RBP Type	Canonical_RBPs
Diseases	Cancer
Drug	N.A.
Main interacting RNAs	mRNA
Moonlighting functions	N.A.
Localizations	Stress granucleNucleoli
BulkPerturb-seq	DataSet_01_326 DataSet_01_328

Ensembl ID	ENSG00000163950	Gene ID	7884	Accession	10904
Symbol	SLBP	Alias	HBP	Full Name	stem-loop histone mRNA binding protein
Status	Confidence	Length	19614 bases	Strand	Minus strand
Position	4 : 1692731 - 1712344	RNA binding domain	SLBP_RNA_bind
Summary	This gene encodes a protein that binds to the stem-loop structure in replication-dependent histone mRNAs. Histone mRNAs do not contain introns or polyadenylation signals, and are processed by endonucleolytic cleavage. The stem-loop structure is essential for efficient processing but this structure also controls the transport, translation and stability of histone mRNAs. Expression of the protein is regulated during the cell cycle, increasing more than 10-fold during the latter part of G1. [provided by RefSeq, Jul 2008]

Protein	Domain	Pfam ID	E-value	Domain number
ENSP00000418658	SLBP_RNA_bind	PF15247	2.7e-29	1
ENSP00000426891	SLBP_RNA_bind	PF15247	2.7e-29	1
ENSP00000406322	SLBP_RNA_bind	PF15247	5.5e-29	1
ENSP00000417686	SLBP_RNA_bind	PF15247	7.4e-29	1
ENSP00000316490	SLBP_RNA_bind	PF15247	7.8e-29	1
ENSP00000417359	SLBP_RNA_bind	PF15247	4.6e-16	1

Pubmed ID	Full Name	Cell	Author	Time	Doi

Pubmed ID	Title	Author	Time	Journal
26377992	A multiprotein occupancy map of the mRNP on the 3' end of histone mRNAs.	Lionel Brooks	2015-11-01	RNA (New York, N.Y.)
32266261	Pinning Down the Transcription: A Role for Peptidyl-Prolyl cis-trans Isomerase Pin1 in Gene Expression.	Xiangming Hu	2020-01-01	Frontiers in cell and developmental biology
25379382	Contribution of protein phosphorylation to binding-induced folding of the SLBP-histone mRNA complex probed by phosphorus-31 NMR.	Roopa Thapar	2014-01-01	FEBS open bio
22907757	The prolyl isomerase Pin1 targets stem-loop binding protein (SLBP) to dissociate the SLBP-histone mRNA complex linking histone mRNA decay with SLBP ubiquitination.	Nithya Krishnan	2012-11-01	Molecular and cellular biology
31162604	Discovering sequence and structure landscapes in RNA interaction motifs.	Marta Adinolfi	2019-06-04	Nucleic acids research
25934501	The end of the message: multiple protein-RNA interactions define the mRNA polyadenylation site.	Yongsheng Shi	2015-05-01	Genes & development
34416372	Stem-loop binding protein and metal carcinogenesis.	R Beatrix Bradford	2021-11-01	Seminars in cancer biology
29104761	Fiat Lux: illuminating the cell cycle.	Gianmaria Liccardi	2017-01-01	Cell death discovery
36018788	PRIESSTESS: interpretable, high-performing models of the sequence and structure preferences of RNA-binding proteins.	U Kaitlin Laverty	2022-10-28	Nucleic acids research
35013239	Proximity labeling identifies a repertoire of site-specific R-loop modulators.	Qingqing Yan	2022-01-10	Nature communications
15546920	The human histone gene expression regulator HBP/SLBP is required for histone and DNA synthesis, cell cycle progression and cell proliferation in mitotic cells.	Xiujie Zhao	2004-12-01	Journal of cell science
27798610	Fluorescent indicators for simultaneous reporting of all four cell cycle phases.	T Bryce Bajar	2016-12-01	Nature methods
35037047	53BP1-ACLY-SLBP-coordinated activation of replication-dependent histone biogenesis maintains genomic integrity.	TingTing Wu	2022-02-22	Nucleic acids research
31230714	Programmable RNA-Guided RNA Effector Proteins Built from Human Parts.	Simone Rauch	2019-06-27	Cell
29357066	The Temporal Regulation of S Phase Proteins During G1.	D Gavin Grant	2017-01-01	Advances in experimental medicine and biology
18927579	Metabolism and regulation of canonical histone mRNAs: life without a poly(A) tail.	F William Marzluff	2008-11-01	Nature reviews. Genetics
36835083	Basic Methods of Cell Cycle Analysis.	Anna Ligasová	2023-02-12	International journal of molecular sciences
23329046	Structure of histone mRNA stem-loop, human stem-loop binding protein, and 3'hExo ternary complex.	Dazhi Tan	2013-01-18	Science (New York, N.Y.)
37516934	Uridylation of the histone mRNA stem-loop weakens binding interactions with SLBP while maintaining interactions with 3'hExo.	Morgan Shine	2023-01-01	RNA biology
23941746	Replication stress-induced alternative mRNA splicing alters properties of the histone RNA-binding protein HBP/SLBP: a key factor in the control of histone gene expression.	J M Alexander Rattray	2013-09-06	Bioscience reports
28289156	U7 snRNP is recruited to histone pre-mRNA in a FLASH-dependent manner by two separate regions of the stem-loop binding protein.	Aleksandra Skrajna	2017-06-01	RNA (New York, N.Y.)
23286197	Assembly of the SLIP1-SLBP complex on histone mRNA requires heterodimerization and sequential binding of SLBP followed by SLIP1.	Nitin Bansal	2013-01-22	Biochemistry
23142872	Systematic reconstruction of RNA functional motifs with high-throughput microfluidics.	Lance Martin	2012-12-01	Nature methods

Name	Transcript ID	bp	Protein	Translation ID
SLBP-206	ENST00000489418	1810	270aa	ENSP00000417686
SLBP-202	ENST00000429429	1623	231aa	ENSP00000406322
SLBP-201	ENST00000318386	1635	277aa	ENSP00000316490
SLBP-204	ENST00000483348	1030	225aa	ENSP00000426891
SLBP-205	ENST00000488267	987	235aa	ENSP00000418658
SLBP-203	ENST00000480936	558	186aa	ENSP00000417359

Pathway ID	Pathway Name	Source

ensgID	Trait	pValue	Pubmed ID
70714	Hip	6E-10	25673412
70715	Body Mass Index	6E-10	25673412
75904	Body Height	2E-11	20881960
92275	Cartilage	1E-6	27701424
104601	Hip	8E-7	25673412
104602	Body Mass Index	8E-7	25673412

ensgID	SNP	Chromosome	Position	Trait	PubmedID	Or or BEAT	EFO ID

Ensembl ID	Source				Target
	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id
ENSG00000163950

Ensembl ID	Source				Target
	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id
ENSG00000163950	homo_sapiens	ENSP00000417686	100	100	nomascus_leucogenys	ENSNLEP00000000061	97.4729	97.4729
ENSG00000163950	homo_sapiens	ENSP00000417686	99.2593	99.2593	pan_paniscus	ENSPPAP00000020194	99.2593	99.2593
ENSG00000163950	homo_sapiens	ENSP00000417686	94.8148	94.8148	pongo_abelii	ENSPPYP00000035397	65.9794	65.9794
ENSG00000163950	homo_sapiens	ENSP00000417686	93.7037	93.7037	pan_troglodytes	ENSPTRP00000088685	93.0147	93.0147
ENSG00000163950	homo_sapiens	ENSP00000417686	100	100	gorilla_gorilla	ENSGGOP00000003115	100	100
ENSG00000163950	homo_sapiens	ENSP00000417686	83.7037	77.4074	ornithorhynchus_anatinus	ENSOANP00000022449	62.4309	57.7348
ENSG00000163950	homo_sapiens	ENSP00000417686	86.6667	79.2593	sarcophilus_harrisii	ENSSHAP00000044433	69.8507	63.8806
ENSG00000163950	homo_sapiens	ENSP00000417686	60	56.6667	notamacropus_eugenii	ENSMEUP00000002289	91.0112	85.9551
ENSG00000163950	homo_sapiens	ENSP00000417686	86.6667	81.1111	dasypus_novemcinctus	ENSDNOP00000030210	84.1727	78.777
ENSG00000163950	homo_sapiens	ENSP00000417686	74.0741	68.8889	echinops_telfairi	ENSETEP00000003790	85.4701	79.4872
ENSG00000163950	homo_sapiens	ENSP00000417686	85.1852	80.3704	callithrix_jacchus	ENSCJAP00000083351	56.9307	53.7129
ENSG00000163950	homo_sapiens	ENSP00000417686	98.1481	97.4074	cercocebus_atys	ENSCATP00000009888	94.9821	94.2652
ENSG00000163950	homo_sapiens	ENSP00000417686	100	99.2593	macaca_fascicularis	ENSMFAP00000054840	97.4729	96.7509
ENSG00000163950	homo_sapiens	ENSP00000417686	100	99.2593	macaca_mulatta	ENSMMUP00000059768	77.3639	76.7908
ENSG00000163950	homo_sapiens	ENSP00000417686	81.4815	80.7407	macaca_nemestrina	ENSMNEP00000001793	96.9163	96.0352
ENSG00000163950	homo_sapiens	ENSP00000417686	87.037	86.2963	papio_anubis	ENSPANP00000035784	74.3671	73.7342
ENSG00000163950	homo_sapiens	ENSP00000417686	81.4815	80	mandrillus_leucophaeus	ENSMLEP00000005683	85.6031	84.0467
ENSG00000163950	homo_sapiens	ENSP00000417686	74.8148	72.2222	tursiops_truncatus	ENSTTRP00000010328	93.5185	90.2778
ENSG00000163950	homo_sapiens	ENSP00000417686	60.3704	57.4074	tursiops_truncatus	ENSTTRP00000003760	92.0904	87.5706
ENSG00000163950	homo_sapiens	ENSP00000417686	89.6296	84.8148	vulpes_vulpes	ENSVVUP00000021176	44.4037	42.0183
ENSG00000163950	homo_sapiens	ENSP00000417686	81.8519	77.4074	mus_spretus	MGP_SPRETEiJ_P0070174	88.4	83.6
ENSG00000163950	homo_sapiens	ENSP00000417686	85.5556	81.8519	equus_asinus	ENSEASP00005052652	75.9868	72.6974
ENSG00000163950	homo_sapiens	ENSP00000417686	90.7407	85.9259	capra_hircus	ENSCHIP00000020855	89.0909	84.3636
ENSG00000163950	homo_sapiens	ENSP00000417686	76.2963	72.5926	loxodonta_africana	ENSLAFP00000010814	85.124	80.9917
ENSG00000163950	homo_sapiens	ENSP00000417686	91.8519	89.2593	panthera_leo	ENSPLOP00000006543	88.5714	86.0714
ENSG00000163950	homo_sapiens	ENSP00000417686	85.1852	81.1111	ailuropoda_melanoleuca	ENSAMEP00000043697	32.3034	30.7584
ENSG00000163950	homo_sapiens	ENSP00000417686	86.2963	78.8889	bos_indicus_hybrid	ENSBIXP00005002173	52.8345	48.2993
ENSG00000163950	homo_sapiens	ENSP00000417686	93.7037	90	equus_caballus	ENSECAP00000009611	90.681	87.0968
ENSG00000163950	homo_sapiens	ENSP00000417686	91.8519	88.1481	canis_lupus_familiaris	ENSCAFP00845000279	87.9433	84.3972
ENSG00000163950	homo_sapiens	ENSP00000417686	83.3333	80.7407	panthera_pardus	ENSPPRP00000026238	86.2069	83.5249
ENSG00000163950	homo_sapiens	ENSP00000417686	67.037	65.5556	marmota_marmota_marmota	ENSMMMP00000010354	94.2708	92.1875
ENSG00000163950	homo_sapiens	ENSP00000417686	91.8519	88.1481	balaenoptera_musculus	ENSBMSP00010013841	88.8889	85.3047
ENSG00000163950	homo_sapiens	ENSP00000417686	87.037	84.0741	cavia_porcellus	ENSCPOP00000000027	85.4545	82.5455
ENSG00000163950	homo_sapiens	ENSP00000417686	82.2222	78.5185	felis_catus	ENSFCAP00000052855	68.0982	65.0307
ENSG00000163950	homo_sapiens	ENSP00000417686	91.8519	88.1481	ursus_americanus	ENSUAMP00000016308	89.5307	85.9206
ENSG00000163950	homo_sapiens	ENSP00000417686	85.9259	78.5185	monodelphis_domestica	ENSMODP00000005298	81.4035	74.386
ENSG00000163950	homo_sapiens	ENSP00000417686	80	75.5556	bison_bison_bison	ENSBBBP00000027408	91.5254	86.4407
ENSG00000163950	homo_sapiens	ENSP00000417686	91.4815	87.4074	monodon_monoceros	ENSMMNP00015012002	88.5305	84.5878
ENSG00000163950	homo_sapiens	ENSP00000417686	90.3704	84.0741	sus_scrofa	ENSSSCP00000009249	88.7273	82.5455
ENSG00000163950	homo_sapiens	ENSP00000417686	95.1852	92.963	microcebus_murinus	ENSMICP00000045277	95.1852	92.963
ENSG00000163950	homo_sapiens	ENSP00000417686	87.7778	84.8148	octodon_degus	ENSODEP00000017156	89.7727	86.7424
ENSG00000163950	homo_sapiens	ENSP00000417686	91.1111	87.037	jaculus_jaculus	ENSJJAP00000001732	90.4412	86.3971
ENSG00000163950	homo_sapiens	ENSP00000417686	92.5926	88.1481	jaculus_jaculus	ENSJJAP00000019653	90.9091	86.5455
ENSG00000163950	homo_sapiens	ENSP00000417686	90.7407	86.2963	ovis_aries_rambouillet	ENSOARP00020030965	89.0909	84.7273
ENSG00000163950	homo_sapiens	ENSP00000417686	67.4074	65.1852	ursus_maritimus	ENSUMAP00000007967	94.7917	91.6667
ENSG00000163950	homo_sapiens	ENSP00000417686	77.037	72.5926	delphinapterus_leucas	ENSDLEP00000022993	60.1156	56.6474
ENSG00000163950	homo_sapiens	ENSP00000417686	81.1111	79.2593	physeter_catodon	ENSPCTP00005010135	92.7966	90.678
ENSG00000163950	homo_sapiens	ENSP00000417686	92.963	88.5185	mus_caroli	MGP_CAROLIEiJ_P0067548	91.2727	86.9091
ENSG00000163950	homo_sapiens	ENSP00000417686	93.3333	88.8889	mus_musculus	ENSMUSP00000062930	91.6364	87.2727
ENSG00000163950	homo_sapiens	ENSP00000417686	75.1852	71.8519	dipodomys_ordii	ENSDORP00000023260	93.9815	89.8148
ENSG00000163950	homo_sapiens	ENSP00000417686	64.8148	62.2222	mustela_putorius_furo	ENSMPUP00000011048	89.7436	86.1538
ENSG00000163950	homo_sapiens	ENSP00000417686	97.4074	96.2963	aotus_nancymaae	ENSANAP00000034309	94.9458	93.8628
ENSG00000163950	homo_sapiens	ENSP00000417686	68.5185	67.037	saimiri_boliviensis_boliviensis	ENSSBOP00000035483	98.9305	96.7914
ENSG00000163950	homo_sapiens	ENSP00000417686	87.7778	84.8148	chlorocebus_sabaeus	ENSCSAP00000011690	86.1818	83.2727
ENSG00000163950	homo_sapiens	ENSP00000417686	62.963	61.1111	tupaia_belangeri	ENSTBEP00000003539	67.4603	65.4762
ENSG00000163950	homo_sapiens	ENSP00000417686	94.0741	88.5185	mesocricetus_auratus	ENSMAUP00000007955	92.3636	86.9091
ENSG00000163950	homo_sapiens	ENSP00000417686	90.7407	86.6667	phocoena_sinus	ENSPSNP00000026343	73.1343	69.8507
ENSG00000163950	homo_sapiens	ENSP00000417686	78.5185	75.9259	camelus_dromedarius	ENSCDRP00005007475	88.7029	85.7741
ENSG00000163950	homo_sapiens	ENSP00000417686	94.8148	92.963	carlito_syrichta	ENSTSYP00000017477	94.8148	92.963
ENSG00000163950	homo_sapiens	ENSP00000417686	66.2963	64.8148	panthera_tigris_altaica	ENSPTIP00000016200	93.2292	91.1458
ENSG00000163950	homo_sapiens	ENSP00000417686	93.7037	88.5185	rattus_norvegicus	ENSRNOP00000047799	92	86.9091
ENSG00000163950	homo_sapiens	ENSP00000417686	60.3704	52.5926	rattus_norvegicus	ENSRNOP00000076822	67.3554	58.6777
ENSG00000163950	homo_sapiens	ENSP00000417686	94.8148	92.5926	prolemur_simus	ENSPSMP00000002796	92.4188	90.2527
ENSG00000163950	homo_sapiens	ENSP00000417686	93.7037	87.4074	microtus_ochrogaster	ENSMOCP00000017127	92	85.8182
ENSG00000163950	homo_sapiens	ENSP00000417686	94.4444	88.5185	peromyscus_maniculatus_bairdii	ENSPEMP00000020389	92.7273	86.9091
ENSG00000163950	homo_sapiens	ENSP00000417686	76.2963	72.5926	bos_mutus	ENSBMUP00000028670	84.7737	80.6584
ENSG00000163950	homo_sapiens	ENSP00000417686	93.3333	88.8889	mus_spicilegus	ENSMSIP00000024125	91.6364	87.2727
ENSG00000163950	homo_sapiens	ENSP00000417686	94.0741	88.1481	cricetulus_griseus_chok1gshd	ENSCGRP00001007351	92.3636	86.5455
ENSG00000163950	homo_sapiens	ENSP00000417686	91.4815	85.1852	cricetulus_griseus_chok1gshd	ENSCGRP00001011314	91.8216	85.5019
ENSG00000163950	homo_sapiens	ENSP00000417686	86.6667	81.1111	pteropus_vampyrus	ENSPVAP00000002652	89.6552	83.908
ENSG00000163950	homo_sapiens	ENSP00000417686	73.7037	70	myotis_lucifugus	ENSMLUP00000004026	85.4077	81.1159
ENSG00000163950	homo_sapiens	ENSP00000417686	87.037	77.7778	vombatus_ursinus	ENSVURP00010027764	79.932	71.4286
ENSG00000163950	homo_sapiens	ENSP00000417686	88.5185	84.0741	rhinolophus_ferrumequinum	ENSRFEP00010016634	55.0691	52.3041
ENSG00000163950	homo_sapiens	ENSP00000417686	92.2222	88.8889	neovison_vison	ENSNVIP00000029114	89.2473	86.0215
ENSG00000163950	homo_sapiens	ENSP00000417686	89.6296	84.8148	bos_taurus	ENSBTAP00000062520	60.5	57.25
ENSG00000163950	homo_sapiens	ENSP00000417686	80	75.5556	heterocephalus_glaber_female	ENSHGLP00000040524	78.2609	73.913
ENSG00000163950	homo_sapiens	ENSP00000417686	98.1481	97.4074	rhinopithecus_bieti	ENSRBIP00000030622	94.9821	94.2652
ENSG00000163950	homo_sapiens	ENSP00000417686	91.8519	88.1481	canis_lupus_dingo	ENSCAFP00020015350	90.1818	86.5455
ENSG00000163950	homo_sapiens	ENSP00000417686	92.5926	88.5185	sciurus_vulgaris	ENSSVLP00005013958	90.9091	86.9091
ENSG00000163950	homo_sapiens	ENSP00000417686	87.037	79.2593	phascolarctos_cinereus	ENSPCIP00000017788	79.661	72.5424
ENSG00000163950	homo_sapiens	ENSP00000417686	91.1111	86.6667	nannospalax_galili	ENSNGAP00000021693	89.4545	85.0909
ENSG00000163950	homo_sapiens	ENSP00000417686	90	85.1852	bos_grunniens	ENSBGRP00000028940	57.7197	54.6318
ENSG00000163950	homo_sapiens	ENSP00000417686	87.4074	85.1852	chinchilla_lanigera	ENSCLAP00000011836	88.3895	86.1423
ENSG00000163950	homo_sapiens	ENSP00000417686	91.4815	86.2963	cervus_hanglu_yarkandensis	ENSCHYP00000039401	89.8182	84.7273
ENSG00000163950	homo_sapiens	ENSP00000417686	90.3704	84.8148	catagonus_wagneri	ENSCWAP00000028107	87.4552	82.0788
ENSG00000163950	homo_sapiens	ENSP00000417686	92.963	89.6296	ictidomys_tridecemlineatus	ENSSTOP00000025519	91.2727	88
ENSG00000163950	homo_sapiens	ENSP00000417686	95.9259	92.5926	otolemur_garnettii	ENSOGAP00000008719	95.9259	92.5926
ENSG00000163950	homo_sapiens	ENSP00000417686	63.3333	60.3704	cebus_imitator	ENSCCAP00000016690	90	85.7895
ENSG00000163950	homo_sapiens	ENSP00000417686	91.4815	88.1481	urocitellus_parryii	ENSUPAP00010003324	51.2448	49.3776
ENSG00000163950	homo_sapiens	ENSP00000417686	90.7407	85.1852	moschus_moschiferus	ENSMMSP00000014743	89.0909	83.6364
ENSG00000163950	homo_sapiens	ENSP00000417686	94.4444	94.0741	rhinopithecus_roxellana	ENSRROP00000011493	93.0657	92.7007
ENSG00000163950	homo_sapiens	ENSP00000417686	93.3333	88.8889	mus_pahari	MGP_PahariEiJ_P0030761	91.6364	87.2727
ENSG00000163950	homo_sapiens	ENSP00000417686	94.8148	92.963	propithecus_coquereli	ENSPCOP00000011751	94.8148	92.963
ENSG00000163950	homo_sapiens	ENSP00000417686	41.4815	27.4074	caenorhabditis_elegans	R06F6.1.1	29.3194	19.3717
ENSG00000163950	homo_sapiens	ENSP00000417686	38.1481	25.9259	drosophila_melanogaster	FBpp0084778	37.3188	25.3623
ENSG00000163950	homo_sapiens	ENSP00000417686	25.1852	18.8889	ciona_intestinalis	ENSCINP00000030129	51.5152	38.6364
ENSG00000163950	homo_sapiens	ENSP00000417686	29.6296	25.1852	petromyzon_marinus	ENSPMAP00000003295	71.4286	60.7143
ENSG00000163950	homo_sapiens	ENSP00000417686	68.5185	53.7037	callorhinchus_milii	ENSCMIP00000023039	56.7485	44.4785
ENSG00000163950	homo_sapiens	ENSP00000417686	67.037	54.0741	latimeria_chalumnae	ENSLACP00000016591	61.7747	49.8294
ENSG00000163950	homo_sapiens	ENSP00000417686	69.2593	55.5556	lepisosteus_oculatus	ENSLOCP00000013532	62.7517	50.3356
ENSG00000163950	homo_sapiens	ENSP00000417686	59.6296	45.9259	clupea_harengus	ENSCHAP00000000914	61.4504	47.3282
ENSG00000163950	homo_sapiens	ENSP00000417686	60	47.037	danio_rerio	ENSDARP00000140437	53.6424	42.053
ENSG00000163950	homo_sapiens	ENSP00000417686	57.4074	43.3333	carassius_auratus	ENSCARP00000119203	56.5693	42.7007
ENSG00000163950	homo_sapiens	ENSP00000417686	53.7037	43.3333	carassius_auratus	ENSCARP00000015857	67.4419	54.4186
ENSG00000163950	homo_sapiens	ENSP00000417686	61.4815	49.2593	astyanax_mexicanus	ENSAMXP00000014954	61.0294	48.8971
ENSG00000163950	homo_sapiens	ENSP00000417686	55.1852	47.037	ictalurus_punctatus	ENSIPUP00000024802	57.3077	48.8462
ENSG00000163950	homo_sapiens	ENSP00000417686	64.0741	51.4815	esox_lucius	ENSELUP00000057022	62.2302	50
ENSG00000163950	homo_sapiens	ENSP00000417686	55.1852	44.8148	electrophorus_electricus	ENSEEEP00000017713	62.8692	51.0549
ENSG00000163950	homo_sapiens	ENSP00000417686	64.4444	51.1111	oncorhynchus_kisutch	ENSOKIP00005046811	63.7363	50.5494
ENSG00000163950	homo_sapiens	ENSP00000417686	58.1481	47.037	oncorhynchus_kisutch	ENSOKIP00005016828	58.3643	47.2119
ENSG00000163950	homo_sapiens	ENSP00000417686	54.8148	43.7037	oncorhynchus_mykiss	ENSOMYP00000009949	57.3643	45.7364
ENSG00000163950	homo_sapiens	ENSP00000417686	64.4444	51.1111	oncorhynchus_mykiss	ENSOMYP00000098886	63.7363	50.5494
ENSG00000163950	homo_sapiens	ENSP00000417686	57.037	46.2963	salmo_salar	ENSSSAP00000072174	61.1111	49.6032
ENSG00000163950	homo_sapiens	ENSP00000417686	64.0741	51.4815	salmo_trutta	ENSSTUP00000067972	63.37	50.9158
ENSG00000163950	homo_sapiens	ENSP00000417686	61.4815	50.3704	gadus_morhua	ENSGMOP00000016433	61.0294	50
ENSG00000163950	homo_sapiens	ENSP00000417686	58.8889	46.2963	fundulus_heteroclitus	ENSFHEP00000025339	60.4563	47.5285
ENSG00000163950	homo_sapiens	ENSP00000417686	60.7407	47.4074	poecilia_reticulata	ENSPREP00000006585	60.7407	47.4074
ENSG00000163950	homo_sapiens	ENSP00000417686	61.1111	47.7778	xiphophorus_maculatus	ENSXMAP00000001324	60.4396	47.2527
ENSG00000163950	homo_sapiens	ENSP00000417686	58.8889	48.1481	oryzias_latipes	ENSORLP00000040501	59.3284	48.5075
ENSG00000163950	homo_sapiens	ENSP00000417686	62.5926	50.3704	cyclopterus_lumpus	ENSCLMP00005008536	60.7914	48.9209
ENSG00000163950	homo_sapiens	ENSP00000417686	61.8519	48.5185	oreochromis_niloticus	ENSONIP00000066025	60.0719	47.1223
ENSG00000163950	homo_sapiens	ENSP00000417686	61.1111	47.7778	haplochromis_burtoni	ENSHBUP00000022848	59.3525	46.4029
ENSG00000163950	homo_sapiens	ENSP00000417686	61.1111	47.7778	astatotilapia_calliptera	ENSACLP00000010290	59.3525	46.4029
ENSG00000163950	homo_sapiens	ENSP00000417686	60.7407	46.2963	sparus_aurata	ENSSAUP00010028250	58.7814	44.8029
ENSG00000163950	homo_sapiens	ENSP00000417686	60.7407	48.1481	lates_calcarifer	ENSLCAP00010021754	57.9505	45.9364
ENSG00000163950	homo_sapiens	ENSP00000417686	68.1481	54.8148	xenopus_tropicalis	ENSXETP00000008408	72.4409	58.2677
ENSG00000163950	homo_sapiens	ENSP00000417686	80.3704	71.8519	chrysemys_picta_bellii	ENSCPBP00000000912	77.7778	69.534
ENSG00000163950	homo_sapiens	ENSP00000417686	74.0741	64.4444	sphenodon_punctatus	ENSSPUP00000020831	76.3359	66.4122
ENSG00000163950	homo_sapiens	ENSP00000417686	72.2222	64.0741	crocodylus_porosus	ENSCPRP00005001817	61.7089	54.7468
ENSG00000163950	homo_sapiens	ENSP00000417686	67.037	57.4074	laticauda_laticaudata	ENSLLTP00000006343	72.9839	62.5
ENSG00000163950	homo_sapiens	ENSP00000417686	65.9259	57.037	notechis_scutatus	ENSNSUP00000010935	72.3577	62.6016
ENSG00000163950	homo_sapiens	ENSP00000417686	67.4074	58.5185	pseudonaja_textilis	ENSPTXP00000015894	73.3871	63.7097
ENSG00000163950	homo_sapiens	ENSP00000417686	78.5185	71.4815	anas_platyrhynchos_platyrhynchos	ENSAPLP00000015887	53.5354	48.7374
ENSG00000163950	homo_sapiens	ENSP00000417686	80	70.7407	gallus_gallus	ENSGALP00010023223	48.8688	43.2127
ENSG00000163950	homo_sapiens	ENSP00000417686	71.1111	63.7037	meleagris_gallopavo	ENSMGAP00000013806	80.6723	72.2689
ENSG00000163950	homo_sapiens	ENSP00000417686	77.037	68.1481	serinus_canaria	ENSSCAP00000020894	75.9124	67.1533
ENSG00000163950	homo_sapiens	ENSP00000417686	76.2963	68.1481	parus_major	ENSPMJP00000022665	68.6667	61.3333
ENSG00000163950	homo_sapiens	ENSP00000417686	57.7778	45.5556	neolamprologus_brichardi	ENSNBRP00000007763	60	47.3077
ENSG00000163950	homo_sapiens	ENSP00000417686	67.037	58.1481	naja_naja	ENSNNAP00000012112	72.6908	63.0522
ENSG00000163950	homo_sapiens	ENSP00000417686	73.7037	64.4444	podarcis_muralis	ENSPMRP00000005605	75.9542	66.4122
ENSG00000163950	homo_sapiens	ENSP00000417686	75.1852	66.6667	geospiza_fortis	ENSGFOP00000010383	73.8182	65.4545
ENSG00000163950	homo_sapiens	ENSP00000417686	77.037	68.8889	taeniopygia_guttata	ENSTGUP00000010961	75.9124	67.8832
ENSG00000163950	homo_sapiens	ENSP00000417686	71.8519	59.6296	erpetoichthys_calabaricus	ENSECRP00000027609	66.2116	54.9488
ENSG00000163950	homo_sapiens	ENSP00000417686	61.1111	47.037	kryptolebias_marmoratus	ENSKMAP00000010898	59.3525	45.6835
ENSG00000163950	homo_sapiens	ENSP00000417686	71.4815	61.1111	salvator_merianae	ENSSMRP00000029637	73.6641	62.9771
ENSG00000163950	homo_sapiens	ENSP00000417686	58.5185	47.7778	oryzias_javanicus	ENSOJAP00000037242	60.076	49.0494
ENSG00000163950	homo_sapiens	ENSP00000417686	56.6667	48.8889	amphilophus_citrinellus	ENSACIP00000028825	59.0734	50.9653
ENSG00000163950	homo_sapiens	ENSP00000417686	59.6296	48.1481	dicentrarchus_labrax	ENSDLAP00005009814	58.5455	47.2727
ENSG00000163950	homo_sapiens	ENSP00000417686	61.1111	48.5185	amphiprion_percula	ENSAPEP00000024776	58.5106	46.4539
ENSG00000163950	homo_sapiens	ENSP00000417686	62.2222	49.2593	oryzias_sinensis	ENSOSIP00000048890	41.5842	32.9208
ENSG00000163950	homo_sapiens	ENSP00000417686	79.6296	71.1111	gopherus_evgoodei	ENSGEVP00005002340	77.6173	69.3141
ENSG00000163950	homo_sapiens	ENSP00000417686	79.2593	71.1111	chelonoidis_abingdonii	ENSCABP00000005369	76.7025	68.8172
ENSG00000163950	homo_sapiens	ENSP00000417686	61.1111	48.5185	seriola_dumerili	ENSSDUP00000001035	60	47.6364
ENSG00000163950	homo_sapiens	ENSP00000417686	47.037	35.9259	cottoperca_gobio	ENSCGOP00000008893	44.2509	33.7979
ENSG00000163950	homo_sapiens	ENSP00000417686	79.6296	71.1111	struthio_camelus_australis	ENSSCUP00000021083	75.1748	67.1329
ENSG00000163950	homo_sapiens	ENSP00000417686	78.5185	71.1111	anser_brachyrhynchus	ENSABRP00000009954	75.4448	68.3274
ENSG00000163950	homo_sapiens	ENSP00000417686	56.2963	45.1852	gasterosteus_aculeatus	ENSGACP00000025905	61.7886	49.5935
ENSG00000163950	homo_sapiens	ENSP00000417686	60	48.5185	cynoglossus_semilaevis	ENSCSEP00000031730	59.1241	47.8102
ENSG00000163950	homo_sapiens	ENSP00000417686	60.7407	47.4074	poecilia_formosa	ENSPFOP00000000431	60.7407	47.4074
ENSG00000163950	homo_sapiens	ENSP00000417686	53.7037	43.3333	myripristis_murdjan	ENSMMDP00005030778	54.5113	43.985
ENSG00000163950	homo_sapiens	ENSP00000417686	60	47.7778	myripristis_murdjan	ENSMMDP00005012803	57.2438	45.583
ENSG00000163950	homo_sapiens	ENSP00000417686	60.3704	48.5185	sander_lucioperca	ENSSLUP00000030206	59.9265	48.1618
ENSG00000163950	homo_sapiens	ENSP00000417686	78.1481	69.2593	strigops_habroptila	ENSSHBP00005016129	54.6632	48.4456
ENSG00000163950	homo_sapiens	ENSP00000417686	61.1111	48.5185	amphiprion_ocellaris	ENSAOCP00000019280	58.5106	46.4539
ENSG00000163950	homo_sapiens	ENSP00000417686	64.8148	57.037	terrapene_carolina_triunguis	ENSTMTP00000003238	75.7576	66.6667
ENSG00000163950	homo_sapiens	ENSP00000417686	62.963	50	hucho_hucho	ENSHHUP00000016159	61.8182	49.0909
ENSG00000163950	homo_sapiens	ENSP00000417686	64.0741	51.1111	hucho_hucho	ENSHHUP00000013091	63.37	50.5494
ENSG00000163950	homo_sapiens	ENSP00000417686	61.4815	49.2593	betta_splendens	ENSBSLP00000010062	58.042	46.5035
ENSG00000163950	homo_sapiens	ENSP00000417686	60	48.8889	pygocentrus_nattereri	ENSPNAP00000031265	60.9023	49.6241
ENSG00000163950	homo_sapiens	ENSP00000417686	63.7037	51.8519	anabas_testudineus	ENSATEP00000023572	60.7774	49.47
ENSG00000163950	homo_sapiens	ENSP00000417686	36.6667	29.2593	seriola_lalandi_dorsalis	ENSSLDP00000029675	58.9286	47.0238
ENSG00000163950	homo_sapiens	ENSP00000417686	47.037	35.9259	seriola_lalandi_dorsalis	ENSSLDP00000009517	48.289	36.8821
ENSG00000163950	homo_sapiens	ENSP00000417686	59.6296	48.5185	labrus_bergylta	ENSLBEP00000032786	58.3333	47.4638
ENSG00000163950	homo_sapiens	ENSP00000417686	61.1111	47.7778	pundamilia_nyererei	ENSPNYP00000007116	59.3525	46.4029
ENSG00000163950	homo_sapiens	ENSP00000417686	58.8889	45.5556	mastacembelus_armatus	ENSMAMP00000001444	56.5836	43.7722
ENSG00000163950	homo_sapiens	ENSP00000417686	62.2222	49.2593	stegastes_partitus	ENSSPAP00000005173	59.7865	47.331
ENSG00000163950	homo_sapiens	ENSP00000417686	64.4444	50.7407	oncorhynchus_tshawytscha	ENSOTSP00005101131	63.7363	50.1832
ENSG00000163950	homo_sapiens	ENSP00000417686	53.7037	42.5926	oncorhynchus_tshawytscha	ENSOTSP00005085120	60.6695	48.1172
ENSG00000163950	homo_sapiens	ENSP00000417686	61.4815	48.5185	acanthochromis_polyacanthus	ENSAPOP00000003464	58.8652	46.4539
ENSG00000163950	homo_sapiens	ENSP00000417686	78.5185	70	aquila_chrysaetos_chrysaetos	ENSACCP00020000143	77.3723	68.9781
ENSG00000163950	homo_sapiens	ENSP00000417686	58.1481	45.9259	nothobranchius_furzeri	ENSNFUP00015030570	56.6787	44.7653
ENSG00000163950	homo_sapiens	ENSP00000417686	60	47.4074	cyprinodon_variegatus	ENSCVAP00000030797	60.9023	48.1203
ENSG00000163950	homo_sapiens	ENSP00000417686	59.6296	48.8889	denticeps_clupeoides	ENSDCDP00000062907	62.6459	51.3619
ENSG00000163950	homo_sapiens	ENSP00000417686	60	49.2593	larimichthys_crocea	ENSLCRP00005028676	58.9091	48.3636
ENSG00000163950	homo_sapiens	ENSP00000417686	60.3704	48.5185	takifugu_rubripes	ENSTRUP00000001645	59.2727	47.6364
ENSG00000163950	homo_sapiens	ENSP00000417686	77.037	69.2593	ficedula_albicollis	ENSFALP00000010440	75.9124	68.2482
ENSG00000163950	homo_sapiens	ENSP00000417686	60.3704	47.4074	hippocampus_comes	ENSHCOP00000010760	59.9265	47.0588
ENSG00000163950	homo_sapiens	ENSP00000417686	58.1481	45.5556	cyprinus_carpio_carpio	ENSCCRP00000030760	56.4748	44.2446
ENSG00000163950	homo_sapiens	ENSP00000417686	58.1481	44.0741	cyprinus_carpio_carpio	ENSCCRP00000016929	50.974	38.6364
ENSG00000163950	homo_sapiens	ENSP00000417686	78.8889	70	coturnix_japonica	ENSCJPP00005004914	77.7372	68.9781
ENSG00000163950	homo_sapiens	ENSP00000417686	60.7407	47.4074	poecilia_latipinna	ENSPLAP00000006203	60.7407	47.4074
ENSG00000163950	homo_sapiens	ENSP00000417686	61.8519	46.6667	sinocyclocheilus_grahami	ENSSGRP00000039954	60.7273	45.8182
ENSG00000163950	homo_sapiens	ENSP00000417686	58.5185	45.5556	sinocyclocheilus_grahami	ENSSGRP00000038727	53.5593	41.6949
ENSG00000163950	homo_sapiens	ENSP00000417686	61.1111	47.7778	maylandia_zebra	ENSMZEP00005023046	59.3525	46.4029
ENSG00000163950	homo_sapiens	ENSP00000417686	54.0741	44.0741	tetraodon_nigroviridis	ENSTNIP00000000887	62.3932	50.8547
ENSG00000163950	homo_sapiens	ENSP00000417686	67.037	54.0741	paramormyrops_kingsleyae	ENSPKIP00000021992	56.2112	45.3416
ENSG00000163950	homo_sapiens	ENSP00000417686	65.1852	53.7037	scleropages_formosus	ENSSFOP00015030273	64.2336	52.9197
ENSG00000163950	homo_sapiens	ENSP00000417686	51.1111	40	leptobrachium_leishanense	ENSLLEP00000003135	62.4434	48.8688
ENSG00000163950	homo_sapiens	ENSP00000417686	67.4074	52.5926	leptobrachium_leishanense	ENSLLEP00000005436	63.4146	49.4774
ENSG00000163950	homo_sapiens	ENSP00000417686	60.3704	47.037	scophthalmus_maximus	ENSSMAP00000026208	53.268	41.5033
ENSG00000163950	homo_sapiens	ENSP00000417686	57.7778	48.1481	oryzias_melastigma	ENSOMEP00000028026	59.542	49.6183

Go ID	Go term	No. evidence	Entries	Species	Category
GO:0002191	involved_in cap-dependent translational initiation	1	IDA	Homo_sapiens(9606)	Process
GO:0003723	enables RNA binding	1	HDA	Homo_sapiens(9606)	Function
GO:0003729	enables mRNA binding	2	IBA,IDA	Homo_sapiens(9606)	Function
GO:0005515	enables protein binding	1	IPI	Homo_sapiens(9606)	Function
GO:0005634	located_in nucleus	1	IDA	Homo_sapiens(9606)	Component
GO:0005654	located_in nucleoplasm	2	IDA,TAS	Homo_sapiens(9606)	Component
GO:0005730	located_in nucleolus	1	IDA	Homo_sapiens(9606)	Component
GO:0005737	is_active_in cytoplasm	3	IBA,IDA,NAS	Homo_sapiens(9606)	Component
GO:0005829	located_in cytosol	2	IDA,TAS	Homo_sapiens(9606)	Component
GO:0006398	involved_in mRNA 3-end processing by stem-loop binding and cleavage	2	IBA,ISS	Homo_sapiens(9606)	Process
GO:0042802	enables identical protein binding	1	IPI	Homo_sapiens(9606)	Function
GO:0051028	involved_in mRNA transport	2	IBA,IDA	Homo_sapiens(9606)	Process
GO:0062073	part_of histone mRNA stem-loop binding complex	1	IPI	Homo_sapiens(9606)	Component
GO:0071204	part_of histone pre-mRNA 3end processing complex	2	IBA,ISS	Homo_sapiens(9606)	Component
GO:0071207	enables histone pre-mRNA stem-loop binding	2	IBA,ISS	Homo_sapiens(9606)	Function
GO:0071208	enables histone pre-mRNA DCP binding	1	ISS	Homo_sapiens(9606)	Function
GO:1990904	part_of ribonucleoprotein complex	1	TAS	Homo_sapiens(9606)	Component