Ensembl ID ENSG00000163565 Gene ID 3428 Accession 5395
Gene Symbol IFI16 Alias PYHIN2;IFNGIP1 Full Name interferon gamma inducible protein 16
Position 1 : 158999968 - 159055155 Length 55188 bases Strand Plus strand
Status Confidence Main interacting RNAsN.A.RBP type Non-canonical_RBPs
Summary This gene encodes a member of the HIN-200 (hematopoietic interferon-inducible nuclear antigens with 200 amino acid repeats) family of cytokines. The encoded protein contains domains involved in DNA binding, transcriptional regulation, and protein-protein interactions. The protein localizes to the nucleoplasm and nucleoli, and interacts with p53 and retinoblastoma-1. It modulates p53 function, and inhibits cell growth in the Ras/Raf signaling pathway. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2011]

ENSG00000163565 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000163565 IFI16 1.60 1.08e-76 KIRC
ENSG00000163565 IFI16 0.65 6.81e-12 HNSC
ENSG00000163565 IFI16 1.04 2.84e-23 LUSC
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000163565 IFI16 breast cancer 14990579
ENSG00000163565 IFI16 tumours 15569046
ENSG00000163565 IFI16 prostate cancer 16494870
ENSG00000163565 IFI16 prostate cancer 17339605
ENSG00000163565 IFI16 cancer 17510972
ENSG00000163565 IFI16 tumor 17569615
ENSG00000163565 IFI16 breast cancer 17981541
ENSG00000163565 IFI16 breast cancer 17981542
ENSG00000163565 IFI16 cancers 17981573
ENSG00000163565 IFI16 Wilms tumor 18231640
ENSG00000163565 IFI16 tumors 19170058
ENSG00000163565 IFI16 tumor 19553003
ENSG00000163565 IFI16 prostate cancer 20052289
ENSG00000163565 IFI16 tumors 20066894
ENSG00000163565 IFI16 Tumor 21488755
ENSG00000163565 IFI16 cancer 21573174
ENSG00000163565 IFI16 tumor 22320325
ENSG00000163565 IFI16 tumor 22618232
ENSG00000163565 IFI16 cancers 23956879
ENSG00000163565 IFI16 cancer 24086395
ENSG00000163565 IFI16 tumors 24413532
ENSG00000163565 IFI16 liver cancer 24491427
ENSG00000163565 IFI16 tumor 25050461
ENSG00000163565 IFI16 cancer 25375629
ENSG00000163565 IFI16 tumor 25466628
ENSG00000163565 IFI16 tumor 25665578
ENSG00000163565 IFI16 breast cancer 26646320
ENSG00000163565 IFI16 tumors 27047543
ENSG00000163565 IFI16 cancer 27063514
ENSG00000163565 IFI16 cancer 27411336
ENSG00000163565 IFI16 tumor 27412599
ENSG00000163565 IFI16 colorectal cancer 27988520
ENSG00000163565 IFI16 breast cancer 28415616
ENSG00000163565 IFI16 breast tumors 28533483
ENSG00000163565 IFI16 cancer 28611294
ENSG00000163565 IFI16 cancer 28849002
ENSG00000163565 IFI16 tumour 28990231
ENSG00000163565 IFI16 breast cancer 29300844
ENSG00000163565 IFI16 tumor 29691417
ENSG00000163565 IFI16 cancer 29807326
ENSG00000163565 IFI16 tumor 30540779
ENSG00000163565 IFI16 tumors 30980272
ENSG00000163565 IFI16 tumor 31036052
ENSG00000163565 IFI16 tumor 31333597
ENSG00000163565 IFI16 HNSCC 31861809
ENSG00000163565 IFI16 cervical cancer 31896065
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000163565 IFI16 SARC 0.0018 low
ENSG00000163565 IFI16 UVM 0.0018 high
ENSG00000163565 IFI16 PAAD 0.0018 high
ENSG00000163565 IFI16 UCEC 0.0054 high
ENSG00000163565 IFI16 ACC 0.016 low
ENSG00000163565 IFI16 LUSC 0.017 low
ENSG00000163565 IFI16 PCPG 0.033 low
ENSG00000163565 IFI16 BRCA 0.011 low
ENSG00000163565 IFI16 UCS 0.025 low
ENSG00000163565 IFI16 ESCA 0.0053 low
ENSG00000163565 IFI16 OV 0.018 low
ENSG00000163565 IFI16 DLBC 0.0061 high
ENSG00000163565 IFI16 LAML 0.032 high
ENSG00000163565 IFI16 GBM 0.012 high
ENSG00000163565 IFI16 SKCM 0.013 low
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000163565 IFI16 LUSC Amp 2.684200 0.253819 0.546312 0.516966
ENSG00000163565 IFI16 LUAD Amp 9.742700 0.272565 0.557111 0.718992
ENSG00000163565 IFI16 CESC Amp 1.821446 0.172790 0.615009 0.532203
ENSG00000163565 IFI16 SARC Amp 2.776502 0.364105 0.707519 0.354086
ENSG00000163565 IFI16 ESCA Amp 0.735859 0.261946 0.497022 0.494565
ENSG00000163565 IFI16 SKCM Amp 2.251285 0.168663 0.686593 0.539510
ENSG00000163565 IFI16 LIHC Amp 12.132852 0.318396 0.898961 0.735135
ENSG00000163565 IFI16 DLBC Amp 1.831764 0.288647 0.669663 0.270833
ENSG00000163565 IFI16 BLCA Amp 15.951883 0.492858 0.690277 0.473039
ENSG00000163565 IFI16 BRCA Amp 12.880891 0.291115 0.780928 0.730556
ENSG00000163565 IFI16 UCEC Amp 3.486963 0.159050 0.829806 0.441558
ENSG00000163565 IFI16 OV Amp 2.751246 0.396468 0.666227 0.575130