Functions and Diseases

RBP Type Canonical_RBPs
Diseases Cancer
Drug N.A.
Main interacting RNAs mRNA
Moonlighting functions N.A.
Localizations N.A.
BulkPerturb-seq N.A.

Description

Ensembl ID ENSG00000174740 Gene ID 140886 Accession 13629
Symbol PABPC5 Alias PABP5 Full Name poly(A) binding protein cytoplasmic 5
Status Confidence Length 3990 bases Strand Plus strand
Position X : 91434595 - 91438584 RNA binding domain RRM_5 , RRM_1
Summary This gene encodes a protein that binds to the polyA tail found at the 3' end of most eukaryotic mRNAs. It is thought to play a role in the regulation of mRNA metabolic processes in the cytoplasm. This gene is located in a gene-poor region within the X-specific 13d-sY43 subinterval of the chromosome Xq21.3/Yp11.2 homology block. It is located close to translocation breakpoints associated with premature ovarian failure, and is therefore a potential candidate gene for this disorder. [provided by RefSeq, May 2010]

RNA binding domains (RBDs)

Protein Domain Pfam ID E-value Domain number
ENSP00000308012 RRM_1 PF00076 2.2e-76 1
ENSP00000308012 RRM_1 PF00076 2.2e-76 2
ENSP00000308012 RRM_1 PF00076 2.2e-76 3
ENSP00000308012 RRM_1 PF00076 2.2e-76 4
ENSP00000308012 RRM_5 PF13893 1.5e-11 5
ENSP00000308012 RRM_5 PF13893 1.5e-11 6
ENSP00000362197 RRM_1 PF00076 7.1e-42 1
ENSP00000362197 RRM_1 PF00076 7.1e-42 2

RNA binding proteomes (RBPomes)

Pubmed ID Full Name Cell Author Time Doi

Literatures on RNA binding capacity

Pubmed ID Title Author Time Journal
23275553 Alternative translation initiation augments the human mitochondrial proteome. Lawrence Kazak 2013-02-01 Nucleic acids research

Transcripts

Name Transcript ID bp Protein Translation ID
PABPC5-202 ENST00000373105 1262 218aa ENSP00000362197
PABPC5-201 ENST00000312600 3206 382aa ENSP00000308012

Gene Model

Pathways

Pathway ID Pathway Name Source

Phenotypes

ensgID Trait pValue Pubmed ID
686573-hydroxy-1-methylpropylmercapturic acid7E-726053186
68658Smoking7E-726053186
86076Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis4E-822808956

GWAS

ensgIDSNPChromosomePosition TraitPubmedIDOr or BEAT EFO ID

Protein-Protein Interaction (PPI)

Paralogs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id
ENSG00000174740homo_sapiensENSP0000028607022.151912.2363homo_sapiensENSP0000030801227.486915.1832
ENSG00000174740homo_sapiensENSP0000029490429.80316.2562homo_sapiensENSP0000030801231.675417.2775
ENSG00000174740homo_sapiensENSP0000031300747.32738.2075homo_sapiensENSP0000030801278.795863.6126
ENSG00000174740homo_sapiensENSP0000028158945.800336.6086homo_sapiensENSP0000030801275.654460.4712
ENSG00000174740homo_sapiensENSP0000035216228.610414.4414homo_sapiensENSP0000030801227.486913.8743
ENSG00000174740homo_sapiensENSP0000030440523.064812.4803homo_sapiensENSP0000030801238.219920.6806
ENSG00000174740homo_sapiensENSP0000035863523.75612.3596homo_sapiensENSP0000030801238.743520.1571
ENSG00000174740homo_sapiensENSP0000038526928.834414.1104homo_sapiensENSP0000030801224.607312.0419
ENSG00000174740homo_sapiensENSP0000026203128.501215.4791homo_sapiensENSP0000030801230.366516.4921
ENSG00000174740homo_sapiensENSP0000038622626.279113.7209homo_sapiensENSP0000030801229.581215.445
ENSG00000174740homo_sapiensENSP0000027162822.641512.5homo_sapiensENSP0000030801225.130913.8743
ENSG00000174740homo_sapiensENSP0000031174711.95817.32436homo_sapiensENSP0000030801220.942412.8272
ENSG00000174740homo_sapiensENSP0000034853822.594115.0628homo_sapiensENSP0000030801214.13619.42408
ENSG00000174740homo_sapiensENSP0000036088930.327916.1202homo_sapiensENSP0000030801229.057615.445
ENSG00000174740homo_sapiensENSP0000036834123.305115.678homo_sapiensENSP0000030801214.39799.68586
ENSG00000174740homo_sapiensENSP0000038047929.80515.8774homo_sapiensENSP0000030801228.010514.9215
ENSG00000174740homo_sapiensENSP0000046323378.648760.8108homo_sapiensENSP0000030801276.17858.9005
ENSG00000174740homo_sapiensENSP0000036194946.060637.2727homo_sapiensENSP0000030801279.581264.3979
ENSG00000174740homo_sapiensENSP0000043435920.751310.9123homo_sapiensENSP0000030801230.366515.9686
ENSG00000174740homo_sapiensENSP0000037327728.146514.8741homo_sapiensENSP0000030801232.19917.0157
ENSG00000174740homo_sapiensENSP0000024018522.705311.8357homo_sapiensENSP0000030801224.607312.8272
ENSG00000174740homo_sapiensENSP0000021707346.203635.3796homo_sapiensENSP0000030801274.869157.3298
ENSG00000174740homo_sapiensENSP0000036262172.558homo_sapiensENSP0000030801237.958130.3665
ENSG00000174740homo_sapiensENSP0000036261872.558homo_sapiensENSP0000030801237.958130.3665

Orthologs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id
ENSG00000174740homo_sapiensENSP00000308012100100nomascus_leucogenysENSNLEP00000027296100100
ENSG00000174740homo_sapiensENSP0000030801210099.7382pan_paniscusENSPPAP0000000162710099.7382
ENSG00000174740homo_sapiensENSP00000308012100100pongo_abeliiENSPPYP00000022977100100
ENSG00000174740homo_sapiensENSP00000308012100100pan_troglodytesENSPTRP00000056253100100
ENSG00000174740homo_sapiensENSP00000308012100100gorilla_gorillaENSGGOP00000027578100100
ENSG00000174740homo_sapiensENSP0000030801281.675478.7958echinops_telfairiENSETEP0000000959881.462178.5901
ENSG00000174740homo_sapiensENSP0000030801210099.4764callithrix_jacchusENSCJAP0000004570110099.4764
ENSG00000174740homo_sapiensENSP0000030801210099.7382cercocebus_atysENSCATP0000004097410099.7382
ENSG00000174740homo_sapiensENSP0000030801210099.7382macaca_nemestrinaENSMNEP0000002832810099.7382
ENSG00000174740homo_sapiensENSP0000030801210099.7382papio_anubisENSPANP0000001508710099.7382
ENSG00000174740homo_sapiensENSP0000030801210099.7382mandrillus_leucophaeusENSMLEP0000000828810099.7382
ENSG00000174740homo_sapiensENSP0000030801298.429396.8586vulpes_vulpesENSVVUP0000001790698.429396.8586
ENSG00000174740homo_sapiensENSP0000030801297.120495.0262mus_spretusMGP_SPRETEiJ_P009635197.375395.2756
ENSG00000174740homo_sapiensENSP0000030801298.691196.5969capra_hircusENSCHIP0000002030698.691196.5969
ENSG00000174740homo_sapiensENSP0000030801298.691196.8586panthera_leoENSPLOP0000002185198.691196.8586
ENSG00000174740homo_sapiensENSP0000030801298.429397.1204ailuropoda_melanoleucaENSAMEP0000002116898.429397.1204
ENSG00000174740homo_sapiensENSP0000030801298.952996.5969bos_indicus_hybridENSBIXP0000500961698.952996.5969
ENSG00000174740homo_sapiensENSP0000030801298.691197.644oryctolagus_cuniculusENSOCUP0000000939698.691197.644
ENSG00000174740homo_sapiensENSP0000030801298.691197.3822equus_caballusENSECAP0000000234998.691197.3822
ENSG00000174740homo_sapiensENSP0000030801298.429396.8586canis_lupus_familiarisENSCAFP0084503601798.429396.8586
ENSG00000174740homo_sapiensENSP0000030801298.691196.8586panthera_pardusENSPPRP0000001936098.691196.8586
ENSG00000174740homo_sapiensENSP0000030801298.691197.9058marmota_marmota_marmotaENSMMMP0000000377998.691197.9058
ENSG00000174740homo_sapiensENSP0000030801299.214797.9058balaenoptera_musculusENSBMSP0001002456299.214797.9058
ENSG00000174740homo_sapiensENSP0000030801298.429394.2408cavia_porcellusENSCPOP0000001518998.429394.2408
ENSG00000174740homo_sapiensENSP0000030801298.429396.5969ursus_americanusENSUAMP0000001717598.429396.5969
ENSG00000174740homo_sapiensENSP0000030801256.020954.1885bison_bison_bisonENSBBBP0000001172598.165194.9541
ENSG00000174740homo_sapiensENSP0000030801299.214797.9058monodon_monocerosENSMMNP0001501349299.214797.9058
ENSG00000174740homo_sapiensENSP0000030801298.952996.5969sus_scrofaENSSSCP0000004971998.952996.5969
ENSG00000174740homo_sapiensENSP0000030801297.64496.3351microcebus_murinusENSMICP0000004970597.64496.3351
ENSG00000174740homo_sapiensENSP0000030801255.759254.9738jaculus_jaculusENSJJAP0000000757897.706496.3303
ENSG00000174740homo_sapiensENSP0000030801298.691196.8586ovis_aries_rambouilletENSOARP0002002547498.691196.8586
ENSG00000174740homo_sapiensENSP0000030801298.429396.3351ursus_maritimusENSUMAP0000003319998.429396.3351
ENSG00000174740homo_sapiensENSP0000030801256.806356.2827ochotona_princepsENSOPRP0000000077798.1997.2851
ENSG00000174740homo_sapiensENSP0000030801299.214797.9058delphinapterus_leucasENSDLEP0000000339099.214797.9058
ENSG00000174740homo_sapiensENSP0000030801298.952997.3822physeter_catodonENSPCTP0000502697498.952997.3822
ENSG00000174740homo_sapiensENSP0000030801297.120494.5026mus_caroliMGP_CAROLIEiJ_P009258897.375394.7507
ENSG00000174740homo_sapiensENSP0000030801297.120495.0262mus_musculusENSMUSP0000004775697.375395.2756
ENSG00000174740homo_sapiensENSP0000030801298.429396.3351mustela_putorius_furoENSMPUP0000001834798.429396.3351
ENSG00000174740homo_sapiensENSP00000308012100100aotus_nancymaaeENSANAP00000000627100100
ENSG00000174740homo_sapiensENSP0000030801210099.7382saimiri_boliviensis_boliviensisENSSBOP0000000166710099.7382
ENSG00000174740homo_sapiensENSP0000030801298.952997.1204vicugna_pacosENSVPAP0000000097998.952997.1204
ENSG00000174740homo_sapiensENSP0000030801210099.7382chlorocebus_sabaeusENSCSAP0000001792610099.7382
ENSG00000174740homo_sapiensENSP0000030801298.952997.9058tupaia_belangeriENSTBEP0000001431098.952997.9058
ENSG00000174740homo_sapiensENSP0000030801299.214797.9058phocoena_sinusENSPSNP0000002392799.214797.9058
ENSG00000174740homo_sapiensENSP0000030801298.952997.1204camelus_dromedariusENSCDRP0000503134298.952997.1204
ENSG00000174740homo_sapiensENSP0000030801298.167597.644carlito_syrichtaENSTSYP0000002452598.167597.644
ENSG00000174740homo_sapiensENSP0000030801298.691196.8586panthera_tigris_altaicaENSPTIP0000000056898.691196.8586
ENSG00000174740homo_sapiensENSP0000030801297.64495.288rattus_norvegicusENSRNOP0000000446297.64495.288
ENSG00000174740homo_sapiensENSP0000030801298.167596.8586prolemur_simusENSPSMP0000003341398.167596.8586
ENSG00000174740homo_sapiensENSP0000030801297.64495.288microtus_ochrogasterENSMOCP0000000199197.64495.288
ENSG00000174740homo_sapiensENSP0000030801297.120493.9791sorex_araneusENSSARP0000001266497.120493.9791
ENSG00000174740homo_sapiensENSP0000030801297.905894.7644peromyscus_maniculatus_bairdiiENSPEMP0000000022797.905894.7644
ENSG00000174740homo_sapiensENSP0000030801298.952996.5969bos_mutusENSBMUP0000001364598.952996.5969
ENSG00000174740homo_sapiensENSP0000030801297.120494.7644mus_spicilegusENSMSIP0000000166097.375395.0131
ENSG00000174740homo_sapiensENSP0000030801299.214797.1204pteropus_vampyrusENSPVAP0000000610899.214797.1204
ENSG00000174740homo_sapiensENSP0000030801298.429395.8115myotis_lucifugusENSMLUP0000001682098.429395.8115
ENSG00000174740homo_sapiensENSP0000030801298.952996.8586rhinolophus_ferrumequinumENSRFEP0001000709198.952996.8586
ENSG00000174740homo_sapiensENSP0000030801298.429396.5969neovison_visonENSNVIP0000001821598.429396.5969
ENSG00000174740homo_sapiensENSP0000030801298.952996.5969bos_taurusENSBTAP0000002656698.952996.5969
ENSG00000174740homo_sapiensENSP0000030801297.905895.288heterocephalus_glaber_femaleENSHGLP0000005013297.905895.288
ENSG00000174740homo_sapiensENSP0000030801210099.7382rhinopithecus_bietiENSRBIP0000000237810099.7382
ENSG00000174740homo_sapiensENSP0000030801299.214798.4293sciurus_vulgarisENSSVLP0000502918498.186597.4093
ENSG00000174740homo_sapiensENSP0000030801270.418869.8953procavia_capensisENSPCAP0000001450197.818297.0909
ENSG00000174740homo_sapiensENSP0000030801256.020954.4503nannospalax_galiliENSNGAP0000000367198.165195.4128
ENSG00000174740homo_sapiensENSP0000030801298.952996.5969bos_grunniensENSBGRP0000004203298.952996.5969
ENSG00000174740homo_sapiensENSP0000030801298.429395.5497chinchilla_lanigeraENSCLAP0000000083198.429395.5497
ENSG00000174740homo_sapiensENSP0000030801298.429396.3351cervus_hanglu_yarkandensisENSCHYP0000002951698.429396.3351
ENSG00000174740homo_sapiensENSP0000030801299.214797.1204catagonus_wagneriENSCWAP0000001791399.214797.1204
ENSG00000174740homo_sapiensENSP0000030801298.167596.5969otolemur_garnettiiENSOGAP0000000615898.167596.5969
ENSG00000174740homo_sapiensENSP00000308012100100cebus_imitatorENSCCAP00000028388100100
ENSG00000174740homo_sapiensENSP0000030801299.214798.1675urocitellus_parryiiENSUPAP0001002769099.214798.1675
ENSG00000174740homo_sapiensENSP0000030801298.691196.8586moschus_moschiferusENSMMSP0000001205998.691196.8586
ENSG00000174740homo_sapiensENSP0000030801210099.7382rhinopithecus_roxellanaENSRROP0000002594510099.7382
ENSG00000174740homo_sapiensENSP0000030801297.382295.5497mus_pahariMGP_PahariEiJ_P009020197.382295.5497
ENSG00000174740homo_sapiensENSP0000030801298.167597.1204propithecus_coquereliENSPCOP0000000028398.167597.1204

Gene Ontology

Go ID Go term No. evidence Entries Species Category
GO:0003730enables mRNA 3-UTR binding1IBAHomo_sapiens(9606)Function
GO:0005515enables protein binding1IPIHomo_sapiens(9606)Function
GO:0005634is_active_in nucleus1IBAHomo_sapiens(9606)Component
GO:0005759located_in mitochondrial matrix1IEAHomo_sapiens(9606)Component
GO:0005829is_active_in cytosol1IBAHomo_sapiens(9606)Component
GO:0008143enables poly(A) binding1IBAHomo_sapiens(9606)Function
GO:0008266enables poly(U) RNA binding1IBAHomo_sapiens(9606)Function
GO:0010494is_active_in cytoplasmic stress granule1IBAHomo_sapiens(9606)Component
GO:1990904part_of ribonucleoprotein complex1IBAHomo_sapiens(9606)Component

Expression