Functions and Diseases

RBP Type Canonical_RBPs
Diseases Cancer Disease
Drug N.A.
Main interacting RNAs mRNA
Moonlighting functions TF
Localizations N.A.
BulkPerturb-seq DataSet_02_64

Description

Ensembl ID ENSG00000169057 Gene ID 4204 Accession 6990
Symbol MECP2 Alias RS;RTS;RTT;PPMX;MRX16;MRX79;MRXSL;AUTSX3;MRXS13 Full Name methyl-CpG binding protein 2
Status Confidence Length 76165 bases Strand Minus strand
Position X : 154021573 - 154097737 RNA binding domain MBD
Summary DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MECP2, MBD1 and MBD2 can also repress transcription from methylated gene promoters. In contrast to other MBD family members, MECP2 is X-linked and subject to X inactivation. MECP2 is dispensible in stem cells, but is essential for embryonic development. MECP2 gene mutations are the cause of most cases of Rett syndrome, a progressive neurologic developmental disorder and one of the most common causes of cognitive disability in females. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2015]

RNA binding domains (RBDs)

Protein Domain Pfam ID E-value Domain number
ENSP00000301948 MBD PF01429 3e-16 1
ENSP00000395535 MBD PF01429 3.2e-16 1
ENSP00000486978 MBD PF01429 7.2e-14 1
ENSP00000384865 MBD PF01429 8.3e-14 1

RNA binding proteomes (RBPomes)

Pubmed ID Full Name Cell Author Time Doi

Literatures on RNA binding capacity

Pubmed ID Title Author Time Journal
30703685 Alternative splicing of neuronal genes: new mechanisms and new therapies. Diane Lipscombe 2019-08-01 Current opinion in neurobiology
37182097 Potential role of N6-adenine DNA methylation in alternative splicing and endosymbiosis in Paramecium bursaria. Bo Pan 2023-05-19 iScience
28594324 MeCP2 regulates Tet1-catalyzed demethylation, CTCF binding, and learning-dependent alternative splicing of the BDNF gene in Turtle. Zhaoqing Zheng 2017-06-08 eLife
33552148 MeCP2: The Genetic Driver of Rett Syndrome Epigenetics. V Katrina Good 2021-01-01 Frontiers in genetics
36443876 Gene body methylation in cancer: molecular mechanisms and clinical applications. Qi Wang 2022-11-28 Clinical epigenetics
18820302 MECP2 genomic structure and function: insights from ENCODE. Jasmine Singh 2008-11-01 Nucleic acids research
22344696 Widespread occurrence of 5-methylcytosine in human coding and non-coding RNA. E Jeffrey Squires 2012-06-01 Nucleic acids research
33585981 Ectopic expression of pericentric HSATII RNA results in nuclear RNA accumulation, MeCP2 recruitment, and cell division defects. C Catherine Landers 2021-03-01 Chromosoma
28329686 Demethylated HSATII DNA and HSATII RNA Foci Sequester PRC1 and MeCP2 into Cancer-Specific Nuclear Bodies. L Lisa Hall 2017-03-21 Cell reports
36857328 Rett syndrome severity estimation with the BioStamp nPoint using interactions between heart rate variability and body movement. Byappanahalli Pradyumna Suresha 2023-01-01 PloS one
21070191 A brain-derived MeCP2 complex supports a role for MeCP2 in RNA processing. W Steven Long 2011-10-01 Bioscience reports
25663474 CXCR3 in carcinoma progression. Bo Ma 2015-07-01 Histology and histopathology
32681172 Regulation, diversity and function of MECP2 exon and 3'UTR isoforms. Carvalho Deivid Rodrigues 2020-09-30 Human molecular genetics
30781346 Antiglycative Activity and RAGE Expression in Rett Syndrome. Valeria Cordone 2019-02-15 Cells
34048843 Proteomic and transcriptional changes associated with MeCP2 dysfunction reveal nodes for therapeutic intervention in Rett syndrome. Ketan Marballi 2021-09-01 Neurochemistry international
31329578 Aberrant DNA methylation defines isoform usage in cancer, with functional implications. Yun-Ching Chen 2019-07-01 PLoS computational biology
23457515 Reduced syncytin-1 expression levels in placental syndromes correlates with epigenetic hypermethylation of the ERVW-1 promoter region. Matthias Ruebner 2013-01-01 PloS one
29637074 Gaussian-Based Smooth Dielectric Function: A Surface-Free Approach for Modeling Macromolecular Binding in Solvents. Arghya Chakravorty 2018-01-01 Frontiers in molecular biosciences
36323715 Bioinformatics analysis of prognostic value and immunological role of MeCP2 in pan-cancer. Yanfeng Wang 2022-11-02 Scientific reports

Transcripts

Name Transcript ID bp Protein Translation ID
MECP2-201 ENST00000303391 10467 486aa ENSP00000301948
MECP2-205 ENST00000453960 10343 498aa ENSP00000395535
MECP2-216 ENST00000628176 1712 172aa ENSP00000486978
MECP2-203 ENST00000407218 1174 184aa ENSP00000384865
MECP2-223 ENST00000637917 159 53aa ENSP00000489847
MECP2-209 ENST00000486506 2907 No protein -
MECP2-202 ENST00000369957 784 37aa ENSP00000358973
MECP2-211 ENST00000496908 342 No protein -
MECP2-219 ENST00000631210 490 No protein -
MECP2-208 ENST00000481807 436 No protein -
MECP2-210 ENST00000488293 1198 No protein -
MECP2-206 ENST00000460227 1298 No protein -
MECP2-207 ENST00000463644 1088 No protein -
MECP2-204 ENST00000415944 413 49aa ENSP00000416267
MECP2-213 ENST00000625300 350 No protein -
MECP2-214 ENST00000626422 835 No protein -
MECP2-218 ENST00000630151 322 41aa ENSP00000486089
MECP2-228 ENST00000676382 313 No protein -
MECP2-212 ENST00000611468 366 No protein -
MECP2-221 ENST00000637533 140 No protein -
MECP2-226 ENST00000675526 769 61aa ENSP00000501710
MECP2-229 ENST00000700484 197 No protein -
MECP2-222 ENST00000637791 101 No protein -
MECP2-227 ENST00000675841 1201 No protein -
MECP2-224 ENST00000638041 100 No protein -
MECP2-225 ENST00000674996 397 58aa ENSP00000502832
MECP2-215 ENST00000627864 581 No protein -
MECP2-220 ENST00000637467 101 No protein -
MECP2-217 ENST00000629277 2558 No protein -

Gene Model

Pathways

Pathway ID Pathway Name Source

Phenotypes

ensgID Trait pValue Pubmed ID
49137Child Development Disorders, Pervasive4.8814100E-005-
49138Child Development Disorders, Pervasive5.9476100E-005-
49173Child Development Disorders, Pervasive4.8814100E-005-
50579Child Development Disorders, Pervasive4.6750400E-006-
50580Child Development Disorders, Pervasive2.5642600E-005-
50581Child Development Disorders, Pervasive3.4092400E-006-
50582Child Development Disorders, Pervasive2.8884900E-006-
50583Child Development Disorders, Pervasive1.0967600E-006-
50586Child Development Disorders, Pervasive1.0401500E-005-
50591Child Development Disorders, Pervasive4.7229200E-006-
50623Child Development Disorders, Pervasive4.6750400E-006-
50624Child Development Disorders, Pervasive2.5642600E-005-
50625Child Development Disorders, Pervasive3.4092400E-006-
50626Child Development Disorders, Pervasive2.8884900E-006-
50627Child Development Disorders, Pervasive1.0967600E-006-
50632Child Development Disorders, Pervasive1.0401500E-005-
50635Child Development Disorders, Pervasive4.7229200E-006-
51310Child Development Disorders, Pervasive3.3854300E-005-
51311Child Development Disorders, Pervasive2.9114700E-005-
51312Child Development Disorders, Pervasive1.3535900E-005-
51315Child Development Disorders, Pervasive3.5188000E-005-
51347Child Development Disorders, Pervasive3.3854300E-005-
51348Child Development Disorders, Pervasive2.9114700E-005-
51349Child Development Disorders, Pervasive1.3535900E-005-
51358Child Development Disorders, Pervasive3.5188000E-005-
72282Lupus Erythematosus, Systemic2E-1526502338
76835Arthritis, Rheumatoid5E-1624390342
77284Arthritis, Rheumatoid3E-1224390342

GWAS

ensgIDSNPChromosomePosition TraitPubmedIDOr or BEAT EFO ID

Protein-Protein Interaction (PPI)

Paralogs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id
ENSG00000169057homo_sapiensENSP0000039408029.268316.899homo_sapiensENSP0000039553533.734919.4779

Orthologs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id
ENSG00000169057homo_sapiensENSP0000039553531.325331.3253nomascus_leucogenysENSNLEP00000036087100100
ENSG00000169057homo_sapiensENSP0000039553594.979994.7791pan_paniscusENSPPAP0000002167495.943295.7404
ENSG00000169057homo_sapiensENSP00000395535100100pongo_abeliiENSPPYP00000033017100100
ENSG00000169057homo_sapiensENSP00000395535100100pan_troglodytesENSPTRP00000081799100100
ENSG00000169057homo_sapiensENSP00000395535100100gorilla_gorillaENSGGOP00000044548100100
ENSG00000169057homo_sapiensENSP0000039553530.722929.5181ornithorhynchus_anatinusENSOANP0000004187093.292789.6341
ENSG00000169057homo_sapiensENSP0000039553589.959885.1406sarcophilus_harrisiiENSSHAP0000000906589.421284.6307
ENSG00000169057homo_sapiensENSP0000039553590.361485.1406notamacropus_eugeniiENSMEUP000000025239084.8
ENSG00000169057homo_sapiensENSP0000039553583.734981.1245dasypus_novemcinctusENSDNOP0000001040291.648488.7912
ENSG00000169057homo_sapiensENSP0000039553569.879568.2731erinaceus_europaeusENSEEUP0000000280974.678172.9614
ENSG00000169057homo_sapiensENSP0000039553551.204850.8032erinaceus_europaeusENSEEUP0000001370595.505694.7566
ENSG00000169057homo_sapiensENSP0000039553587.550284.3373echinops_telfairiENSETEP0000000798088.798485.5397
ENSG00000169057homo_sapiensENSP0000039553599.799299.5984callithrix_jacchusENSCJAP0000002657810099.7988
ENSG00000169057homo_sapiensENSP0000039553597.791296.988cercocebus_atysENSCATP0000000527297.205696.4072
ENSG00000169057homo_sapiensENSP0000039553510099.7992macaca_fascicularisENSMFAP0000002060110099.7992
ENSG00000169057homo_sapiensENSP0000039553510099.7992macaca_mulattaENSMMUP0000005595310099.7992
ENSG00000169057homo_sapiensENSP0000039553510099.7992macaca_nemestrinaENSMNEP0000000376610099.7992
ENSG00000169057homo_sapiensENSP0000039553599.799299.5984papio_anubisENSPANP0000004424399.799299.5984
ENSG00000169057homo_sapiensENSP0000039553595.180794.3775mandrillus_leucophaeusENSMLEP0000001720795.180794.3775
ENSG00000169057homo_sapiensENSP0000039553596.787195.5823tursiops_truncatusENSTTRP0000000436296.787195.5823
ENSG00000169057homo_sapiensENSP0000039553594.176793.3735vulpes_vulpesENSVVUP0000004158292.504991.716
ENSG00000169057homo_sapiensENSP0000039553595.783194.9799mus_spretusMGP_SPRETEiJ_P009557795.019994.2231
ENSG00000169057homo_sapiensENSP0000039553588.554287.751equus_asinusENSEASP0000502822488.376887.5751
ENSG00000169057homo_sapiensENSP0000039553592.771191.3655capra_hircusENSCHIP0000002691696.049994.5946
ENSG00000169057homo_sapiensENSP0000039553590.160688.755loxodonta_africanaENSLAFP0000001367495.735694.2431
ENSG00000169057homo_sapiensENSP0000039553597.389696.5863panthera_leoENSPLOP0000001553197.389696.5863
ENSG00000169057homo_sapiensENSP0000039553597.389696.3855ailuropoda_melanoleucaENSAMEP0000003299297.389696.3855
ENSG00000169057homo_sapiensENSP0000039553596.98895.5823bos_indicus_hybridENSBIXP0000503257896.98895.5823
ENSG00000169057homo_sapiensENSP0000039553594.779194.1767oryctolagus_cuniculusENSOCUP0000004855497.319696.701
ENSG00000169057homo_sapiensENSP0000039553597.99296.988equus_caballusENSECAP0000004804297.99296.988
ENSG00000169057homo_sapiensENSP0000039553593.975992.7711canis_lupus_familiarisENSCAFP0084503770193.975992.7711
ENSG00000169057homo_sapiensENSP0000039553597.389696.5863panthera_pardusENSPPRP0000001044497.389696.5863
ENSG00000169057homo_sapiensENSP0000039553598.99698.5944marmota_marmota_marmotaENSMMMP0000001118298.797698.3968
ENSG00000169057homo_sapiensENSP0000039553594.578392.3695balaenoptera_musculusENSBMSP0001002748892.899490.7298
ENSG00000169057homo_sapiensENSP0000039553592.168790.3614cavia_porcellusENSCPOP0000001131691.071489.2857
ENSG00000169057homo_sapiensENSP0000039553597.389696.5863felis_catusENSFCAP0000004954297.389696.5863
ENSG00000169057homo_sapiensENSP0000039553573.092470.6827ursus_americanusENSUAMP0000002638682.727380
ENSG00000169057homo_sapiensENSP0000039553587.951882.9317monodelphis_domesticaENSMODP0000001458881.564276.9088
ENSG00000169057homo_sapiensENSP0000039553596.586395.3815monodon_monocerosENSMMNP0001501761896.586395.3815
ENSG00000169057homo_sapiensENSP0000039553589.156687.3494sus_scrofaENSSSCP0000001360696.312494.3601
ENSG00000169057homo_sapiensENSP0000039553598.594498.1928microcebus_murinusENSMICP0000000468798.00497.6048
ENSG00000169057homo_sapiensENSP0000039553591.566389.9598octodon_degusENSODEP0000000601890.836789.243
ENSG00000169057homo_sapiensENSP0000039553597.389696.1847jaculus_jaculusENSJJAP0000002239697.389696.1847
ENSG00000169057homo_sapiensENSP0000039553597.188895.7831ovis_aries_rambouilletENSOARP0002002846397.188895.7831
ENSG00000169057homo_sapiensENSP0000039553531.124529.3173ursus_maritimusENSUMAP0000002856090.116384.8837
ENSG00000169057homo_sapiensENSP0000039553593.172791.9679delphinapterus_leucasENSDLEP0000001480595.473394.2387
ENSG00000169057homo_sapiensENSP0000039553595.983994.5783physeter_catodonENSPCTP0000503094295.983994.5783
ENSG00000169057homo_sapiensENSP0000039553596.184795.3815mus_caroliMGP_CAROLIEiJ_P009182395.608894.8104
ENSG00000169057homo_sapiensENSP0000039553595.983994.7791mus_musculusENSMUSP0000003377095.409294.2116
ENSG00000169057homo_sapiensENSP0000039553597.590496.7871dipodomys_ordiiENSDORP0000002615997.296.4
ENSG00000169057homo_sapiensENSP0000039553591.967989.9598mustela_putorius_furoENSMPUP0000000899994.628192.562
ENSG00000169057homo_sapiensENSP0000039553593.975992.9719aotus_nancymaaeENSANAP0000000354893.787692.7856
ENSG00000169057homo_sapiensENSP0000039553594.578393.9759saimiri_boliviensis_boliviensisENSSBOP0000001674295.537594.929
ENSG00000169057homo_sapiensENSP0000039553595.783195.5823chlorocebus_sabaeusENSCSAP0000000308499.582599.3737
ENSG00000169057homo_sapiensENSP0000039553596.586395.5823mesocricetus_auratusENSMAUP0000002008595.436594.4444
ENSG00000169057homo_sapiensENSP0000039553596.586395.3815phocoena_sinusENSPSNP0000003026196.586395.3815
ENSG00000169057homo_sapiensENSP0000039553559.036156.2249camelus_dromedariusENSCDRP0000501622190.461586.1538
ENSG00000169057homo_sapiensENSP0000039553594.578393.7751carlito_syrichtaENSTSYP0000001894292.352991.5686
ENSG00000169057homo_sapiensENSP0000039553540.562239.5582panthera_tigris_altaicaENSPTIP0000000093892.660690.367
ENSG00000169057homo_sapiensENSP0000039553596.586395.1807rattus_norvegicusENSRNOP0000009465892.591.1538
ENSG00000169057homo_sapiensENSP0000039553594.377593.7751prolemur_simusENSPSMP0000003286194.377593.7751
ENSG00000169057homo_sapiensENSP0000039553596.385595.3815microtus_ochrogasterENSMOCP0000000170994.674693.6884
ENSG00000169057homo_sapiensENSP0000039553589.558286.9478sorex_araneusENSSARP0000001166995.095992.3241
ENSG00000169057homo_sapiensENSP0000039553596.385595.3815peromyscus_maniculatus_bairdiiENSPEMP0000001565995.049594.0594
ENSG00000169057homo_sapiensENSP0000039553559.437856.0241bos_mutusENSBMUP0000001939391.35886.1111
ENSG00000169057homo_sapiensENSP0000039553596.184795.3815mus_spicilegusENSMSIP0000002902195.418394.6215
ENSG00000169057homo_sapiensENSP0000039553597.389696.1847cricetulus_griseus_chok1gshdENSCGRP0000101767596.230295.0397
ENSG00000169057homo_sapiensENSP0000039553571.285170.4819pteropus_vampyrusENSPVAP0000000044271.572670.7661
ENSG00000169057homo_sapiensENSP0000039553592.369591.9679myotis_lucifugusENSMLUP0000001300595.634195.2183
ENSG00000169057homo_sapiensENSP0000039553590.361485.5422vombatus_ursinusENSVURP0001002790689.820485.0299
ENSG00000169057homo_sapiensENSP0000039553576.907670.0803vombatus_ursinusENSVURP0001001955380.462273.3193
ENSG00000169057homo_sapiensENSP0000039553597.791297.1888rhinolophus_ferrumequinumENSRFEP0001000630797.791297.1888
ENSG00000169057homo_sapiensENSP0000039553592.369590.9639neovison_visonENSNVIP0000003102494.845493.4021
ENSG00000169057homo_sapiensENSP0000039553596.98895.5823bos_taurusENSBTAP0000005457996.98895.5823
ENSG00000169057homo_sapiensENSP0000039553574.096471.4859heterocephalus_glaber_femaleENSHGLP0000000113988.489285.3717
ENSG00000169057homo_sapiensENSP0000039553594.979994.1767rhinopithecus_bietiENSRBIP0000003898294.979994.1767
ENSG00000169057homo_sapiensENSP0000039553593.975992.7711canis_lupus_dingoENSCAFP0002002814493.975992.7711
ENSG00000169057homo_sapiensENSP0000039553598.99698.5944sciurus_vulgarisENSSVLP0000502262298.99698.5944
ENSG00000169057homo_sapiensENSP0000039553590.763185.9438phascolarctos_cinereusENSPCIP0000002160389.860885.0895
ENSG00000169057homo_sapiensENSP0000039553594.979992.5703procavia_capensisENSPCAP0000001097895.74993.3198
ENSG00000169057homo_sapiensENSP0000039553597.590496.5863nannospalax_galiliENSNGAP0000000623697.394896.3928
ENSG00000169057homo_sapiensENSP0000039553596.385594.9799bos_grunniensENSBGRP0000003710996.774295.3629
ENSG00000169057homo_sapiensENSP0000039553595.983994.1767chinchilla_lanigeraENSCLAP0000000227796.565794.7475
ENSG00000169057homo_sapiensENSP0000039553593.775192.1687cervus_hanglu_yarkandensisENSCHYP0000003730296.090594.4444
ENSG00000169057homo_sapiensENSP0000039553588.554287.3494catagonus_wagneriENSCWAP0000001173891.68490.4366
ENSG00000169057homo_sapiensENSP0000039553595.582395.1807ictidomys_tridecemlineatusENSSTOP0000002624197.942497.5309
ENSG00000169057homo_sapiensENSP0000039553595.783195.1807otolemur_garnettiiENSOGAP0000001353298.148197.5309
ENSG00000169057homo_sapiensENSP0000039553598.795297.5904cebus_imitatorENSCCAP0000003914698.795297.5904
ENSG00000169057homo_sapiensENSP0000039553598.99698.5944urocitellus_parryiiENSUPAP0001001353598.99698.5944
ENSG00000169057homo_sapiensENSP0000039553568.072364.8594moschus_moschiferusENSMMSP0000002080490.641786.3636
ENSG00000169057homo_sapiensENSP0000039553596.787195.1807moschus_moschiferusENSMMSP0000002037596.593294.99
ENSG00000169057homo_sapiensENSP0000039553594.979994.1767rhinopithecus_roxellanaENSRROP0000004324294.979994.1767
ENSG00000169057homo_sapiensENSP0000039553596.184795.3815mus_pahariMGP_PahariEiJ_P008945095.039794.246
ENSG00000169057homo_sapiensENSP0000039553594.176793.3735propithecus_coquereliENSPCOP0000002525893.893
ENSG00000169057homo_sapiensENSP0000039553518.273115.261petromyzon_marinusENSPMAP0000000858169.465758.0153
ENSG00000169057homo_sapiensENSP0000039553515.461812.8514eptatretus_burgeriENSEBUP0000001186960.629950.3937
ENSG00000169057homo_sapiensENSP0000039553551.00442.1687callorhinchus_miliiENSCMIP0000000791363.184152.2388
ENSG00000169057homo_sapiensENSP0000039553575.301268.6747latimeria_chalumnaeENSLACP0000001280881.699374.5098
ENSG00000169057homo_sapiensENSP0000039553566.666759.0361lepisosteus_oculatusENSLOCP0000001813166.533158.9178
ENSG00000169057homo_sapiensENSP000003955355039.759clupea_harengusENSCHAP0000005517850.100639.839
ENSG00000169057homo_sapiensENSP0000039553560.040251.6064danio_rerioENSDARP0000010939957.061149.0458
ENSG00000169057homo_sapiensENSP0000039553561.646652.2088carassius_auratusENSCARP0000011975256.433847.7941
ENSG00000169057homo_sapiensENSP0000039553562.048252.4096carassius_auratusENSCARP0000011096256.801547.9779
ENSG00000169057homo_sapiensENSP0000039553561.445851.8072carassius_auratusENSCARP0000003129856.353647.5138
ENSG00000169057homo_sapiensENSP0000039553561.24551.8072astyanax_mexicanusENSAMXP0000004696149.836642.1569
ENSG00000169057homo_sapiensENSP0000039553561.646652.2088ictalurus_punctatusENSIPUP0000001920157.598548.7805
ENSG00000169057homo_sapiensENSP0000039553559.437851.004esox_luciusENSELUP0000003902748.287141.4356
ENSG00000169057homo_sapiensENSP0000039553557.831349.1968electrophorus_electricusENSEEEP0000000674656.2547.8516
ENSG00000169057homo_sapiensENSP0000039553563.654654.4177oncorhynchus_kisutchENSOKIP0000501432543.365337.0725
ENSG00000169057homo_sapiensENSP0000039553562.650652.6104oncorhynchus_kisutchENSOKIP0000509400538.566132.3857
ENSG00000169057homo_sapiensENSP0000039553558.232949.5984oncorhynchus_mykissENSOMYP0000013330534.606229.4749
ENSG00000169057homo_sapiensENSP0000039553560.642652.008oncorhynchus_mykissENSOMYP0000000971142.655436.5819
ENSG00000169057homo_sapiensENSP0000039553558.634549.1968salmo_salarENSSSAP0000016299148.50540.6977
ENSG00000169057homo_sapiensENSP0000039553562.449853.2129salmo_salarENSSSAP0000004409046.142439.3175
ENSG00000169057homo_sapiensENSP0000039553563.453854.4177salmo_truttaENSSTUP0000002328648.024341.1854
ENSG00000169057homo_sapiensENSP0000039553561.847451.6064salmo_truttaENSSTUP0000001580734.529128.8117
ENSG00000169057homo_sapiensENSP0000039553554.618543.3735gadus_morhuaENSGMOP0000006365837.517229.7931
ENSG00000169057homo_sapiensENSP0000039553558.634546.988fundulus_heteroclitusENSFHEP0000003171533.144226.5607
ENSG00000169057homo_sapiensENSP0000039553563.25351.2048poecilia_reticulataENSPREP0000001856932.077425.9674
ENSG00000169057homo_sapiensENSP0000039553562.650650.8032xiphophorus_maculatusENSXMAP0000003748626.440721.4407
ENSG00000169057homo_sapiensENSP0000039553558.634545.7831oryzias_latipesENSORLP0000004524729.083722.7092
ENSG00000169057homo_sapiensENSP0000039553553.815345.3815cyclopterus_lumpusENSCLMP0000500086051.439543.3781
ENSG00000169057homo_sapiensENSP0000039553565.060253.012oreochromis_niloticusENSONIP0000002928730.111524.5353
ENSG00000169057homo_sapiensENSP0000039553522.891618.6747haplochromis_burtoniENSHBUP0000003365064.406852.5424
ENSG00000169057homo_sapiensENSP0000039553565.461853.2129astatotilapia_callipteraENSACLP0000002013530.783825.0236
ENSG00000169057homo_sapiensENSP0000039553562.851451.6064lates_calcariferENSLCAP0001003788230.388324.9515
ENSG00000169057homo_sapiensENSP0000039553576.706867.8715xenopus_tropicalisENSXETP0000000333781.974372.5322
ENSG00000169057homo_sapiensENSP0000039553533.534129.3173chrysemys_picta_belliiENSCPBP0000000886871.982862.931
ENSG00000169057homo_sapiensENSP0000039553524.698822.2892laticauda_laticaudataENSLLTP0000001011786.619778.169
ENSG00000169057homo_sapiensENSP0000039553575.903669.0763notechis_scutatusENSNSUP0000002047777.777870.7819
ENSG00000169057homo_sapiensENSP0000039553577.309270.4819pseudonaja_textilisENSPTXP0000000676281.052673.8947
ENSG00000169057homo_sapiensENSP0000039553559.036151.6064gallus_gallusENSGALP0001000247441.940136.6619
ENSG00000169057homo_sapiensENSP0000039553577.911670.6827anolis_carolinensisENSACAP0000001227175.048468.0851
ENSG00000169057homo_sapiensENSP0000039553556.024146.1847neolamprologus_brichardiENSNBRP0000001085853.041843.7262
ENSG00000169057homo_sapiensENSP0000039553577.710870.8835naja_najaENSNNAP0000002916781.473774.3158
ENSG00000169057homo_sapiensENSP0000039553528.714926.9076podarcis_muralisENSPMRP0000003356090.506384.8101
ENSG00000169057homo_sapiensENSP0000039553557.028151.8072taeniopygia_guttataENSTGUP0000002149874.345667.5393
ENSG00000169057homo_sapiensENSP0000039553559.638651.4056taeniopygia_guttataENSTGUP0000003124343.294537.3178
ENSG00000169057homo_sapiensENSP0000039553521.887618.4739erpetoichthys_calabaricusENSECRP0000002745066.060655.7576
ENSG00000169057homo_sapiensENSP0000039553562.048251.004kryptolebias_marmoratusENSKMAP0000002013529.289124.0758
ENSG00000169057homo_sapiensENSP0000039553577.108469.2771salvator_merianaeENSSMRP0000000212681.355973.0932
ENSG00000169057homo_sapiensENSP0000039553558.634546.988oryzias_javanicusENSOJAP0000000380930.640124.554
ENSG00000169057homo_sapiensENSP0000039553563.654652.8112dicentrarchus_labraxENSDLAP0000507747729.297624.3068
ENSG00000169057homo_sapiensENSP0000039553550.602442.9719amphiprion_perculaENSAPEP0000003384638.888933.0247
ENSG00000169057homo_sapiensENSP0000039553521.485917.2691oryzias_sinensisENSOSIP0000000330345.922736.9099
ENSG00000169057homo_sapiensENSP0000039553536.947834.5382pelodiscus_sinensisENSPSIP0000000226791.542385.5721
ENSG00000169057homo_sapiensENSP0000039553570.682764.6586gopherus_evgoodeiENSGEVP0000502556980.365373.516
ENSG00000169057homo_sapiensENSP0000039553535.943832.5301chelonoidis_abingdoniiENSCABP0000001500683.644975.7009
ENSG00000169057homo_sapiensENSP0000039553563.453852.8112seriola_dumeriliENSSDUP0000002735730.889525.7087
ENSG00000169057homo_sapiensENSP0000039553560.040249.3976cottoperca_gobioENSCGOP0000003254429.313724.1176
ENSG00000169057homo_sapiensENSP0000039553545.381538.1526gasterosteus_aculeatusENSGACP0000000102449.023941.2148
ENSG00000169057homo_sapiensENSP0000039553561.646649.5984cynoglossus_semilaevisENSCSEP0000002710925.267520.3292
ENSG00000169057homo_sapiensENSP0000039553554.417744.5783poecilia_formosaENSPFOP0000000217950.185241.1111
ENSG00000169057homo_sapiensENSP0000039553558.232948.7952myripristis_murdjanENSMMDP0000504082331.453426.3557
ENSG00000169057homo_sapiensENSP0000039553562.24954.2169strigops_habroptilaENSSHBP0000500882652.364945.6081
ENSG00000169057homo_sapiensENSP0000039553563.25352.008amphiprion_ocellarisENSAOCP0000000774230.201324.8322
ENSG00000169057homo_sapiensENSP0000039553530.522128.7149terrapene_carolina_triunguisENSTMTP0000002621471.698167.4528
ENSG00000169057homo_sapiensENSP0000039553567.670761.245terrapene_carolina_triunguisENSTMTP0000001073779.857872.2749
ENSG00000169057homo_sapiensENSP0000039553563.855454.2169hucho_huchoENSHHUP0000003663948.623941.2844
ENSG00000169057homo_sapiensENSP0000039553532.730928.3133hucho_huchoENSHHUP0000001034060.594852.4164
ENSG00000169057homo_sapiensENSP0000039553555.421745.5823betta_splendensENSBSLP0000002337431.687726.062
ENSG00000169057homo_sapiensENSP0000039553562.650653.2129pygocentrus_nattereriENSPNAP0000001834756.419547.9204
ENSG00000169057homo_sapiensENSP0000039553563.453851.4056anabas_testudineusENSATEP0000006556731.442825.4726
ENSG00000169057homo_sapiensENSP000003955358.032134.81928ciona_savignyiENSCSAVP0000000183622.346413.4078
ENSG00000169057homo_sapiensENSP0000039553563.453852.8112seriola_lalandi_dorsalisENSSLDP0000000796830.889525.7087
ENSG00000169057homo_sapiensENSP0000039553561.847450.8032labrus_bergyltaENSLBEP0000001626529.729724.4208
ENSG00000169057homo_sapiensENSP0000039553565.461853.2129pundamilia_nyerereiENSPNYP0000002702330.783825.0236
ENSG00000169057homo_sapiensENSP0000039553563.855452.008mastacembelus_armatusENSMAMP0000001741230.873825.1456
ENSG00000169057homo_sapiensENSP0000039553563.052251.2048stegastes_partitusENSSPAP0000000687632.238226.1807
ENSG00000169057homo_sapiensENSP0000039553560.24151.8072oncorhynchus_tshawytschaENSOTSP0000501248737.641232.3714
ENSG00000169057homo_sapiensENSP0000039553554.819346.988oncorhynchus_tshawytschaENSOTSP0000501815750.36943.1734
ENSG00000169057homo_sapiensENSP0000039553554.216945.7831acanthochromis_polyacanthusENSAPOP0000000134350.751942.8571
ENSG00000169057homo_sapiensENSP0000039553537.148627.7108nothobranchius_furzeriENSNFUP0001504745253.779140.1163
ENSG00000169057homo_sapiensENSP0000039553563.25351.004nothobranchius_furzeriENSNFUP0001504745928.429622.9242
ENSG00000169057homo_sapiensENSP0000039553555.020144.9799cyprinodon_variegatusENSCVAP0000002049429.242323.9061
ENSG00000169057homo_sapiensENSP0000039553550.401639.759denticeps_clupeoidesENSDCDP0000003545251.329240.4908
ENSG00000169057homo_sapiensENSP0000039553562.650653.2129denticeps_clupeoidesENSDCDP0000004731456.624348.0944
ENSG00000169057homo_sapiensENSP0000039553557.228947.7912denticeps_clupeoidesENSDCDP0000001746559.87450
ENSG00000169057homo_sapiensENSP0000039553562.851452.008larimichthys_croceaENSLCRP0000505607530.477125.2191
ENSG00000169057homo_sapiensENSP0000039553561.044251.004takifugu_rubripesENSTRUP0000006948230.769225.7085
ENSG00000169057homo_sapiensENSP0000039553560.24148.1928hippocampus_comesENSHCOP0000001287335.377428.3019
ENSG00000169057homo_sapiensENSP0000039553561.044251.4056cyprinus_carpio_carpioENSCCRP0000014355155.172446.461
ENSG00000169057homo_sapiensENSP0000039553562.048252.4096cyprinus_carpio_carpioENSCCRP0000010475156.593447.8022
ENSG00000169057homo_sapiensENSP0000039553562.24951.004poecilia_latipinnaENSPLAP0000002628331.093325.4764
ENSG00000169057homo_sapiensENSP0000039553561.445852.2088sinocyclocheilus_grahamiENSSGRP0000006498356.666748.1481
ENSG00000169057homo_sapiensENSP0000039553561.646652.008sinocyclocheilus_grahamiENSSGRP0000003694056.746847.8743
ENSG00000169057homo_sapiensENSP0000039553565.461853.2129maylandia_zebraENSMZEP0000503583930.783825.0236
ENSG00000169057homo_sapiensENSP0000039553544.779140.1606tetraodon_nigroviridisENSTNIP0000000193551.620446.2963
ENSG00000169057homo_sapiensENSP0000039553567.269158.6345paramormyrops_kingsleyaeENSPKIP0000000853260.688452.8986
ENSG00000169057homo_sapiensENSP0000039553569.076359.4378scleropages_formosusENSSFOP0001506759160.563452.1127
ENSG00000169057homo_sapiensENSP0000039553575.100466.2651leptobrachium_leishanenseENSLLEP0000004674981.304371.7391
ENSG00000169057homo_sapiensENSP0000039553563.052251.8072scophthalmus_maximusENSSMAP0000002030129.455924.2026
ENSG00000169057homo_sapiensENSP0000039553560.040247.7912oryzias_melastigmaENSOMEP0000000995431.081124.7401

Gene Ontology

Go ID Go term No. evidence Entries Species Category
GO:0000122involved_in negative regulation of transcription by RNA polymerase II1IBAHomo_sapiens(9606)Process
GO:0000400enables four-way junction DNA binding1IEAHomo_sapiens(9606)Function
GO:0000792part_of heterochromatin2IBA,IDAHomo_sapiens(9606)Component
GO:0001662involved_in behavioral fear response1IEAHomo_sapiens(9606)Process
GO:0001666involved_in response to hypoxia1IEAHomo_sapiens(9606)Process
GO:0001964involved_in startle response1IEAHomo_sapiens(9606)Process
GO:0001976involved_in nervous system process involved in regulation of systemic arterial blood pressure1IEAHomo_sapiens(9606)Process
GO:0002087involved_in regulation of respiratory gaseous exchange by nervous system process1IEAHomo_sapiens(9606)Process
GO:0003676enables nucleic acid binding1EXPHomo_sapiens(9606)Function
GO:0003677enables DNA binding1TASHomo_sapiens(9606)Function
GO:0003682enables chromatin binding1IBAHomo_sapiens(9606)Function
GO:0003700enables DNA-binding transcription factor activity1IEAHomo_sapiens(9606)Function
GO:0003714enables transcription corepressor activity1IDAHomo_sapiens(9606)Function
GO:0003723enables RNA binding1HDAHomo_sapiens(9606)Function
GO:0003729enables mRNA binding1IEAHomo_sapiens(9606)Function
GO:0005515enables protein binding1IPIHomo_sapiens(9606)Function
GO:0005615located_in extracellular space1HDAHomo_sapiens(9606)Component
GO:0005634is_active_in nucleus2IBA,IDAHomo_sapiens(9606)Component
GO:0005654located_in nucleoplasm2IDA,TASHomo_sapiens(9606)Component
GO:0005813located_in centrosome1IMPHomo_sapiens(9606)Component
GO:0005829located_in cytosol1IEAHomo_sapiens(9606)Component
GO:0006020involved_in inositol metabolic process1IEAHomo_sapiens(9606)Process
GO:0006349acts_upstream_of_or_within regulation of gene expression by genomic imprinting1IMPHomo_sapiens(9606)Process
GO:0006541involved_in glutamine metabolic process1IEAHomo_sapiens(9606)Process
GO:0006576involved_in biogenic amine metabolic process1IEAHomo_sapiens(9606)Process
GO:0007052involved_in mitotic spindle organization1IMPHomo_sapiens(9606)Process
GO:0007219involved_in Notch signaling pathway1IEAHomo_sapiens(9606)Process
GO:0007416involved_in synapse assembly1IEAHomo_sapiens(9606)Process
GO:0007507involved_in heart development1IEAHomo_sapiens(9606)Process
GO:0007585involved_in respiratory gaseous exchange by respiratory system1IEAHomo_sapiens(9606)Process
GO:0007616involved_in long-term memory1IEAHomo_sapiens(9606)Process
GO:0008104involved_in protein localization1IEAHomo_sapiens(9606)Process
GO:0008211involved_in glucocorticoid metabolic process1IEAHomo_sapiens(9606)Process
GO:0008284involved_in positive regulation of cell population proliferation1IMPHomo_sapiens(9606)Process
GO:0008327enables methyl-CpG binding1IBAHomo_sapiens(9606)Function
GO:0008344involved_in adult locomotory behavior1IEAHomo_sapiens(9606)Process
GO:0008542involved_in visual learning1IEAHomo_sapiens(9606)Process
GO:0009791involved_in post-embryonic development1IEAHomo_sapiens(9606)Process
GO:0010212involved_in response to ionizing radiation1IEAHomo_sapiens(9606)Process
GO:0010288involved_in response to lead ion1IEAHomo_sapiens(9606)Process
GO:0010385enables double-stranded methylated DNA binding2IBA,IMPHomo_sapiens(9606)Function
GO:0010467involved_in gene expression1IEAHomo_sapiens(9606)Process
GO:0010629involved_in negative regulation of gene expression1IDAHomo_sapiens(9606)Process
GO:0010971involved_in positive regulation of G2/M transition of mitotic cell cycle1IMPHomo_sapiens(9606)Process
GO:0014003involved_in oligodendrocyte development1IEAHomo_sapiens(9606)Process
GO:0014009involved_in glial cell proliferation1IEAHomo_sapiens(9606)Process
GO:0016358involved_in dendrite development1IEAHomo_sapiens(9606)Process
GO:0016525involved_in negative regulation of angiogenesis1IMPHomo_sapiens(9606)Process
GO:0016571involved_in histone methylation1IEAHomo_sapiens(9606)Process
GO:0016573involved_in histone acetylation1IEAHomo_sapiens(9606)Process
GO:0019230involved_in proprioception1IEAHomo_sapiens(9606)Process
GO:0019233involved_in sensory perception of pain1IEAHomo_sapiens(9606)Process
GO:0019904enables protein domain specific binding1IEAHomo_sapiens(9606)Function
GO:0021510involved_in spinal cord development1IEAHomo_sapiens(9606)Process
GO:0021549involved_in cerebellum development1IEAHomo_sapiens(9606)Process
GO:0021591involved_in ventricular system development1IEAHomo_sapiens(9606)Process
GO:0021740involved_in principal sensory nucleus of trigeminal nerve development1IEAHomo_sapiens(9606)Process
GO:0021756involved_in striatum development1IEAHomo_sapiens(9606)Process
GO:0021766involved_in hippocampus development1IEAHomo_sapiens(9606)Process
GO:0021772involved_in olfactory bulb development1IEAHomo_sapiens(9606)Process
GO:0021794involved_in thalamus development1IEAHomo_sapiens(9606)Process
GO:0021987involved_in cerebral cortex development1IEAHomo_sapiens(9606)Process
GO:0031490enables chromatin DNA binding1IEAHomo_sapiens(9606)Function
GO:0031507involved_in heterochromatin formation1IEAHomo_sapiens(9606)Process
GO:0031915involved_in positive regulation of synaptic plasticity1IEAHomo_sapiens(9606)Process
GO:0032048involved_in cardiolipin metabolic process1IEAHomo_sapiens(9606)Process
GO:0032091involved_in negative regulation of protein binding1IEAHomo_sapiens(9606)Process
GO:0032355involved_in response to estradiol1IEAHomo_sapiens(9606)Process
GO:0035176involved_in social behavior1IEAHomo_sapiens(9606)Process
GO:0035197enables siRNA binding1IEAHomo_sapiens(9606)Function
GO:0035865involved_in cellular response to potassium ion1IEAHomo_sapiens(9606)Process
GO:0042220involved_in response to cocaine1IEAHomo_sapiens(9606)Process
GO:0042551involved_in neuron maturation1IEAHomo_sapiens(9606)Process
GO:0042826enables histone deacetylase binding1IEAHomo_sapiens(9606)Function
GO:0043524involved_in negative regulation of neuron apoptotic process1IEAHomo_sapiens(9606)Process
GO:0043537involved_in negative regulation of blood vessel endothelial cell migration1IDAHomo_sapiens(9606)Process
GO:0045322enables unmethylated CpG binding1IEAHomo_sapiens(9606)Function
GO:0045892involved_in negative regulation of DNA-templated transcription1IDAHomo_sapiens(9606)Process
GO:0045944involved_in positive regulation of transcription by RNA polymerase II1IEAHomo_sapiens(9606)Process
GO:0046470involved_in phosphatidylcholine metabolic process1IEAHomo_sapiens(9606)Process
GO:0048286involved_in lung alveolus development1IEAHomo_sapiens(9606)Process
GO:0048712involved_in negative regulation of astrocyte differentiation1IEAHomo_sapiens(9606)Process
GO:0050432involved_in catecholamine secretion1IEAHomo_sapiens(9606)Process
GO:0050807involved_in regulation of synapse organization1IEAHomo_sapiens(9606)Process
GO:0051151involved_in negative regulation of smooth muscle cell differentiation1IEAHomo_sapiens(9606)Process
GO:0051707involved_in response to other organism1IEAHomo_sapiens(9606)Process
GO:0060079involved_in excitatory postsynaptic potential1IEAHomo_sapiens(9606)Process
GO:0060090enables molecular adaptor activity1EXPHomo_sapiens(9606)Function
GO:0060252involved_in positive regulation of glial cell proliferation1IEAHomo_sapiens(9606)Process
GO:0060291involved_in long-term synaptic potentiation1IEAHomo_sapiens(9606)Process
GO:0060999involved_in positive regulation of dendritic spine development1IEAHomo_sapiens(9606)Process
GO:0061000involved_in negative regulation of dendritic spine development1IEAHomo_sapiens(9606)Process
GO:0071317involved_in cellular response to isoquinoline alkaloid1IEAHomo_sapiens(9606)Process
GO:0090063involved_in positive regulation of microtubule nucleation1IMPHomo_sapiens(9606)Process
GO:0090327involved_in negative regulation of locomotion involved in locomotory behavior1IEAHomo_sapiens(9606)Process
GO:0098794located_in postsynapse1IEAHomo_sapiens(9606)Component
GO:0098978located_in glutamatergic synapse1IEAHomo_sapiens(9606)Component
GO:0099191involved_in trans-synaptic signaling by BDNF1IEAHomo_sapiens(9606)Process
GO:0099611involved_in regulation of action potential firing threshold1IEAHomo_sapiens(9606)Process
GO:0140693enables molecular condensate scaffold activity1IMPHomo_sapiens(9606)Function
GO:1900114involved_in positive regulation of histone H3-K9 trimethylation1IEAHomo_sapiens(9606)Process
GO:1901953involved_in positive regulation of anterograde dense core granule transport1IEAHomo_sapiens(9606)Process
GO:1901956involved_in positive regulation of retrograde dense core granule transport1IEAHomo_sapiens(9606)Process
GO:1903860involved_in negative regulation of dendrite extension1IEAHomo_sapiens(9606)Process
GO:1903861involved_in positive regulation of dendrite extension1IEAHomo_sapiens(9606)Process
GO:1903941involved_in negative regulation of respiratory gaseous exchange1IEAHomo_sapiens(9606)Process
GO:1905492involved_in positive regulation of branching morphogenesis of a nerve1IEAHomo_sapiens(9606)Process
GO:1905643involved_in positive regulation of DNA methylation1IDAHomo_sapiens(9606)Process
GO:1990841enables promoter-specific chromatin binding1IEAHomo_sapiens(9606)Function
GO:2000635involved_in negative regulation of primary miRNA processing1IEAHomo_sapiens(9606)Process
GO:2000820involved_in negative regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation1IEAHomo_sapiens(9606)Process

Expression