RBP Type	Canonical_RBPs
Diseases	CancerFlavivirusesHIVRVSARS-COV-2SINVDengueZika
Drug	N.A.
Main interacting RNAs	mRNA
Moonlighting functions	N.A.
Localizations	Stress granucle
BulkPerturb-seq	N.A.

Ensembl ID	ENSG00000161547	Gene ID	6427	Accession	10783
Symbol	SRSF2	Alias	SC35;PR264;SC-35;SFRS2;SFRS2A;SRp30b	Full Name	serine and arginine rich splicing factor 2
Status	Confidence	Length	3219 bases	Strand	Minus strand
Position	17 : 76734115 - 76737333	RNA binding domain	RRM_1
Summary	The protein encoded by this gene is a member of the serine/arginine (SR)-rich family of pre-mRNA splicing factors, which constitute part of the spliceosome. Each of these factors contains an RNA recognition motif (RRM) for binding RNA and an RS domain for binding other proteins. The RS domain is rich in serine and arginine residues and facilitates interaction between different SR splicing factors. In addition to being critical for mRNA splicing, the SR proteins have also been shown to be involved in mRNA export from the nucleus and in translation. Two transcript variants encoding the same protein and one non-coding transcript variant have been found for this gene. In addition, a pseudogene of this gene has been found on chromosome 11. [provided by RefSeq, Sep 2010]

Protein	Domain	Pfam ID	E-value	Domain number
ENSP00000463317	RRM_1	PF00076	7.5e-22	1
ENSP00000350877	RRM_1	PF00076	7.9e-22	1
ENSP00000441780	RRM_1	PF00076	2e-21	1
ENSP00000353089	RRM_1	PF00076	2.2e-21	1
ENSP00000376276	RRM_1	PF00076	2.2e-21	1
ENSP00000391278	RRM_1	PF00076	2.2e-21	1
ENSP00000462425	RRM_1	PF00076	2.2e-21	1

Pubmed ID	Full Name	Cell	Author	Time	Doi

Pubmed ID	Title	Author	Time	Journal
26261309	Disease-associated mutation in SRSF2 misregulates splicing by altering RNA-binding affinities.	Jian Zhang	2015-08-25	Proceedings of the National Academy of Sciences of the United States of America
36623729	Comprehensive analysis of RNA-binding protein SRSF2-dependent alternative splicing signature in malignant proliferation of colorectal carcinoma.	Weizhen Liu	2023-02-01	The Journal of biological chemistry
29433383	Mycobacterium tuberculosis H37Rv infection regulates alternative splicing in Macrophages.	Wei Zhang	2018-01-01	Bioengineered
33973558	Splicing regulation in hematopoiesis.	Sisi Chen	2021-07-01	Current opinion in hematology
32188117	Regulating Divergent Transcriptomes through mRNA Splicing and Its Modulation Using Various Small Compounds.	Ken-Ichi Fujita	2020-03-16	International journal of molecular sciences
22397991	New connections between splicing and human disease.	A Richard Padgett	2012-04-01	Trends in genetics : TIG
23645565	The changing mutational landscape of acute myeloid leukemia and myelodysplastic syndrome.	A Connie Larsson	2013-08-01	Molecular cancer research : MCR
29844105	Inhibition of SF3B1 by molecules targeting the spliceosome results in massive aberrant exon skipping.	Gang Wu	2018-08-01	RNA (New York, N.Y.)
36142830	Integration of TE Induces Cancer Specific Alternative Splicing Events.	Ryung Woo Kim	2022-09-18	International journal of molecular sciences
29858584	SRSF2 mutations drive oncogenesis by activating a global program of aberrant alternative splicing in hematopoietic cells.	Yang Liang	2018-12-01	Leukemia
27528797	ExSurv: A Web Resource for Prognostic Analyses of Exons Across Human Cancers Using Clinical Transcriptomes.	Seyedsasan Hashemikhabir	2016-01-01	Cancer informatics
29235382	Exploiting differential RNA splicing patterns: a potential new group of therapeutic targets in cancer.	Nidhi Jyotsana	2018-02-01	Expert opinion on therapeutic targets
32653017	RNA-binding proteins in tumor progression.	Hai Qin	2020-07-11	Journal of hematology & oncology
29395063	The Augmented R-Loop Is a Unifying Mechanism for Myelodysplastic Syndromes Induced by High-Risk Splicing Factor Mutations.	Liang Chen	2018-02-01	Molecular cell
27579293	High-throughput screening to enhance oncolytic virus immunotherapy.	J K Allan	2016-01-01	Oncolytic virotherapy
34940860	Exploring the multifunctionality of SR proteins.	Irena Slišković	2022-02-28	Biochemical Society transactions
33038983	Spliceosomal factor mutations and mis-splicing in MDS.	E Courtney Hershberger	2020-09-01	Best practice & research. Clinical haematology
28346450	Structural modeling of protein-RNA complexes using crosslinking of segmentally isotope-labeled RNA and MS/MS.	G Dorn	2017-05-01	Nature methods
23498935	Dynamic integration of splicing within gene regulatory pathways.	Ulrich Braunschweig	2013-03-14	Cell
35309140	Spinocerebellar Ataxia 36: From Mutations Toward Therapies.	Samuel Lopez	2022-01-01	Frontiers in genetics
21683323	Expansion of intronic GGCCTG hexanucleotide repeat in NOP56 causes SCA36, a type of spinocerebellar ataxia accompanied by motor neuron involvement.	Hatasu Kobayashi	2011-07-15	American journal of human genetics
22140111	The structure and selectivity of the SR protein SRSF2 RRM domain with RNA.	M Marie Phelan	2012-04-01	Nucleic acids research
31611195	Altered RNA Processing in Cancer Pathogenesis and Therapy.	A Esther Obeng	2019-11-01	Cancer discovery

Name	Transcript ID	bp	Protein	Translation ID
SRSF2-201	ENST00000358156	1867	214aa	ENSP00000350877
SRSF2-202	ENST00000359995	1888	221aa	ENSP00000353089
SRSF2-203	ENST00000392485	2885	221aa	ENSP00000376276
SRSF2-208	ENST00000585202	1359	221aa	ENSP00000462425
SRSF2-206	ENST00000582449	1518	No protein	-
SRSF2-209	ENST00000586778	1001	No protein	-
SRSF2-204	ENST00000452355	1357	221aa	ENSP00000391278
SRSF2-210	ENST00000589919	595	No protein	-
SRSF2-205	ENST00000508921	1390	209aa	ENSP00000441780
SRSF2-211	ENST00000592676	559	No protein	-
SRSF2-207	ENST00000583836	561	130aa	ENSP00000463317

Pathway ID	Pathway Name	Source

ensgID	Trait	pValue	Pubmed ID
70919	Corneal Pachymetry	2E-10	23776548

ensgID	SNP	Chromosome	Position	Trait	PubmedID	Or or BEAT	EFO ID

Ensembl ID	Source				Target
	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id
ENSG00000161547	homo_sapiens	ENSP00000420195	47.3282	35.4962	homo_sapiens	ENSP00000353089	56.1086	42.0814
ENSG00000161547	homo_sapiens	ENSP00000414302	45.5939	32.9502	homo_sapiens	ENSP00000353089	53.8462	38.914
ENSG00000161547	homo_sapiens	ENSP00000480140	59.9291	53.9007	homo_sapiens	ENSP00000353089	76.4706	68.7783

Ensembl ID	Source				Target
	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id
ENSG00000161547	homo_sapiens	ENSP00000353089	93.2127	90.9502	nomascus_leucogenys	ENSNLEP00000003083	95.814	93.4884
ENSG00000161547	homo_sapiens	ENSP00000353089	100	100	pan_paniscus	ENSPPAP00000016625	100	100
ENSG00000161547	homo_sapiens	ENSP00000353089	100	100	pongo_abelii	ENSPPYP00000009735	77.0035	77.0035
ENSG00000161547	homo_sapiens	ENSP00000353089	100	100	pan_troglodytes	ENSPTRP00000043428	100	100
ENSG00000161547	homo_sapiens	ENSP00000353089	86.4253	86.4253	gorilla_gorilla	ENSGGOP00000023883	93.1707	93.1707
ENSG00000161547	homo_sapiens	ENSP00000353089	100	100	ornithorhynchus_anatinus	ENSOANP00000004292	100	100
ENSG00000161547	homo_sapiens	ENSP00000353089	100	100	sarcophilus_harrisii	ENSSHAP00000024112	100	100
ENSG00000161547	homo_sapiens	ENSP00000353089	100	100	notamacropus_eugenii	ENSMEUP00000015299	100	100
ENSG00000161547	homo_sapiens	ENSP00000353089	100	100	dasypus_novemcinctus	ENSDNOP00000000330	100	100
ENSG00000161547	homo_sapiens	ENSP00000353089	100	100	callithrix_jacchus	ENSCJAP00000024666	100	100
ENSG00000161547	homo_sapiens	ENSP00000353089	100	100	cercocebus_atys	ENSCATP00000019715	100	100
ENSG00000161547	homo_sapiens	ENSP00000353089	98.19	98.19	macaca_fascicularis	ENSMFAP00000057512	98.6364	98.6364
ENSG00000161547	homo_sapiens	ENSP00000353089	100	100	macaca_mulatta	ENSMMUP00000029499	100	100
ENSG00000161547	homo_sapiens	ENSP00000353089	100	100	macaca_nemestrina	ENSMNEP00000014574	100	100
ENSG00000161547	homo_sapiens	ENSP00000353089	100	100	papio_anubis	ENSPANP00000016220	100	100
ENSG00000161547	homo_sapiens	ENSP00000353089	85.5204	85.0679	mandrillus_leucophaeus	ENSMLEP00000005949	100	99.4709
ENSG00000161547	homo_sapiens	ENSP00000353089	100	100	mus_spretus	MGP_SPRETEiJ_P0032666	100	100
ENSG00000161547	homo_sapiens	ENSP00000353089	100	100	capra_hircus	ENSCHIP00000016931	100	100
ENSG00000161547	homo_sapiens	ENSP00000353089	68.3258	58.371	loxodonta_africana	ENSLAFP00000006280	71.564	61.1374
ENSG00000161547	homo_sapiens	ENSP00000353089	96.3801	96.3801	panthera_leo	ENSPLOP00000009799	99.5327	99.5327
ENSG00000161547	homo_sapiens	ENSP00000353089	100	100	ailuropoda_melanoleuca	ENSAMEP00000014349	100	100
ENSG00000161547	homo_sapiens	ENSP00000353089	100	100	bos_indicus_hybrid	ENSBIXP00005028292	100	100
ENSG00000161547	homo_sapiens	ENSP00000353089	100	100	canis_lupus_familiaris	ENSCAFP00845022908	100	100
ENSG00000161547	homo_sapiens	ENSP00000353089	95.9276	95.9276	marmota_marmota_marmota	ENSMMMP00000018075	97.6959	97.6959
ENSG00000161547	homo_sapiens	ENSP00000353089	100	100	balaenoptera_musculus	ENSBMSP00010026594	100	100
ENSG00000161547	homo_sapiens	ENSP00000353089	100	100	felis_catus	ENSFCAP00000050437	100	100
ENSG00000161547	homo_sapiens	ENSP00000353089	100	100	ursus_americanus	ENSUAMP00000016880	100	100
ENSG00000161547	homo_sapiens	ENSP00000353089	100	100	monodelphis_domestica	ENSMODP00000001920	100	100
ENSG00000161547	homo_sapiens	ENSP00000353089	100	100	bison_bison_bison	ENSBBBP00000011775	100	100
ENSG00000161547	homo_sapiens	ENSP00000353089	100	100	monodon_monoceros	ENSMMNP00015025566	100	100
ENSG00000161547	homo_sapiens	ENSP00000353089	99.5475	99.5475	sus_scrofa	ENSSSCP00000040547	99.5475	99.5475
ENSG00000161547	homo_sapiens	ENSP00000353089	100	100	microcebus_murinus	ENSMICP00000049554	100	100
ENSG00000161547	homo_sapiens	ENSP00000353089	100	100	octodon_degus	ENSODEP00000019981	100	100
ENSG00000161547	homo_sapiens	ENSP00000353089	100	100	jaculus_jaculus	ENSJJAP00000010122	100	100
ENSG00000161547	homo_sapiens	ENSP00000353089	100	100	ovis_aries_rambouillet	ENSOARP00020020365	100	100
ENSG00000161547	homo_sapiens	ENSP00000353089	100	100	physeter_catodon	ENSPCTP00005020023	100	100
ENSG00000161547	homo_sapiens	ENSP00000353089	100	100	mus_caroli	MGP_CAROLIEiJ_P0031221	100	100
ENSG00000161547	homo_sapiens	ENSP00000353089	100	100	mus_musculus	ENSMUSP00000090059	100	100
ENSG00000161547	homo_sapiens	ENSP00000353089	88.6878	88.6878	dipodomys_ordii	ENSDORP00000013597	96.0784	96.0784
ENSG00000161547	homo_sapiens	ENSP00000353089	81.448	80.9955	mustela_putorius_furo	ENSMPUP00000013309	80.7175	80.2691
ENSG00000161547	homo_sapiens	ENSP00000353089	100	100	aotus_nancymaae	ENSANAP00000000501	100	100
ENSG00000161547	homo_sapiens	ENSP00000353089	84.6154	84.6154	saimiri_boliviensis_boliviensis	ENSSBOP00000029124	95.4082	95.4082
ENSG00000161547	homo_sapiens	ENSP00000353089	100	100	chlorocebus_sabaeus	ENSCSAP00000001430	100	100
ENSG00000161547	homo_sapiens	ENSP00000353089	100	100	tupaia_belangeri	ENSTBEP00000012414	100	100
ENSG00000161547	homo_sapiens	ENSP00000353089	100	100	mesocricetus_auratus	ENSMAUP00000025853	100	100
ENSG00000161547	homo_sapiens	ENSP00000353089	100	100	phocoena_sinus	ENSPSNP00000030784	100	100
ENSG00000161547	homo_sapiens	ENSP00000353089	61.086	54.2986	camelus_dromedarius	ENSCDRP00005027239	68.8775	61.2245
ENSG00000161547	homo_sapiens	ENSP00000353089	90.4977	90.4977	carlito_syrichta	ENSTSYP00000005957	90.4977	90.4977
ENSG00000161547	homo_sapiens	ENSP00000353089	100	100	rattus_norvegicus	ENSRNOP00000059012	100	100
ENSG00000161547	homo_sapiens	ENSP00000353089	100	100	prolemur_simus	ENSPSMP00000010910	100	100
ENSG00000161547	homo_sapiens	ENSP00000353089	36.6516	28.5068	bos_mutus	ENSBMUP00000021484	45	35
ENSG00000161547	homo_sapiens	ENSP00000353089	50.2262	47.5113	bos_mutus	ENSBMUP00000014864	60.989	57.6923
ENSG00000161547	homo_sapiens	ENSP00000353089	100	100	mus_spicilegus	ENSMSIP00000031636	100	100
ENSG00000161547	homo_sapiens	ENSP00000353089	100	100	cricetulus_griseus_chok1gshd	ENSCGRP00001026054	100	100
ENSG00000161547	homo_sapiens	ENSP00000353089	42.9864	34.8416	myotis_lucifugus	ENSMLUP00000022051	46.5686	37.7451
ENSG00000161547	homo_sapiens	ENSP00000353089	100	100	vombatus_ursinus	ENSVURP00010014313	100	100
ENSG00000161547	homo_sapiens	ENSP00000353089	100	100	rhinolophus_ferrumequinum	ENSRFEP00010023312	100	100
ENSG00000161547	homo_sapiens	ENSP00000353089	51.1312	48.4163	neovison_vison	ENSNVIP00000016709	61.7486	58.4699
ENSG00000161547	homo_sapiens	ENSP00000353089	100	100	bos_taurus	ENSBTAP00000024299	100	100
ENSG00000161547	homo_sapiens	ENSP00000353089	53.8462	49.7738	heterocephalus_glaber_female	ENSHGLP00000024220	49.1736	45.4545
ENSG00000161547	homo_sapiens	ENSP00000353089	100	100	rhinopithecus_bieti	ENSRBIP00000021018	100	100
ENSG00000161547	homo_sapiens	ENSP00000353089	100	100	canis_lupus_dingo	ENSCAFP00020007753	100	100
ENSG00000161547	homo_sapiens	ENSP00000353089	100	100	sciurus_vulgaris	ENSSVLP00005028345	100	100
ENSG00000161547	homo_sapiens	ENSP00000353089	100	100	phascolarctos_cinereus	ENSPCIP00000006332	100	100
ENSG00000161547	homo_sapiens	ENSP00000353089	100	100	nannospalax_galili	ENSNGAP00000023041	100	100
ENSG00000161547	homo_sapiens	ENSP00000353089	100	100	bos_grunniens	ENSBGRP00000018656	100	100
ENSG00000161547	homo_sapiens	ENSP00000353089	85.9728	85.9728	chinchilla_lanigera	ENSCLAP00000018151	99.4764	99.4764
ENSG00000161547	homo_sapiens	ENSP00000353089	100	100	cervus_hanglu_yarkandensis	ENSCHYP00000028858	100	100
ENSG00000161547	homo_sapiens	ENSP00000353089	99.5475	99.5475	catagonus_wagneri	ENSCWAP00000026509	99.5475	99.5475
ENSG00000161547	homo_sapiens	ENSP00000353089	81.9005	81.9005	ictidomys_tridecemlineatus	ENSSTOP00000023495	99.4505	99.4505
ENSG00000161547	homo_sapiens	ENSP00000353089	100	100	otolemur_garnettii	ENSOGAP00000019998	100	100
ENSG00000161547	homo_sapiens	ENSP00000353089	99.095	99.095	cebus_imitator	ENSCCAP00000039432	99.095	99.095
ENSG00000161547	homo_sapiens	ENSP00000353089	100	100	urocitellus_parryii	ENSUPAP00010001026	100	100
ENSG00000161547	homo_sapiens	ENSP00000353089	100	100	moschus_moschiferus	ENSMMSP00000032028	100	100
ENSG00000161547	homo_sapiens	ENSP00000353089	100	100	rhinopithecus_roxellana	ENSRROP00000038100	100	100
ENSG00000161547	homo_sapiens	ENSP00000353089	100	100	mus_pahari	MGP_PahariEiJ_P0037947	100	100
ENSG00000161547	homo_sapiens	ENSP00000353089	100	100	propithecus_coquereli	ENSPCOP00000023334	100	100
ENSG00000161547	homo_sapiens	ENSP00000353089	57.9186	44.7964	caenorhabditis_elegans	EEED8.7a.1	65.3061	50.5102
ENSG00000161547	homo_sapiens	ENSP00000353089	58.8235	50.6787	drosophila_melanogaster	FBpp0297362	66.6667	57.4359
ENSG00000161547	homo_sapiens	ENSP00000353089	59.7285	52.9412	ciona_intestinalis	ENSCINP00000008678	79.5181	70.4819
ENSG00000161547	homo_sapiens	ENSP00000353089	67.8733	56.1086	petromyzon_marinus	ENSPMAP00000006158	69.7674	57.6744
ENSG00000161547	homo_sapiens	ENSP00000353089	63.8009	55.6561	eptatretus_burgeri	ENSEBUP00000013851	70.8543	61.809
ENSG00000161547	homo_sapiens	ENSP00000353089	71.9457	59.7285	eptatretus_burgeri	ENSEBUP00000000841	40.874	33.9332
ENSG00000161547	homo_sapiens	ENSP00000353089	83.2579	74.6606	callorhinchus_milii	ENSCMIP00000043938	85.5814	76.7442
ENSG00000161547	homo_sapiens	ENSP00000353089	94.5701	91.8552	latimeria_chalumnae	ENSLACP00000015214	94.5701	91.8552
ENSG00000161547	homo_sapiens	ENSP00000353089	89.1403	86.4253	lepisosteus_oculatus	ENSLOCP00000013821	91.6279	88.8372
ENSG00000161547	homo_sapiens	ENSP00000353089	88.2353	82.3529	clupea_harengus	ENSCHAP00000009326	82.9787	77.4468
ENSG00000161547	homo_sapiens	ENSP00000353089	82.3529	73.3032	clupea_harengus	ENSCHAP00000006979	62.543	55.6701
ENSG00000161547	homo_sapiens	ENSP00000353089	82.8054	76.9231	danio_rerio	ENSDARP00000131299	83.1818	77.2727
ENSG00000161547	homo_sapiens	ENSP00000353089	89.5928	82.8054	danio_rerio	ENSDARP00000074623	88	81.3333
ENSG00000161547	homo_sapiens	ENSP00000353089	87.3303	80.543	carassius_auratus	ENSCARP00000086572	87.7273	80.9091
ENSG00000161547	homo_sapiens	ENSP00000353089	88.2353	80.9955	carassius_auratus	ENSCARP00000096781	88.6364	81.3636
ENSG00000161547	homo_sapiens	ENSP00000353089	87.3303	80.543	carassius_auratus	ENSCARP00000059540	87.7273	80.9091
ENSG00000161547	homo_sapiens	ENSP00000353089	83.2579	79.638	astyanax_mexicanus	ENSAMXP00000030712	87.2038	83.4123
ENSG00000161547	homo_sapiens	ENSP00000353089	86.8778	82.3529	ictalurus_punctatus	ENSIPUP00000005838	87.2727	82.7273
ENSG00000161547	homo_sapiens	ENSP00000353089	80.543	75.1131	esox_lucius	ENSELUP00000018045	80.9091	75.4545
ENSG00000161547	homo_sapiens	ENSP00000353089	83.7104	79.638	esox_lucius	ENSELUP00000024617	86.0465	81.8605
ENSG00000161547	homo_sapiens	ENSP00000353089	87.7828	82.8054	electrophorus_electricus	ENSEEEP00000042191	87.3874	82.4324
ENSG00000161547	homo_sapiens	ENSP00000353089	42.5339	40.2715	oncorhynchus_kisutch	ENSOKIP00005060900	77.686	73.5537
ENSG00000161547	homo_sapiens	ENSP00000353089	83.2579	78.733	oncorhynchus_kisutch	ENSOKIP00005019499	87.2038	82.4645
ENSG00000161547	homo_sapiens	ENSP00000353089	79.638	74.2081	oncorhynchus_kisutch	ENSOKIP00005006069	83.0189	77.3585
ENSG00000161547	homo_sapiens	ENSP00000353089	83.2579	77.8281	oncorhynchus_kisutch	ENSOKIP00005045088	82.8829	77.4775
ENSG00000161547	homo_sapiens	ENSP00000353089	83.2579	78.733	oncorhynchus_mykiss	ENSOMYP00000095282	87.2038	82.4645
ENSG00000161547	homo_sapiens	ENSP00000353089	79.638	74.2081	oncorhynchus_mykiss	ENSOMYP00000006292	83.0189	77.3585
ENSG00000161547	homo_sapiens	ENSP00000353089	83.2579	77.8281	oncorhynchus_mykiss	ENSOMYP00000006308	82.8829	77.4775
ENSG00000161547	homo_sapiens	ENSP00000353089	80.9955	75.1131	salmo_salar	ENSSSAP00000080713	83.6449	77.5701
ENSG00000161547	homo_sapiens	ENSP00000353089	83.2579	77.8281	salmo_salar	ENSSSAP00000001737	82.8829	77.4775
ENSG00000161547	homo_sapiens	ENSP00000353089	83.2579	77.8281	salmo_salar	ENSSSAP00000162348	82.8829	77.4775
ENSG00000161547	homo_sapiens	ENSP00000353089	81.9005	77.3756	salmo_trutta	ENSSTUP00000114114	86.6029	81.8182
ENSG00000161547	homo_sapiens	ENSP00000353089	79.638	74.2081	salmo_trutta	ENSSTUP00000018044	83.0189	77.3585
ENSG00000161547	homo_sapiens	ENSP00000353089	80.9955	75.1131	salmo_trutta	ENSSTUP00000116234	83.6449	77.5701
ENSG00000161547	homo_sapiens	ENSP00000353089	79.638	74.2081	salmo_trutta	ENSSTUP00000033079	83.0189	77.3585
ENSG00000161547	homo_sapiens	ENSP00000353089	85.5204	80.0905	gadus_morhua	ENSGMOP00000001666	87.5	81.9444
ENSG00000161547	homo_sapiens	ENSP00000353089	81.448	75.1131	gadus_morhua	ENSGMOP00000008177	74.3802	68.595
ENSG00000161547	homo_sapiens	ENSP00000353089	86.8778	81.448	fundulus_heteroclitus	ENSFHEP00000027397	81.3559	76.2712
ENSG00000161547	homo_sapiens	ENSP00000353089	86.8778	82.3529	poecilia_reticulata	ENSPREP00000005249	81.3559	77.1186
ENSG00000161547	homo_sapiens	ENSP00000353089	85.9728	81.448	xiphophorus_maculatus	ENSXMAP00000015708	81.1966	76.9231
ENSG00000161547	homo_sapiens	ENSP00000353089	78.2805	72.8507	oryzias_latipes	ENSORLP00000001513	81.9905	76.3033
ENSG00000161547	homo_sapiens	ENSP00000353089	87.3303	79.638	oryzias_latipes	ENSORLP00000026065	80.7531	73.6402
ENSG00000161547	homo_sapiens	ENSP00000353089	85.5204	79.638	cyclopterus_lumpus	ENSCLMP00005047475	84.7534	78.9238
ENSG00000161547	homo_sapiens	ENSP00000353089	84.1629	77.8281	cyclopterus_lumpus	ENSCLMP00005003647	71.8147	66.4093
ENSG00000161547	homo_sapiens	ENSP00000353089	83.2579	78.2805	oreochromis_niloticus	ENSONIP00000053904	84.4037	79.3578
ENSG00000161547	homo_sapiens	ENSP00000353089	82.8054	78.2805	oreochromis_niloticus	ENSONIP00000025157	68.797	65.0376
ENSG00000161547	homo_sapiens	ENSP00000353089	82.8054	77.8281	haplochromis_burtoni	ENSHBUP00000012321	84.7222	79.6296
ENSG00000161547	homo_sapiens	ENSP00000353089	83.2579	78.733	haplochromis_burtoni	ENSHBUP00000029071	81.7778	77.3333
ENSG00000161547	homo_sapiens	ENSP00000353089	83.2579	78.733	astatotilapia_calliptera	ENSACLP00000040083	81.7778	77.3333
ENSG00000161547	homo_sapiens	ENSP00000353089	82.8054	77.8281	astatotilapia_calliptera	ENSACLP00000026285	84.7222	79.6296
ENSG00000161547	homo_sapiens	ENSP00000353089	84.1629	79.1855	sparus_aurata	ENSSAUP00010051291	76.8595	72.314
ENSG00000161547	homo_sapiens	ENSP00000353089	81.9005	77.8281	sparus_aurata	ENSSAUP00010046081	82.6484	78.5388
ENSG00000161547	homo_sapiens	ENSP00000353089	78.733	74.6606	lates_calcarifer	ENSLCAP00010028851	81.6901	77.4648
ENSG00000161547	homo_sapiens	ENSP00000353089	95.4751	92.7602	xenopus_tropicalis	ENSXETP00000110332	95.9091	93.1818
ENSG00000161547	homo_sapiens	ENSP00000353089	100	100	chrysemys_picta_bellii	ENSCPBP00000040742	100	100
ENSG00000161547	homo_sapiens	ENSP00000353089	93.6652	93.2127	sphenodon_punctatus	ENSSPUP00000009820	98.5714	98.0952
ENSG00000161547	homo_sapiens	ENSP00000353089	98.19	98.19	crocodylus_porosus	ENSCPRP00005010147	98.6364	98.6364
ENSG00000161547	homo_sapiens	ENSP00000353089	99.5475	98.19	laticauda_laticaudata	ENSLLTP00000016695	99.5475	98.19
ENSG00000161547	homo_sapiens	ENSP00000353089	99.5475	98.6425	notechis_scutatus	ENSNSUP00000021775	99.5475	98.6425
ENSG00000161547	homo_sapiens	ENSP00000353089	99.5475	98.6425	pseudonaja_textilis	ENSPTXP00000004457	99.5475	98.6425
ENSG00000161547	homo_sapiens	ENSP00000353089	98.19	98.19	anas_platyrhynchos_platyrhynchos	ENSAPLP00000003666	98.19	98.19
ENSG00000161547	homo_sapiens	ENSP00000353089	98.19	98.19	gallus_gallus	ENSGALP00010043722	98.19	98.19
ENSG00000161547	homo_sapiens	ENSP00000353089	84.1629	84.1629	meleagris_gallopavo	ENSMGAP00000003850	84.5455	84.5455
ENSG00000161547	homo_sapiens	ENSP00000353089	97.7376	97.7376	parus_major	ENSPMJP00000010558	97.7376	97.7376
ENSG00000161547	homo_sapiens	ENSP00000353089	99.095	99.095	anolis_carolinensis	ENSACAP00000008371	99.095	99.095
ENSG00000161547	homo_sapiens	ENSP00000353089	82.8054	77.8281	neolamprologus_brichardi	ENSNBRP00000027634	85.514	80.3738
ENSG00000161547	homo_sapiens	ENSP00000353089	99.5475	98.6425	naja_naja	ENSNNAP00000029720	99.5475	98.6425
ENSG00000161547	homo_sapiens	ENSP00000353089	99.095	99.095	podarcis_muralis	ENSPMRP00000012172	99.095	99.095
ENSG00000161547	homo_sapiens	ENSP00000353089	97.7376	97.7376	taeniopygia_guttata	ENSTGUP00000022960	97.7376	97.7376
ENSG00000161547	homo_sapiens	ENSP00000353089	90.0452	86.8778	erpetoichthys_calabaricus	ENSECRP00000022020	90.8676	87.6712
ENSG00000161547	homo_sapiens	ENSP00000353089	85.0679	79.638	kryptolebias_marmoratus	ENSKMAP00000012606	82.0961	76.8559
ENSG00000161547	homo_sapiens	ENSP00000353089	99.095	99.095	salvator_merianae	ENSSMRP00000030174	99.095	99.095
ENSG00000161547	homo_sapiens	ENSP00000353089	88.6878	80.9955	oryzias_javanicus	ENSOJAP00000047889	82.3529	75.2101
ENSG00000161547	homo_sapiens	ENSP00000353089	79.638	75.1131	oryzias_javanicus	ENSOJAP00000002552	81.8605	77.2093
ENSG00000161547	homo_sapiens	ENSP00000353089	69.2308	65.1584	amphilophus_citrinellus	ENSACIP00000023818	88.9535	83.7209
ENSG00000161547	homo_sapiens	ENSP00000353089	81.448	76.0181	amphilophus_citrinellus	ENSACIP00000012307	86.1244	80.3828
ENSG00000161547	homo_sapiens	ENSP00000353089	83.2579	76.4706	dicentrarchus_labrax	ENSDLAP00005080334	80.7018	74.1228
ENSG00000161547	homo_sapiens	ENSP00000353089	82.8054	78.733	amphiprion_percula	ENSAPEP00000033069	83.1818	79.0909
ENSG00000161547	homo_sapiens	ENSP00000353089	82.8054	76.4706	amphiprion_percula	ENSAPEP00000008840	85.1163	78.6047
ENSG00000161547	homo_sapiens	ENSP00000353089	87.7828	80.543	oryzias_sinensis	ENSOSIP00000001600	81.1715	74.477
ENSG00000161547	homo_sapiens	ENSP00000353089	77.8281	71.9457	oryzias_sinensis	ENSOSIP00000013653	82.2967	76.0766
ENSG00000161547	homo_sapiens	ENSP00000353089	100	100	gopherus_evgoodei	ENSGEVP00005017121	100	100
ENSG00000161547	homo_sapiens	ENSP00000353089	100	100	chelonoidis_abingdonii	ENSCABP00000011490	100	100
ENSG00000161547	homo_sapiens	ENSP00000353089	82.3529	77.3756	seriola_dumerili	ENSSDUP00000020293	85.446	80.2817
ENSG00000161547	homo_sapiens	ENSP00000353089	83.7104	79.638	seriola_dumerili	ENSSDUP00000018998	82.9596	78.9238
ENSG00000161547	homo_sapiens	ENSP00000353089	83.7104	76.9231	cottoperca_gobio	ENSCGOP00000006040	66.5468	61.1511
ENSG00000161547	homo_sapiens	ENSP00000353089	83.2579	78.2805	cottoperca_gobio	ENSCGOP00000034535	84.0183	78.9954
ENSG00000161547	homo_sapiens	ENSP00000353089	98.19	98.19	anser_brachyrhynchus	ENSABRP00000022418	98.19	98.19
ENSG00000161547	homo_sapiens	ENSP00000353089	77.8281	73.7557	gasterosteus_aculeatus	ENSGACP00000004058	86	81.5
ENSG00000161547	homo_sapiens	ENSP00000353089	84.6154	78.733	gasterosteus_aculeatus	ENSGACP00000019647	73.913	68.7747
ENSG00000161547	homo_sapiens	ENSP00000353089	83.2579	78.2805	cynoglossus_semilaevis	ENSCSEP00000020952	84.7926	79.7235
ENSG00000161547	homo_sapiens	ENSP00000353089	85.9728	81.448	poecilia_formosa	ENSPFOP00000020482	79.8319	75.6302
ENSG00000161547	homo_sapiens	ENSP00000353089	87.7828	83.2579	myripristis_murdjan	ENSMMDP00005044939	89.4009	84.7926
ENSG00000161547	homo_sapiens	ENSP00000353089	85.5204	78.733	myripristis_murdjan	ENSMMDP00005007419	84.375	77.6786
ENSG00000161547	homo_sapiens	ENSP00000353089	84.1629	78.2805	sander_lucioperca	ENSSLUP00000006190	84.1629	78.2805
ENSG00000161547	homo_sapiens	ENSP00000353089	82.3529	76.9231	sander_lucioperca	ENSSLUP00000013328	76.1506	71.1297
ENSG00000161547	homo_sapiens	ENSP00000353089	98.19	98.19	strigops_habroptila	ENSSHBP00005014224	98.19	98.19
ENSG00000161547	homo_sapiens	ENSP00000353089	82.8054	78.733	amphiprion_ocellaris	ENSAOCP00000016886	83.1818	79.0909
ENSG00000161547	homo_sapiens	ENSP00000353089	82.8054	76.0181	amphiprion_ocellaris	ENSAOCP00000031066	85.1163	78.1395
ENSG00000161547	homo_sapiens	ENSP00000353089	100	100	terrapene_carolina_triunguis	ENSTMTP00000025167	100	100
ENSG00000161547	homo_sapiens	ENSP00000353089	83.2579	77.3756	hucho_hucho	ENSHHUP00000013698	82.8829	77.027
ENSG00000161547	homo_sapiens	ENSP00000353089	83.2579	78.733	hucho_hucho	ENSHHUP00000057893	82.8829	78.3784
ENSG00000161547	homo_sapiens	ENSP00000353089	83.2579	78.733	hucho_hucho	ENSHHUP00000025861	87.2038	82.4645
ENSG00000161547	homo_sapiens	ENSP00000353089	79.638	73.3032	hucho_hucho	ENSHHUP00000001172	87.5622	80.597
ENSG00000161547	homo_sapiens	ENSP00000353089	82.8054	79.1855	betta_splendens	ENSBSLP00000034392	81.3333	77.7778
ENSG00000161547	homo_sapiens	ENSP00000353089	86.8778	82.3529	pygocentrus_nattereri	ENSPNAP00000025409	87.2727	82.7273
ENSG00000161547	homo_sapiens	ENSP00000353089	63.3484	58.8235	anabas_testudineus	ENSATEP00000026206	88.6076	82.2785
ENSG00000161547	homo_sapiens	ENSP00000353089	84.1629	80.0905	anabas_testudineus	ENSATEP00000005781	80.8696	76.9565
ENSG00000161547	homo_sapiens	ENSP00000353089	61.991	54.2986	ciona_savignyi	ENSCSAVP00000015651	76.9663	67.4157
ENSG00000161547	homo_sapiens	ENSP00000353089	83.7104	79.638	seriola_lalandi_dorsalis	ENSSLDP00000022699	82.9596	78.9238
ENSG00000161547	homo_sapiens	ENSP00000353089	84.1629	76.0181	seriola_lalandi_dorsalis	ENSSLDP00000004262	83.4081	75.3363
ENSG00000161547	homo_sapiens	ENSP00000353089	83.7104	75.5656	labrus_bergylta	ENSLBEP00000030133	77.4059	69.8745
ENSG00000161547	homo_sapiens	ENSP00000353089	83.2579	78.733	labrus_bergylta	ENSLBEP00000036430	84.7926	80.1843
ENSG00000161547	homo_sapiens	ENSP00000353089	82.8054	77.8281	pundamilia_nyererei	ENSPNYP00000017186	84.7222	79.6296
ENSG00000161547	homo_sapiens	ENSP00000353089	83.2579	78.733	pundamilia_nyererei	ENSPNYP00000001417	81.7778	77.3333
ENSG00000161547	homo_sapiens	ENSP00000353089	84.1629	80.0905	mastacembelus_armatus	ENSMAMP00000004131	80.8696	76.9565
ENSG00000161547	homo_sapiens	ENSP00000353089	79.638	74.2081	oncorhynchus_tshawytscha	ENSOTSP00005081671	83.0189	77.3585
ENSG00000161547	homo_sapiens	ENSP00000353089	83.2579	77.8281	oncorhynchus_tshawytscha	ENSOTSP00005080084	82.8829	77.4775
ENSG00000161547	homo_sapiens	ENSP00000353089	83.2579	77.8281	oncorhynchus_tshawytscha	ENSOTSP00005005124	82.8829	77.4775
ENSG00000161547	homo_sapiens	ENSP00000353089	55.2036	50.6787	oncorhynchus_tshawytscha	ENSOTSP00005067225	76.7296	70.4403
ENSG00000161547	homo_sapiens	ENSP00000353089	83.2579	78.733	oncorhynchus_tshawytscha	ENSOTSP00005055799	87.2038	82.4645
ENSG00000161547	homo_sapiens	ENSP00000353089	83.2579	75.5656	acanthochromis_polyacanthus	ENSAPOP00000025172	84.7926	76.9585
ENSG00000161547	homo_sapiens	ENSP00000353089	87.3303	83.2579	acanthochromis_polyacanthus	ENSAPOP00000020790	85.3982	81.4159
ENSG00000161547	homo_sapiens	ENSP00000353089	98.19	98.19	aquila_chrysaetos_chrysaetos	ENSACCP00020012233	98.19	98.19
ENSG00000161547	homo_sapiens	ENSP00000353089	85.0679	79.638	nothobranchius_furzeri	ENSNFUP00015011376	81.0345	75.8621
ENSG00000161547	homo_sapiens	ENSP00000353089	85.0679	80.0905	cyprinodon_variegatus	ENSCVAP00000032199	81.0345	76.2931
ENSG00000161547	homo_sapiens	ENSP00000353089	85.9728	79.1855	denticeps_clupeoides	ENSDCDP00000015087	84.0708	77.4336
ENSG00000161547	homo_sapiens	ENSP00000353089	84.1629	79.638	denticeps_clupeoides	ENSDCDP00000001370	86.5116	81.8605
ENSG00000161547	homo_sapiens	ENSP00000353089	83.2579	76.9231	larimichthys_crocea	ENSLCRP00005010001	80.3493	74.2358
ENSG00000161547	homo_sapiens	ENSP00000353089	82.8054	78.733	larimichthys_crocea	ENSLCRP00005000202	82.8054	78.733
ENSG00000161547	homo_sapiens	ENSP00000353089	87.7828	81.448	takifugu_rubripes	ENSTRUP00000046346	84.7162	78.6026
ENSG00000161547	homo_sapiens	ENSP00000353089	80.9955	73.3032	takifugu_rubripes	ENSTRUP00000069110	79.5556	72
ENSG00000161547	homo_sapiens	ENSP00000353089	57.0136	51.5837	ficedula_albicollis	ENSFALP00000029606	49.2188	44.5312
ENSG00000161547	homo_sapiens	ENSP00000353089	79.638	75.5656	hippocampus_comes	ENSHCOP00000012509	85.4369	81.068
ENSG00000161547	homo_sapiens	ENSP00000353089	88.6878	81.9005	cyprinus_carpio_carpio	ENSCCRP00000144778	89.0909	82.2727
ENSG00000161547	homo_sapiens	ENSP00000353089	88.2353	80.9955	cyprinus_carpio_carpio	ENSCCRP00000071633	87.8378	80.6306
ENSG00000161547	homo_sapiens	ENSP00000353089	98.19	98.19	coturnix_japonica	ENSCJPP00005026607	98.19	98.19
ENSG00000161547	homo_sapiens	ENSP00000353089	85.9728	81.448	poecilia_latipinna	ENSPLAP00000019600	80.5085	76.2712
ENSG00000161547	homo_sapiens	ENSP00000353089	88.6878	81.448	sinocyclocheilus_grahami	ENSSGRP00000022210	88.2883	81.0811
ENSG00000161547	homo_sapiens	ENSP00000353089	88.2353	80.9955	sinocyclocheilus_grahami	ENSSGRP00000045851	88.6364	81.3636
ENSG00000161547	homo_sapiens	ENSP00000353089	83.2579	78.733	maylandia_zebra	ENSMZEP00005005430	81.7778	77.3333
ENSG00000161547	homo_sapiens	ENSP00000353089	84.6154	79.638	tetraodon_nigroviridis	ENSTNIP00000003918	83.1111	78.2222
ENSG00000161547	homo_sapiens	ENSP00000353089	88.6878	82.8054	paramormyrops_kingsleyae	ENSPKIP00000007096	85.2174	79.5652
ENSG00000161547	homo_sapiens	ENSP00000353089	85.0679	81.448	paramormyrops_kingsleyae	ENSPKIP00000026235	62.0462	59.4059
ENSG00000161547	homo_sapiens	ENSP00000353089	90.4977	84.1629	scleropages_formosus	ENSSFOP00015006087	87.3362	81.2227
ENSG00000161547	homo_sapiens	ENSP00000353089	90.9502	85.9728	scleropages_formosus	ENSSFOP00015000783	80.4	76
ENSG00000161547	homo_sapiens	ENSP00000353089	31.2217	30.3167	leptobrachium_leishanense	ENSLLEP00000016935	93.2432	90.5405
ENSG00000161547	homo_sapiens	ENSP00000353089	82.8054	75.5656	scophthalmus_maximus	ENSSMAP00000024086	77.8723	71.0638
ENSG00000161547	homo_sapiens	ENSP00000353089	82.3529	77.8281	scophthalmus_maximus	ENSSMAP00000009497	84.6512	80
ENSG00000161547	homo_sapiens	ENSP00000353089	88.6878	80.9955	oryzias_melastigma	ENSOMEP00000006521	83.7607	76.4957
ENSG00000161547	homo_sapiens	ENSP00000353089	80.543	75.5656	oryzias_melastigma	ENSOMEP00000031581	83.5681	78.4038

Go ID	Go term	No. evidence	Entries	Species	Category
GO:0000398	involved_in mRNA splicing, via spliceosome	1	IBA	Homo_sapiens(9606)	Process
GO:0003714	enables transcription corepressor activity	1	NAS	Homo_sapiens(9606)	Function
GO:0003723	enables RNA binding	2	HDA,IBA	Homo_sapiens(9606)	Function
GO:0005515	enables protein binding	1	IPI	Homo_sapiens(9606)	Function
GO:0005634	located_in nucleus	1	IDA	Homo_sapiens(9606)	Component
GO:0005654	located_in nucleoplasm	2	IDA,TAS	Homo_sapiens(9606)	Component
GO:0005829	located_in cytosol	1	IDA	Homo_sapiens(9606)	Component
GO:0006397	involved_in mRNA processing	1	TAS	Homo_sapiens(9606)	Process
GO:0008380	involved_in RNA splicing	1	TAS	Homo_sapiens(9606)	Process
GO:0016605	NOT located_in PML body	1	IDA	Homo_sapiens(9606)	Component
GO:0016607	is_active_in nuclear speck	3	IBA,IDA,TAS	Homo_sapiens(9606)	Component
GO:0045892	involved_in negative regulation of DNA-templated transcription	1	IEA	Homo_sapiens(9606)	Process