Ensembl ID ENSG00000165392 Gene ID 7486 Accession 12791
Gene Symbol WRN Alias RECQ3;RECQL2;RECQL3 Full Name WRN RecQ like helicase
Position 8 : 31033788 - 31176138 Length 142351 bases Strand Plus strand
Status Confidence Main interacting RNAsN.A.RBP type Canonical_RBPs
Summary This gene encodes a member of the RecQ subfamily of DNA helicase proteins. The encoded nuclear protein is important in the maintenance of genome stability and plays a role in DNA repair, replication, transcription and telomere maintenance. This protein contains a N-terminal 3' to 5' exonuclease domain, an ATP-dependent helicase domain and RQC (RecQ helicase conserved region) domain in its central region, and a C-terminal HRDC (helicase RNase D C-terminal) domain and nuclear localization signal. Defects in this gene are the cause of Werner syndrome, an autosomal recessive disorder characterized by accelerated aging and an elevated risk for certain cancers. [provided by RefSeq, Aug 2017]

ENSG00000165392 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000165392 WRN 1.13 1.30e-13 KICH
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000165392 WRN vulvar cancer 10206685
ENSG00000165392 WRN cancer 10364153
ENSG00000165392 WRN cancer 10506209
ENSG00000165392 WRN cancer 10606667
ENSG00000165392 WRN cancer 11032027
ENSG00000165392 WRN cancer 11138010
ENSG00000165392 WRN cancer 11275547
ENSG00000165392 WRN cancer 11427532
ENSG00000165392 WRN cancer 11452021
ENSG00000165392 WRN cancer 11717307
ENSG00000165392 WRN cancer 11765063
ENSG00000165392 WRN cancer 11979727
ENSG00000165392 WRN cancer 12242278
ENSG00000165392 WRN cancer 12478586
ENSG00000165392 WRN cancer 12483516
ENSG00000165392 WRN cancer 12488583
ENSG00000165392 WRN cancers 12595564
ENSG00000165392 WRN cancer 12771022
ENSG00000165392 WRN tumor 12827497
ENSG00000165392 WRN cancer 12842909
ENSG00000165392 WRN cancer 12934712
ENSG00000165392 WRN cancer 12937274
ENSG00000165392 WRN cancers 14657658
ENSG00000165392 WRN cancer 14712220
ENSG00000165392 WRN cancer 15084309
ENSG00000165392 WRN cancer 15135730
ENSG00000165392 WRN tumor 15149862
ENSG00000165392 WRN cancer 15235603
ENSG00000165392 WRN tumor 15355988
ENSG00000165392 WRN cancer 15498034
ENSG00000165392 WRN cancer 15735006
ENSG00000165392 WRN cancer 15743673
ENSG00000165392 WRN cancer 15889139
ENSG00000165392 WRN cancer 15964827
ENSG00000165392 WRN cancer 16030011
ENSG00000165392 WRN cancer 16246145
ENSG00000165392 WRN cancer 16362795
ENSG00000165392 WRN cancer 16405962
ENSG00000165392 WRN cancer 16412221
ENSG00000165392 WRN familial breast cancer 16501249
ENSG00000165392 WRN cancer 16503984
ENSG00000165392 WRN tumor 16584908
ENSG00000165392 WRN cancer 16622405
ENSG00000165392 WRN tumour 16636668
ENSG00000165392 WRN ovarian cancer 16714450
ENSG00000165392 WRN cancer 16720342
ENSG00000165392 WRN tumor 16723399
ENSG00000165392 WRN DLBCL 16738949
ENSG00000165392 WRN cancer 16798775
ENSG00000165392 WRN cancer 17115688
ENSG00000165392 WRN cancer 17156731
ENSG00000165392 WRN breast cancer 17301258
ENSG00000165392 WRN cancer 17314245
ENSG00000165392 WRN cancer 17364146
ENSG00000165392 WRN tumors 17372756
ENSG00000165392 WRN familial breast cancer 17412712
ENSG00000165392 WRN cancer 17452246
ENSG00000165392 WRN cancer 17541157
ENSG00000165392 WRN cancer 17623900
ENSG00000165392 WRN tumor 17624410
ENSG00000165392 WRN cancer 17717003
ENSG00000165392 WRN breast cancer 17764108
ENSG00000165392 WRN cancers 17875398
ENSG00000165392 WRN cancer 17917271
ENSG00000165392 WRN cancer 17996922
ENSG00000165392 WRN cancer 18003859
ENSG00000165392 WRN tumor 18006573
ENSG00000165392 WRN cancer 18074021
ENSG00000165392 WRN cancer 18083760
ENSG00000165392 WRN colorectal cancer 18084250
ENSG00000165392 WRN cancer 18195102
ENSG00000165392 WRN cancer 18203716
ENSG00000165392 WRN tumors 18204436
ENSG00000165392 WRN cancers 18250621
ENSG00000165392 WRN cancer 18312465
ENSG00000165392 WRN cancer 18414032
ENSG00000165392 WRN cancer 18430459
ENSG00000165392 WRN cancer 18504617
ENSG00000165392 WRN cancer 18583366
ENSG00000165392 WRN cancer 18616953
ENSG00000165392 WRN cancer 18719387
ENSG00000165392 WRN cancer 18722555
ENSG00000165392 WRN tumor 18805512
ENSG00000165392 WRN colon cancers 18832519
ENSG00000165392 WRN cancer 18852298
ENSG00000165392 WRN colorectal cancers 19002263
ENSG00000165392 WRN cancer 19083132
ENSG00000165392 WRN breast cancer 19205873
ENSG00000165392 WRN tumors 19236379
ENSG00000165392 WRN cancer 19283071
ENSG00000165392 WRN cancer 19372586
ENSG00000165392 WRN cancer 19487340
ENSG00000165392 WRN cancer 19572017
ENSG00000165392 WRN cancer 19628477
ENSG00000165392 WRN cancer 19657341
ENSG00000165392 WRN Tumors 19686742
ENSG00000165392 WRN cancer 19812417
ENSG00000165392 WRN cancer 19906698
ENSG00000165392 WRN Colorectal cancer 19945966
ENSG00000165392 WRN cancer 20075015
ENSG00000165392 WRN cancer 20081208
ENSG00000165392 WRN cancer 20097625
ENSG00000165392 WRN cancer 20445776
ENSG00000165392 WRN cancer 20451470
ENSG00000165392 WRN cancer 20600238
ENSG00000165392 WRN pancreatic cancer 20657174
ENSG00000165392 WRN cancer 20663905
ENSG00000165392 WRN cancer 20691646
ENSG00000165392 WRN rectal cancers 21037082
ENSG00000165392 WRN cancer 21107010
ENSG00000165392 WRN tumor 21151896
ENSG00000165392 WRN cancer 21215367
ENSG00000165392 WRN Cancer 21220316
ENSG00000165392 WRN tumor 21267443
ENSG00000165392 WRN cancers 21365542
ENSG00000165392 WRN cancer 21389352
ENSG00000165392 WRN cancer 21436139
ENSG00000165392 WRN cancer 21549004
ENSG00000165392 WRN cancers 21571861
ENSG00000165392 WRN colon cancers 21738611
ENSG00000165392 WRN cancer 21752281
ENSG00000165392 WRN tumour 21786128
ENSG00000165392 WRN AML 21942242
ENSG00000165392 WRN cancer 21963973
ENSG00000165392 WRN cancer 21977309
ENSG00000165392 WRN prostate cancer 22037268
ENSG00000165392 WRN Esophageal cancer 22173703
ENSG00000165392 WRN tumor 22301954
ENSG00000165392 WRN cancer 22351772
ENSG00000165392 WRN cancer 22390926
ENSG00000165392 WRN cancer 22410776
ENSG00000165392 WRN cancer 22467216
ENSG00000165392 WRN cancer 22544709
ENSG00000165392 WRN tumor 22545052
ENSG00000165392 WRN cancer 22576367
ENSG00000165392 WRN anaplastic thyroid cancer 22654876
ENSG00000165392 WRN tumor 22682314
ENSG00000165392 WRN cancer 22689923
ENSG00000165392 WRN cancer 22713343
ENSG00000165392 WRN cancers 22778947
ENSG00000165392 WRN cervical cancer 22797812
ENSG00000165392 WRN cancer 22871734
ENSG00000165392 WRN tumours 23036272
ENSG00000165392 WRN cancer 23050038
ENSG00000165392 WRN cancer 23050959
ENSG00000165392 WRN cancer 23161009
ENSG00000165392 WRN colon cancer 23566654
ENSG00000165392 WRN cancer 23627586
ENSG00000165392 WRN cancer 23650516
ENSG00000165392 WRN cancer 23867477
ENSG00000165392 WRN cancer 23894508
ENSG00000165392 WRN tumor 23933816
ENSG00000165392 WRN cancer 24036544
ENSG00000165392 WRN gastric cancer 24119900
ENSG00000165392 WRN tumor 24308539
ENSG00000165392 WRN tumors 24356923
ENSG00000165392 WRN gastric cancer 24359226
ENSG00000165392 WRN cancers 24608430
ENSG00000165392 WRN breast cancer 24705211
ENSG00000165392 WRN cancer 24709634
ENSG00000165392 WRN tumor 24709898
ENSG00000165392 WRN cancer 24757718
ENSG00000165392 WRN inherited cancer syndromes 24758503
ENSG00000165392 WRN cancer 24880691
ENSG00000165392 WRN Jejunal Cancer 25018888
ENSG00000165392 WRN cancer 25198671
ENSG00000165392 WRN cancer 25352544
ENSG00000165392 WRN cancer 25400656
ENSG00000165392 WRN Cancer 25468760
ENSG00000165392 WRN cancer 25545408
ENSG00000165392 WRN cancer 25555679
ENSG00000165392 WRN cancers 25620975
ENSG00000165392 WRN cancer 25729389
ENSG00000165392 WRN cancer 25730140
ENSG00000165392 WRN cancer 25801465
ENSG00000165392 WRN tumor 25810110
ENSG00000165392 WRN cancer 25906194
ENSG00000165392 WRN breast cancer 25923920
ENSG00000165392 WRN cancer 25945795
ENSG00000165392 WRN cancer 26037922
ENSG00000165392 WRN Cancer 26241669
ENSG00000165392 WRN breast cancer 26296701
ENSG00000165392 WRN cancer 26455304
ENSG00000165392 WRN breast cancers 26459098
ENSG00000165392 WRN Breast Cancer 26690424
ENSG00000165392 WRN cancers 26808708
ENSG00000165392 WRN cancer 26877874
ENSG00000165392 WRN breast cancer 26959889
ENSG00000165392 WRN cancer 26967246
ENSG00000165392 WRN cancer 27034008
ENSG00000165392 WRN Metastatic Colorectal Cancer 27121793
ENSG00000165392 WRN tumor 27411922
ENSG00000165392 WRN cancer 27413734
ENSG00000165392 WRN breast cancer 27449045
ENSG00000165392 WRN cancer 27471552
ENSG00000165392 WRN tumor 27559010
ENSG00000165392 WRN breast cancer 27571987
ENSG00000165392 WRN cancer 27764811
ENSG00000165392 WRN cancer 27859906
ENSG00000165392 WRN cancers 27863399
ENSG00000165392 WRN cancer 27902925
ENSG00000165392 WRN cancer 27931782
ENSG00000165392 WRN tumor 28092266
ENSG00000165392 WRN breast cancers 28254786
ENSG00000165392 WRN cancer 28276523
ENSG00000165392 WRN bone tumors 28421271
ENSG00000165392 WRN Cancer 28440612
ENSG00000165392 WRN tumor 28494349
ENSG00000165392 WRN breast cancer 28977883
ENSG00000165392 WRN cancer 29043077
ENSG00000165392 WRN cancer 29080750
ENSG00000165392 WRN cancer 29084988
ENSG00000165392 WRN Tumor 29581016
ENSG00000165392 WRN cancer 29616805
ENSG00000165392 WRN tumors 29755661
ENSG00000165392 WRN cancer 29774115
ENSG00000165392 WRN cancer 29998112
ENSG00000165392 WRN tumors 30107528
ENSG00000165392 WRN cancer 30137433
ENSG00000165392 WRN tumors 30234181
ENSG00000165392 WRN cancer 30400178
ENSG00000165392 WRN tumor 30431131
ENSG00000165392 WRN tumors 30487607
ENSG00000165392 WRN cancer 30532073
ENSG00000165392 WRN tumor 30562637
ENSG00000165392 WRN breast cancer 30584360
ENSG00000165392 WRN cancer 30584990
ENSG00000165392 WRN cancer 30625228
ENSG00000165392 WRN cancer 30657978
ENSG00000165392 WRN cancers 30678288
ENSG00000165392 WRN tumors 30703342
ENSG00000165392 WRN cancers 30890607
ENSG00000165392 WRN cancer 30898619
ENSG00000165392 WRN endometrial cancer 30910006
ENSG00000165392 WRN cancers 30971823
ENSG00000165392 WRN cancer 30971826
ENSG00000165392 WRN cancer 31114910
ENSG00000165392 WRN tumor 31119048
ENSG00000165392 WRN cancer 31210839
ENSG00000165392 WRN breast cancer 31333776
ENSG00000165392 WRN tumors 31341965
ENSG00000165392 WRN tumors 31360874
ENSG00000165392 WRN breast cancer 31409076
ENSG00000165392 WRN cancer 31570747
ENSG00000165392 WRN cancer 31772289
ENSG00000165392 WRN cancer 8722214
ENSG00000165392 WRN cancer 8913739
ENSG00000165392 WRN tumor 9885239
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
ENSG00000165392 WRN prostate adenocarcinoma sequence_alteration 4.402% (64/1454) 1 entry
ENSG00000165392 WRN prostate adenocarcinoma missense_variant 4.402% (64/1454) 1 entry
ENSG00000165392 WRN colorectal adenocarcinoma stop_gained 6.516% (78/1197) 2 entries
ENSG00000165392 WRN colorectal adenocarcinoma missense_variant 6.516% (78/1197) 3 entries
ENSG00000165392 WRN esophageal adenocarcinoma sequence_alteration 7.534% (33/438) 1 entry
ENSG00000165392 WRN colorectal adenocarcinoma sequence_alteration 6.516% (78/1197) 2 entries
ENSG00000165392 WRN breast ductal adenocarcinoma sequence_alteration 8.104% (50/617) 1 entry
ENSG00000165392 WRN prostate carcinoma sequence_alteration 2.062% (10/485) 1 entry
ENSG00000165392 WRN colon adenocarcinoma frameshift_variant 3.117% (24/770) 1 entry
ENSG00000165392 WRN bladder transitional cell carcinoma missense_variant 1.46% (2/137) 1 entry
ENSG00000165392 WRN skin melanoma missense_variant 2.585% (25/967) 5 entries
ENSG00000165392 WRN oral squamous cell carcinoma frameshift_variant 2.871% (6/209) 1 entry
ENSG00000165392 WRN brain glioblastoma sequence_alteration 0.324% (3/926) 2 entries
ENSG00000165392 WRN breast ductal adenocarcinoma missense_variant 8.104% (50/617) 1 entry
ENSG00000165392 WRN laryngeal squamous cell carcinoma missense_variant 7.692% (2/26) 1 entry
ENSG00000165392 WRN esophageal squamous cell carcinoma missense_variant 1.329% (9/677) 3 entries
ENSG00000165392 WRN esophageal adenocarcinoma stop_gained 7.534% (33/438) 1 entry
ENSG00000165392 WRN melanoma sequence_alteration 5.941% (6/101) 2 entries
ENSG00000165392 WRN squamous cell lung carcinoma missense_variant 1.818% (15/825) 1 entry
ENSG00000165392 WRN basal cell carcinoma missense_variant 5.172% (3/58) 1 entry
ENSG00000165392 WRN prostate carcinoma frameshift_variant 2.062% (10/485) 1 entry
ENSG00000165392 WRN clear cell renal carcinoma missense_variant 0.4917% (8/1627) 1 entry
ENSG00000165392 WRN colon adenocarcinoma missense_variant 3.117% (24/770) 6 entries
ENSG00000165392 WRN clear cell renal carcinoma sequence_alteration 0.4917% (8/1627) 1 entry
ENSG00000165392 WRN colon adenocarcinoma sequence_alteration 3.117% (24/770) 2 entries
ENSG00000165392 WRN esophageal adenocarcinoma missense_variant 7.534% (33/438) 1 entry
ENSG00000165392 WRN hepatocellular carcinoma missense_variant 0.9989% (9/901) 2 entries
ENSG00000165392 WRN small cell lung carcinoma missense_variant 1.548% (5/323) 2 entries
ENSG00000165392 WRN cecum adenocarcinoma missense_variant 1.515% (2/132) 2 entries
ENSG00000165392 WRN prostate carcinoma missense_variant 2.062% (10/485) 2 entries
ENSG00000165392 WRN head and neck squamous cell carcinoma missense_variant 0.8043% (6/746) 1 entry
ENSG00000165392 WRN central nervous system primitive neuroectodermal neoplasm sequence_alteration 1.126% (5/444) 1 entry
ENSG00000165392 WRN squamous cell lung carcinoma sequence_alteration 1.818% (15/825) 1 entry
ENSG00000165392 WRN Cervical Small Cell Carcinoma missense_variant 33.33% (2/6) 1 entry
ENSG00000165392 WRN ependymoma sequence_alteration 4.348% (2/46) 1 entry
ENSG00000165392 WRN hemangioblastoma sequence_alteration 9.375% (3/32) 1 entry
ENSG00000165392 WRN Gallbladder Adenocarcinoma missense_variant 2.299% (2/87) 2 entries
ENSG00000165392 WRN melanoma conservative_inframe_deletion 5.941% (6/101) 1 entry
ENSG00000165392 WRN oral squamous cell carcinoma missense_variant 2.871% (6/209) 3 entries
ENSG00000165392 WRN colon adenocarcinoma stop_gained 3.117% (24/770) 2 entries
ENSG00000165392 WRN head and neck squamous cell carcinoma sequence_alteration 0.8043% (6/746) 1 entry
ENSG00000165392 WRN ovarian serous adenocarcinoma missense_variant 0.4458% (3/673) 1 entry
ENSG00000165392 WRN lung adenocarcinoma missense_variant 2.049% (25/1220) 3 entries
ENSG00000165392 WRN central nervous system primitive neuroectodermal neoplasm missense_variant 1.126% (5/444) 1 entry
ENSG00000165392 WRN Pleural Epithelioid Mesothelioma missense_variant 0.6329% (1/158) 1 entry
ENSG00000165392 WRN esophageal squamous cell carcinoma frameshift_variant 1.329% (9/677) 1 entry
ENSG00000165392 WRN nasopharyngeal squamous cell carcinoma stop_gained 1.198% (2/167) 1 entry
ENSG00000165392 WRN rectal adenocarcinoma missense_variant 0.4367% (1/229) 1 entry
ENSG00000165392 WRN Parathyroid Gland Carcinoma missense_variant 5.263% (1/19) 1 entry
ENSG00000165392 WRN mucosal melanoma missense_variant 7.143% (1/14) 1 entry
ENSG00000165392 WRN small cell lung carcinoma stop_gained 1.548% (5/323) 1 entry
ENSG00000165392 WRN large cell lung carcinoma missense_variant 5.556% (1/18) 1 entry
ENSG00000165392 WRN HER2 Positive Breast Carcinoma missense_variant 5.495% (10/182) 1 entry
ENSG00000165392 WRN polycythemia vera missense_variant 2.083% (1/48) 1 entry
ENSG00000165392 WRN colon carcinoma missense_variant 12.5% (1/8) 1 entry
ENSG00000165392 WRN colonic neoplasm missense_variant 6.667% (1/15) 1 entry
ENSG00000165392 WRN prostate carcinoma stop_gained 2.062% (10/485) 1 entry
ENSG00000165392 WRN Unclassified Renal Cell Carcinoma sequence_alteration 3.846% (1/26) 1 entry
ENSG00000165392 WRN gastric intestinal type adenocarcinoma missense_variant 3.529% (3/85) 1 entry
ENSG00000165392 WRN melanoma stop_gained 5.941% (6/101) 1 entry
ENSG00000165392 WRN hairy cell leukemia missense_variant 4.762% (1/21) 1 entry
ENSG00000165392 WRN adrenal cortex carcinoma missense_variant 0.6098% (1/164) 1 entry
ENSG00000165392 WRN clear cell renal carcinoma stop_gained 0.4917% (8/1627) 1 entry
ENSG00000165392 WRN lung adenocarcinoma stop_gained 2.049% (25/1220) 1 entry
ENSG00000165392 WRN Merkel cell skin cancer sequence_alteration 6.667% (2/30) 1 entry
ENSG00000165392 WRN renal carcinoma missense_variant 14.29% (1/7) 1 entry
ENSG00000165392 WRN nasopharyngeal squamous cell carcinoma missense_variant 1.198% (2/167) 1 entry
ENSG00000165392 WRN non-small cell lung carcinoma missense_variant 1.613% (1/62) 1 entry
ENSG00000165392 WRN skin melanoma sequence_alteration 2.585% (25/967) 1 entry
ENSG00000165392 WRN melanoma missense_variant 5.941% (6/101) 1 entry
ENSG00000165392 WRN osteosarcoma sequence_alteration 0.8621% (1/116) 1 entry
ENSG00000165392 WRN gastric intestinal type adenocarcinoma frameshift_variant 3.529% (3/85) 1 entry
ENSG00000165392 WRN gastric intestinal type adenocarcinoma conservative_inframe_deletion 3.529% (3/85) 1 entry
ENSG00000165392 WRN Merkel cell skin cancer missense_variant 6.667% (2/30) 1 entry
ENSG00000165392 WRN hemangioblastoma missense_variant 9.375% (3/32) 1 entry
ENSG00000165392 WRN small cell lung carcinoma sequence_alteration 1.548% (5/323) 1 entry
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000165392 WRN MESO 0.0022 high
ENSG00000165392 WRN STAD 0.019 low
ENSG00000165392 WRN PAAD 0.014 high
ENSG00000165392 WRN UCEC 0.029 high
ENSG00000165392 WRN THCA 0.008 high
ENSG00000165392 WRN ACC 0.031 high
ENSG00000165392 WRN LGG 1e-04 high
ENSG00000165392 WRN HNSC 0.017 low
ENSG00000165392 WRN READ 0.0047 low
ENSG00000165392 WRN KIRP 0.00032 high
ENSG00000165392 WRN THYM 0.021 low
ENSG00000165392 WRN COAD 0.0023 low
ENSG00000165392 WRN ESCA 0.036 low
ENSG00000165392 WRN OV 0.021 low
ENSG00000165392 WRN KIRC 0.0089 low
ENSG00000165392 WRN LAML 0.00039 low
ENSG00000165392 WRN LIHC 0.00092 high
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000165392 WRN LUSC Del 0.839359 0.067639 0.440535 0.626747
ENSG00000165392 WRN LUAD Del 1.001255 0.055601 0.449199 0.498062
ENSG00000165392 WRN READ Del 1.944011 0.103016 0.657755 0.557576
ENSG00000165392 WRN COAD Del 2.472621 0.060734 0.661991 0.399113
ENSG00000165392 WRN UCS Del 0.834845 0.212663 0.635762 0.500000
ENSG00000165392 WRN LIHC Del 1.113594 0.072567 0.702095 0.672973
ENSG00000165392 WRN BLCA Del 1.046542 0.083322 0.504403 0.585784
ENSG00000165392 WRN BRCA Del 4.091931 0.087815 0.576956 0.485185
ENSG00000165392 WRN PRAD Del 2.713788 0.095502 0.576446 0.459350
ENSG00000165392 WRN UCEC Del 1.186609 0.054233 0.653799 0.192950
ENSG00000165392 WRN OV Del 3.567618 0.227749 0.732763 0.595855