RBP Type
Non-canonical_RBPs
Diseases
Drug
N.A.
Main interacting RNAs
N.A.
Moonlighting functions
N.A.
Localizations
Nucleoli
BulkPerturb-seq
N.A.
Ensembl ID ENSG00000163565 Gene ID
3428 Accession
5395
Symbol
IFI16
Alias
PYHIN2;IFNGIP1
Full Name
interferon gamma inducible protein 16
Status
Confidence
Length
55188 bases
Strand
Plus strand
Position
1 : 158999968 - 159055155
RNA binding domain
N.A.
Summary
This gene encodes a member of the HIN-200 (hematopoietic interferon-inducible nuclear antigens with 200 amino acid repeats) family of cytokines. The encoded protein contains domains involved in DNA binding, transcriptional regulation, and protein-protein interactions. The protein localizes to the nucleoplasm and nucleoli, and interacts with p53 and retinoblastoma-1. It modulates p53 function, and inhibits cell growth in the Ras/Raf signaling pathway. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2011]
RNA binding domains (RBDs)
Protein
Domain
Pfam ID
E-value
Domain number
RNA binding proteomes (RBPomes)
Pubmed ID
Full Name
Cell
Author
Time
Doi
Literatures on RNA binding capacity
Pubmed ID
Title
Author
Time
Journal
35072006 Innate immune sensing of influenza A viral RNA through IFI16 promotes pyroptotic cell death.
Shalabh Mishra
2022-01-21
iScience
33208978 Global analysis of RNA-binding protein dynamics by comparative and enhanced RNA interactome capture.
I Joel Perez-Perri
2021-01-01
Nature protocols
37077526 Interplay between RNA viruses and cGAS/STING axis in innate immunity.
Lucia Amurri
2023-01-01
Frontiers in cellular and infection microbiology
30799147 System-wide Profiling of RNA-Binding Proteins Uncovers Key Regulators of Virus Infection.
Manuel Garcia-Moreno
2019-04-04
Molecular cell
32380061 Discovery of Widespread Host Protein Interactions with the Pre-replicated Genome of CHIKV Using VIR-CLASP.
Byungil Kim
2020-05-21
Molecular cell
26907212 Autoantigens as Partners in Initiation and Propagation of Autoimmune Rheumatic Diseases.
Antony Rosen
2016-05-20
Annual review of immunology
25371285 2014 Colorado alphaherpesvirus latency symposium.
J Randall Cohrs
2014-12-01
Journal of neurovirology
28073693 Crosstalk between Cytoplasmic RIG-I and STING Sensing Pathways.
Alessandra Zevini
2017-03-01
Trends in immunology
26121674 BRCA1 Regulates IFI16 Mediated Nuclear Innate Sensing of Herpes Viral DNA and Subsequent Induction of the Innate Inflammasome and Interferon-β Responses.
Dipanjan Dutta
2015-06-01
PLoS pathogens
29132393 Interferon-γ-inducible protein 16 (IFI16) is required for the maintenance of Epstein-Barr virus latency.
Gina Pisano
2017-11-13
Virology journal
26134128 Herpesvirus Genome Recognition Induced Acetylation of Nuclear IFI16 Is Essential for Its Cytoplasmic Translocation, Inflammasome and IFN-β Responses.
Ahmed Mairaj Ansari
2015-07-01
PLoS pathogens
25375629 IFI16 restricts HSV-1 replication by accumulating on the hsv-1 genome, repressing HSV-1 gene expression, and directly or indirectly modulating histone modifications.
E Karen Johnson
2014-11-01
PLoS pathogens
Name
Transcript ID
bp
Protein
Translation ID
IFI16-212
ENST00000566111
856
83aa
ENSP00000458084
IFI16-205
ENST00000426592
761
167aa
ENSP00000406406
IFI16-206
ENST00000447473
951
180aa
ENSP00000407052
IFI16-203
ENST00000368131
2734
729aa
ENSP00000357113
IFI16-201
ENST00000295809
2883
785aa
ENSP00000295809
IFI16-204
ENST00000368132
2704
729aa
ENSP00000357114
IFI16-209
ENST00000483916
4138
No protein
-
IFI16-210
ENST00000493884
4138
No protein
-
IFI16-202
ENST00000359709
2609
729aa
ENSP00000352740
IFI16-207
ENST00000448393
2245
673aa
ENSP00000404325
IFI16-213
ENST00000567661
546
74aa
ENSP00000456094
IFI16-208
ENST00000474473
1095
229aa
ENSP00000456129
IFI16-211
ENST00000562225
1108
No protein
-
Pathway ID
Pathway Name
Source
ensgID
Trait
pValue
Pubmed ID
37479 Platelet Function Tests 4.2500000E-007 - 39831 Platelet Function Tests 3.4000000E-006 - 59433 Blood Pressure 9.2912734E-005 - 60207 Blood Pressure 1.3910835E-007 - 73386 Leukocyte Count 5E-47 23263863 74523 Autoimmune Diseases 8E-7 21383967 88822 Energy Intake 1E-6 23251661 101259 Periodontitis 3E-8 26962152 101260 Tooth 3E-8 26962152 101355 Neutrophils 3E-6 25884002 101356 HIV-1 3E-6 25884002
ensgID SNP Chromosome Position
Trait PubmedID Or or BEAT
EFO ID
Protein-Protein Interaction (PPI)
Ensembl ID
Source
Target
Species
Protein ID
Perc_pos
Perc_id
Species
Protein ID
Perc_pos
Perc_id
ENSG00000163565 homo_sapiens ENSP00000357122 54.065 43.0894 homo_sapiens ENSP00000295809 33.8853 27.0064 ENSG00000163565 homo_sapiens ENSP00000357123 61.6708 42.2604 homo_sapiens ENSP00000295809 31.9745 21.9108 ENSG00000163565 homo_sapiens ENSP00000357112 52.4781 36.4431 homo_sapiens ENSP00000295809 22.9299 15.9236
Ensembl ID
Source
Target
Species
Protein ID
Perc_pos
Perc_id
Species
Protein ID
Perc_pos
Perc_id
ENSG00000163565 homo_sapiens ENSP00000295809 86.242 82.6752 nomascus_leucogenys ENSNLEP00000015957 93.6376 89.7649 ENSG00000163565 homo_sapiens ENSP00000295809 91.8471 91.2102 pan_paniscus ENSPPAP00000013418 98.3629 97.6808 ENSG00000163565 homo_sapiens ENSP00000295809 97.0701 95.0318 pongo_abelii ENSPPYP00000000774 96.5779 94.5501 ENSG00000163565 homo_sapiens ENSP00000295809 91.9745 91.3376 pan_troglodytes ENSPTRP00000065596 98.4993 97.8172 ENSG00000163565 homo_sapiens ENSP00000295809 98.7261 97.8344 gorilla_gorilla ENSGGOP00000005994 98.7261 97.8344 ENSG00000163565 homo_sapiens ENSP00000295809 23.5669 14.3949 sarcophilus_harrisii ENSSHAP00000006431 48.9418 29.8942 ENSG00000163565 homo_sapiens ENSP00000295809 85.7325 82.4204 cercocebus_atys ENSCATP00000015644 92.3182 88.7517 ENSG00000163565 homo_sapiens ENSP00000295809 83.949 79.7452 macaca_fascicularis ENSMFAP00000029096 85.8073 81.5104 ENSG00000163565 homo_sapiens ENSP00000295809 85.7325 82.1656 macaca_mulatta ENSMMUP00000005985 92.3182 88.4774 ENSG00000163565 homo_sapiens ENSP00000295809 85.8599 81.9108 macaca_nemestrina ENSMNEP00000030357 92.4554 88.203 ENSG00000163565 homo_sapiens ENSP00000295809 85.4777 81.4013 papio_anubis ENSPANP00000011185 92.5517 88.1379 ENSG00000163565 homo_sapiens ENSP00000295809 85.6051 82.1656 mandrillus_leucophaeus ENSMLEP00000020240 92.1811 88.4774 ENSG00000163565 homo_sapiens ENSP00000295809 27.7707 19.8726 tursiops_truncatus ENSTTRP00000001755 44.6721 31.9672 ENSG00000163565 homo_sapiens ENSP00000295809 28.4076 19.8726 vulpes_vulpes ENSVVUP00000022331 42.5573 29.771 ENSG00000163565 homo_sapiens ENSP00000295809 9.68153 7.38854 mus_spretus MGP_SPRETEiJ_P0022457 56.2963 42.963 ENSG00000163565 homo_sapiens ENSP00000295809 20.6369 11.0828 mus_spretus MGP_SPRETEiJ_P0022460 36.4045 19.5506 ENSG00000163565 homo_sapiens ENSP00000295809 22.6752 16.4331 equus_asinus ENSEASP00005004390 42.1801 30.5687 ENSG00000163565 homo_sapiens ENSP00000295809 30.1911 22.5478 equus_asinus ENSEASP00005004366 45.3155 33.8432 ENSG00000163565 homo_sapiens ENSP00000295809 28.535 21.2739 equus_asinus ENSEASP00005004360 43.6647 32.5536 ENSG00000163565 homo_sapiens ENSP00000295809 32.3567 24.2038 equus_asinus ENSEASP00005050767 44.6397 33.3919 ENSG00000163565 homo_sapiens ENSP00000295809 27.6433 21.1465 capra_hircus ENSCHIP00000018103 41.6507 31.8618 ENSG00000163565 homo_sapiens ENSP00000295809 28.2803 19.4904 panthera_leo ENSPLOP00000027286 47.4359 32.6923 ENSG00000163565 homo_sapiens ENSP00000295809 32.4841 22.9299 ailuropoda_melanoleuca ENSAMEP00000030524 39.2308 27.6923 ENSG00000163565 homo_sapiens ENSP00000295809 26.242 18.9809 bos_indicus_hybrid ENSBIXP00005012675 44.1113 31.9058 ENSG00000163565 homo_sapiens ENSP00000295809 30.3185 22.4204 equus_caballus ENSECAP00000039565 45.5067 33.652 ENSG00000163565 homo_sapiens ENSP00000295809 31.9745 23.8217 equus_caballus ENSECAP00000012351 45.2252 33.6937 ENSG00000163565 homo_sapiens ENSP00000295809 24.4586 18.5987 equus_caballus ENSECAP00000029664 42.4779 32.3009 ENSG00000163565 homo_sapiens ENSP00000295809 29.2994 21.6561 equus_caballus ENSECAP00000013622 44.8343 33.1384 ENSG00000163565 homo_sapiens ENSP00000295809 12.2293 8.40764 panthera_pardus ENSPPRP00000002355 36.7816 25.2874 ENSG00000163565 homo_sapiens ENSP00000295809 32.7389 22.1656 marmota_marmota_marmota ENSMMMP00000025669 31.3033 21.1937 ENSG00000163565 homo_sapiens ENSP00000295809 12.1019 9.80892 marmota_marmota_marmota ENSMMMP00000025667 40.7725 33.0472 ENSG00000163565 homo_sapiens ENSP00000295809 31.465 21.9108 balaenoptera_musculus ENSBMSP00010005135 44.7464 31.1594 ENSG00000163565 homo_sapiens ENSP00000295809 4.84076 4.20382 cavia_porcellus ENSCPOP00000014669 27.1429 23.5714 ENSG00000163565 homo_sapiens ENSP00000295809 29.4268 20.3822 felis_catus ENSFCAP00000061143 33.7719 23.3918 ENSG00000163565 homo_sapiens ENSP00000295809 23.4395 17.0701 ursus_americanus ENSUAMP00000035084 46.1153 33.584 ENSG00000163565 homo_sapiens ENSP00000295809 24.586 16.051 monodelphis_domestica ENSMODP00000039043 48.4925 31.6583 ENSG00000163565 homo_sapiens ENSP00000295809 28.2803 20.6369 bison_bison_bison ENSBBBP00000013696 42.3664 30.916 ENSG00000163565 homo_sapiens ENSP00000295809 29.6815 21.5287 monodon_monoceros ENSMMNP00015009977 44.0454 31.9471 ENSG00000163565 homo_sapiens ENSP00000295809 30.828 21.4013 sus_scrofa ENSSSCP00000034497 41.3675 28.7179 ENSG00000163565 homo_sapiens ENSP00000295809 59.7452 47.5159 microcebus_murinus ENSMICP00000029338 52.3438 41.6295 ENSG00000163565 homo_sapiens ENSP00000295809 5.09554 4.33121 octodon_degus ENSODEP00000012099 27.972 23.7762 ENSG00000163565 homo_sapiens ENSP00000295809 22.1656 16.3057 jaculus_jaculus ENSJJAP00000012399 42.1307 30.9927 ENSG00000163565 homo_sapiens ENSP00000295809 28.1529 21.2739 ovis_aries_rambouillet ENSOARP00020011501 42.4184 32.0537 ENSG00000163565 homo_sapiens ENSP00000295809 32.1019 22.0382 ursus_maritimus ENSUMAP00000001988 34.7107 23.8292 ENSG00000163565 homo_sapiens ENSP00000295809 29.9363 21.5287 delphinapterus_leucas ENSDLEP00000017092 44.3396 31.8868 ENSG00000163565 homo_sapiens ENSP00000295809 30.3185 21.9108 physeter_catodon ENSPCTP00005003772 44.6529 32.2702 ENSG00000163565 homo_sapiens ENSP00000295809 10.0637 7.64331 mus_caroli MGP_CAROLIEiJ_P0021376 58.5185 44.4444 ENSG00000163565 homo_sapiens ENSP00000295809 17.3248 10.7006 mus_caroli MGP_CAROLIEiJ_P0021374 28.0412 17.3196 ENSG00000163565 homo_sapiens ENSP00000295809 10.7006 8.40764 mus_caroli MGP_CAROLIEiJ_P0021379 38.3562 30.137 ENSG00000163565 homo_sapiens ENSP00000295809 21.0191 14.3949 mus_caroli MGP_CAROLIEiJ_P0021380 39.2857 26.9048 ENSG00000163565 homo_sapiens ENSP00000295809 16.5605 10.0637 mus_caroli MGP_CAROLIEiJ_P0021375 28.2609 17.1739 ENSG00000163565 homo_sapiens ENSP00000295809 30.7006 19.1083 mus_caroli MGP_CAROLIEiJ_P0021384 25.5026 15.873 ENSG00000163565 homo_sapiens ENSP00000295809 30.5732 23.3121 mus_caroli MGP_CAROLIEiJ_P0021387 43.4783 33.1522 ENSG00000163565 homo_sapiens ENSP00000295809 30.828 18.5987 mus_musculus ENSMUSP00000048129 24.7444 14.9284 ENSG00000163565 homo_sapiens ENSP00000295809 20.7643 14.0127 mus_musculus ENSMUSP00000061900 38.8095 26.1905 ENSG00000163565 homo_sapiens ENSP00000295809 30.7006 18.3439 mus_musculus ENSMUSP00000122424 27.6693 16.5327 ENSG00000163565 homo_sapiens ENSP00000295809 16.6879 9.80892 mus_musculus ENSMUSP00000117222 22.3549 13.1399 ENSG00000163565 homo_sapiens ENSP00000295809 36.8153 28.0255 mus_musculus ENSMUSP00000106845 46.6882 35.5412 ENSG00000163565 homo_sapiens ENSP00000295809 30.1911 17.3248 mus_musculus ENSMUSP00000134646 25.7329 14.7666 ENSG00000163565 homo_sapiens ENSP00000295809 20.5096 11.2102 mus_musculus ENSMUSP00000000266 36.1798 19.7753 ENSG00000163565 homo_sapiens ENSP00000295809 11.8471 8.28025 mus_musculus ENSMUSP00000115105 42.4658 29.6804 ENSG00000163565 homo_sapiens ENSP00000295809 17.707 10.5732 mus_musculus ENSMUSP00000083039 23.6395 14.1156 ENSG00000163565 homo_sapiens ENSP00000295809 5.22293 4.71338 dipodomys_ordii ENSDORP00000024321 28.8732 26.0563 ENSG00000163565 homo_sapiens ENSP00000295809 29.9363 22.1656 mustela_putorius_furo ENSMPUP00000012988 44.8473 33.2061 ENSG00000163565 homo_sapiens ENSP00000295809 86.4968 82.1656 chlorocebus_sabaeus ENSCSAP00000015600 93.2692 88.5989 ENSG00000163565 homo_sapiens ENSP00000295809 25.3503 18.0892 tupaia_belangeri ENSTBEP00000011655 48.6553 34.7188 ENSG00000163565 homo_sapiens ENSP00000295809 12.2293 8.28025 mesocricetus_auratus ENSMAUP00000003727 30 20.3125 ENSG00000163565 homo_sapiens ENSP00000295809 20.8917 14.2675 mesocricetus_auratus ENSMAUP00000008809 39.3285 26.8585 ENSG00000163565 homo_sapiens ENSP00000295809 3.18471 2.67516 mesocricetus_auratus ENSMAUP00000012033 17.4825 14.6853 ENSG00000163565 homo_sapiens ENSP00000295809 29.4268 21.0191 phocoena_sinus ENSPSNP00000005651 43.5849 31.1321 ENSG00000163565 homo_sapiens ENSP00000295809 29.172 20.5096 camelus_dromedarius ENSCDRP00005014550 44.3798 31.2015 ENSG00000163565 homo_sapiens ENSP00000295809 12.3567 8.40764 panthera_tigris_altaica ENSPTIP00000001472 37.1647 25.2874 ENSG00000163565 homo_sapiens ENSP00000295809 28.9172 17.5796 rattus_norvegicus ENSRNOP00000095970 27.9901 17.016 ENSG00000163565 homo_sapiens ENSP00000295809 10.3185 6.75159 rattus_norvegicus ENSRNOP00000092123 59.1241 38.6861 ENSG00000163565 homo_sapiens ENSP00000295809 29.172 17.707 rattus_norvegicus ENSRNOP00000089486 26.69 16.2005 ENSG00000163565 homo_sapiens ENSP00000295809 49.5541 39.2357 prolemur_simus ENSPSMP00000024121 51.3193 40.6332 ENSG00000163565 homo_sapiens ENSP00000295809 20.5096 14.3949 microtus_ochrogaster ENSMOCP00000021764 38.4248 26.969 ENSG00000163565 homo_sapiens ENSP00000295809 10.1911 7.7707 microtus_ochrogaster ENSMOCP00000015609 43.4783 33.1522 ENSG00000163565 homo_sapiens ENSP00000295809 28.2803 16.8153 peromyscus_maniculatus_bairdii ENSPEMP00000031575 26.6827 15.8654 ENSG00000163565 homo_sapiens ENSP00000295809 30.9554 16.9427 peromyscus_maniculatus_bairdii ENSPEMP00000035628 30.2993 16.5835 ENSG00000163565 homo_sapiens ENSP00000295809 28.4076 20.8917 bos_mutus ENSBMUP00000000108 42.8023 31.4779 ENSG00000163565 homo_sapiens ENSP00000295809 4.84076 3.43949 mus_spicilegus ENSMSIP00000006073 22.3529 15.8824 ENSG00000163565 homo_sapiens ENSP00000295809 20.6369 14.0127 mus_spicilegus ENSMSIP00000038411 38.5714 26.1905 ENSG00000163565 homo_sapiens ENSP00000295809 9.68153 7.38854 mus_spicilegus ENSMSIP00000038409 56.2963 42.963 ENSG00000163565 homo_sapiens ENSP00000295809 10.0637 7.64331 mus_spicilegus ENSMSIP00000038413 57.6642 43.7956 ENSG00000163565 homo_sapiens ENSP00000295809 4.58599 3.82166 mus_spicilegus ENSMSIP00000008448 17.6471 14.7059 ENSG00000163565 homo_sapiens ENSP00000295809 3.69427 3.3121 mus_spicilegus ENSMSIP00000008887 22.6562 20.3125 ENSG00000163565 homo_sapiens ENSP00000295809 30.4459 18.3439 mus_spicilegus ENSMSIP00000038406 25.3446 15.2704 ENSG00000163565 homo_sapiens ENSP00000295809 3.18471 2.67516 cricetulus_griseus_chok1gshd ENSCGRP00001028062 17.3611 14.5833 ENSG00000163565 homo_sapiens ENSP00000295809 11.465 8.66242 cricetulus_griseus_chok1gshd ENSCGRP00001022652 29.1262 22.0065 ENSG00000163565 homo_sapiens ENSP00000295809 20.8917 15.0318 cricetulus_griseus_chok1gshd ENSCGRP00001027247 40.2948 28.9926 ENSG00000163565 homo_sapiens ENSP00000295809 23.949 15.0318 vombatus_ursinus ENSVURP00010003291 49.6042 31.1346 ENSG00000163565 homo_sapiens ENSP00000295809 24.0764 17.4522 neovison_vison ENSNVIP00000028465 43.8515 31.7865 ENSG00000163565 homo_sapiens ENSP00000295809 28.4076 21.0191 bos_taurus ENSBTAP00000015297 42.5573 31.4886 ENSG00000163565 homo_sapiens ENSP00000295809 26.3694 18.4713 heterocephalus_glaber_female ENSHGLP00000013641 37.5681 26.3158 ENSG00000163565 homo_sapiens ENSP00000295809 87.1338 83.1847 rhinopithecus_bieti ENSRBIP00000019732 93.8272 89.5748 ENSG00000163565 homo_sapiens ENSP00000295809 27.7707 19.4904 canis_lupus_dingo ENSCAFP00020025014 46.5812 32.6923 ENSG00000163565 homo_sapiens ENSP00000295809 26.7516 18.2166 sciurus_vulgaris ENSSVLP00005007849 33.2805 22.6624 ENSG00000163565 homo_sapiens ENSP00000295809 15.5414 9.93631 phascolarctos_cinereus ENSPCIP00000000930 42.9577 27.4648 ENSG00000163565 homo_sapiens ENSP00000295809 32.2293 24.9682 procavia_capensis ENSPCAP00000010660 32.4775 25.1605 ENSG00000163565 homo_sapiens ENSP00000295809 28.4076 20.8917 bos_grunniens ENSBGRP00000019098 42.8023 31.4779 ENSG00000163565 homo_sapiens ENSP00000295809 5.6051 5.09554 chinchilla_lanigera ENSCLAP00000017225 30.9859 28.169 ENSG00000163565 homo_sapiens ENSP00000295809 28.2803 20.6369 cervus_hanglu_yarkandensis ENSCHYP00000020453 42.2053 30.7985 ENSG00000163565 homo_sapiens ENSP00000295809 29.2994 21.2739 catagonus_wagneri ENSCWAP00000021159 43.6433 31.6888 ENSG00000163565 homo_sapiens ENSP00000295809 21.1465 17.1975 ictidomys_tridecemlineatus ENSSTOP00000026473 48.2558 39.2442 ENSG00000163565 homo_sapiens ENSP00000295809 58.2166 44.7134 otolemur_garnettii ENSOGAP00000005699 57.9949 44.5431 ENSG00000163565 homo_sapiens ENSP00000295809 21.6561 17.8344 urocitellus_parryii ENSUPAP00010013533 41.4634 34.1463 ENSG00000163565 homo_sapiens ENSP00000295809 23.0573 15.6688 moschus_moschiferus ENSMMSP00000024176 36.1277 24.5509 ENSG00000163565 homo_sapiens ENSP00000295809 87.1338 83.1847 rhinopithecus_roxellana ENSRROP00000016325 93.8272 89.5748 ENSG00000163565 homo_sapiens ENSP00000295809 9.80892 7.89809 mus_pahari MGP_PahariEiJ_P0076640 60.1562 48.4375 ENSG00000163565 homo_sapiens ENSP00000295809 16.051 10.0637 mus_pahari MGP_PahariEiJ_P0076639 32.3907 20.3085 ENSG00000163565 homo_sapiens ENSP00000295809 11.465 8.15287 mus_pahari MGP_PahariEiJ_P0076643 41.0959 29.2237 ENSG00000163565 homo_sapiens ENSP00000295809 20.5096 14.5223 mus_pahari MGP_PahariEiJ_P0076645 38.2423 27.0784 ENSG00000163565 homo_sapiens ENSP00000295809 16.051 10.0637 mus_pahari MGP_PahariEiJ_P0076638 30.8824 19.3627
Go ID
Go term
No. evidence
Entries
Species
Category
GO:0000122 involved_in negative regulation of transcription by RNA polymerase II 2 IDA,IMP Homo_sapiens(9606) Process GO:0001819 involved_in positive regulation of cytokine production 1 TAS Homo_sapiens(9606) Process GO:0002218 involved_in activation of innate immune response 2 IBA,IDA Homo_sapiens(9606) Process GO:0003690 enables double-stranded DNA binding 2 IBA,IDA Homo_sapiens(9606) Function GO:0003723 enables RNA binding 1 HDA Homo_sapiens(9606) Function GO:0005515 enables protein binding 1 IPI Homo_sapiens(9606) Function GO:0005634 located_in nucleus 1 IDA Homo_sapiens(9606) Component GO:0005654 is_active_in nucleoplasm 2 IBA,IDA Homo_sapiens(9606) Component GO:0005730 is_active_in nucleolus 2 IBA,IDA Homo_sapiens(9606) Component GO:0005829 is_active_in cytosol 4 IBA,IDA,IPI,TAS Homo_sapiens(9606) Component GO:0006914 involved_in autophagy 1 IEA Homo_sapiens(9606) Process GO:0006954 involved_in inflammatory response 1 IEA Homo_sapiens(9606) Process GO:0008134 enables transcription factor binding 1 IDA Homo_sapiens(9606) Function GO:0010506 involved_in regulation of autophagy 1 IEP Homo_sapiens(9606) Process GO:0016020 located_in membrane 1 HDA Homo_sapiens(9606) Component GO:0016607 located_in nuclear speck 1 IDA Homo_sapiens(9606) Component GO:0030099 involved_in myeloid cell differentiation 1 NAS Homo_sapiens(9606) Process GO:0030224 involved_in monocyte differentiation 1 IDA Homo_sapiens(9606) Process GO:0032731 involved_in positive regulation of interleukin-1 beta production 1 IDA Homo_sapiens(9606) Process GO:0035458 involved_in cellular response to interferon-beta 1 IBA Homo_sapiens(9606) Process GO:0040029 involved_in epigenetic regulation of gene expression 1 IMP Homo_sapiens(9606) Process GO:0042149 involved_in cellular response to glucose starvation 1 IDA Homo_sapiens(9606) Process GO:0042771 acts_upstream_of_or_within intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator 1 IDA Homo_sapiens(9606) Process GO:0043392 involved_in negative regulation of DNA binding 1 IDA Homo_sapiens(9606) Process GO:0045071 involved_in negative regulation of viral genome replication 1 IDA Homo_sapiens(9606) Process GO:0045087 involved_in innate immune response 1 IEA Homo_sapiens(9606) Process GO:0045824 involved_in negative regulation of innate immune response 1 IDA Homo_sapiens(9606) Process GO:0045892 involved_in negative regulation of DNA-templated transcription 1 IDA Homo_sapiens(9606) Process GO:0045944 involved_in positive regulation of transcription by RNA polymerase II 2 IDA,IMP Homo_sapiens(9606) Process GO:0051607 involved_in defense response to virus 2 IDA,IMP Homo_sapiens(9606) Process GO:0071479 involved_in cellular response to ionizing radiation 1 IDA Homo_sapiens(9606) Process GO:0072332 involved_in intrinsic apoptotic signaling pathway by p53 class mediator 1 IMP Homo_sapiens(9606) Process GO:0097202 involved_in activation of cysteine-type endopeptidase activity 1 IMP Homo_sapiens(9606) Process GO:2000117 involved_in negative regulation of cysteine-type endopeptidase activity 1 IDA Homo_sapiens(9606) Process
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