Ensembl ID ENSG00000169057 Gene ID 4204 Accession 6990
Gene Symbol MECP2 Alias RS;RTS;RTT;PPMX;MRX16;MRX79;MRXSL;AUTSX3;MRXS13 Full Name methyl-CpG binding protein 2
Position X : 154021573 - 154097737 Length 76165 bases Strand Minus strand
Status Confidence Main interacting RNAsmRNARBP type Canonical_RBPs
Summary DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MECP2, MBD1 and MBD2 can also repress transcription from methylated gene promoters. In contrast to other MBD family members, MECP2 is X-linked and subject to X inactivation. MECP2 is dispensible in stem cells, but is essential for embryonic development. MECP2 gene mutations are the cause of most cases of Rett syndrome, a progressive neurologic developmental disorder and one of the most common causes of cognitive disability in females. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2015]

ENSG00000169057 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000169057 MECP2 -0.7 3.15e-12 BLCA
ENSG00000169057 MECP2 -0.3 1.15e-16 BRCA
ENSG00000169057 MECP2 1.14 4.34e-25 KICH
ENSG00000169057 MECP2 -0.5 3.12e-15 LUSC
ENSG00000169057 MECP2 -0.4 5.03e-17 PRAD
ENSG00000169057 MECP2 -0.5 5.89e-12 KIRP
ENSG00000169057 MECP2 -1.0 6.13e-45 UCEC
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000169057 MECP2 prostate cancer 16331274
ENSG00000169057 MECP2 lung tumors 17140695
ENSG00000169057 MECP2 prostate cancer 18666890
ENSG00000169057 MECP2 breast tumors 19383923
ENSG00000169057 MECP2 cancer 19835573
ENSG00000169057 MECP2 breast cancer 21105050
ENSG00000169057 MECP2 cervical cancer 23751476
ENSG00000169057 MECP2 DLBCL 23828858
ENSG00000169057 MECP2 cervical cancer 24518025
ENSG00000169057 MECP2 cancer 25108072
ENSG00000169057 MECP2 tumor 25227661
ENSG00000169057 MECP2 cancer 25539566
ENSG00000169057 MECP2 cancer 25613065
ENSG00000169057 MECP2 tumor 25767377
ENSG00000169057 MECP2 tumor 25881111
ENSG00000169057 MECP2 tumors 25970424
ENSG00000169057 MECP2 tumor 26189965
ENSG00000169057 MECP2 prostate cancer 26235378
ENSG00000169057 MECP2 tumors 26312503
ENSG00000169057 MECP2 tumor 26379313
ENSG00000169057 MECP2 gastric cancer 27166996
ENSG00000169057 MECP2 cancer 28131747
ENSG00000169057 MECP2 cancers 28380454
ENSG00000169057 MECP2 cancer 28416772
ENSG00000169057 MECP2 gastric cancer 28704505
ENSG00000169057 MECP2 cancer 28759023
ENSG00000169057 MECP2 gastric cancer 28767600
ENSG00000169057 MECP2 tumor 29143227
ENSG00000169057 MECP2 tumor 29750041
ENSG00000169057 MECP2 cancer 30391648
ENSG00000169057 MECP2 tumor 30433866
ENSG00000169057 MECP2 cancer 30546056
ENSG00000169057 MECP2 cancer 30864705
ENSG00000169057 MECP2 breast cancer 30940798
ENSG00000169057 MECP2 cancer 31443448
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000169057 MECP2 MESO 0.034 low
ENSG00000169057 MECP2 SARC 0.0029 low
ENSG00000169057 MECP2 UVM 0.0063 high
ENSG00000169057 MECP2 PAAD 0.0014 low
ENSG00000169057 MECP2 UCEC 0.00011 high
ENSG00000169057 MECP2 LGG 0.01 high
ENSG00000169057 MECP2 LUSC 0.0095 high
ENSG00000169057 MECP2 READ 0.029 high
ENSG00000169057 MECP2 KICH 0.048 high
ENSG00000169057 MECP2 LUAD 0.0022 low
ENSG00000169057 MECP2 THYM 0.026 high
ENSG00000169057 MECP2 COAD 0.032 high
ENSG00000169057 MECP2 LAML 0.028 high
ENSG00000169057 MECP2 CESC 0.00024 low
ENSG00000169057 MECP2 LIHC 0.039 high
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency