6533
ENSG00000174953homo_sapiensENSP0000041707887.797678.7698chrysemys_picta_belliiENSCPBP0000002644490.676281.3525
ENSG00000174953homo_sapiensENSP0000041707825.49622.9167sphenodon_punctatusENSSPUP0000000100785.099376.4901
ENSG00000174953homo_sapiensENSP0000041707877.480269.246sphenodon_punctatusENSSPUP0000000098090.81481.1628
ENSG00000174953homo_sapiensENSP0000041707812.698410.4167sphenodon_punctatusENSSPUP0000000102685.90670.4698
ENSG00000174953homo_sapiensENSP000004170786.150795.55556sphenodon_punctatusENSSPUP0000000102084.931576.7123
ENSG00000174953homo_sapiensENSP0000041707888.194478.5714crocodylus_porosusENSCPRP0000500984289.79880
ENSG00000174953homo_sapiensENSP0000041707888.095277.2817laticauda_laticaudataENSLLTP0000000625789.878578.8462
ENSG00000174953homo_sapiensENSP0000041707887.797677.6786notechis_scutatusENSNSUP0000002580589.574979.251
ENSG00000174953homo_sapiensENSP0000041707888.194477.7778pseudonaja_textilisENSPTXP0000000676889.979879.3522
ENSG00000174953homo_sapiensENSP0000041707888.392978.7698anas_platyrhynchos_platyrhynchosENSAPLP0000001242690.09180.2831
ENSG00000174953homo_sapiensENSP0000041707888.492178.9683gallus_gallusENSGALP0001000182790.374980.6484
ENSG00000174953homo_sapiensENSP0000041707880.853272.3214meleagris_gallopavoENSMGAP0000001129991.882882.1871
ENSG00000174953homo_sapiensENSP0000041707881.646873.5119serinus_canariaENSSCAP0000001189990.439681.4286
ENSG00000174953homo_sapiensENSP0000041707887.103277.5794parus_majorENSPMJP0000000833789.318479.5524
ENSG00000174953homo_sapiensENSP0000041707874.603266.9643anolis_carolinensisENSACAP0000001949091.151581.8182
ENSG00000174953homo_sapiensENSP0000041707872.519861.5079neolamprologus_brichardiENSNBRP0000000286181.584869.1964
ENSG00000174953homo_sapiensENSP0000041707888.194477.5794naja_najaENSNNAP0000000484789.79878.9899
ENSG00000174953homo_sapiensENSP0000041707888.888978.1746podarcis_muralisENSPMRP0000001473090.322679.4355
ENSG00000174953homo_sapiensENSP0000041707882.043673.7103geospiza_fortisENSGFOP0000000031290.879181.6484
ENSG00000174953homo_sapiensENSP0000041707886.408777.4802taeniopygia_guttataENSTGUP0000001167183.190174.5941
ENSG00000174953homo_sapiensENSP0000041707874.702465.0794erpetoichthys_calabaricusENSECRP0000001090979.936369.6391
ENSG00000174953homo_sapiensENSP0000041707876.289765.377kryptolebias_marmoratusENSKMAP0000002635669.592859.638
ENSG00000174953homo_sapiensENSP0000041707887.99678.1746salvator_merianaeENSSMRP0000000417789.686679.6764
ENSG00000174953homo_sapiensENSP0000041707876.686564.5833oryzias_javanicusENSOJAP0000002189976.157664.1379
ENSG00000174953homo_sapiensENSP0000041707872.023861.1111amphilophus_citrinellusENSACIP0000002101683.930671.2139
ENSG00000174953homo_sapiensENSP0000041707881.349267.9564dicentrarchus_labraxENSDLAP0000501476177.067764.3797
ENSG00000174953homo_sapiensENSP0000041707880.853268.5516amphiprion_perculaENSAPEP0000000201576.886865.1887
ENSG00000174953homo_sapiensENSP0000041707837.599230.4563oryzias_sinensisENSOSIP0000003123669.797456.5378
ENSG00000174953homo_sapiensENSP0000041707839.087333.3333oryzias_sinensisENSOSIP0000003874783.298171.0359
ENSG00000174953homo_sapiensENSP0000041707882.539774.0079pelodiscus_sinensisENSPSIP0000001421591.6382.1586
ENSG00000174953homo_sapiensENSP0000041707887.698478.373gopherus_evgoodeiENSGEVP0000501139090.481180.8598
ENSG00000174953homo_sapiensENSP0000041707887.00478.0754chelonoidis_abingdoniiENSCABP0000000248087.963978.9368
ENSG00000174953homo_sapiensENSP0000041707880.853267.9564seriola_dumeriliENSSDUP0000003292376.886864.6226
ENSG00000174953homo_sapiensENSP0000041707847.321436.6071cottoperca_gobioENSCGOP0000005180961.867747.8599
ENSG00000174953homo_sapiensENSP0000041707878.075469.4444struthio_camelus_australisENSSCUP0000001491987.347477.6915
ENSG00000174953homo_sapiensENSP0000041707888.293678.5714anser_brachyrhynchusENSABRP0000002346290.08180.1619
ENSG00000174953homo_sapiensENSP0000041707878.968366.8651gasterosteus_aculeatusENSGACP0000001360078.50166.4694
ENSG00000174953homo_sapiensENSP0000041707879.960366.4683cynoglossus_semilaevisENSCSEP0000002101075.397662.6754
ENSG00000174953homo_sapiensENSP0000041707880.357166.5675poecilia_formosaENSPFOP0000000979076.271263.1827
ENSG00000174953homo_sapiensENSP0000041707881.051668.4524myripristis_murdjanENSMMDP0000502944177.294265.2791
ENSG00000174953homo_sapiensENSP0000041707880.654867.2619sander_luciopercaENSSLUP0000004328575.627963.0698
ENSG00000174953homo_sapiensENSP0000041707887.797679.0675strigops_habroptilaENSSHBP0000500073290.583481.5763
ENSG00000174953homo_sapiensENSP0000041707880.952468.4524amphiprion_ocellarisENSAOCP0000001945677.126765.2174
ENSG00000174953homo_sapiensENSP0000041707887.698478.6706terrapene_carolina_triunguisENSTMTP0000000402190.296281.001
ENSG00000174953homo_sapiensENSP0000041707863.988155.2579hucho_huchoENSHHUP0000005837081.234370.1511
ENSG00000174953homo_sapiensENSP0000041707879.960367.1627betta_splendensENSBSLP0000001596875.609863.5084
ENSG00000174953homo_sapiensENSP0000041707879.464369.4444pygocentrus_nattereriENSPNAP0000002830077.76767.9612
ENSG00000174953homo_sapiensENSP0000041707882.142968.9484anabas_testudineusENSATEP0000002235177.09564.7114
ENSG00000174953homo_sapiensENSP0000041707858.333343.5516ciona_savignyiENSCSAVP0000001383072.413854.064
ENSG00000174953homo_sapiensENSP0000041707842.162736.5079seriola_lalandi_dorsalisENSSLDP0000001980485.513174.0443
ENSG00000174953homo_sapiensENSP000004170788.234137.24206seriola_lalandi_dorsalisENSSLDP0000001499783.838473.7374
ENSG00000174953homo_sapiensENSP0000041707879.464365.7738labrus_bergyltaENSLBEP0000003112175.211362.2535
ENSG00000174953homo_sapiensENSP000004170786.349215.75397pundamilia_nyerereiENSPNYP0000000609668.817262.3656
ENSG00000174953homo_sapiensENSP0000041707870.734158.4325pundamilia_nyerereiENSPNYP0000001015074.039561.163
ENSG00000174953homo_sapiensENSP0000041707879.067566.1706mastacembelus_armatusENSMAMP0000001959575.402163.1031
ENSG00000174953homo_sapiensENSP0000041707880.654868.1548stegastes_partitusENSSPAP0000002951076.266464.4465
ENSG00000174953homo_sapiensENSP0000041707860.218351.8849oncorhynchus_tshawytschaENSOTSP0000502822382.472871.0598
ENSG00000174953homo_sapiensENSP0000041707880.952468.4524acanthochromis_polyacanthusENSAPOP0000001895676.836264.9717
ENSG00000174953homo_sapiensENSP0000041707888.690579.8611aquila_chrysaetos_chrysaetosENSACCP0002000119488.866880.0199
ENSG00000174953homo_sapiensENSP0000041707879.662766.9643nothobranchius_furzeriENSNFUP0001500079376.768664.5315
ENSG00000174953homo_sapiensENSP0000041707879.861166.7659cyprinodon_variegatusENSCVAP0000000419975.163462.8385
ENSG00000174953homo_sapiensENSP0000041707879.960367.6587denticeps_clupeoidesENSDCDP0000004349478.48166.407
ENSG00000174953homo_sapiensENSP0000041707881.051667.4603larimichthys_croceaENSLCRP0000502583775.299562.6728
ENSG00000174953homo_sapiensENSP0000041707880.257966.6667takifugu_rubripesENSTRUP0000000285877.342364.2447
ENSG00000174953homo_sapiensENSP0000041707882.142973.9087ficedula_albicollisENSFALP0000001787289.128180.1938
ENSG00000174953homo_sapiensENSP0000041707875.793663.0952hippocampus_comesENSHCOP0000000249479.08965.8385
ENSG00000174953homo_sapiensENSP0000041707880.853268.8492cyprinus_carpio_carpioENSCCRP0000017696279.745667.9061
ENSG00000174953homo_sapiensENSP0000041707888.690579.2659coturnix_japonicaENSCJPP0000502282390.030280.4632
ENSG00000174953homo_sapiensENSP0000041707880.158766.9643poecilia_latipinnaENSPLAP0000002466776.082963.5593
ENSG00000174953homo_sapiensENSP0000041707862.599252.4802sinocyclocheilus_grahamiENSSGRP0000005682373.801261.8713
ENSG00000174953homo_sapiensENSP0000041707880.952468.254maylandia_zebraENSMZEP0000500206676.691764.6617
ENSG00000174953homo_sapiensENSP0000041707878.86965.4762tetraodon_nigroviridisENSTNIP0000001050878.63565.2819
ENSG00000174953homo_sapiensENSP0000041707880.257969.3452paramormyrops_kingsleyaeENSPKIP0000002826379.861869.003
ENSG00000174953homo_sapiensENSP0000041707879.265969.9405scleropages_formosusENSSFOP0001503053877.347568.2478
ENSG00000174953homo_sapiensENSP0000041707882.043671.0317leptobrachium_leishanenseENSLLEP0000001400085.082373.6626
ENSG00000174953homo_sapiensENSP0000041707880.357167.4603scophthalmus_maximusENSSMAP000000194817260.4444
ENSG00000174953homo_sapiensENSP0000041707879.365166.369oryzias_melastigmaENSOMEP0000000976076.190563.7143

Gene Ontology

Go ID Go term No. evidence Entries Species Category
GO:0000287enables magnesium ion binding1IDAHomo_sapiens(9606)Function
GO:0000781located_in chromosome, telomeric region1IDAHomo_sapiens(9606)Component
GO:0000976enables transcription cis-regulatory region binding1ISSHomo_sapiens(9606)Function
GO:0000978enables RNA polymerase II cis-regulatory region sequence-specific DNA binding1IDAHomo_sapiens(9606)Function
GO:0001503involved_in ossification1ISSHomo_sapiens(9606)Process
GO:0002151enables G-quadruplex RNA binding3IBA,IDA,IMPHomo_sapiens(9606)Function
GO:0002735involved_in positive regulation of myeloid dendritic cell cytokine production1IEAHomo_sapiens(9606)Process
GO:0003678enables DNA helicase activity2IBA,IDAHomo_sapiens(9606)Function
GO:0003697enables single-stranded DNA binding1IDAHomo_sapiens(9606)Function
GO:0003723enables RNA binding2HDA,IDAHomo_sapiens(9606)Function
GO:0003724enables RNA helicase activity2IBA,IDAHomo_sapiens(9606)Function
GO:0003725enables double-stranded RNA binding1IDAHomo_sapiens(9606)Function
GO:0003730enables mRNA 3-UTR binding1IDAHomo_sapiens(9606)Function
GO:0005515enables protein binding1IPIHomo_sapiens(9606)Function
GO:0005524enables ATP binding1ISSHomo_sapiens(9606)Function
GO:0005622is_active_in intracellular anatomical structure1IBAHomo_sapiens(9606)Component
GO:0005634is_active_in nucleus2IBA,IDAHomo_sapiens(9606)Component
GO:0005654located_in nucleoplasm1IDAHomo_sapiens(9606)Component
GO:0005737is_active_in cytoplasm2IBA,IDAHomo_sapiens(9606)Component
GO:0005739located_in mitochondrion1IDAHomo_sapiens(9606)Component
GO:0005829located_in cytosol2IDA,TASHomo_sapiens(9606)Component
GO:0006359involved_in regulation of transcription by RNA polymerase III1IMPHomo_sapiens(9606)Process
GO:0007283involved_in spermatogenesis1ISSHomo_sapiens(9606)Process
GO:0008094enables ATP-dependent activity, acting on DNA1IDAHomo_sapiens(9606)Function
GO:0010494located_in cytoplasmic stress granule1IDAHomo_sapiens(9606)Component
GO:0010501involved_in RNA secondary structure unwinding1IDAHomo_sapiens(9606)Process
GO:0010628involved_in positive regulation of gene expression1ISSHomo_sapiens(9606)Process
GO:0016607located_in nuclear speck1IDAHomo_sapiens(9606)Component
GO:0016887enables ATP hydrolysis activity1IEAHomo_sapiens(9606)Function
GO:0017148involved_in negative regulation of translation1IDAHomo_sapiens(9606)Process
GO:0030154involved_in cell differentiation1IEAHomo_sapiens(9606)Process
GO:0030424located_in axon1ISSHomo_sapiens(9606)Component
GO:0030425located_in dendrite1ISSHomo_sapiens(9606)Component
GO:0031442involved_in positive regulation of mRNA 3-end processing1IMPHomo_sapiens(9606)Process
GO:0032206involved_in positive regulation of telomere maintenance1IMPHomo_sapiens(9606)Process
GO:0032508involved_in DNA duplex unwinding1IEAHomo_sapiens(9606)Process
GO:0032727involved_in positive regulation of interferon-alpha production1IMPHomo_sapiens(9606)Process
GO:0034605involved_in cellular response to heat1IDAHomo_sapiens(9606)Process
GO:0034644involved_in cellular response to UV1IMPHomo_sapiens(9606)Process
GO:0035925enables mRNA 3-UTR AU-rich region binding1IDAHomo_sapiens(9606)Function
GO:0042826enables histone deacetylase binding1ISSHomo_sapiens(9606)Function
GO:0043123involved_in positive regulation of I-kappaB kinase/NF-kappaB signaling1ISSHomo_sapiens(9606)Process
GO:0043204located_in perikaryon1ISSHomo_sapiens(9606)Component
GO:0043330involved_in response to exogenous dsRNA1IEAHomo_sapiens(9606)Process
GO:0043488involved_in regulation of mRNA stability1IMPHomo_sapiens(9606)Process
GO:0044806involved_in G-quadruplex DNA unwinding1IDAHomo_sapiens(9606)Process
GO:0045087involved_in innate immune response1IEAHomo_sapiens(9606)Process
GO:0045944involved_in positive regulation of transcription by RNA polymerase II1ISSHomo_sapiens(9606)Process
GO:0045995involved_in regulation of embryonic development1ISSHomo_sapiens(9606)Process
GO:0048027enables mRNA 5-UTR binding1IDAHomo_sapiens(9606)Function
GO:0051607involved_in defense response to virus1IEAHomo_sapiens(9606)Process
GO:0051880enables G-quadruplex DNA binding2IBA,IDAHomo_sapiens(9606)Function
GO:0051891involved_in positive regulation of cardioblast differentiation1ISSHomo_sapiens(9606)Process
GO:0060261involved_in positive regulation of transcription initiation by RNA polymerase II1IMPHomo_sapiens(9606)Process
GO:0061003involved_in positive regulation of dendritic spine morphogenesis1ISSHomo_sapiens(9606)Process
GO:0061158involved_in 3-UTR-mediated mRNA destabilization1IMPHomo_sapiens(9606)Process
GO:0070034enables telomerase RNA binding1IDAHomo_sapiens(9606)Function
GO:0070062located_in extracellular exosome1HDAHomo_sapiens(9606)Component
GO:0070883enables pre-miRNA binding1ISSHomo_sapiens(9606)Function
GO:0090669involved_in telomerase RNA stabilization1IDAHomo_sapiens(9606)Process
GO:1900153involved_in positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay1IMPHomo_sapiens(9606)Process
GO:1901534involved_in positive regulation of hematopoietic progenitor cell differentiation1ISSHomo_sapiens(9606)Process
GO:1903843involved_in cellular response to arsenite ion1IDAHomo_sapiens(9606)Process
GO:1904358involved_in positive regulation of telomere maintenance via telomere lengthening1IMPHomo_sapiens(9606)Process
GO:1904582involved_in positive regulation of intracellular mRNA localization1ISSHomo_sapiens(9606)Process
GO:2000767involved_in positive regulation of cytoplasmic translation1IMPHomo_sapiens(9606)Process

Expression