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RBP World!
Functions and Diseases
| RBP Type | Non-canonical_RBPs |
| Diseases | CancerFlavivirusesSARS-COV-2Dengue |
| Drug | N.A. |
| Main interacting RNAs | N.A. |
| Moonlighting functions | N.A. |
| Localizations | Stress granucle |
| BulkPerturb-seq | N.A. |
Description
| Ensembl ID | ENSG00000170248 | Gene ID | 10015 | Accession | 8766 |
| Symbol | PDCD6IP | Alias | AIP1;ALIX;HP95;DRIP4;MCPH29 | Full Name | programmed cell death 6 interacting protein |
| Status | Confidence | Length | 71137 bases | Strand | Plus strand |
| Position | 3 : 33798571 - 33869707 | RNA binding domain | N.A. | ||
| Summary | This gene encodes a protein that functions within the ESCRT pathway in the abscission stage of cytokinesis, in intralumenal endosomal vesicle formation, and in enveloped virus budding. Studies using mouse cells have shown that overexpression of this protein can block apoptosis. In addition, the product of this gene binds to the product of the PDCD6 gene, a protein required for apoptosis, in a calcium-dependent manner. This gene product also binds to endophilins, proteins that regulate membrane shape during endocytosis. Overexpression of this gene product and endophilins results in cytoplasmic vacuolization, which may be partly responsible for the protection against cell death. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. Related pseudogenes have been identified on chromosome 15. [provided by RefSeq, Jan 2012] | ||||
RNA binding domains (RBDs)
| Protein | Domain | Pfam ID | E-value | Domain number |
|---|
RNA binding proteomes (RBPomes)
| Pubmed ID | Full Name | Cell | Author | Time | Doi |
|---|
Literatures on RNA binding capacity
| Pubmed ID | Title | Author | Time | Journal |
|---|
Transcripts
| Name | Transcript ID | bp | Protein | Translation ID |
|---|---|---|---|---|
| PDCD6IP-201 | ENST00000307296 | 5884 | 868aa | ENSP00000307387 |
| PDCD6IP-218 | ENST00000648706 | 6049 | 300aa | ENSP00000497537 |
| PDCD6IP-205 | ENST00000435909 | 587 | 72aa | ENSP00000393777 |
| PDCD6IP-204 | ENST00000430877 | 582 | 78aa | ENSP00000398895 |
| PDCD6IP-203 | ENST00000413073 | 566 | 153aa | ENSP00000406693 |
| PDCD6IP-210 | ENST00000477798 | 587 | No protein | - |
| PDCD6IP-217 | ENST00000498147 | 802 | No protein | - |
| PDCD6IP-212 | ENST00000484478 | 596 | No protein | - |
| PDCD6IP-215 | ENST00000494810 | 619 | No protein | - |
| PDCD6IP-207 | ENST00000459659 | 662 | No protein | - |
| PDCD6IP-202 | ENST00000412887 | 842 | 95aa | ENSP00000415150 |
| PDCD6IP-211 | ENST00000482561 | 626 | No protein | - |
| PDCD6IP-213 | ENST00000487821 | 750 | No protein | - |
| PDCD6IP-208 | ENST00000465122 | 894 | No protein | - |
| PDCD6IP-216 | ENST00000495235 | 428 | No protein | - |
| PDCD6IP-214 | ENST00000489869 | 842 | No protein | - |
| PDCD6IP-209 | ENST00000473593 | 540 | No protein | - |
| PDCD6IP-206 | ENST00000457054 | 5962 | 873aa | ENSP00000411825 |
Phenotypes
| ensgID | Trait | pValue | Pubmed ID |
|---|---|---|---|
| 14809 | Hemoglobin A, Glycosylated | 4.008E-05 | 19875614 |
| 15929 | Stroke | 5.7034959E-004 | 19369658 |
| 15949 | Stroke | 5.4640000E-004 | 19369658 |
| 15989 | Stroke | 4.4964743E-005 | 19369658 |
| 24149 | Body Fat Distribution | 8.9840000E-005 | - |
| 24193 | Body Fat Distribution | 4.9970000E-005 | - |
| 24257 | Body Fat Distribution | 9.5100000E-005 | - |
| 26860 | Blood Pressure | 8.9510000E-005 | - |
| 29465 | Cholesterol, LDL | 2.5570000E-005 | - |
| 48381 | Child Development Disorders, Pervasive | 1.8592900E-005 | - |
| 55141 | Lactate Dehydrogenases | 5.0320000E-005 | - |
| 81702 | Conduct Disorder | 9E-6 | 23942779 |
| 86751 | Neuroticism | 2E-8 | 27089181 |
| 104941 | Cognition | 3E-6 | 24684796 |
| 105469 | Influenza A Virus, H1N1 Subtype | 2E-8 | 26379185 |
GWAS
| ensgID | SNP | Chromosome | Position | Trait | PubmedID | Or or BEAT | EFO ID |
|---|
Protein-Protein Interaction (PPI)
Paralogs
| Ensembl ID | Source | Target | ||||||
|---|---|---|---|---|---|---|---|---|
| Species | Protein ID | Perc_pos | Perc_id | Species | Protein ID | Perc_pos | Perc_id | |
| ENSG00000170248 | ||||||||
Orthologs
| Ensembl ID | Source | Target | ||||||
|---|---|---|---|---|---|---|---|---|
| Species | Protein ID | Perc_pos | Perc_id | Species | Protein ID | Perc_pos | Perc_id | |
| ENSG00000170248 | homo_sapiens | ENSP00000307387 | 99.8848 | 99.6544 | nomascus_leucogenys | ENSNLEP00000005834 | 96.0133 | 95.7918 |
| ENSG00000170248 | homo_sapiens | ENSP00000307387 | 98.8479 | 98.7327 | pan_paniscus | ENSPPAP00000012463 | 97.9452 | 97.831 |
| ENSG00000170248 | homo_sapiens | ENSP00000307387 | 99.7696 | 99.5392 | pongo_abelii | ENSPPYP00000015692 | 91.6402 | 91.4286 |
| ENSG00000170248 | homo_sapiens | ENSP00000307387 | 99.8848 | 99.8848 | pan_troglodytes | ENSPTRP00000025415 | 99.3127 | 99.3127 |
| ENSG00000170248 | homo_sapiens | ENSP00000307387 | 99.7696 | 99.5392 | cercocebus_atys | ENSCATP00000033153 | 99.1982 | 98.9691 |
| ENSG00000170248 | homo_sapiens | ENSP00000307387 | 99.8848 | 99.5392 | macaca_fascicularis | ENSMFAP00000024775 | 99.8848 | 99.5392 |
| ENSG00000170248 | homo_sapiens | ENSP00000307387 | 99.8848 | 99.6544 | macaca_mulatta | ENSMMUP00000018492 | 99.8848 | 99.6544 |
| ENSG00000170248 | homo_sapiens | ENSP00000307387 | 99.8848 | 99.6544 | macaca_nemestrina | ENSMNEP00000041701 | 99.3127 | 99.0836 |
| ENSG00000170248 | homo_sapiens | ENSP00000307387 | 99.7696 | 99.5392 | papio_anubis | ENSPANP00000052213 | 99.1982 | 98.9691 |
| ENSG00000170248 | homo_sapiens | ENSP00000307387 | 99.7696 | 99.5392 | papio_anubis | ENSPANP00000054244 | 99.7696 | 99.5392 |
| ENSG00000170248 | homo_sapiens | ENSP00000307387 | 99.7696 | 99.5392 | mandrillus_leucophaeus | ENSMLEP00000007691 | 99.1982 | 98.9691 |
| ENSG00000170248 | homo_sapiens | ENSP00000307387 | 98.6175 | 97.235 | equus_asinus | ENSEASP00005010267 | 98.0527 | 96.6781 |
| ENSG00000170248 | homo_sapiens | ENSP00000307387 | 97.5806 | 96.4286 | capra_hircus | ENSCHIP00000033807 | 96.25 | 95.1136 |
| ENSG00000170248 | homo_sapiens | ENSP00000307387 | 84.2166 | 80.8756 | balaenoptera_musculus | ENSBMSP00010006189 | 92.5316 | 88.8608 |
| ENSG00000170248 | homo_sapiens | ENSP00000307387 | 97.5806 | 95.9677 | balaenoptera_musculus | ENSBMSP00010031232 | 96.8 | 95.2 |
| ENSG00000170248 | homo_sapiens | ENSP00000307387 | 89.5161 | 88.3641 | bison_bison_bison | ENSBBBP00000024345 | 89.1055 | 87.9587 |
| ENSG00000170248 | homo_sapiens | ENSP00000307387 | 97.8111 | 96.659 | ovis_aries_rambouillet | ENSOARP00020033365 | 96.4773 | 95.3409 |
| ENSG00000170248 | homo_sapiens | ENSP00000307387 | 97.6959 | 95.9677 | physeter_catodon | ENSPCTP00005009362 | 97.1363 | 95.4181 |
| ENSG00000170248 | homo_sapiens | ENSP00000307387 | 98.5023 | 97.4654 | mustela_putorius_furo | ENSMPUP00000013136 | 98.389 | 97.3533 |
| ENSG00000170248 | homo_sapiens | ENSP00000307387 | 99.0783 | 98.6175 | aotus_nancymaae | ENSANAP00000033970 | 99.0783 | 98.6175 |
| ENSG00000170248 | homo_sapiens | ENSP00000307387 | 99.8848 | 99.6544 | chlorocebus_sabaeus | ENSCSAP00000005596 | 99.8848 | 99.6544 |
| ENSG00000170248 | homo_sapiens | ENSP00000307387 | 98.7327 | 98.0415 | prolemur_simus | ENSPSMP00000015126 | 98.1672 | 97.48 |
| ENSG00000170248 | homo_sapiens | ENSP00000307387 | 97.3502 | 95.5069 | myotis_lucifugus | ENSMLUP00000006097 | 93.0617 | 91.2996 |
| ENSG00000170248 | homo_sapiens | ENSP00000307387 | 98.0415 | 96.4286 | rhinolophus_ferrumequinum | ENSRFEP00010007818 | 97.7038 | 96.0964 |
| ENSG00000170248 | homo_sapiens | ENSP00000307387 | 97.5806 | 96.1982 | bos_taurus | ENSBTAP00000023165 | 96.8 | 95.4286 |
| ENSG00000170248 | homo_sapiens | ENSP00000307387 | 99.8848 | 99.6544 | rhinopithecus_bieti | ENSRBIP00000021290 | 99.3127 | 99.0836 |
| ENSG00000170248 | homo_sapiens | ENSP00000307387 | 98.2719 | 97.235 | otolemur_garnettii | ENSOGAP00000005407 | 94.1501 | 93.1567 |
| ENSG00000170248 | homo_sapiens | ENSP00000307387 | 99.0783 | 98.6175 | cebus_imitator | ENSCCAP00000030041 | 98.5109 | 98.0527 |
| ENSG00000170248 | homo_sapiens | ENSP00000307387 | 99.8848 | 99.6544 | rhinopithecus_roxellana | ENSRROP00000018588 | 99.3127 | 99.0836 |
| ENSG00000170248 | homo_sapiens | ENSP00000307387 | 85.2535 | 73.7327 | xenopus_tropicalis | ENSXETP00000038820 | 82.9596 | 71.7489 |
Gene Ontology
| Go ID | Go term | No. evidence | Entries | Species | Category |
|---|---|---|---|---|---|
| GO:0000281 | involved_in mitotic cytokinesis | 2 | IBA,IDA | Homo_sapiens(9606) | Process |
| GO:0000915 | involved_in actomyosin contractile ring assembly | 1 | ISS | Homo_sapiens(9606) | Process |
| GO:0001772 | located_in immunological synapse | 1 | IDA | Homo_sapiens(9606) | Component |
| GO:0005515 | enables protein binding | 1 | IPI | Homo_sapiens(9606) | Function |
| GO:0005768 | is_active_in endosome | 1 | IBA | Homo_sapiens(9606) | Component |
| GO:0005815 | located_in microtubule organizing center | 1 | IEA | Homo_sapiens(9606) | Component |
| GO:0005829 | located_in cytosol | 1 | TAS | Homo_sapiens(9606) | Component |
| GO:0005923 | located_in bicellular tight junction | 1 | IEA | Homo_sapiens(9606) | Component |
| GO:0005925 | located_in focal adhesion | 1 | HDA | Homo_sapiens(9606) | Component |
| GO:0006915 | involved_in apoptotic process | 1 | IEA | Homo_sapiens(9606) | Process |
| GO:0006997 | NOT involved_in nucleus organization | 1 | IMP | Homo_sapiens(9606) | Process |
| GO:0007080 | NOT involved_in mitotic metaphase plate congression | 1 | IMP | Homo_sapiens(9606) | Process |
| GO:0010824 | involved_in regulation of centrosome duplication | 1 | IMP | Homo_sapiens(9606) | Process |
| GO:0015031 | involved_in protein transport | 1 | IEA | Homo_sapiens(9606) | Process |
| GO:0016020 | located_in membrane | 1 | HDA | Homo_sapiens(9606) | Component |
| GO:0031871 | enables proteinase activated receptor binding | 1 | IPI | Homo_sapiens(9606) | Function |
| GO:0036258 | involved_in multivesicular body assembly | 1 | NAS | Homo_sapiens(9606) | Process |
| GO:0039702 | involved_in viral budding via host ESCRT complex | 2 | IGI,NAS | Homo_sapiens(9606) | Process |
| GO:0042470 | located_in melanosome | 1 | IEA | Homo_sapiens(9606) | Component |
| GO:0042641 | located_in actomyosin | 1 | ISS | Homo_sapiens(9606) | Component |
| GO:0042803 | enables protein homodimerization activity | 1 | IPI | Homo_sapiens(9606) | Function |
| GO:0045199 | involved_in maintenance of epithelial cell apical/basal polarity | 1 | ISS | Homo_sapiens(9606) | Process |
| GO:0046755 | involved_in viral budding | 1 | IDA | Homo_sapiens(9606) | Process |
| GO:0048306 | enables calcium-dependent protein binding | 1 | IPI | Homo_sapiens(9606) | Function |
| GO:0051260 | involved_in protein homooligomerization | 1 | IDA | Homo_sapiens(9606) | Process |
| GO:0061952 | involved_in midbody abscission | 1 | IMP | Homo_sapiens(9606) | Process |
| GO:0070062 | located_in extracellular exosome | 2 | HDA,IDA | Homo_sapiens(9606) | Component |
| GO:0070830 | involved_in bicellular tight junction assembly | 1 | ISS | Homo_sapiens(9606) | Process |
| GO:0070971 | located_in endoplasmic reticulum exit site | 1 | IMP | Homo_sapiens(9606) | Component |
| GO:0090543 | located_in Flemming body | 1 | IDA | Homo_sapiens(9606) | Component |
| GO:0090559 | involved_in regulation of membrane permeability | 1 | ISS | Homo_sapiens(9606) | Process |
| GO:0090611 | involved_in ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway | 1 | IMP | Homo_sapiens(9606) | Process |
| GO:1901673 | NOT involved_in regulation of mitotic spindle assembly | 1 | IMP | Homo_sapiens(9606) | Process |
| GO:1903543 | involved_in positive regulation of exosomal secretion | 1 | IMP | Homo_sapiens(9606) | Process |
| GO:1903551 | involved_in regulation of extracellular exosome assembly | 1 | IMP | Homo_sapiens(9606) | Process |
| GO:1903553 | involved_in positive regulation of extracellular exosome assembly | 1 | IMP | Homo_sapiens(9606) | Process |
| GO:1903561 | located_in extracellular vesicle | 1 | HDA | Homo_sapiens(9606) | Component |