Ensembl ID ENSG00000170248 Gene ID 10015 Accession 8766
Gene Symbol PDCD6IP Alias AIP1;ALIX;HP95;DRIP4;MCPH29 Full Name programmed cell death 6 interacting protein
Position 3 : 33798571 - 33869707 Length 71137 bases Strand Plus strand
Status Confidence Main interacting RNAsN.A.RBP type Non-canonical_RBPs
Summary This gene encodes a protein that functions within the ESCRT pathway in the abscission stage of cytokinesis, in intralumenal endosomal vesicle formation, and in enveloped virus budding. Studies using mouse cells have shown that overexpression of this protein can block apoptosis. In addition, the product of this gene binds to the product of the PDCD6 gene, a protein required for apoptosis, in a calcium-dependent manner. This gene product also binds to endophilins, proteins that regulate membrane shape during endocytosis. Overexpression of this gene product and endophilins results in cytoplasmic vacuolization, which may be partly responsible for the protection against cell death. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. Related pseudogenes have been identified on chromosome 15. [provided by RefSeq, Jan 2012]

ENSG00000170248 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000170248 PDCD6IP -0.7 8.95e-46 KIRC
ENSG00000170248 PDCD6IP -0.6 1.76e-14 HNSC
ENSG00000170248 PDCD6IP -0.8 1.75e-42 COAD
ENSG00000170248 PDCD6IP -0.7 2.79e-45 LUSC
ENSG00000170248 PDCD6IP -0.4 4.14e-18 LUAD
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000170248 PDCD6IP cancer 16319398
ENSG00000170248 PDCD6IP cancers 17591932
ENSG00000170248 PDCD6IP Tumor 21528537
ENSG00000170248 PDCD6IP prostate cancer 24391718
ENSG00000170248 PDCD6IP non-small cell lung cancer 24870593
ENSG00000170248 PDCD6IP Tumour 25429432
ENSG00000170248 PDCD6IP cancer 25644331
ENSG00000170248 PDCD6IP Breast Cancer 26063962
ENSG00000170248 PDCD6IP primary cancer 26473288
ENSG00000170248 PDCD6IP cancer 26861306
ENSG00000170248 PDCD6IP tumor 27075363
ENSG00000170248 PDCD6IP GBM 27770278
ENSG00000170248 PDCD6IP Tumor 28257101
ENSG00000170248 PDCD6IP tumour 28326167
ENSG00000170248 PDCD6IP tumor 29357442
ENSG00000170248 PDCD6IP tumor 29681222
ENSG00000170248 PDCD6IP cancer 29930202
ENSG00000170248 PDCD6IP invasive breast cancer 29954076
ENSG00000170248 PDCD6IP Tumor 30021161
ENSG00000170248 PDCD6IP cancer 30181294
ENSG00000170248 PDCD6IP malignant tumours 30906545
ENSG00000170248 PDCD6IP tumour 31007874
ENSG00000170248 PDCD6IP prostate cancer 31018022
ENSG00000170248 PDCD6IP tumor 31167148
ENSG00000170248 PDCD6IP cancer 31172941
ENSG00000170248 PDCD6IP tumor 31638563
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000170248 PDCD6IP UVM 0.01 low
ENSG00000170248 PDCD6IP PAAD 0.0014 high
ENSG00000170248 PDCD6IP ACC 0.046 low
ENSG00000170248 PDCD6IP LGG 0.00066 high
ENSG00000170248 PDCD6IP READ 0.0049 low
ENSG00000170248 PDCD6IP KIRP 0.028 low
ENSG00000170248 PDCD6IP KICH 0.0023 high
ENSG00000170248 PDCD6IP LUAD 0.016 high
ENSG00000170248 PDCD6IP PCPG 0.011 low
ENSG00000170248 PDCD6IP COAD 0.00082 low
ENSG00000170248 PDCD6IP PRAD 0.025 high
ENSG00000170248 PDCD6IP BLCA 0.044 high
ENSG00000170248 PDCD6IP SKCM 0.00028 low
ENSG00000170248 PDCD6IP CESC 0.03 high
ENSG00000170248 PDCD6IP LIHC 0.00013 high
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000170248 PDCD6IP BRCA Del 0.941721 0.065761 0.416382 0.218519
ENSG00000170248 PDCD6IP STAD Del 1.604594 0.073404 0.323451 0.299320
ENSG00000170248 PDCD6IP MESO Del 2.384758 0.190397 0.590854 0.206897
ENSG00000170248 PDCD6IP KIRC Del 49.614712 0.176136 0.516880 0.880682