Functions and Diseases

RBP Type Canonical_RBPs
Diseases N.A.
Drug Drug
Main interacting RNAs N.A.
Moonlighting functions N.A.
Localizations Stress granucle
BulkPerturb-seq

Description

Ensembl ID ENSG00000173273 Gene ID 8658 Accession 11941
Symbol TNKS Alias TIN1;ARTD5;PARPL;TINF1;TNKS1;pART5;PARP5A;PARP-5a Full Name tankyrase
Status Confidence Length 226435 bases Strand Plus strand
Position 8 : 9555912 - 9782346 RNA binding domain PARP
Summary Enables histone binding activity; pentosyltransferase activity; and zinc ion binding activity. Involved in several processes, including negative regulation of maintenance of mitotic sister chromatid cohesion, telomeric; protein ADP-ribosylation; and regulation of nucleobase-containing compound metabolic process. Acts upstream of or within peptidyl-serine phosphorylation; peptidyl-threonine phosphorylation; and protein ADP-ribosylation. Located in several cellular components, including chromosome, telomeric region; mitotic spindle pole; and nucleus. [provided by Alliance of Genome Resources, Apr 2022]

RNA binding domains (RBDs)

Protein Domain Pfam ID E-value Domain number
ENSP00000429890 PARP PF00644 1.4e-25 1
ENSP00000311579 PARP PF00644 2.4e-25 1

RNA binding proteomes (RBPomes)

Pubmed ID Full Name Cell Author Time Doi

Literatures on RNA binding capacity

Pubmed ID Title Author Time Journal

Transcripts

Name Transcript ID bp Protein Translation ID
TNKS-201 ENST00000310430 9622 1327aa ENSP00000311579
TNKS-210 ENST00000520408 1964 617aa ENSP00000428299
TNKS-212 ENST00000522110 2900 243aa ENSP00000430920
TNKS-202 ENST00000517770 4339 1316aa ENSP00000428185
TNKS-205 ENST00000518281 3897 1090aa ENSP00000429890
TNKS-204 ENST00000518027 766 No protein -
TNKS-211 ENST00000521039 745 No protein -
TNKS-208 ENST00000519392 556 No protein -
TNKS-203 ENST00000517989 603 No protein -
TNKS-209 ENST00000519930 357 33aa ENSP00000518575
TNKS-206 ENST00000518635 502 68aa ENSP00000431098
TNKS-207 ENST00000519191 496 No protein -

Gene Model

Pathways

Pathway ID Pathway Name Source

Phenotypes

ensgID Trait pValue Pubmed ID
11944Asthma3.438001E-0511022011
46742Platelet Function Tests1.8462000E-005-
87206Bone Density2E-627397699
94302Multiple Myeloma7E-623502783

GWAS

ensgIDSNPChromosomePosition TraitPubmedIDOr or BEAT EFO ID

Protein-Protein Interaction (PPI)

Paralogs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id

Orthologs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id

Gene Ontology

Go ID Go term No. evidence Entries Species Category
GO:0000139located_in Golgi membrane1IEAHomo_sapiens(9606)Component
GO:0000209involved_in protein polyubiquitination1IDAHomo_sapiens(9606)Process
GO:0000242located_in pericentriolar material1TASHomo_sapiens(9606)Component
GO:0000781located_in chromosome, telomeric region1IDAHomo_sapiens(9606)Component
GO:0003950enables NAD+ ADP-ribosyltransferase activity3IBA,IDA,TASHomo_sapiens(9606)Function
GO:0005515enables protein binding1IPIHomo_sapiens(9606)Function
GO:0005634is_active_in nucleus1IBAHomo_sapiens(9606)Component
GO:0005643part_of nuclear pore1TASHomo_sapiens(9606)Component
GO:0005654located_in nucleoplasm1IDAHomo_sapiens(9606)Component
GO:0005737is_active_in cytoplasm1IBAHomo_sapiens(9606)Component
GO:0005794located_in Golgi apparatus1IDAHomo_sapiens(9606)Component
GO:0005829located_in cytosol1TASHomo_sapiens(9606)Component
GO:0007052involved_in mitotic spindle organization1TASHomo_sapiens(9606)Process
GO:0008270enables zinc ion binding1IDAHomo_sapiens(9606)Function
GO:0015031involved_in protein transport1IEAHomo_sapiens(9606)Process
GO:0016055involved_in Wnt signaling pathway1IEAHomo_sapiens(9606)Process
GO:0016604located_in nuclear body1IDAHomo_sapiens(9606)Component
GO:0016779enables nucleotidyltransferase activity1IEAHomo_sapiens(9606)Function
GO:0018105acts_upstream_of_or_within peptidyl-serine phosphorylation1IDAHomo_sapiens(9606)Process
GO:0018107acts_upstream_of_or_within peptidyl-threonine phosphorylation1IDAHomo_sapiens(9606)Process
GO:0031965located_in nuclear membrane2IDA,TASHomo_sapiens(9606)Component
GO:0032210involved_in regulation of telomere maintenance via telomerase1TASHomo_sapiens(9606)Process
GO:0032212involved_in positive regulation of telomere maintenance via telomerase2IDA,IMPHomo_sapiens(9606)Process
GO:0042393enables histone binding1IPIHomo_sapiens(9606)Function
GO:0045944involved_in positive regulation of transcription by RNA polymerase II1IDAHomo_sapiens(9606)Process
GO:0051028involved_in mRNA transport1IEAHomo_sapiens(9606)Process
GO:0051225involved_in spindle assembly1TASHomo_sapiens(9606)Process
GO:0051301involved_in cell division1IEAHomo_sapiens(9606)Process
GO:0051973involved_in positive regulation of telomerase activity1IDAHomo_sapiens(9606)Process
GO:0070198involved_in protein localization to chromosome, telomeric region2IBA,IMPHomo_sapiens(9606)Process
GO:0070212involved_in protein poly-ADP-ribosylation2IDA,IMPHomo_sapiens(9606)Process
GO:0070213involved_in protein auto-ADP-ribosylation1IDAHomo_sapiens(9606)Process
GO:0090263involved_in positive regulation of canonical Wnt signaling pathway3IBA,IMP,TASHomo_sapiens(9606)Process
GO:0097431located_in mitotic spindle pole1IDAHomo_sapiens(9606)Component
GO:1904355involved_in positive regulation of telomere capping3IBA,IDA,IMPHomo_sapiens(9606)Process
GO:1904357involved_in negative regulation of telomere maintenance via telomere lengthening1IMPHomo_sapiens(9606)Process
GO:1904743involved_in negative regulation of telomeric DNA binding2IDA,IMPHomo_sapiens(9606)Process
GO:1904908involved_in negative regulation of maintenance of mitotic sister chromatid cohesion, telomeric1IMPHomo_sapiens(9606)Process
GO:1990404enables NAD+-protein ADP-ribosyltransferase activity1IDAHomo_sapiens(9606)Function

Expression