Functions and Diseases

RBP Type Canonical_RBPs
Diseases Cancer Disease
Drug N.A.
Main interacting RNAs N.A.
Moonlighting functions N.A.
Localizations Stress granucle
BulkPerturb-seq DataSet_01_243

Description

Ensembl ID ENSG00000165392 Gene ID 7486 Accession 12791
Symbol WRN Alias RECQ3;RECQL2;RECQL3 Full Name WRN RecQ like helicase
Status Confidence Length 142351 bases Strand Plus strand
Position 8 : 31033788 - 31176138 RNA binding domain DEAD , DNA_pol_A_exo1 , HRDC
Summary This gene encodes a member of the RecQ subfamily of DNA helicase proteins. The encoded nuclear protein is important in the maintenance of genome stability and plays a role in DNA repair, replication, transcription and telomere maintenance. This protein contains a N-terminal 3' to 5' exonuclease domain, an ATP-dependent helicase domain and RQC (RecQ helicase conserved region) domain in its central region, and a C-terminal HRDC (helicase RNase D C-terminal) domain and nuclear localization signal. Defects in this gene are the cause of Werner syndrome, an autosomal recessive disorder characterized by accelerated aging and an elevated risk for certain cancers. [provided by RefSeq, Aug 2017]

RNA binding domains (RBDs)

Protein Domain Pfam ID E-value Domain number
ENSP00000298139 DEAD PF00270 3.9e-15 1
ENSP00000298139 HRDC PF00570 5.2e-11 2
ENSP00000298139 DNA_pol_A_exo1 PF01612 1.8e-36 3

RNA binding proteomes (RBPomes)

Pubmed ID Full Name Cell Author Time Doi

Literatures on RNA binding capacity

Pubmed ID Title Author Time Journal

Transcripts

Name Transcript ID bp Protein Translation ID
WRN-204 ENST00000650667 5051 79aa ENSP00000498593
WRN-201 ENST00000298139 7575 1432aa ENSP00000298139
WRN-205 ENST00000651642 627 209aa ENSP00000498779
WRN-203 ENST00000521620 3593 No protein -
WRN-202 ENST00000520169 629 No protein -
WRN-206 ENST00000651946 772 No protein -

Gene Model

Pathways

Pathway ID Pathway Name Source

Phenotypes

ensgID Trait pValue Pubmed ID
10207Exercise Test6.31966375083062E-617903301
14258Iron2.8850000E-00419880490
14273Iron3.1610000E-00419880490
14280Iron9.2310000E-00419880490
14281Iron8.2240000E-00419880490
14369Iron6.7920000E-00419880490
23830Waist-Hip Ratio7.8790000E-005-
25276Waist-Hip Ratio9.2880000E-005-
68038Angiotensin-Converting Enzyme Inhibitors2E-628084903
68039Cough2E-628084903
73835Immunoglobulins3E-623382691
83503Longevity6E-825918517
87813Immunoglobulins1E-623382691
93091Exercise Test6E-617903301
105083Immunoglobulins1E-623382691

GWAS

ensgIDSNPChromosomePosition TraitPubmedIDOr or BEAT EFO ID

Protein-Protein Interaction (PPI)

Paralogs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id
ENSG00000165392homo_sapiensENSP0000034723232.674718.8426homo_sapiensENSP0000029813932.332418.6453
ENSG00000165392homo_sapiensENSP0000041673943.759626.0401homo_sapiensENSP0000029813919.832411.8017
ENSG00000165392homo_sapiensENSP0000048231327.980115.5629homo_sapiensENSP0000029813923.603413.1285
ENSG00000165392homo_sapiensENSP0000031763632.290618.5671homo_sapiensENSP0000029813922.346412.8492

Orthologs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id
ENSG00000165392homo_sapiensENSP0000029813998.114596.0894nomascus_leucogenysENSNLEP0000004589598.046196.0223
ENSG00000165392homo_sapiensENSP0000029813997.276596.7179pan_paniscusENSPPAP0000002762099.145998.5765
ENSG00000165392homo_sapiensENSP0000029813998.32496.3687pongo_abeliiENSPPYP0000003636194.496692.6174
ENSG00000165392homo_sapiensENSP0000029813999.092298.3939pan_troglodytesENSPTRP0000009199698.132897.4412
ENSG00000165392homo_sapiensENSP0000029813997.136996.5782gorilla_gorillaENSGGOP0000002457796.933896.3763
ENSG00000165392homo_sapiensENSP0000029813973.952559.3575ornithorhynchus_anatinusENSOANP0000000947668.102954.6624
ENSG00000165392homo_sapiensENSP0000029813970.041955.9358sarcophilus_harrisiiENSSHAP0000000640869.99355.8967
ENSG00000165392homo_sapiensENSP0000029813945.949737.0112notamacropus_eugeniiENSMEUP0000000758948.41838.9993
ENSG00000165392homo_sapiensENSP0000029813958.72951.9553choloepus_hoffmanniENSCHOP0000000794463.185655.8978
ENSG00000165392homo_sapiensENSP0000029813979.469370.6006dasypus_novemcinctusENSDNOP0000000658083.126473.8495
ENSG00000165392homo_sapiensENSP0000029813958.170450.3492erinaceus_europaeusENSEEUP0000000456465.901957.0411
ENSG00000165392homo_sapiensENSP0000029813962.849254.8184echinops_telfairiENSETEP0000001613364.102655.9117
ENSG00000165392homo_sapiensENSP0000029813993.156488.338callithrix_jacchusENSCJAP0000008032193.091488.2763
ENSG00000165392homo_sapiensENSP0000029813995.041992.2486cercocebus_atysENSCATP0000003539895.980393.1594
ENSG00000165392homo_sapiensENSP0000029813996.089493.2263macaca_fascicularisENSMFAP0000002358196.493793.6185
ENSG00000165392homo_sapiensENSP0000029813996.159293.2263macaca_mulattaENSMMUP0000002982896.563893.6185
ENSG00000165392homo_sapiensENSP0000029813996.508493.6452macaca_nemestrinaENSMNEP0000001722996.508493.6452
ENSG00000165392homo_sapiensENSP0000029813996.298993.5754papio_anubisENSPANP0000001813296.704193.9691
ENSG00000165392homo_sapiensENSP0000029813995.181692.2486mandrillus_leucophaeusENSMLEP0000002817597.079894.0883
ENSG00000165392homo_sapiensENSP0000029813979.189970.3911tursiops_truncatusENSTTRP0000001167083.875774.5562
ENSG00000165392homo_sapiensENSP0000029813984.14874.581vulpes_vulpesENSVVUP0000002705282.817973.4021
ENSG00000165392homo_sapiensENSP0000029813981.773769.7626mus_spretusMGP_SPRETEiJ_P008761183.583271.3062
ENSG00000165392homo_sapiensENSP0000029813985.265474.8603equus_asinusENSEASP0000502488786.965876.3533
ENSG00000165392homo_sapiensENSP0000029813983.519672.4162capra_hircusENSCHIP0000001364285.124673.8078
ENSG00000165392homo_sapiensENSP0000029813984.078274.7905loxodonta_africanaENSLAFP0000000370385.390175.9574
ENSG00000165392homo_sapiensENSP0000029813983.868773.8827panthera_leoENSPLOP0000000245185.785775.5714
ENSG00000165392homo_sapiensENSP0000029813983.589473.9525ailuropoda_melanoleucaENSAMEP0000002382982.324672.8336
ENSG00000165392homo_sapiensENSP0000029813983.170472.8352bos_indicus_hybridENSBIXP0000500528884.588174.0767
ENSG00000165392homo_sapiensENSP0000029813980.796171.8575oryctolagus_cuniculusENSOCUP0000001087285.073575.6618
ENSG00000165392homo_sapiensENSP0000029813984.776574.162equus_caballusENSECAP0000000029684.07273.5457
ENSG00000165392homo_sapiensENSP0000029813984.14874.6508canis_lupus_familiarisENSCAFP0084502196576.556567.9161
ENSG00000165392homo_sapiensENSP0000029813984.078274.2318panthera_pardusENSPPRP0000001960085.693975.6584
ENSG00000165392homo_sapiensENSP0000029813983.100673.324marmota_marmota_marmotaENSMMMP0000001626683.100673.324
ENSG00000165392homo_sapiensENSP0000029813986.452577.1648balaenoptera_musculusENSBMSP0001001987388.113978.6477
ENSG00000165392homo_sapiensENSP0000029813983.100672.905cavia_porcellusENSCPOP0000000267481.395371.409
ENSG00000165392homo_sapiensENSP0000029813984.357574.581felis_catusENSFCAP0000001801285.917575.9602
ENSG00000165392homo_sapiensENSP0000029813981.494471.9274ursus_americanusENSUAMP0000002757485.6275.5686
ENSG00000165392homo_sapiensENSP0000029813969.343654.6089monodelphis_domesticaENSMODP0000003791074.493658.6647
ENSG00000165392homo_sapiensENSP0000029813983.449773.1844bison_bison_bisonENSBBBP0000001370085.11474.6439
ENSG00000165392homo_sapiensENSP0000029813985.893976.4665monodon_monocerosENSMMNP0001501337285.714376.3066
ENSG00000165392homo_sapiensENSP0000029813984.706775.6285sus_scrofaENSSSCP0000001678682.742273.8745
ENSG00000165392homo_sapiensENSP0000029813984.497275.1397microcebus_murinusENSMICP0000000969685.391775.9351
ENSG00000165392homo_sapiensENSP0000029813983.240273.0447octodon_degusENSODEP0000000538785.142974.7143
ENSG00000165392homo_sapiensENSP0000029813981.773769.2039jaculus_jaculusENSJJAP0000001274583.942671.0394
ENSG00000165392homo_sapiensENSP0000029813971.159262.7793ursus_maritimusENSUMAP0000000950385.774475.6734
ENSG00000165392homo_sapiensENSP0000029813965.642557.8911ochotona_princepsENSOPRP0000000139768.663360.5551
ENSG00000165392homo_sapiensENSP0000029813985.82476.5363delphinapterus_leucasENSDLEP0000000875385.704376.4296
ENSG00000165392homo_sapiensENSP0000029813985.614576.3268physeter_catodonENSPCTP0000502763084.785675.5878
ENSG00000165392homo_sapiensENSP0000029813981.843669.3436mus_caroliMGP_CAROLIEiJ_P008413783.654570.8779
ENSG00000165392homo_sapiensENSP0000029813981.703969.4134mus_musculusENSMUSP0000003399183.511870.9493
ENSG00000165392homo_sapiensENSP0000029813980.865970.8799dipodomys_ordiiENSDORP0000000253684.095973.711
ENSG00000165392homo_sapiensENSP0000029813983.659273.324mustela_putorius_furoENSMPUP0000001012585.755275.1611
ENSG00000165392homo_sapiensENSP0000029813988.268283.6592aotus_nancymaaeENSANAP0000003011091.197786.4358
ENSG00000165392homo_sapiensENSP0000029813993.784988.6173saimiri_boliviensis_boliviensisENSSBOP0000002135793.916188.7413
ENSG00000165392homo_sapiensENSP0000029813980.377171.2989vicugna_pacosENSVPAP0000001024780.489571.3986
ENSG00000165392homo_sapiensENSP0000029813992.667690.014chlorocebus_sabaeusENSCSAP0000001188994.853592.1372
ENSG00000165392homo_sapiensENSP0000029813955.097847.2067tupaia_belangeriENSTBEP0000001106455.097847.2067
ENSG00000165392homo_sapiensENSP0000029813982.192770.8799mesocricetus_auratusENSMAUP0000001733084.071472.5
ENSG00000165392homo_sapiensENSP0000029813985.684476.3966phocoena_sinusENSPSNP0000002623987.455577.9758
ENSG00000165392homo_sapiensENSP0000029813983.72974.6508camelus_dromedariusENSCDRP0000502628882.975873.9792
ENSG00000165392homo_sapiensENSP0000029813986.731878.5615carlito_syrichtaENSTSYP0000001164088.524680.1853
ENSG00000165392homo_sapiensENSP0000029813983.868774.0223panthera_tigris_altaicaENSPTIP0000002456085.541375.4986
ENSG00000165392homo_sapiensENSP0000029813981.005668.9944rattus_norvegicusENSRNOP0000005559682.857170.5714
ENSG00000165392homo_sapiensENSP0000029813983.659274.8603prolemur_simusENSPSMP0000001111683.834875.0175
ENSG00000165392homo_sapiensENSP0000029813981.145269.7626microtus_ochrogasterENSMOCP0000001448983.53771.8188
ENSG00000165392homo_sapiensENSP0000029813966.340854.8184sorex_araneusENSSARP0000000561068.296256.4342
ENSG00000165392homo_sapiensENSP0000029813982.681671.3687peromyscus_maniculatus_bairdiiENSPEMP0000002363284.874573.2617
ENSG00000165392homo_sapiensENSP0000029813980.446970.1117bos_mutusENSBMUP0000002502080.785470.4067
ENSG00000165392homo_sapiensENSP0000029813981.773769.6229mus_spicilegusENSMSIP0000003148083.583271.1635
ENSG00000165392homo_sapiensENSP0000029813982.541970.7402cricetulus_griseus_chok1gshdENSCGRP0000101608984.428672.3571
ENSG00000165392homo_sapiensENSP0000029813978.072667.9469pteropus_vampyrusENSPVAP0000001217878.181868.042
ENSG00000165392homo_sapiensENSP0000029813984.98675.2095myotis_lucifugusENSMLUP0000000536687.806677.7056
ENSG00000165392homo_sapiensENSP0000029813968.715154.3994vombatus_ursinusENSVURP0001001572274.040658.6155
ENSG00000165392homo_sapiensENSP0000029813984.776575.0698rhinolophus_ferrumequinumENSRFEP0001000525683.724174.1379
ENSG00000165392homo_sapiensENSP0000029813980.935870.3212neovison_visonENSNVIP0000001770882.904272.0315
ENSG00000165392homo_sapiensENSP0000029813983.030772.6257bos_taurusENSBTAP0000002877884.686674.0741
ENSG00000165392homo_sapiensENSP0000029813983.938574.7905heterocephalus_glaber_femaleENSHGLP0000004910685.9876.6094
ENSG00000165392homo_sapiensENSP0000029813994.203990.9916rhinopithecus_bietiENSRBIP0000001549296.771993.472
ENSG00000165392homo_sapiensENSP0000029813983.868774.4413canis_lupus_dingoENSCAFP0002000140685.602375.98
ENSG00000165392homo_sapiensENSP0000029813986.452577.7235sciurus_vulgarisENSSVLP0000502324587.926179.0483
ENSG00000165392homo_sapiensENSP0000029813968.575454.1899phascolarctos_cinereusENSPCIP0000002690774.676859.0114
ENSG00000165392homo_sapiensENSP0000029813969.203959.7765procavia_capensisENSPCAP0000001300969.300759.8601
ENSG00000165392homo_sapiensENSP0000029813982.472172.1369nannospalax_galiliENSNGAP0000001825884.417473.8385
ENSG00000165392homo_sapiensENSP0000029813983.379973.1145bos_grunniensENSBGRP0000003966385.042774.5726
ENSG00000165392homo_sapiensENSP0000029813984.636973.9525chinchilla_lanigeraENSCLAP0000000106082.900172.435
ENSG00000165392homo_sapiensENSP0000029813981.284971.2989cervus_hanglu_yarkandensisENSCHYP0000002264985.777575.2395
ENSG00000165392homo_sapiensENSP0000029813984.776575.9078catagonus_wagneriENSCWAP0000001776286.282977.2566
ENSG00000165392homo_sapiensENSP0000029813985.963776.7458ictidomys_tridecemlineatusENSSTOP0000001219985.013875.8978
ENSG00000165392homo_sapiensENSP0000029813981.703972.067otolemur_garnettiiENSOGAP0000000859885.339275.2735
ENSG00000165392homo_sapiensENSP0000029813993.854888.4777cebus_imitatorENSCCAP0000001203293.920388.5395
ENSG00000165392homo_sapiensENSP0000029813984.357574.2318moschus_moschiferusENSMMSP0000000150386.039975.7122
ENSG00000165392homo_sapiensENSP0000029813996.438593.3659rhinopithecus_roxellanaENSRROP0000004489896.505993.4312
ENSG00000165392homo_sapiensENSP0000029813980.726369.2039mus_pahariMGP_PahariEiJ_P004703682.512570.7352
ENSG00000165392homo_sapiensENSP0000029813958.589450.9777propithecus_coquereliENSPCOP0000000457379.980969.5901
ENSG00000165392homo_sapiensENSP0000029813935.125720.7402caenorhabditis_elegansF18C5.2.147.632628.125
ENSG00000165392homo_sapiensENSP0000029813943.086626.3966ciona_intestinalisENSCINP0000000456251.67531.6583
ENSG00000165392homo_sapiensENSP0000029813923.184415.1536eptatretus_burgeriENSEBUP0000000890153.634935.0565
ENSG00000165392homo_sapiensENSP0000029813923.044715.5028eptatretus_burgeriENSEBUP0000002465050.847534.2065
ENSG00000165392homo_sapiensENSP0000029813952.304540.9218callorhinchus_miliiENSCMIP0000002621068.52753.6139
ENSG00000165392homo_sapiensENSP0000029813964.17649.0223latimeria_chalumnaeENSLACP0000000175662.559647.7876
ENSG00000165392homo_sapiensENSP0000029813965.153647.9749lepisosteus_oculatusENSLOCP0000001322763.729546.9262
ENSG00000165392homo_sapiensENSP0000029813960.684444.1341clupea_harengusENSCHAP0000002451458.995242.9056
ENSG00000165392homo_sapiensENSP0000029813960.963743.8547danio_rerioENSDARP0000013316460.793943.7326
ENSG00000165392homo_sapiensENSP0000029813961.312943.8547carassius_auratusENSCARP0000006495864.134445.8729
ENSG00000165392homo_sapiensENSP0000029813961.871545.6006astyanax_mexicanusENSAMXP0000001034261.699245.4735
ENSG00000165392homo_sapiensENSP0000029813962.849245.5307ictalurus_punctatusENSIPUP0000000292162.981145.6263
ENSG00000165392homo_sapiensENSP0000029813961.452544.2039esox_luciusENSELUP0000003800259.299242.655
ENSG00000165392homo_sapiensENSP0000029813939.17629.7486electrophorus_electricusENSEEEP0000001795971.556154.3367
ENSG00000165392homo_sapiensENSP0000029813961.731844.7626oncorhynchus_kisutchENSOKIP0000510753059.209642.9337
ENSG00000165392homo_sapiensENSP0000029813961.173244.4832oncorhynchus_mykissENSOMYP0000013269856.40741.0174
ENSG00000165392homo_sapiensENSP0000029813962.220744.6229salmo_salarENSSSAP0000003731860.121543.1174
ENSG00000165392homo_sapiensENSP0000029813962.011244.4832salmo_truttaENSSTUP0000001610460.531743.422
ENSG00000165392homo_sapiensENSP0000029813968.296151.257xenopus_tropicalisENSXETP0000006358468.583551.4727
ENSG00000165392homo_sapiensENSP0000029813972.206756.7737chrysemys_picta_belliiENSCPBP0000001841769.53654.6738
ENSG00000165392homo_sapiensENSP000002981393.491622.86313sphenodon_punctatusENSSPUP0000002291483.333368.3333
ENSG00000165392homo_sapiensENSP0000029813910.19558.17039sphenodon_punctatusENSSPUP0000002289883.90867.2414
ENSG00000165392homo_sapiensENSP0000029813970.530755.3073crocodylus_porosusENSCPRP0000500165069.368154.3956
ENSG00000165392homo_sapiensENSP0000029813963.268248.0447laticauda_laticaudataENSLLTP0000000164970.341653.4161
ENSG00000165392homo_sapiensENSP0000029813935.893929.5391notechis_scutatusENSNSUP0000002104879.443665.3787
ENSG00000165392homo_sapiensENSP0000029813956.773744.5531pseudonaja_textilisENSPTXP0000001756174.79358.6937
ENSG00000165392homo_sapiensENSP0000029813964.874351.0475anas_platyrhynchos_platyrhynchosENSAPLP0000000144168.763954.1081
ENSG00000165392homo_sapiensENSP0000029813967.946953.1425gallus_gallusENSGALP0001001073365.433851.1769
ENSG00000165392homo_sapiensENSP0000029813967.737452.3743meleagris_gallopavoENSMGAP0000002159365.807350.882
ENSG00000165392homo_sapiensENSP0000029813967.388351.1871serinus_canariaENSSCAP0000000534066.368650.4127
ENSG00000165392homo_sapiensENSP0000029813966.969351.0475parus_majorENSPMJP0000000689865.238149.7279
ENSG00000165392homo_sapiensENSP0000029813964.804547.3464anolis_carolinensisENSACAP0000000309568.689950.185
ENSG00000165392homo_sapiensENSP0000029813955.097843.2263naja_najaENSNNAP0000002052476.231959.8068
ENSG00000165392homo_sapiensENSP0000029813961.731847.905podarcis_muralisENSPMRP0000003366869.551553.9732
ENSG00000165392homo_sapiensENSP0000029813966.480450.3492geospiza_fortisENSGFOP0000001609465.882449.8962
ENSG00000165392homo_sapiensENSP0000029813967.248651.1871taeniopygia_guttataENSTGUP0000000182466.459650.5866
ENSG00000165392homo_sapiensENSP0000029813961.382746.0196erpetoichthys_calabaricusENSECRP0000001142868.564751.4041
ENSG00000165392homo_sapiensENSP0000029813967.527951.257salvator_merianaeENSSMRP0000002406966.142350.2052
ENSG00000165392homo_sapiensENSP0000029813970.879955.8659pelodiscus_sinensisENSPSIP0000001498568.120853.6913
ENSG00000165392homo_sapiensENSP0000029813971.857556.2151gopherus_evgoodeiENSGEVP0000501393469.153254.0995
ENSG00000165392homo_sapiensENSP0000029813936.592230.3073chelonoidis_abingdoniiENSCABP0000001960181.49367.4961
ENSG00000165392homo_sapiensENSP0000029813970.949754.8883struthio_camelus_australisENSSCUP0000002548570.949754.8883
ENSG00000165392homo_sapiensENSP0000029813967.807352.7933anser_brachyrhynchusENSABRP0000002341368.865253.617
ENSG00000165392homo_sapiensENSP0000029813964.036349.162strigops_habroptilaENSSHBP0000502046867.525851.8409
ENSG00000165392homo_sapiensENSP0000029813965.223552.4441terrapene_carolina_triunguisENSTMTP0000001066871.243357.2845
ENSG00000165392homo_sapiensENSP0000029813962.011244.5531hucho_huchoENSHHUP0000004844160.244243.2836
ENSG00000165392homo_sapiensENSP0000029813960.474944.6927pygocentrus_nattereriENSPNAP0000001579361.418445.3901
ENSG00000165392homo_sapiensENSP0000029813918.016810.2654ciona_savignyiENSCSAVP0000001721244.482825.3448
ENSG00000165392homo_sapiensENSP0000029813953.072639.176oncorhynchus_tshawytschaENSOTSP0000506298266.666749.2105
ENSG00000165392homo_sapiensENSP0000029813953.002838.9665oncorhynchus_tshawytschaENSOTSP0000503561166.69649.0334
ENSG00000165392homo_sapiensENSP0000029813968.365952.7933aquila_chrysaetos_chrysaetosENSACCP0002002201466.193451.1156
ENSG00000165392homo_sapiensENSP0000029813960.614544.6927denticeps_clupeoidesENSDCDP0000004787562.762146.2762
ENSG00000165392homo_sapiensENSP0000029813961.382744.2737cyprinus_carpio_carpioENSCCRP0000017239163.649545.9088
ENSG00000165392homo_sapiensENSP0000029813965.921852.095coturnix_japonicaENSCJPP0000501023063.870150.4736
ENSG00000165392homo_sapiensENSP0000029813941.969330.3073sinocyclocheilus_grahamiENSSGRP0000008348866.926548.3296
ENSG00000165392homo_sapiensENSP0000029813950.977738.1983paramormyrops_kingsleyaeENSPKIP0000001101365.062448.7522
ENSG00000165392homo_sapiensENSP0000029813963.128546.0196scleropages_formosusENSSFOP0001500942760.146443.8456
ENSG00000165392homo_sapiensENSP0000029813965.01448.324leptobrachium_leishanenseENSLLEP0000001731564.563147.9889

Gene Ontology

Go ID Go term No. evidence Entries Species Category
GO:0000287enables magnesium ion binding1IDAHomo_sapiens(9606)Function
GO:0000400enables four-way junction DNA binding1IDAHomo_sapiens(9606)Function
GO:0000403enables Y-form DNA binding1IDAHomo_sapiens(9606)Function
GO:0000405enables bubble DNA binding1IDAHomo_sapiens(9606)Function
GO:0000723involved_in telomere maintenance3IBA,IMP,TASHomo_sapiens(9606)Process
GO:0000724involved_in double-strand break repair via homologous recombination1IBAHomo_sapiens(9606)Process
GO:0000731involved_in DNA synthesis involved in DNA repair1IDAHomo_sapiens(9606)Process
GO:0000781located_in chromosome, telomeric region1IDAHomo_sapiens(9606)Component
GO:0003677enables DNA binding1IDAHomo_sapiens(9606)Function
GO:0003678enables DNA helicase activity2IDA,IMPHomo_sapiens(9606)Function
GO:0003682enables chromatin binding1IEAHomo_sapiens(9606)Function
GO:0004527enables exonuclease activity2IDA,IMPHomo_sapiens(9606)Function
GO:0005515enables protein binding1IPIHomo_sapiens(9606)Function
GO:0005524enables ATP binding1IEAHomo_sapiens(9606)Function
GO:0005634is_active_in nucleus1IBAHomo_sapiens(9606)Component
GO:0005654is_active_in nucleoplasm3IBA,IDA,TASHomo_sapiens(9606)Component
GO:0005657located_in replication fork1ISSHomo_sapiens(9606)Component
GO:0005694is_active_in chromosome1IBAHomo_sapiens(9606)Component
GO:0005730located_in nucleolus1IDAHomo_sapiens(9606)Component
GO:0005737is_active_in cytoplasm1IBAHomo_sapiens(9606)Component
GO:0005813located_in centrosome1IDAHomo_sapiens(9606)Component
GO:0006259involved_in DNA metabolic process1IDAHomo_sapiens(9606)Process
GO:0006260involved_in DNA replication2IMP,ISSHomo_sapiens(9606)Process
GO:0006268involved_in DNA unwinding involved in DNA replication1IBAHomo_sapiens(9606)Process
GO:0006284involved_in base-excision repair1IDAHomo_sapiens(9606)Process
GO:0006302involved_in double-strand break repair1IMPHomo_sapiens(9606)Process
GO:0006974involved_in DNA damage response1IDAHomo_sapiens(9606)Process
GO:0006979involved_in response to oxidative stress1IDAHomo_sapiens(9606)Process
GO:0008340involved_in determination of adult lifespan1IEAHomo_sapiens(9606)Process
GO:0008408enables 3-5 exonuclease activity1IDAHomo_sapiens(9606)Function
GO:0009267acts_upstream_of_or_within cellular response to starvation1IDAHomo_sapiens(9606)Process
GO:0009378enables four-way junction helicase activity2IBA,IDAHomo_sapiens(9606)Function
GO:0010225involved_in response to UV-C1IDAHomo_sapiens(9606)Process
GO:0016607located_in nuclear speck1IDAHomo_sapiens(9606)Component
GO:0016887enables ATP hydrolysis activity1IDAHomo_sapiens(9606)Function
GO:0030145enables manganese ion binding1IDAHomo_sapiens(9606)Function
GO:0031297involved_in replication fork processing2IDA,IMPHomo_sapiens(9606)Process
GO:0032201involved_in telomere maintenance via semi-conservative replication1TASHomo_sapiens(9606)Process
GO:0032405enables MutLalpha complex binding1IDAHomo_sapiens(9606)Function
GO:0032508involved_in DNA duplex unwinding1IDAHomo_sapiens(9606)Process
GO:0040009involved_in regulation of growth rate1IEAHomo_sapiens(9606)Process
GO:0042803enables protein homodimerization activity1IDAHomo_sapiens(9606)Function
GO:0043138enables 3-5 DNA helicase activity3IBA,IDA,TASHomo_sapiens(9606)Function
GO:0044806involved_in G-quadruplex DNA unwinding3IBA,IDA,ISSHomo_sapiens(9606)Process
GO:0044877enables protein-containing complex binding1IDAHomo_sapiens(9606)Function
GO:0051345involved_in positive regulation of hydrolase activity1IDAHomo_sapiens(9606)Process
GO:0051880enables G-quadruplex DNA binding1IDAHomo_sapiens(9606)Function
GO:0061749enables forked DNA-dependent helicase activity1IDAHomo_sapiens(9606)Function
GO:0061820involved_in telomeric D-loop disassembly3IDA,IGI,TASHomo_sapiens(9606)Process
GO:0061821enables telomeric D-loop binding1IDAHomo_sapiens(9606)Function
GO:0061849enables telomeric G-quadruplex DNA binding1IDAHomo_sapiens(9606)Function
GO:0070337enables 3-flap-structured DNA binding1IDAHomo_sapiens(9606)Function
GO:0071480involved_in cellular response to gamma radiation1IDAHomo_sapiens(9606)Process
GO:0090398involved_in cellular senescence1IMPHomo_sapiens(9606)Process
GO:0090399involved_in replicative senescence1IEAHomo_sapiens(9606)Process
GO:0090656involved_in t-circle formation1TASHomo_sapiens(9606)Process
GO:0098530involved_in positive regulation of strand invasion1IDAHomo_sapiens(9606)Process
GO:1902570acts_upstream_of_or_within protein localization to nucleolus1IDAHomo_sapiens(9606)Process
GO:1905773enables 8-hydroxy-2-deoxyguanosine DNA binding1IDAHomo_sapiens(9606)Function

Expression