RBP Type	Canonical_RBPs
Diseases	CancerSARS-COV-2
Drug	Drug
Main interacting RNAs	N.A.
Moonlighting functions	E3 ligase
Localizations	N.A.
BulkPerturb-seq	N.A.

Ensembl ID	ENSG00000167986	Gene ID	1642	Accession	2717
Symbol	DDB1	Alias	XPE;DDBA;XAP1;XPCE;XPE-BF;UV-DDB1;WHIKERS	Full Name	damage specific DNA binding protein 1
Status	Confidence	Length	43146 bases	Strand	Minus strand
Position	11 : 61299451 - 61342596	RNA binding domain	CPSF_A
Summary	The protein encoded by this gene is the large subunit (p127) of the heterodimeric DNA damage-binding (DDB) complex while another protein (p48) forms the small subunit. This protein complex functions in nucleotide-excision repair and binds to DNA following UV damage. Defective activity of this complex causes the repair defect in patients with xeroderma pigmentosum complementation group E (XPE) - an autosomal recessive disorder characterized by photosensitivity and early onset of carcinomas. However, it remains for mutation analysis to demonstrate whether the defect in XPE patients is in this gene or the gene encoding the small subunit. In addition, Best vitelliform mascular dystrophy is mapped to the same region as this gene on 11q, but no sequence alternations of this gene are demonstrated in Best disease patients. The protein encoded by this gene also functions as an adaptor molecule for the cullin 4 (CUL4) ubiquitin E3 ligase complex by facilitating the binding of substrates to this complex and the ubiquitination of proteins. [provided by RefSeq, May 2012]

Protein	Domain	Pfam ID	E-value	Domain number
ENSP00000506457	CPSF_A	PF03178	4e-86	1
ENSP00000504954	CPSF_A	PF03178	4.5e-86	1
ENSP00000506134	CPSF_A	PF03178	4.7e-86	1
ENSP00000504878	CPSF_A	PF03178	5.2e-86	1
ENSP00000301764	CPSF_A	PF03178	5.4e-86	1
ENSP00000506223	CPSF_A	PF03178	5.4e-86	1
ENSP00000506685	CPSF_A	PF03178	5.4e-86	1
ENSP00000505437	CPSF_A	PF03178	6e-86	1
ENSP00000440269	CPSF_A	PF03178	3.1e-77	1
ENSP00000505717	CPSF_A	PF03178	6.8e-73	1
ENSP00000445844	CPSF_A	PF03178	1.2e-09	1

Pubmed ID	Full Name	Cell	Author	Time	Doi

Pubmed ID	Title	Author	Time	Journal
36333315	Translation regulatory factor BZW1 regulates preimplantation embryo development and compaction by restricting global non-AUG Initiation.	Jue Zhang	2022-11-04	Nature communications
22319459	Raf1 Is a DCAF for the Rik1 DDB1-like protein and has separable roles in siRNA generation and chromatin modification.	Alessia Buscaino	2012-02-01	PLoS genetics
30704981	Inhibition of HBV Transcription From cccDNA With Nitazoxanide by Targeting the HBx-DDB1 Interaction.	Kazuma Sekiba	2019-01-01	Cellular and molecular gastroenterology and hepatology
24206017	Measuring cereblon as a biomarker of response or resistance to lenalidomide and pomalidomide requires use of standardized reagents and understanding of gene complexity.	K Anita Gandhi	2014-01-01	British journal of haematology

Name	Transcript ID	bp	Protein	Translation ID
DDB1-201	ENST00000301764	4245	1140aa	ENSP00000301764
DDB1-225	ENST00000679588	4184	1084aa	ENSP00000506134
DDB1-228	ENST00000680075	3981	1066aa	ENSP00000504954
DDB1-226	ENST00000679712	4033	1069aa	ENSP00000504878
DDB1-232	ENST00000680357	4363	217aa	ENSP00000506385
DDB1-236	ENST00000680717	3937	1027aa	ENSP00000506457
DDB1-233	ENST00000680367	4426	1140aa	ENSP00000506223
DDB1-243	ENST00000681803	4348	1140aa	ENSP00000506685
DDB1-234	ENST00000680452	3110	No protein	-
DDB1-206	ENST00000535283	4920	370aa	ENSP00000441825
DDB1-240	ENST00000681188	4329	78aa	ENSP00000506472
DDB1-235	ENST00000680602	4001	1061aa	ENSP00000505437
DDB1-237	ENST00000680881	4335	No protein	-
DDB1-242	ENST00000681580	1629	No protein	-
DDB1-244	ENST00000681815	2205	No protein	-
DDB1-238	ENST00000680959	3114	No protein	-
DDB1-245	ENST00000681935	4138	1107aa	ENSP00000505717
DDB1-230	ENST00000680250	4459	No protein	-
DDB1-231	ENST00000680345	2623	No protein	-
DDB1-203	ENST00000451943	1224	No protein	-
DDB1-223	ENST00000545894	2282	No protein	-
DDB1-217	ENST00000540166	3906	1092aa	ENSP00000440269
DDB1-212	ENST00000538470	858	No protein	-
DDB1-227	ENST00000679855	3902	No protein	-
DDB1-213	ENST00000539332	1767	No protein	-
DDB1-241	ENST00000681368	3088	No protein	-
DDB1-222	ENST00000543658	571	162aa	ENSP00000445844
DDB1-204	ENST00000535147	2789	No protein	-
DDB1-209	ENST00000537877	1375	No protein	-
DDB1-202	ENST00000414411	1904	No protein	-
DDB1-207	ENST00000535967	1404	No protein	-
DDB1-216	ENST00000539739	1624	No protein	-
DDB1-218	ENST00000540784	1119	No protein	-
DDB1-211	ENST00000538280	227	No protein	-
DDB1-224	ENST00000545930	1278	No protein	-
DDB1-239	ENST00000681067	4180	No protein	-
DDB1-229	ENST00000680096	2873	No protein	-
DDB1-205	ENST00000535174	896	No protein	-
DDB1-215	ENST00000539712	1020	No protein	-
DDB1-219	ENST00000541513	958	No protein	-
DDB1-221	ENST00000543162	2592	No protein	-
DDB1-208	ENST00000537120	1215	No protein	-
DDB1-214	ENST00000539426	805	165aa	ENSP00000445554
DDB1-210	ENST00000538129	475	No protein	-
DDB1-220	ENST00000542337	558	146aa	ENSP00000444105

Pathway ID	Pathway Name	Source

ensgID	Trait	pValue	Pubmed ID

ensgID	SNP	Chromosome	Position	Trait	PubmedID	Or or BEAT	EFO ID

Ensembl ID	Source				Target
	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id
ENSG00000167986	homo_sapiens	ENSP00000305790	41.9885	22.7609	homo_sapiens	ENSP00000301764	44.8246	24.2982
ENSG00000167986	homo_sapiens	ENSP00000484669	32.6403	16.7013	homo_sapiens	ENSP00000301764	41.3158	21.1404

Ensembl ID	Source				Target
	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id
ENSG00000167986	homo_sapiens	ENSP00000301764	98.1579	97.8947	nomascus_leucogenys	ENSNLEP00000002855	98.2441	97.9807
ENSG00000167986	homo_sapiens	ENSP00000301764	99.1228	99.0351	pan_paniscus	ENSPPAP00000024544	98.5179	98.4307
ENSG00000167986	homo_sapiens	ENSP00000301764	100	100	pongo_abelii	ENSPPYP00000003683	100	100
ENSG00000167986	homo_sapiens	ENSP00000301764	99.1228	99.0351	pan_troglodytes	ENSPTRP00000081878	98.5179	98.4307
ENSG00000167986	homo_sapiens	ENSP00000301764	99.1228	99.0351	gorilla_gorilla	ENSGGOP00000048367	98.5179	98.4307
ENSG00000167986	homo_sapiens	ENSP00000301764	98.7719	97.9825	ornithorhynchus_anatinus	ENSOANP00000007759	98.7719	97.9825
ENSG00000167986	homo_sapiens	ENSP00000301764	99.2105	99.0351	sarcophilus_harrisii	ENSSHAP00000013570	97.0815	96.9099
ENSG00000167986	homo_sapiens	ENSP00000301764	88.7719	88.4211	notamacropus_eugenii	ENSMEUP00000001016	90.4379	90.0804
ENSG00000167986	homo_sapiens	ENSP00000301764	76.4912	76.2281	choloepus_hoffmanni	ENSCHOP00000010080	79.4895	79.216
ENSG00000167986	homo_sapiens	ENSP00000301764	94.1228	93.6842	dasypus_novemcinctus	ENSDNOP00000011548	97.192	96.7391
ENSG00000167986	homo_sapiens	ENSP00000301764	76.5789	76.3158	erinaceus_europaeus	ENSEEUP00000002953	76.7135	76.4499
ENSG00000167986	homo_sapiens	ENSP00000301764	61.9298	61.5789	echinops_telfairi	ENSETEP00000000855	61.9842	61.633
ENSG00000167986	homo_sapiens	ENSP00000301764	100	100	callithrix_jacchus	ENSCJAP00000035865	100	100
ENSG00000167986	homo_sapiens	ENSP00000301764	98.6842	98.5088	cercocebus_atys	ENSCATP00000044056	98.4252	98.2502
ENSG00000167986	homo_sapiens	ENSP00000301764	99.8246	99.8246	macaca_fascicularis	ENSMFAP00000030087	100	100
ENSG00000167986	homo_sapiens	ENSP00000301764	99.0351	98.9474	macaca_mulatta	ENSMMUP00000069687	98.4307	98.3435
ENSG00000167986	homo_sapiens	ENSP00000301764	99.1228	99.0351	macaca_nemestrina	ENSMNEP00000015252	98.5179	98.4307
ENSG00000167986	homo_sapiens	ENSP00000301764	100	100	papio_anubis	ENSPANP00000000430	100	100
ENSG00000167986	homo_sapiens	ENSP00000301764	99.1228	99.0351	mandrillus_leucophaeus	ENSMLEP00000040250	98.5179	98.4307
ENSG00000167986	homo_sapiens	ENSP00000301764	85.7895	85.3509	tursiops_truncatus	ENSTTRP00000010491	87.4776	87.0304
ENSG00000167986	homo_sapiens	ENSP00000301764	99.9123	99.8246	vulpes_vulpes	ENSVVUP00000006429	99.9123	99.8246
ENSG00000167986	homo_sapiens	ENSP00000301764	99.8246	99.7368	mus_spretus	MGP_SPRETEiJ_P0050121	99.8246	99.7368
ENSG00000167986	homo_sapiens	ENSP00000301764	99.7368	99.7368	equus_asinus	ENSEASP00005011644	99.7368	99.7368
ENSG00000167986	homo_sapiens	ENSP00000301764	99.8246	99.7368	capra_hircus	ENSCHIP00000013716	99.8246	99.7368
ENSG00000167986	homo_sapiens	ENSP00000301764	99.8246	99.6491	loxodonta_africana	ENSLAFP00000009624	99.8246	99.6491
ENSG00000167986	homo_sapiens	ENSP00000301764	99.9123	99.9123	panthera_leo	ENSPLOP00000008688	99.9123	99.9123
ENSG00000167986	homo_sapiens	ENSP00000301764	99.9123	99.9123	ailuropoda_melanoleuca	ENSAMEP00000017485	95.4736	95.4736
ENSG00000167986	homo_sapiens	ENSP00000301764	99.2982	99.1228	bos_indicus_hybrid	ENSBIXP00005003242	79.7183	79.5775
ENSG00000167986	homo_sapiens	ENSP00000301764	99.9123	99.9123	oryctolagus_cuniculus	ENSOCUP00000001429	99.9123	99.9123
ENSG00000167986	homo_sapiens	ENSP00000301764	99.6491	99.6491	equus_caballus	ENSECAP00000074581	88.3359	88.3359
ENSG00000167986	homo_sapiens	ENSP00000301764	99.9123	99.9123	canis_lupus_familiaris	ENSCAFP00845018193	99.9123	99.9123
ENSG00000167986	homo_sapiens	ENSP00000301764	99.9123	99.9123	panthera_pardus	ENSPPRP00000022952	99.9123	99.9123
ENSG00000167986	homo_sapiens	ENSP00000301764	99.9123	99.8246	marmota_marmota_marmota	ENSMMMP00000001387	99.9123	99.8246
ENSG00000167986	homo_sapiens	ENSP00000301764	99.8246	99.4737	balaenoptera_musculus	ENSBMSP00010010513	95.3099	94.9749
ENSG00000167986	homo_sapiens	ENSP00000301764	99.6491	99.1228	cavia_porcellus	ENSCPOP00000027409	99.6491	99.1228
ENSG00000167986	homo_sapiens	ENSP00000301764	99.9123	99.9123	felis_catus	ENSFCAP00000024813	99.9123	99.9123
ENSG00000167986	homo_sapiens	ENSP00000301764	94.1228	94.0351	ursus_americanus	ENSUAMP00000022657	93.2233	93.1364
ENSG00000167986	homo_sapiens	ENSP00000301764	89.1228	88.5965	monodelphis_domestica	ENSMODP00000025457	99.0253	98.4405
ENSG00000167986	homo_sapiens	ENSP00000301764	99.8246	99.7368	bison_bison_bison	ENSBBBP00000024789	99.8246	99.7368
ENSG00000167986	homo_sapiens	ENSP00000301764	99.8246	99.4737	monodon_monoceros	ENSMMNP00015023883	99.8246	99.4737
ENSG00000167986	homo_sapiens	ENSP00000301764	99.7368	99.6491	sus_scrofa	ENSSSCP00000013928	99.8244	99.7366
ENSG00000167986	homo_sapiens	ENSP00000301764	99.9123	99.8246	microcebus_murinus	ENSMICP00000012517	99.9123	99.8246
ENSG00000167986	homo_sapiens	ENSP00000301764	99.4737	98.7719	octodon_degus	ENSODEP00000003153	99.2995	98.5989
ENSG00000167986	homo_sapiens	ENSP00000301764	99.8246	99.6491	jaculus_jaculus	ENSJJAP00000015706	99.8246	99.6491
ENSG00000167986	homo_sapiens	ENSP00000301764	99.4737	99.1228	ovis_aries_rambouillet	ENSOARP00020015969	91.5254	91.2026
ENSG00000167986	homo_sapiens	ENSP00000301764	94.1228	94.0351	ursus_maritimus	ENSUMAP00000016040	97.7231	97.6321
ENSG00000167986	homo_sapiens	ENSP00000301764	84.5614	84.0351	ochotona_princeps	ENSOPRP00000007573	84.5614	84.0351
ENSG00000167986	homo_sapiens	ENSP00000301764	98.4211	97.807	delphinapterus_leucas	ENSDLEP00000001400	95.8155	95.2178
ENSG00000167986	homo_sapiens	ENSP00000301764	99.8246	99.4737	physeter_catodon	ENSPCTP00005028154	99.8246	99.4737
ENSG00000167986	homo_sapiens	ENSP00000301764	99.9123	99.7368	mus_caroli	MGP_CAROLIEiJ_P0048141	99.9123	99.7368
ENSG00000167986	homo_sapiens	ENSP00000301764	99.7368	99.6491	mus_musculus	ENSMUSP00000025649	99.7368	99.6491
ENSG00000167986	homo_sapiens	ENSP00000301764	84.1228	82.0175	dipodomys_ordii	ENSDORP00000000116	93.561	91.2195
ENSG00000167986	homo_sapiens	ENSP00000301764	96.6667	96.5789	mustela_putorius_furo	ENSMPUP00000014091	98.9228	98.833
ENSG00000167986	homo_sapiens	ENSP00000301764	100	100	aotus_nancymaae	ENSANAP00000007973	100	100
ENSG00000167986	homo_sapiens	ENSP00000301764	99.9123	99.9123	saimiri_boliviensis_boliviensis	ENSSBOP00000006064	99.9123	99.9123
ENSG00000167986	homo_sapiens	ENSP00000301764	86.0526	85.9649	vicugna_pacos	ENSVPAP00000007407	87.9032	87.8136
ENSG00000167986	homo_sapiens	ENSP00000301764	100	100	chlorocebus_sabaeus	ENSCSAP00000002685	100	100
ENSG00000167986	homo_sapiens	ENSP00000301764	99.9123	99.8246	mesocricetus_auratus	ENSMAUP00000012727	99.9123	99.8246
ENSG00000167986	homo_sapiens	ENSP00000301764	99.8246	99.386	phocoena_sinus	ENSPSNP00000017573	99.8246	99.386
ENSG00000167986	homo_sapiens	ENSP00000301764	99.8246	99.7368	camelus_dromedarius	ENSCDRP00005013126	99.8246	99.7368
ENSG00000167986	homo_sapiens	ENSP00000301764	99.4737	99.1228	carlito_syrichta	ENSTSYP00000007462	99.6485	99.297
ENSG00000167986	homo_sapiens	ENSP00000301764	98.0702	98.0702	panthera_tigris_altaica	ENSPTIP00000004430	98.0702	98.0702
ENSG00000167986	homo_sapiens	ENSP00000301764	99.9123	99.7368	rattus_norvegicus	ENSRNOP00000028188	99.9123	99.7368
ENSG00000167986	homo_sapiens	ENSP00000301764	99.9123	99.7368	prolemur_simus	ENSPSMP00000030622	99.9123	99.7368
ENSG00000167986	homo_sapiens	ENSP00000301764	99.9123	99.5614	microtus_ochrogaster	ENSMOCP00000023924	99.9123	99.5614
ENSG00000167986	homo_sapiens	ENSP00000301764	63.6842	63.0702	sorex_araneus	ENSSARP00000003012	66.9124	66.2673
ENSG00000167986	homo_sapiens	ENSP00000301764	99.9123	99.8246	peromyscus_maniculatus_bairdii	ENSPEMP00000011695	99.9123	99.8246
ENSG00000167986	homo_sapiens	ENSP00000301764	99.8246	99.7368	bos_mutus	ENSBMUP00000022875	99.8246	99.7368
ENSG00000167986	homo_sapiens	ENSP00000301764	99.8246	99.7368	mus_spicilegus	ENSMSIP00000036624	98.7847	98.6979
ENSG00000167986	homo_sapiens	ENSP00000301764	99.9123	99.8246	cricetulus_griseus_chok1gshd	ENSCGRP00001016252	99.9123	99.8246
ENSG00000167986	homo_sapiens	ENSP00000301764	99.8246	99.7368	pteropus_vampyrus	ENSPVAP00000003641	99.8246	99.7368
ENSG00000167986	homo_sapiens	ENSP00000301764	99.5614	99.2982	myotis_lucifugus	ENSMLUP00000012054	99.6488	99.3854
ENSG00000167986	homo_sapiens	ENSP00000301764	99.4737	99.2105	vombatus_ursinus	ENSVURP00010004154	99.4737	99.2105
ENSG00000167986	homo_sapiens	ENSP00000301764	99.8246	99.7368	rhinolophus_ferrumequinum	ENSRFEP00010002421	99.8246	99.7368
ENSG00000167986	homo_sapiens	ENSP00000301764	99.9123	99.9123	neovison_vison	ENSNVIP00000028189	99.9123	99.9123
ENSG00000167986	homo_sapiens	ENSP00000301764	99.8246	99.7368	bos_taurus	ENSBTAP00000028740	93.0499	92.9681
ENSG00000167986	homo_sapiens	ENSP00000301764	39.386	39.2982	heterocephalus_glaber_female	ENSHGLP00000025896	99.7778	99.5556
ENSG00000167986	homo_sapiens	ENSP00000301764	100	100	rhinopithecus_bieti	ENSRBIP00000019339	100	100
ENSG00000167986	homo_sapiens	ENSP00000301764	94.1228	94.0351	canis_lupus_dingo	ENSCAFP00020015849	98.9852	98.893
ENSG00000167986	homo_sapiens	ENSP00000301764	99.9123	99.7368	sciurus_vulgaris	ENSSVLP00005011413	99.9123	99.7368
ENSG00000167986	homo_sapiens	ENSP00000301764	99.4737	99.0351	phascolarctos_cinereus	ENSPCIP00000003212	99.4737	99.0351
ENSG00000167986	homo_sapiens	ENSP00000301764	81.0526	80.614	procavia_capensis	ENSPCAP00000010463	81.5534	81.1121
ENSG00000167986	homo_sapiens	ENSP00000301764	99.6491	99.386	nannospalax_galili	ENSNGAP00000006337	99.6491	99.386
ENSG00000167986	homo_sapiens	ENSP00000301764	99.7368	99.2105	chinchilla_lanigera	ENSCLAP00000005820	99.7368	99.2105
ENSG00000167986	homo_sapiens	ENSP00000301764	99.2982	99.1228	cervus_hanglu_yarkandensis	ENSCHYP00000014313	98.2639	98.0903
ENSG00000167986	homo_sapiens	ENSP00000301764	99.6491	99.386	catagonus_wagneri	ENSCWAP00000029063	99.6491	99.386
ENSG00000167986	homo_sapiens	ENSP00000301764	99.9123	99.8246	ictidomys_tridecemlineatus	ENSSTOP00000006801	99.9123	99.8246
ENSG00000167986	homo_sapiens	ENSP00000301764	99.8246	99.6491	otolemur_garnettii	ENSOGAP00000014421	99.8246	99.6491
ENSG00000167986	homo_sapiens	ENSP00000301764	100	100	cebus_imitator	ENSCCAP00000036063	100	100
ENSG00000167986	homo_sapiens	ENSP00000301764	99.8246	99.7368	urocitellus_parryii	ENSUPAP00010005335	99.8246	99.7368
ENSG00000167986	homo_sapiens	ENSP00000301764	99.8246	99.6491	moschus_moschiferus	ENSMMSP00000019907	99.8246	99.6491
ENSG00000167986	homo_sapiens	ENSP00000301764	99.1228	98.9474	rhinopithecus_roxellana	ENSRROP00000036042	98.5179	98.3435
ENSG00000167986	homo_sapiens	ENSP00000301764	99.9123	99.7368	mus_pahari	MGP_PahariEiJ_P0021136	99.9123	99.7368
ENSG00000167986	homo_sapiens	ENSP00000301764	98.7719	98.5088	propithecus_coquereli	ENSPCOP00000007867	98.5989	98.3363
ENSG00000167986	homo_sapiens	ENSP00000301764	61.6667	38.2456	caenorhabditis_elegans	M18.5.1	61.9929	38.448
ENSG00000167986	homo_sapiens	ENSP00000301764	76.4035	61.0526	drosophila_melanogaster	FBpp0082177	76.4035	61.0526
ENSG00000167986	homo_sapiens	ENSP00000301764	77.7193	62.5439	ciona_intestinalis	ENSCINP00000015292	77.3799	62.2707
ENSG00000167986	homo_sapiens	ENSP00000301764	84.0351	77.4561	petromyzon_marinus	ENSPMAP00000009366	94.1061	86.7387
ENSG00000167986	homo_sapiens	ENSP00000301764	72.7193	67.1053	eptatretus_burgeri	ENSEBUP00000023727	91.7035	84.6239
ENSG00000167986	homo_sapiens	ENSP00000301764	95.8772	92.193	callorhinchus_milii	ENSCMIP00000026284	95.542	91.8706
ENSG00000167986	homo_sapiens	ENSP00000301764	96.8421	93.6842	latimeria_chalumnae	ENSLACP00000020033	96.6725	93.5201
ENSG00000167986	homo_sapiens	ENSP00000301764	81.9298	76.0526	lepisosteus_oculatus	ENSLOCP00000000018	89.4636	83.046
ENSG00000167986	homo_sapiens	ENSP00000301764	95.5263	91.1404	clupea_harengus	ENSCHAP00000012285	95.5263	91.1404
ENSG00000167986	homo_sapiens	ENSP00000301764	93.5965	88.3333	danio_rerio	ENSDARP00000130126	93.4326	88.1786
ENSG00000167986	homo_sapiens	ENSP00000301764	13.4211	12.3684	carassius_auratus	ENSCARP00000088616	91.0714	83.9286
ENSG00000167986	homo_sapiens	ENSP00000301764	95.7895	91.3158	carassius_auratus	ENSCARP00000050740	95.7895	91.3158
ENSG00000167986	homo_sapiens	ENSP00000301764	25.614	24.2982	astyanax_mexicanus	ENSAMXP00000052495	96.0526	91.1184
ENSG00000167986	homo_sapiens	ENSP00000301764	95.7018	90.1754	ictalurus_punctatus	ENSIPUP00000008267	95.7018	90.1754
ENSG00000167986	homo_sapiens	ENSP00000301764	95.3509	90.7895	esox_lucius	ENSELUP00000025124	95.4346	90.8692
ENSG00000167986	homo_sapiens	ENSP00000301764	94.9123	89.7368	electrophorus_electricus	ENSEEEP00000002205	94.333	89.1892
ENSG00000167986	homo_sapiens	ENSP00000301764	95	90.5263	oncorhynchus_kisutch	ENSOKIP00005012475	94.9167	90.447
ENSG00000167986	homo_sapiens	ENSP00000301764	94.1228	89.2982	oncorhynchus_kisutch	ENSOKIP00005045252	93.958	89.1419
ENSG00000167986	homo_sapiens	ENSP00000301764	95	90.5263	oncorhynchus_mykiss	ENSOMYP00000029392	94.9167	90.447
ENSG00000167986	homo_sapiens	ENSP00000301764	94.4737	89.386	oncorhynchus_mykiss	ENSOMYP00000055477	94.2257	89.1514
ENSG00000167986	homo_sapiens	ENSP00000301764	94.2982	89.9123	salmo_salar	ENSSSAP00000098959	93.8045	89.4415
ENSG00000167986	homo_sapiens	ENSP00000301764	95.4386	90.5263	salmo_salar	ENSSSAP00000076675	95.5224	90.6058
ENSG00000167986	homo_sapiens	ENSP00000301764	94.2982	89.9123	salmo_trutta	ENSSTUP00000027596	93.8045	89.4415
ENSG00000167986	homo_sapiens	ENSP00000301764	95.3509	90.614	salmo_trutta	ENSSTUP00000010396	95.4346	90.6936
ENSG00000167986	homo_sapiens	ENSP00000301764	95	89.8246	gadus_morhua	ENSGMOP00000020854	95.2507	90.0616
ENSG00000167986	homo_sapiens	ENSP00000301764	85.1754	81.1404	fundulus_heteroclitus	ENSFHEP00000034388	94.2718	89.8058
ENSG00000167986	homo_sapiens	ENSP00000301764	91.0526	86.4035	poecilia_reticulata	ENSPREP00000006475	94.1924	89.3829
ENSG00000167986	homo_sapiens	ENSP00000301764	90.5263	86.0526	xiphophorus_maculatus	ENSXMAP00000000022	95.4672	90.7493
ENSG00000167986	homo_sapiens	ENSP00000301764	92.2807	86.4035	oryzias_latipes	ENSORLP00000001737	93.4281	87.4778
ENSG00000167986	homo_sapiens	ENSP00000301764	95.7895	90.8772	cyclopterus_lumpus	ENSCLMP00005001621	95.6217	90.718
ENSG00000167986	homo_sapiens	ENSP00000301764	95.7895	91.4035	oreochromis_niloticus	ENSONIP00000071715	95.7895	91.4035
ENSG00000167986	homo_sapiens	ENSP00000301764	95.7895	91.4035	haplochromis_burtoni	ENSHBUP00000007296	95.7895	91.4035
ENSG00000167986	homo_sapiens	ENSP00000301764	95.7895	91.4035	astatotilapia_calliptera	ENSACLP00000018313	95.7895	91.4035
ENSG00000167986	homo_sapiens	ENSP00000301764	96.0526	91.4912	sparus_aurata	ENSSAUP00010004485	96.0526	91.4912
ENSG00000167986	homo_sapiens	ENSP00000301764	95	90	lates_calcarifer	ENSLCAP00010040539	95.2507	90.2375
ENSG00000167986	homo_sapiens	ENSP00000301764	95.5263	92.3684	xenopus_tropicalis	ENSXETP00000109123	94.5312	91.4062
ENSG00000167986	homo_sapiens	ENSP00000301764	98.9474	97.6316	chrysemys_picta_bellii	ENSCPBP00000024940	98.9474	97.6316
ENSG00000167986	homo_sapiens	ENSP00000301764	98.8596	97.807	sphenodon_punctatus	ENSSPUP00000025248	98.9464	97.8929
ENSG00000167986	homo_sapiens	ENSP00000301764	94.2982	91.6667	laticauda_laticaudata	ENSLLTP00000002619	91.6454	89.0878
ENSG00000167986	homo_sapiens	ENSP00000301764	98.5088	96.7544	notechis_scutatus	ENSNSUP00000004345	98.5088	96.7544
ENSG00000167986	homo_sapiens	ENSP00000301764	98.5088	96.7544	pseudonaja_textilis	ENSPTXP00000018372	98.5088	96.7544
ENSG00000167986	homo_sapiens	ENSP00000301764	89.5614	88.0702	anas_platyrhynchos_platyrhynchos	ENSAPLP00000006857	97.2381	95.619
ENSG00000167986	homo_sapiens	ENSP00000301764	93.5965	91.4912	gallus_gallus	ENSGALP00010028369	95.6951	93.5426
ENSG00000167986	homo_sapiens	ENSP00000301764	92.2807	89.9123	meleagris_gallopavo	ENSMGAP00000004938	91.8777	89.5197
ENSG00000167986	homo_sapiens	ENSP00000301764	94.1228	92.3684	serinus_canaria	ENSSCAP00000013199	96.5797	94.7795
ENSG00000167986	homo_sapiens	ENSP00000301764	94.0351	92.3684	parus_major	ENSPMJP00000008394	96.4896	94.7795
ENSG00000167986	homo_sapiens	ENSP00000301764	98.5088	96.9298	anolis_carolinensis	ENSACAP00000017490	98.5088	96.9298
ENSG00000167986	homo_sapiens	ENSP00000301764	95.8772	91.4912	neolamprologus_brichardi	ENSNBRP00000025658	95.8772	91.4912
ENSG00000167986	homo_sapiens	ENSP00000301764	98.5088	96.8421	naja_naja	ENSNNAP00000000528	98.5088	96.8421
ENSG00000167986	homo_sapiens	ENSP00000301764	98.4211	96.6667	podarcis_muralis	ENSPMRP00000002701	98.4211	96.6667
ENSG00000167986	homo_sapiens	ENSP00000301764	89.2982	87.7193	geospiza_fortis	ENSGFOP00000016578	96.4929	94.7867
ENSG00000167986	homo_sapiens	ENSP00000301764	98.8596	97.6316	taeniopygia_guttata	ENSTGUP00000006648	98.6865	97.4606
ENSG00000167986	homo_sapiens	ENSP00000301764	87.2807	83.2456	erpetoichthys_calabaricus	ENSECRP00000030483	93.6911	89.3597
ENSG00000167986	homo_sapiens	ENSP00000301764	90.4386	86.0526	kryptolebias_marmoratus	ENSKMAP00000003119	95.907	91.2558
ENSG00000167986	homo_sapiens	ENSP00000301764	98.5965	97.1053	salvator_merianae	ENSSMRP00000002693	98.5965	97.1053
ENSG00000167986	homo_sapiens	ENSP00000301764	95.4386	90.3509	oryzias_javanicus	ENSOJAP00000001275	95.859	90.7489
ENSG00000167986	homo_sapiens	ENSP00000301764	82.5439	78.8596	amphilophus_citrinellus	ENSACIP00000026665	95.9225	91.6412
ENSG00000167986	homo_sapiens	ENSP00000301764	96.0526	91.4912	dicentrarchus_labrax	ENSDLAP00005051979	96.0526	91.4912
ENSG00000167986	homo_sapiens	ENSP00000301764	96.0526	91.1404	amphiprion_percula	ENSAPEP00000000123	96.0526	91.1404
ENSG00000167986	homo_sapiens	ENSP00000301764	93.4211	88.2456	oryzias_sinensis	ENSOSIP00000007981	93.9982	88.7908
ENSG00000167986	homo_sapiens	ENSP00000301764	97.1053	95.614	pelodiscus_sinensis	ENSPSIP00000015016	98.4875	96.9751
ENSG00000167986	homo_sapiens	ENSP00000301764	98.9474	97.7193	gopherus_evgoodei	ENSGEVP00005009010	98.9474	97.7193
ENSG00000167986	homo_sapiens	ENSP00000301764	97.193	95.5263	chelonoidis_abingdonii	ENSCABP00000012302	97.7072	96.0317
ENSG00000167986	homo_sapiens	ENSP00000301764	96.0526	91.3158	seriola_dumerili	ENSSDUP00000006352	96.0526	91.3158
ENSG00000167986	homo_sapiens	ENSP00000301764	96.0526	91.3158	cottoperca_gobio	ENSCGOP00000006481	96.0526	91.3158
ENSG00000167986	homo_sapiens	ENSP00000301764	97.2807	95.7895	struthio_camelus_australis	ENSSCUP00000000150	98.0548	96.5517
ENSG00000167986	homo_sapiens	ENSP00000301764	93.2456	91.9298	anser_brachyrhynchus	ENSABRP00000026177	98.6085	97.2171
ENSG00000167986	homo_sapiens	ENSP00000301764	91.0526	86.6667	gasterosteus_aculeatus	ENSGACP00000022712	95.1421	90.5591
ENSG00000167986	homo_sapiens	ENSP00000301764	91.2281	85.7895	cynoglossus_semilaevis	ENSCSEP00000019584	91.4688	86.0158
ENSG00000167986	homo_sapiens	ENSP00000301764	95.4386	90.7895	poecilia_formosa	ENSPFOP00000003124	95.3549	90.7099
ENSG00000167986	homo_sapiens	ENSP00000301764	94.4737	89.386	myripristis_murdjan	ENSMMDP00005050064	93.6522	88.6087
ENSG00000167986	homo_sapiens	ENSP00000301764	95.9649	91.4035	sander_lucioperca	ENSSLUP00000038401	95.9649	91.4035
ENSG00000167986	homo_sapiens	ENSP00000301764	98.7719	97.4561	strigops_habroptila	ENSSHBP00005022189	98.7719	97.4561
ENSG00000167986	homo_sapiens	ENSP00000301764	95.8772	91.0526	amphiprion_ocellaris	ENSAOCP00000019570	95.8772	91.0526
ENSG00000167986	homo_sapiens	ENSP00000301764	98.9474	97.7193	terrapene_carolina_triunguis	ENSTMTP00000020574	98.9474	97.7193
ENSG00000167986	homo_sapiens	ENSP00000301764	95.3509	90.3509	hucho_hucho	ENSHHUP00000041610	95.1006	90.1137
ENSG00000167986	homo_sapiens	ENSP00000301764	95.1754	90.614	hucho_hucho	ENSHHUP00000035553	95.092	90.5346
ENSG00000167986	homo_sapiens	ENSP00000301764	96.0526	91.0526	betta_splendens	ENSBSLP00000025222	96.0526	91.0526
ENSG00000167986	homo_sapiens	ENSP00000301764	91.5789	86.3158	pygocentrus_nattereri	ENSPNAP00000037661	94.3942	88.9693
ENSG00000167986	homo_sapiens	ENSP00000301764	94.2982	89.5614	anabas_testudineus	ENSATEP00000029888	94.7137	89.9559
ENSG00000167986	homo_sapiens	ENSP00000301764	72.1053	57.1053	ciona_savignyi	ENSCSAVP00000008027	76.1816	60.3336
ENSG00000167986	homo_sapiens	ENSP00000301764	25	12.5439	saccharomyces_cerevisiae	YML049C	20.9405	10.507
ENSG00000167986	homo_sapiens	ENSP00000301764	31.0526	13.0702	saccharomyces_cerevisiae	YDR301W	26.087	10.9801
ENSG00000167986	homo_sapiens	ENSP00000301764	96.0526	91.3158	seriola_lalandi_dorsalis	ENSSLDP00000020241	96.0526	91.3158
ENSG00000167986	homo_sapiens	ENSP00000301764	81.4035	77.4561	labrus_bergylta	ENSLBEP00000022242	95.5716	90.9372
ENSG00000167986	homo_sapiens	ENSP00000301764	46.9298	44.7368	pundamilia_nyererei	ENSPNYP00000032109	93.3682	89.0052
ENSG00000167986	homo_sapiens	ENSP00000301764	47.0175	44.386	pundamilia_nyererei	ENSPNYP00000013871	95.3737	90.0356
ENSG00000167986	homo_sapiens	ENSP00000301764	96.0526	91.4035	mastacembelus_armatus	ENSMAMP00000064966	96.0526	91.4035
ENSG00000167986	homo_sapiens	ENSP00000301764	91.0526	86.4912	stegastes_partitus	ENSSPAP00000013106	95.6682	90.8756
ENSG00000167986	homo_sapiens	ENSP00000301764	94.5614	90.0877	oncorhynchus_tshawytscha	ENSOTSP00005055139	94.1485	89.6943
ENSG00000167986	homo_sapiens	ENSP00000301764	93.1579	88.0702	oncorhynchus_tshawytscha	ENSOTSP00005048613	93.6508	88.5362
ENSG00000167986	homo_sapiens	ENSP00000301764	93.1579	88.0702	oncorhynchus_tshawytscha	ENSOTSP00005100505	93.6508	88.5362
ENSG00000167986	homo_sapiens	ENSP00000301764	94.4737	89.4737	acanthochromis_polyacanthus	ENSAPOP00000023266	93.5708	88.6186
ENSG00000167986	homo_sapiens	ENSP00000301764	94.2982	92.193	aquila_chrysaetos_chrysaetos	ENSACCP00020017798	93.5596	91.4708
ENSG00000167986	homo_sapiens	ENSP00000301764	95.5263	90.8772	nothobranchius_furzeri	ENSNFUP00015024546	95.1092	90.4803
ENSG00000167986	homo_sapiens	ENSP00000301764	90.1754	86.1404	cyprinodon_variegatus	ENSCVAP00000016510	95.1852	90.9259
ENSG00000167986	homo_sapiens	ENSP00000301764	95.5263	90.7018	denticeps_clupeoides	ENSDCDP00000058340	95.1092	90.3057
ENSG00000167986	homo_sapiens	ENSP00000301764	95.2632	90.614	larimichthys_crocea	ENSLCRP00005036697	95.2632	90.614
ENSG00000167986	homo_sapiens	ENSP00000301764	93.1579	87.193	takifugu_rubripes	ENSTRUP00000042679	93.1579	87.193
ENSG00000167986	homo_sapiens	ENSP00000301764	86.3158	84.6491	ficedula_albicollis	ENSFALP00000012512	94.1627	92.3445
ENSG00000167986	homo_sapiens	ENSP00000301764	90.7895	86.0526	hippocampus_comes	ENSHCOP00000015095	94.6935	89.753
ENSG00000167986	homo_sapiens	ENSP00000301764	95.614	90.7018	cyprinus_carpio_carpio	ENSCCRP00000001393	95.614	90.7018
ENSG00000167986	homo_sapiens	ENSP00000301764	91.0526	86.4912	cyprinus_carpio_carpio	ENSCCRP00000001428	94.6217	89.8815
ENSG00000167986	homo_sapiens	ENSP00000301764	92.807	91.2281	coturnix_japonica	ENSCJPP00005015983	97.1534	95.5005
ENSG00000167986	homo_sapiens	ENSP00000301764	95.3509	90.614	poecilia_latipinna	ENSPLAP00000013643	95.4346	90.6936
ENSG00000167986	homo_sapiens	ENSP00000301764	89.2982	84.2982	sinocyclocheilus_grahami	ENSSGRP00000041925	91.137	86.034
ENSG00000167986	homo_sapiens	ENSP00000301764	95.7895	91.3158	maylandia_zebra	ENSMZEP00005018434	95.7895	91.3158
ENSG00000167986	homo_sapiens	ENSP00000301764	77.3684	71.2281	tetraodon_nigroviridis	ENSTNIP00000012438	88.0239	81.0379
ENSG00000167986	homo_sapiens	ENSP00000301764	91.7544	86.8421	paramormyrops_kingsleyae	ENSPKIP00000000663	91.5937	86.69
ENSG00000167986	homo_sapiens	ENSP00000301764	95.4386	90.7018	scleropages_formosus	ENSSFOP00015017367	95.6063	90.8612
ENSG00000167986	homo_sapiens	ENSP00000301764	96.4912	92.8947	leptobrachium_leishanense	ENSLLEP00000032402	96.4912	92.8947
ENSG00000167986	homo_sapiens	ENSP00000301764	94.6491	89.4737	scophthalmus_maximus	ENSSMAP00000015534	93.8261	88.6957
ENSG00000167986	homo_sapiens	ENSP00000301764	91.7544	86.5789	oryzias_melastigma	ENSOMEP00000005155	94.6606	89.3213

Go ID	Go term	No. evidence	Entries	Species	Category
GO:0000781	located_in chromosome, telomeric region	1	HDA	Homo_sapiens(9606)	Component
GO:0003677	enables DNA binding	1	TAS	Homo_sapiens(9606)	Function
GO:0003684	contributes_to damaged DNA binding	1	IDA	Homo_sapiens(9606)	Function
GO:0005515	enables protein binding	1	IPI	Homo_sapiens(9606)	Function
GO:0005615	located_in extracellular space	1	HDA	Homo_sapiens(9606)	Component
GO:0005634	is_active_in nucleus	4	IBA,IDA,NAS	Homo_sapiens(9606)	Component
GO:0005654	located_in nucleoplasm	2	IDA,TAS	Homo_sapiens(9606)	Component
GO:0005730	is_active_in nucleolus	1	IDA	Homo_sapiens(9606)	Component
GO:0005737	located_in cytoplasm	1	IDA	Homo_sapiens(9606)	Component
GO:0006281	involved_in DNA repair	1	IBA	Homo_sapiens(9606)	Process
GO:0006289	involved_in nucleotide-excision repair	1	TAS	Homo_sapiens(9606)	Process
GO:0006511	involved_in ubiquitin-dependent protein catabolic process	2	IDA,IMP	Homo_sapiens(9606)	Process
GO:0006915	involved_in apoptotic process	1	IEA	Homo_sapiens(9606)	Process
GO:0006974	involved_in DNA damage response	3	EXP,IMP,ISS	Homo_sapiens(9606)	Process
GO:0007056	involved_in spindle assembly involved in female meiosis	1	IDA	Homo_sapiens(9606)	Process
GO:0010498	acts_upstream_of_or_within proteasomal protein catabolic process	1	IMP	Homo_sapiens(9606)	Process
GO:0016055	involved_in Wnt signaling pathway	1	IEA	Homo_sapiens(9606)	Process
GO:0016567	involved_in protein ubiquitination	3	IDA,IEA,IMP	Homo_sapiens(9606)	Process
GO:0019076	involved_in viral release from host cell	1	IMP	Homo_sapiens(9606)	Process
GO:0030674	enables protein-macromolecule adaptor activity	1	IPI	Homo_sapiens(9606)	Function
GO:0031464	part_of Cul4A-RING E3 ubiquitin ligase complex	2	EXP,IDA	Homo_sapiens(9606)	Component
GO:0031465	part_of Cul4B-RING E3 ubiquitin ligase complex	1	IDA	Homo_sapiens(9606)	Component
GO:0032991	part_of protein-containing complex	1	IMP	Homo_sapiens(9606)	Component
GO:0034644	involved_in cellular response to UV	2	EXP,ISS	Homo_sapiens(9606)	Process
GO:0035234	involved_in ectopic germ cell programmed cell death	1	IEA	Homo_sapiens(9606)	Process
GO:0035861	is_active_in site of double-strand break	1	IBA	Homo_sapiens(9606)	Component
GO:0042752	involved_in regulation of circadian rhythm	1	IEA	Homo_sapiens(9606)	Process
GO:0043066	involved_in negative regulation of apoptotic process	1	IEA	Homo_sapiens(9606)	Process
GO:0043161	involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	3	IBA,IDA,IMP	Homo_sapiens(9606)	Process
GO:0044725	involved_in epigenetic programming in the zygotic pronuclei	1	IDA	Homo_sapiens(9606)	Process
GO:0044877	enables protein-containing complex binding	1	IPI	Homo_sapiens(9606)	Function
GO:0045070	involved_in positive regulation of viral genome replication	1	IMP	Homo_sapiens(9606)	Process
GO:0045722	involved_in positive regulation of gluconeogenesis	1	ISS	Homo_sapiens(9606)	Process
GO:0045732	involved_in positive regulation of protein catabolic process	2	IDA,IMP	Homo_sapiens(9606)	Process
GO:0046726	involved_in positive regulation by virus of viral protein levels in host cell	1	IMP	Homo_sapiens(9606)	Process
GO:0048511	involved_in rhythmic process	1	IEA	Homo_sapiens(9606)	Process
GO:0051093	involved_in negative regulation of developmental process	1	IEA	Homo_sapiens(9606)	Process
GO:0051702	involved_in biological process involved in interaction with symbiont	1	IDA	Homo_sapiens(9606)	Process
GO:0070062	located_in extracellular exosome	1	HDA	Homo_sapiens(9606)	Component
GO:0070914	involved_in UV-damage excision repair	1	IDA	Homo_sapiens(9606)	Process
GO:0071987	enables WD40-repeat domain binding	1	IPI	Homo_sapiens(9606)	Function
GO:0080008	part_of Cul4-RING E3 ubiquitin ligase complex	2	IDA,IMP	Homo_sapiens(9606)	Component
GO:0097602	enables cullin family protein binding	2	IDA,IPI	Homo_sapiens(9606)	Function
GO:0160072	enables ubiquitin ligase complex scaffold activity	1	IDA	Homo_sapiens(9606)	Function
GO:1901990	involved_in regulation of mitotic cell cycle phase transition	1	IMP	Homo_sapiens(9606)	Process
GO:2000242	involved_in negative regulation of reproductive process	1	IEA	Homo_sapiens(9606)	Process