Functions and Diseases

RBP Type Non-canonical_RBPs
Diseases CancerSARS-COV-2
Drug N.A.
Main interacting RNAs N.A.
Moonlighting functions N.A.
Localizations N.A.
BulkPerturb-seq N.A.

Description

Ensembl ID ENSG00000164924 Gene ID 7534 Accession 12855
Symbol YWHAZ Alias HEL4;YWHAD;KCIP-1;HEL-S-3;POPCHAS;HEL-S-93;14-3-3-zeta Full Name tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta
Status Confidence Length 36819 bases Strand Minus strand
Position 8 : 100916523 - 100953341 RNA binding domain N.A.
Summary This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 99% identical to the mouse, rat and sheep orthologs. The encoded protein interacts with IRS1 protein, suggesting a role in regulating insulin sensitivity. Several transcript variants that differ in the 5' UTR but that encode the same protein have been identified for this gene. [provided by RefSeq, Oct 2008]

RNA binding domains (RBDs)

Protein Domain Pfam ID E-value Domain number

RNA binding proteomes (RBPomes)

Pubmed ID Full Name Cell Author Time Doi

Literatures on RNA binding capacity

Pubmed ID Title Author Time Journal
31396181 MicroRNA Expression Profiling in Newcastle Disease Virus-Infected DF-1 Cells by Deep Sequencing. Yu Chen 2019-01-01 Frontiers in microbiology

Transcripts

Name Transcript ID bp Protein Translation ID
YWHAZ-206 ENST00000395957 5248 245aa ENSP00000379287
YWHAZ-205 ENST00000395956 2974 245aa ENSP00000379286
YWHAZ-201 ENST00000353245 2829 245aa ENSP00000309503
YWHAZ-222 ENST00000523848 664 130aa ENSP00000428860
YWHAZ-219 ENST00000522542 1394 170aa ENSP00000430072
YWHAZ-216 ENST00000521309 1399 125aa ENSP00000429623
YWHAZ-220 ENST00000522819 875 125aa ENSP00000428775
YWHAZ-204 ENST00000395953 994 245aa ENSP00000379283
YWHAZ-202 ENST00000395948 812 168aa ENSP00000379278
YWHAZ-203 ENST00000395951 964 245aa ENSP00000379281
YWHAZ-209 ENST00000419477 891 245aa ENSP00000395114
YWHAZ-218 ENST00000521607 750 246aa ENSP00000430058
YWHAZ-212 ENST00000480304 2247 No protein -
YWHAZ-215 ENST00000518736 883 No protein -
YWHAZ-214 ENST00000517727 876 No protein -
YWHAZ-217 ENST00000521328 511 137aa ENSP00000429041
YWHAZ-208 ENST00000418997 996 98aa ENSP00000416551
YWHAZ-210 ENST00000437293 701 92aa ENSP00000394880
YWHAZ-221 ENST00000523131 567 75aa ENSP00000428381
YWHAZ-223 ENST00000523938 626 51aa ENSP00000430219
YWHAZ-213 ENST00000492736 681 No protein -
YWHAZ-207 ENST00000395958 5011 245aa ENSP00000379288
YWHAZ-211 ENST00000457309 3007 245aa ENSP00000398599

Pathways

Pathway ID Pathway Name Source

Phenotypes

ensgID Trait pValue Pubmed ID
9498Echocardiography6.89189881519342E-617903301
9514Echocardiography3.9499242280721E-617903301
9619Echocardiography5.23231241214006E-517903301
9632Echocardiography7.06755627224442E-517903301
33293Leukoaraiosis7.6854171E-005-
33294Leukoaraiosis9.4322466E-005-
33301Leukoaraiosis5.4593362E-005-
49156Child Development Disorders, Pervasive5.1735600E-005-
49863Child Development Disorders, Pervasive3.3331900E-005-
49876Child Development Disorders, Pervasive2.1484800E-005-
49904Child Development Disorders, Pervasive5.2480500E-005-
49905Child Development Disorders, Pervasive2.8068100E-005-
49919Child Development Disorders, Pervasive1.8036500E-005-
55991gamma-Tocopherol3.5870000E-006-
55996gamma-Tocopherol2.9660000E-006-
102443Body Mass Index7E-625673413
106301Cognition Disorders1E-826252872
106302Cognitive Dysfunction1E-826252872

GWAS

ensgIDSNPChromosomePosition TraitPubmedIDOr or BEAT EFO ID

Protein-Protein Interaction (PPI)

Paralogs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id
ENSG00000164924homo_sapiensENSP0000026433578.431467.0588homo_sapiensENSP0000037928881.632769.7959
ENSG00000164924homo_sapiensENSP0000024897585.365974.7967homo_sapiensENSP0000037928885.714375.102
ENSG00000164924homo_sapiensENSP0000030633084.615474.0891homo_sapiensENSP0000037928885.306174.6939
ENSG00000164924homo_sapiensENSP0000030016193.495986.9919homo_sapiensENSP0000037928893.877587.3469
ENSG00000164924homo_sapiensENSP0000034098983.064570.1613homo_sapiensENSP0000037928884.081671.0204
ENSG00000164924homo_sapiensENSP0000023808190.612279.5918homo_sapiensENSP0000037928890.612279.5918

Orthologs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id
ENSG00000164924homo_sapiensENSP00000379288100100nomascus_leucogenysENSNLEP00000028575100100
ENSG00000164924homo_sapiensENSP0000037928893.061291.4286pan_paniscusENSPPAP0000001592495.798394.1176
ENSG00000164924homo_sapiensENSP0000037928893.061291.4286pan_troglodytesENSPTRP0000008261995.798394.1176
ENSG00000164924homo_sapiensENSP0000037928893.061291.0204gorilla_gorillaENSGGOP0000004499097.435995.2991
ENSG00000164924homo_sapiensENSP0000037928892.244990.2041gorilla_gorillaENSGGOP0000002077993.388491.3223
ENSG00000164924homo_sapiensENSP0000037928899.591899.5918ornithorhynchus_anatinusENSOANP0000004039999.591899.5918
ENSG00000164924homo_sapiensENSP0000037928891.428691.4286choloepus_hoffmanniENSCHOP0000000247697.816697.8166
ENSG00000164924homo_sapiensENSP0000037928861.632750.2041dasypus_novemcinctusENSDNOP0000003122779.057664.3979
ENSG00000164924homo_sapiensENSP0000037928870.612266.5306dasypus_novemcinctusENSDNOP0000002603681.990577.2512
ENSG00000164924homo_sapiensENSP0000037928880.408276.3265dasypus_novemcinctusENSDNOP0000001665396.097691.2195
ENSG00000164924homo_sapiensENSP0000037928855.510255.102echinops_telfairiENSETEP0000000969499.270198.5401
ENSG00000164924homo_sapiensENSP00000379288100100callithrix_jacchusENSCJAP00000032559100100
ENSG00000164924homo_sapiensENSP00000379288100100cercocebus_atysENSCATP00000008202100100
ENSG00000164924homo_sapiensENSP0000037928885.714382.8571cercocebus_atysENSCATP0000003771490.517287.5
ENSG00000164924homo_sapiensENSP0000037928875.10272.2449macaca_nemestrinaENSMNEP0000000920482.142979.0179
ENSG00000164924homo_sapiensENSP00000379288100100papio_anubisENSPANP00000049184100100
ENSG00000164924homo_sapiensENSP0000037928879.183777.551mandrillus_leucophaeusENSMLEP0000001386990.654288.785
ENSG00000164924homo_sapiensENSP00000379288100100tursiops_truncatusENSTTRP00000015069100100
ENSG00000164924homo_sapiensENSP0000037928892.653192.6531vulpes_vulpesENSVVUP0000001791689.019689.0196
ENSG00000164924homo_sapiensENSP0000037928896.326595.9184capra_hircusENSCHIP0000001423492.187591.7969
ENSG00000164924homo_sapiensENSP00000379288100100loxodonta_africanaENSLAFP00000004141100100
ENSG00000164924homo_sapiensENSP0000037928897.142997.1429panthera_leoENSPLOP0000001444296.356396.3563
ENSG00000164924homo_sapiensENSP0000037928897.142997.1429ailuropoda_melanoleucaENSAMEP0000000035796.356396.3563
ENSG00000164924homo_sapiensENSP0000037928832.653128.5714bos_indicus_hybridENSBIXP0000503100772.727363.6364
ENSG00000164924homo_sapiensENSP00000379288100100oryctolagus_cuniculusENSOCUP0000000063697.222297.2222
ENSG00000164924homo_sapiensENSP0000037928890.612288.9796canis_lupus_familiarisENSCAFP0084501766393.670991.9831
ENSG00000164924homo_sapiensENSP0000037928888.163386.1225canis_lupus_familiarisENSCAFP0084503941392.307790.1709
ENSG00000164924homo_sapiensENSP0000037928890.612290.6122canis_lupus_familiarisENSCAFP0084501549599.107199.1071
ENSG00000164924homo_sapiensENSP00000379288100100panthera_pardusENSPPRP00000011451100100
ENSG00000164924homo_sapiensENSP0000037928899.183798.7755marmota_marmota_marmotaENSMMMP0000001180998.380697.9757
ENSG00000164924homo_sapiensENSP00000379288100100balaenoptera_musculusENSBMSP0001002462688.129588.1295
ENSG00000164924homo_sapiensENSP00000379288100100cavia_porcellusENSCPOP00000025259100100
ENSG00000164924homo_sapiensENSP00000379288100100felis_catusENSFCAP00000018314100100
ENSG00000164924homo_sapiensENSP0000037928893.469491.0204monodelphis_domesticaENSMODP0000001990785.767883.5206
ENSG00000164924homo_sapiensENSP00000379288100100bison_bison_bisonENSBBBP00000019920100100
ENSG00000164924homo_sapiensENSP00000379288100100monodon_monocerosENSMMNP00015015683100100
ENSG00000164924homo_sapiensENSP0000037928896.326593.0612microcebus_murinusENSMICP0000002181293.280690.1186
ENSG00000164924homo_sapiensENSP00000379288100100microcebus_murinusENSMICP00000019224100100
ENSG00000164924homo_sapiensENSP0000037928898.367398.3673octodon_degusENSODEP00000004322100100
ENSG00000164924homo_sapiensENSP0000037928810099.5918jaculus_jaculusENSJJAP0000000166710099.5918
ENSG00000164924homo_sapiensENSP00000379288100100ovis_aries_rambouilletENSOARP00020028330100100
ENSG00000164924homo_sapiensENSP0000037928892.244992.2449ursus_maritimusENSUMAP0000000944896.170296.1702
ENSG00000164924homo_sapiensENSP0000037928886.938886.9388ochotona_princepsENSOPRP0000000024395.089395.0893
ENSG00000164924homo_sapiensENSP0000037928889.387888.9796delphinapterus_leucasENSDLEP0000002033695.217494.7826
ENSG00000164924homo_sapiensENSP0000037928860.408255.102physeter_catodonENSPCTP0000502018090.797582.8221
ENSG00000164924homo_sapiensENSP00000379288100100mustela_putorius_furoENSMPUP00000015049100100
ENSG00000164924homo_sapiensENSP00000379288100100saimiri_boliviensis_boliviensisENSSBOP0000000993895.330795.3307
ENSG00000164924homo_sapiensENSP0000037928898.775598.3673vicugna_pacosENSVPAP0000000544699.180398.7705
ENSG00000164924homo_sapiensENSP0000037928899.183799.1837chlorocebus_sabaeusENSCSAP0000000819899.183799.1837
ENSG00000164924homo_sapiensENSP0000037928885.714385.7143mesocricetus_auratusENSMAUP0000000209799.056699.0566
ENSG00000164924homo_sapiensENSP0000037928889.387888.9796phocoena_sinusENSPSNP0000000650497.767997.3214
ENSG00000164924homo_sapiensENSP0000037928810099.5918camelus_dromedariusENSCDRP0000502243610099.5918
ENSG00000164924homo_sapiensENSP00000379288100100carlito_syrichtaENSTSYP0000000562796.456796.4567
ENSG00000164924homo_sapiensENSP0000037928856.734754.6939prolemur_simusENSPSMP0000000280387.421484.2767
ENSG00000164924homo_sapiensENSP0000037928810099.5918microtus_ochrogasterENSMOCP0000000689110099.5918
ENSG00000164924homo_sapiensENSP00000379288100100peromyscus_maniculatus_bairdiiENSPEMP00000025224100100
ENSG00000164924homo_sapiensENSP00000379288100100bos_mutusENSBMUP00000034341100100
ENSG00000164924homo_sapiensENSP0000037928899.591899.5918cricetulus_griseus_chok1gshdENSCGRP0000101283499.591899.5918
ENSG00000164924homo_sapiensENSP0000037928899.591899.5918myotis_lucifugusENSMLUP0000001579398.785498.7854
ENSG00000164924homo_sapiensENSP0000037928877.142972.6531vombatus_ursinusENSVURP0001000916589.150983.9623
ENSG00000164924homo_sapiensENSP0000037928835.918434.6939vombatus_ursinusENSVURP0001001992191.666788.5417
ENSG00000164924homo_sapiensENSP0000037928848.163347.7551vombatus_ursinusENSVURP0001000486694.493.6
ENSG00000164924homo_sapiensENSP0000037928897.142997.1429rhinolophus_ferrumequinumENSRFEP0001002923196.356396.3563
ENSG00000164924homo_sapiensENSP00000379288100100bos_taurusENSBTAP00000000289100100
ENSG00000164924homo_sapiensENSP0000037928893.061289.7959heterocephalus_glaber_femaleENSHGLP0000005711393.061289.7959
ENSG00000164924homo_sapiensENSP0000037928895.918493.0612rhinopithecus_bietiENSRBIP0000001753194.758191.9355
ENSG00000164924homo_sapiensENSP0000037928890.612290.6122rhinopithecus_bietiENSRBIP0000004277595.689795.6897
ENSG00000164924homo_sapiensENSP0000037928886.530684.4898canis_lupus_dingoENSCAFP0002003337289.451587.3418
ENSG00000164924homo_sapiensENSP0000037928888.163386.1225canis_lupus_dingoENSCAFP0002001996692.307790.1709
ENSG00000164924homo_sapiensENSP0000037928892.653192.6531canis_lupus_dingoENSCAFP0002003095999.126699.1266
ENSG00000164924homo_sapiensENSP00000379288100100phascolarctos_cinereusENSPCIP00000005709100100
ENSG00000164924homo_sapiensENSP0000037928853.877653.8776procavia_capensisENSPCAP00000009976100100
ENSG00000164924homo_sapiensENSP00000379288100100nannospalax_galiliENSNGAP00000004642100100
ENSG00000164924homo_sapiensENSP00000379288100100bos_grunniensENSBGRP00000015475100100
ENSG00000164924homo_sapiensENSP00000379288100100chinchilla_lanigeraENSCLAP00000006078100100
ENSG00000164924homo_sapiensENSP0000037928897.55197.551cervus_hanglu_yarkandensisENSCHYP0000001464698.760398.7603
ENSG00000164924homo_sapiensENSP00000379288100100catagonus_wagneriENSCWAP00000020562100100
ENSG00000164924homo_sapiensENSP0000037928893.877591.8367ictidomys_tridecemlineatusENSSTOP0000002417693.877591.8367
ENSG00000164924homo_sapiensENSP0000037928894.693988.5714otolemur_garnettiiENSOGAP0000002066593.927187.8542
ENSG00000164924homo_sapiensENSP0000037928864.081662.0408otolemur_garnettiiENSOGAP0000002114895.151592.1212
ENSG00000164924homo_sapiensENSP0000037928825.306125.3061otolemur_garnettiiENSOGAP00000015799100100
ENSG00000164924homo_sapiensENSP0000037928898.367397.551cebus_imitatorENSCCAP0000000152097.177496.371
ENSG00000164924homo_sapiensENSP0000037928899.591899.5918urocitellus_parryiiENSUPAP0001001590399.591899.5918
ENSG00000164924homo_sapiensENSP00000379288100100moschus_moschiferusENSMMSP00000003555100100
ENSG00000164924homo_sapiensENSP0000037928895.918493.0612rhinopithecus_roxellanaENSRROP0000001568294.758191.9355
ENSG00000164924homo_sapiensENSP00000379288100100propithecus_coquereliENSPCOP0000003054195.703195.7031
ENSG00000164924homo_sapiensENSP0000037928886.530675.5102caenorhabditis_elegansF52D10.3c.185.483974.5968
ENSG00000164924homo_sapiensENSP0000037928831.428624.0816caenorhabditis_elegansM117.3.161.647.2
ENSG00000164924homo_sapiensENSP0000037928887.755177.9592caenorhabditis_elegansM117.2a.386.693677.0161
ENSG00000164924homo_sapiensENSP0000037928890.204180.8163drosophila_melanogasterFBpp008750089.112979.8387
ENSG00000164924homo_sapiensENSP0000037928844.89835.9184ciona_intestinalisENSCINP0000002208472.847758.2781
ENSG00000164924homo_sapiensENSP0000037928834.285726.9388carassius_auratusENSCARP0000013346978.504761.6822
ENSG00000164924homo_sapiensENSP0000037928894.693990.6122xenopus_tropicalisENSXETP0000010494081.690178.169
ENSG00000164924homo_sapiensENSP0000037928899.591899.1837chrysemys_picta_belliiENSCPBP0000000730583.848883.5052
ENSG00000164924homo_sapiensENSP0000037928810098.3673sphenodon_punctatusENSSPUP0000002385410098.3673
ENSG00000164924homo_sapiensENSP0000037928810099.1837crocodylus_porosusENSCPRP0000500521810099.1837
ENSG00000164924homo_sapiensENSP0000037928810099.5918laticauda_laticaudataENSLLTP0000000001110099.5918
ENSG00000164924homo_sapiensENSP0000037928810099.5918notechis_scutatusENSNSUP0000001692010099.5918
ENSG00000164924homo_sapiensENSP0000037928810099.5918pseudonaja_textilisENSPTXP0000000131510099.5918
ENSG00000164924homo_sapiensENSP0000037928810099.1837anas_platyrhynchos_platyrhynchosENSAPLP0000000209179.804679.1531
ENSG00000164924homo_sapiensENSP0000037928810099.1837gallus_gallusENSGALP0001001606310099.1837
ENSG00000164924homo_sapiensENSP0000037928810099.1837meleagris_gallopavoENSMGAP0000001288497.609696.8128
ENSG00000164924homo_sapiensENSP0000037928810099.1837serinus_canariaENSSCAP0000000553210099.1837
ENSG00000164924homo_sapiensENSP0000037928810099.1837parus_majorENSPMJP0000000924410099.1837
ENSG00000164924homo_sapiensENSP0000037928810099.5918anolis_carolinensisENSACAP0000003359510099.5918
ENSG00000164924homo_sapiensENSP0000037928899.591899.1837naja_najaENSNNAP0000001502499.591899.1837
ENSG00000164924homo_sapiensENSP0000037928880.816373.4694podarcis_muralisENSPMRP0000001290151.697146.9974
ENSG00000164924homo_sapiensENSP0000037928895.918493.8775podarcis_muralisENSPMRP0000003179288.01586.1423
ENSG00000164924homo_sapiensENSP0000037928810099.1837geospiza_fortisENSGFOP0000001939910099.1837
ENSG00000164924homo_sapiensENSP0000037928810099.1837taeniopygia_guttataENSTGUP0000001244210099.1837
ENSG00000164924homo_sapiensENSP0000037928810099.5918salvator_merianaeENSSMRP0000002743510099.5918
ENSG00000164924homo_sapiensENSP0000037928899.591899.1837pelodiscus_sinensisENSPSIP0000000391399.591899.1837
ENSG00000164924homo_sapiensENSP0000037928899.591899.1837gopherus_evgoodeiENSGEVP0000501291699.591899.1837
ENSG00000164924homo_sapiensENSP0000037928892.244991.8367chelonoidis_abingdoniiENSCABP0000002913092.622992.2131
ENSG00000164924homo_sapiensENSP0000037928834.693933.8776struthio_camelus_australisENSSCUP0000001285875.892974.1071
ENSG00000164924homo_sapiensENSP0000037928810099.1837anser_brachyrhynchusENSABRP0000000408710099.1837
ENSG00000164924homo_sapiensENSP0000037928874.693963.2653cynoglossus_semilaevisENSCSEP0000002387174.089162.753
ENSG00000164924homo_sapiensENSP0000037928810099.1837strigops_habroptilaENSSHBP0000500176110099.1837
ENSG00000164924homo_sapiensENSP0000037928899.591899.1837terrapene_carolina_triunguisENSTMTP0000000252799.591899.1837
ENSG00000164924homo_sapiensENSP0000037928877.142965.7143ciona_savignyiENSCSAVP0000001730372.692361.9231
ENSG00000164924homo_sapiensENSP0000037928810099.1837aquila_chrysaetos_chrysaetosENSACCP0002000180410099.1837
ENSG00000164924homo_sapiensENSP0000037928810099.1837ficedula_albicollisENSFALP0000000610697.609696.8128
ENSG00000164924homo_sapiensENSP0000037928892.244986.1225leptobrachium_leishanenseENSLLEP0000001431591.869985.7724
ENSG00000164924homo_sapiensENSP0000037928892.653187.7551leptobrachium_leishanenseENSLLEP0000003395587.644883.0116

Gene Ontology

Go ID Go term No. evidence Entries Species Category
GO:0000122involved_in negative regulation of transcription by RNA polymerase II1IDAHomo_sapiens(9606)Process
GO:0003723enables RNA binding1HDAHomo_sapiens(9606)Function
GO:0005515enables protein binding1IPIHomo_sapiens(9606)Function
GO:0005615located_in extracellular space1HDAHomo_sapiens(9606)Component
GO:0005634located_in nucleus1HDAHomo_sapiens(9606)Component
GO:0005654located_in nucleoplasm1TASHomo_sapiens(9606)Component
GO:0005737is_active_in cytoplasm1IBAHomo_sapiens(9606)Component
GO:0005829is_active_in cytosol2IDA,TASHomo_sapiens(9606)Component
GO:0005925located_in focal adhesion1HDAHomo_sapiens(9606)Component
GO:0006468involved_in protein phosphorylation1IMPHomo_sapiens(9606)Process
GO:0007165involved_in signal transduction2IBA,IMPHomo_sapiens(9606)Process
GO:0019901enables protein kinase binding1IPIHomo_sapiens(9606)Function
GO:0031625enables ubiquitin protein ligase binding1IPIHomo_sapiens(9606)Function
GO:0031982located_in vesicle1HDAHomo_sapiens(9606)Component
GO:0042470located_in melanosome1IEAHomo_sapiens(9606)Component
GO:0042802enables identical protein binding1IPIHomo_sapiens(9606)Function
GO:0043066involved_in negative regulation of apoptotic process1TASHomo_sapiens(9606)Process
GO:0044325enables transmembrane transporter binding1IPIHomo_sapiens(9606)Function
GO:0045296enables cadherin binding1HDAHomo_sapiens(9606)Function
GO:0045824involved_in negative regulation of innate immune response1IDAHomo_sapiens(9606)Process
GO:0050815enables phosphoserine residue binding1IDAHomo_sapiens(9606)Function
GO:0051683involved_in establishment of Golgi localization1IMPHomo_sapiens(9606)Process
GO:0070062located_in extracellular exosome1HDAHomo_sapiens(9606)Component
GO:0070372involved_in regulation of ERK1 and ERK2 cascade1IDAHomo_sapiens(9606)Process
GO:0072562located_in blood microparticle1HDAHomo_sapiens(9606)Component
GO:0090128involved_in regulation of synapse maturation2IDA,IMPHomo_sapiens(9606)Process
GO:0090168involved_in Golgi reassembly1IMPHomo_sapiens(9606)Process
GO:0098978is_active_in glutamatergic synapse2IDA,IMPHomo_sapiens(9606)Component
GO:0140297enables DNA-binding transcription factor binding1IPIHomo_sapiens(9606)Function
GO:0140311enables protein sequestering activity1IDAHomo_sapiens(9606)Function
GO:1900181involved_in negative regulation of protein localization to nucleus1IDAHomo_sapiens(9606)Process

Expression