Ensembl ID ENSG00000164924 Gene ID 7534 Accession 12855
Gene Symbol YWHAZ Alias HEL4;YWHAD;KCIP-1;HEL-S-3;POPCHAS;HEL-S-93;14-3-3-zeta Full Name tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta
Position 8 : 100916523 - 100953341 Length 36819 bases Strand Minus strand
Status Confidence Main interacting RNAsN.A.RBP type Non-canonical_RBPs
Summary This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 99% identical to the mouse, rat and sheep orthologs. The encoded protein interacts with IRS1 protein, suggesting a role in regulating insulin sensitivity. Several transcript variants that differ in the 5' UTR but that encode the same protein have been identified for this gene. [provided by RefSeq, Oct 2008]

ENSG00000164924 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000164924 YWHAZ 0.85 1.95e-31 BRCA
ENSG00000164924 YWHAZ 1.21 7.71e-52 LUSC
ENSG00000164924 YWHAZ -1.1 1.15e-12 GBM
ENSG00000164924 YWHAZ 1.40 5.58e-12 CHOL
ENSG00000164924 YWHAZ 0.82 1.76e-24 LUAD
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000164924 YWHAZ cancers 16849584
ENSG00000164924 YWHAZ HNSCCs 18339795
ENSG00000164924 YWHAZ cancer 18407684
ENSG00000164924 YWHAZ tumor 19405126
ENSG00000164924 YWHAZ gastric cancer 19958059
ENSG00000164924 YWHAZ breast cancer 20098429
ENSG00000164924 YWHAZ tumor 21319141
ENSG00000164924 YWHAZ breast cancer 21681549
ENSG00000164924 YWHAZ cancer 21707964
ENSG00000164924 YWHAZ breast cancer 22318550
ENSG00000164924 YWHAZ lung cancer 22912335
ENSG00000164924 YWHAZ cancer 22913272
ENSG00000164924 YWHAZ cancer 22917186
ENSG00000164924 YWHAZ tumor 23355742
ENSG00000164924 YWHAZ tumor 23422756
ENSG00000164924 YWHAZ colon cancer 23737015
ENSG00000164924 YWHAZ tumor 23957735
ENSG00000164924 YWHAZ bladder cancer 24083701
ENSG00000164924 YWHAZ prostate cancer 24114522
ENSG00000164924 YWHAZ breast cancer 24519092
ENSG00000164924 YWHAZ cancer 24564909
ENSG00000164924 YWHAZ cancers 24597767
ENSG00000164924 YWHAZ cancer 24892549
ENSG00000164924 YWHAZ prostate cancer 25156059
ENSG00000164924 YWHAZ breast cancer 25454514
ENSG00000164924 YWHAZ tumors 25877407
ENSG00000164924 YWHAZ cancer 25986937
ENSG00000164924 YWHAZ cervical cancer 26269755
ENSG00000164924 YWHAZ gastric cancer 26429164
ENSG00000164924 YWHAZ tumor 26894994
ENSG00000164924 YWHAZ cancer 27029057
ENSG00000164924 YWHAZ Cancer 27042257
ENSG00000164924 YWHAZ bladder cancer 27167196
ENSG00000164924 YWHAZ AML 27764807
ENSG00000164924 YWHAZ tumor 27811373
ENSG00000164924 YWHAZ tumors 27904785
ENSG00000164924 YWHAZ Tumour 28432311
ENSG00000164924 YWHAZ breast cancer 28721363
ENSG00000164924 YWHAZ cancer 28747658
ENSG00000164924 YWHAZ cancer 28981108
ENSG00000164924 YWHAZ cancer 29363506
ENSG00000164924 YWHAZ lung cancer 29393436
ENSG00000164924 YWHAZ bladder cancer 29512774
ENSG00000164924 YWHAZ tumors 29540729
ENSG00000164924 YWHAZ tumor 29551505
ENSG00000164924 YWHAZ Tumor 29622700
ENSG00000164924 YWHAZ laryngeal cancer 29755572
ENSG00000164924 YWHAZ liver cancer 29858089
ENSG00000164924 YWHAZ cancer 29915393
ENSG00000164924 YWHAZ gastric cancer 29940752
ENSG00000164924 YWHAZ cancer 29977602
ENSG00000164924 YWHAZ Tumor 30082525
ENSG00000164924 YWHAZ Ovarian Cancer 30134224
ENSG00000164924 YWHAZ breast cancer 30185896
ENSG00000164924 YWHAZ gastric cancer 30258124
ENSG00000164924 YWHAZ prostate cancer 30267820
ENSG00000164924 YWHAZ tumors 30272824
ENSG00000164924 YWHAZ gastric cancer 30353914
ENSG00000164924 YWHAZ non-small-cell lung cancer 30378158
ENSG00000164924 YWHAZ prostate cancer 30498638
ENSG00000164924 YWHAZ tumor 30519576
ENSG00000164924 YWHAZ ovarian cancer 30535456
ENSG00000164924 YWHAZ cervical cancer 30611620
ENSG00000164924 YWHAZ cancer 30763573
ENSG00000164924 YWHAZ bladder cancer 30945298
ENSG00000164924 YWHAZ tumour 31043708
ENSG00000164924 YWHAZ tumour 31199037
ENSG00000164924 YWHAZ tumor 31240215
ENSG00000164924 YWHAZ epithelial ovarian cancer 31640760
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000164924 YWHAZ MESO 0.005 high
ENSG00000164924 YWHAZ SARC 0.025 high
ENSG00000164924 YWHAZ CHOL 0.038 low
ENSG00000164924 YWHAZ UCEC 0.00032 high
ENSG00000164924 YWHAZ THCA 0.0021 high
ENSG00000164924 YWHAZ ACC 0.016 high
ENSG00000164924 YWHAZ LGG 0.0072 high
ENSG00000164924 YWHAZ LUSC 0.033 high
ENSG00000164924 YWHAZ HNSC 0.024 high
ENSG00000164924 YWHAZ KICH 0.04 high
ENSG00000164924 YWHAZ LUAD 0.00051 high
ENSG00000164924 YWHAZ THYM 0.013 low
ENSG00000164924 YWHAZ BRCA 0.0045 high
ENSG00000164924 YWHAZ DLBC 0.0027 high
ENSG00000164924 YWHAZ KIRC 0.0011 high
ENSG00000164924 YWHAZ PRAD 0.047 low
ENSG00000164924 YWHAZ GBM 0.0017 high
ENSG00000164924 YWHAZ SKCM 0.004 high
ENSG00000164924 YWHAZ CESC 0.0066 high
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000164924 YWHAZ LUSC Amp 1.355985 0.216302 0.529962 0.614770
ENSG00000164924 YWHAZ LUAD Amp 6.905184 0.233154 0.642440 0.567829
ENSG00000164924 YWHAZ LGG Amp 8.432224 0.135869 0.684120 0.171540
ENSG00000164924 YWHAZ CESC Amp 0.660377 0.126182 0.615148 0.369492
ENSG00000164924 YWHAZ READ Amp 3.176758 0.239358 0.826616 0.630303
ENSG00000164924 YWHAZ COAD Amp 4.992182 0.140754 0.790343 0.558758
ENSG00000164924 YWHAZ ESCA Amp 3.847253 0.427174 0.689959 0.679348
ENSG00000164924 YWHAZ SKCM Amp 1.003347 0.129986 0.759887 0.490463
ENSG00000164924 YWHAZ HNSC Amp 3.505339 0.177576 0.589650 0.685824
ENSG00000164924 YWHAZ LIHC Amp 13.734703 0.340325 1.168628 0.613514
ENSG00000164924 YWHAZ BLCA Amp 45.886739 0.905269 1.021036 0.647059
ENSG00000164924 YWHAZ BRCA Amp 43.584267 0.509617 1.075303 0.609259
ENSG00000164924 YWHAZ STAD Amp 8.742640 0.307204 0.665005 0.639456
ENSG00000164924 YWHAZ PRAD Amp 4.963286 0.104414 0.734480 0.323171
ENSG00000164924 YWHAZ UCEC Amp 0.602297 0.099880 0.760960 0.339518
ENSG00000164924 YWHAZ UVM Amp 9.477347 0.581109 1.507945 0.750000
ENSG00000164924 YWHAZ KICH Amp 0.662421 0.210601 0.966492 0.287879
ENSG00000164924 YWHAZ OV Amp 24.334551 0.752608 0.996937 0.632124