Ensembl ID ENSG00000161547 Gene ID 6427 Accession 10783
Gene Symbol SRSF2 Alias SC35;PR264;SC-35;SFRS2;SFRS2A;SRp30b Full Name serine and arginine rich splicing factor 2
Position 17 : 76734115 - 76737333 Length 3219 bases Strand Minus strand
Status Confidence Main interacting RNAsmRNARBP type Canonical_RBPs
Summary The protein encoded by this gene is a member of the serine/arginine (SR)-rich family of pre-mRNA splicing factors, which constitute part of the spliceosome. Each of these factors contains an RNA recognition motif (RRM) for binding RNA and an RS domain for binding other proteins. The RS domain is rich in serine and arginine residues and facilitates interaction between different SR splicing factors. In addition to being critical for mRNA splicing, the SR proteins have also been shown to be involved in mRNA export from the nucleus and in translation. Two transcript variants encoding the same protein and one non-coding transcript variant have been found for this gene. In addition, a pseudogene of this gene has been found on chromosome 11. [provided by RefSeq, Sep 2010]

ENSG00000161547 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000161547 SRSF2 0.36 2.52e-21 BRCA
ENSG00000161547 SRSF2 0.46 1.99e-13 COAD
ENSG00000161547 SRSF2 0.52 2.62e-20 LUSC
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000161547 SRSF2 AML 10862710
ENSG00000161547 SRSF2 cancer 18025108
ENSG00000161547 SRSF2 tumour 19718710
ENSG00000161547 SRSF2 tumour 20639906
ENSG00000161547 SRSF2 tumours 20659014
ENSG00000161547 SRSF2 tumor 21082031
ENSG00000161547 SRSF2 tumors 21764905
ENSG00000161547 SRSF2 acute myeloid leukemia (AML) 22431577
ENSG00000161547 SRSF2 AML 22722453
ENSG00000161547 SRSF2 tumor 22823977
ENSG00000161547 SRSF2 tumors 23071587
ENSG00000161547 SRSF2 tumors 23280334
ENSG00000161547 SRSF2 cancers 23300180
ENSG00000161547 SRSF2 lung tumors 23518498
ENSG00000161547 SRSF2 AML 23645565
ENSG00000161547 SRSF2 lung cancer 24428911
ENSG00000161547 SRSF2 AML 24989313
ENSG00000161547 SRSF2 bladder cancer 25188512
ENSG00000161547 SRSF2 AML 25220401
ENSG00000161547 SRSF2 tumor 25311867
ENSG00000161547 SRSF2 acute myeloid leukemia (AML) 25412851
ENSG00000161547 SRSF2 bladder cancer 25444900
ENSG00000161547 SRSF2 AML 25550361
ENSG00000161547 SRSF2 AML 25611784
ENSG00000161547 SRSF2 cervical tumor 25717103
ENSG00000161547 SRSF2 breast cancer 25913416
ENSG00000161547 SRSF2 AML 26115659
ENSG00000161547 SRSF2 breast cancer 26257065
ENSG00000161547 SRSF2 Wilms tumor 26315090
ENSG00000161547 SRSF2 tumors 26406946
ENSG00000161547 SRSF2 pancreatic cancer 26498691
ENSG00000161547 SRSF2 Mast Cell Tumors 26562302
ENSG00000161547 SRSF2 cancer 26728853
ENSG00000161547 SRSF2 cancer 26732650
ENSG00000161547 SRSF2 AML 26812887
ENSG00000161547 SRSF2 acute myeloid leukemia (AML) 26820131
ENSG00000161547 SRSF2 breast tumors 26930004
ENSG00000161547 SRSF2 cancer 27019673
ENSG00000161547 SRSF2 AML 27129146
ENSG00000161547 SRSF2 AMLs 27135740
ENSG00000161547 SRSF2 AML with recurrent genetic abnormalities 27137476
ENSG00000161547 SRSF2 AML 27144061
ENSG00000161547 SRSF2 AML 27486981
ENSG00000161547 SRSF2 cancer 27492256
ENSG00000161547 SRSF2 Renal Cancer 27690003
ENSG00000161547 SRSF2 tumor 27756662
ENSG00000161547 SRSF2 AML 27983727
ENSG00000161547 SRSF2 lung cancer 28034912
ENSG00000161547 SRSF2 primary cancer 28076841
ENSG00000161547 SRSF2 cancer 28082404
ENSG00000161547 SRSF2 AML 28152414
ENSG00000161547 SRSF2 AML 28220884
ENSG00000161547 SRSF2 tumors 28810145
ENSG00000161547 SRSF2 cancer 29254178
ENSG00000161547 SRSF2 tumor 29278882
ENSG00000161547 SRSF2 cancer 29283381
ENSG00000161547 SRSF2 renal cancer 29331391
ENSG00000161547 SRSF2 AML 29343972
ENSG00000161547 SRSF2 cancer 29457796
ENSG00000161547 SRSF2 breast cancer 29483847
ENSG00000161547 SRSF2 colorectal cancer 29641532
ENSG00000161547 SRSF2 tumor 29705980
ENSG00000161547 SRSF2 uveal tumors 29738114
ENSG00000161547 SRSF2 AML 29903761
ENSG00000161547 SRSF2 AML 30004607
ENSG00000161547 SRSF2 AML 30142822
ENSG00000161547 SRSF2 cancers 30295127
ENSG00000161547 SRSF2 ovarian cancer 30375398
ENSG00000161547 SRSF2 tumor 30463359
ENSG00000161547 SRSF2 AML 30635631
ENSG00000161547 SRSF2 tumors 30636104
ENSG00000161547 SRSF2 lung tumor 30674935
ENSG00000161547 SRSF2 AML 30704227
ENSG00000161547 SRSF2 Nasopharyngeal Cancer 30773530
ENSG00000161547 SRSF2 AML 30787430
ENSG00000161547 SRSF2 AML 30795628
ENSG00000161547 SRSF2 AMLs 30813354
ENSG00000161547 SRSF2 AML 30848074
ENSG00000161547 SRSF2 AML 31004016
ENSG00000161547 SRSF2 tumor 31024753
ENSG00000161547 SRSF2 cancer 31040692
ENSG00000161547 SRSF2 acute myeloid leukemia (AML) 31040863
ENSG00000161547 SRSF2 AML 31124578
ENSG00000161547 SRSF2 AML 31124956
ENSG00000161547 SRSF2 tumor 31162605
ENSG00000161547 SRSF2 AML 31334570
ENSG00000161547 SRSF2 tumor 31426461
ENSG00000161547 SRSF2 tumors 31634348
ENSG00000161547 SRSF2 cancer of the eye 31671564
ENSG00000161547 SRSF2 acute myeloid leukemia (AML) 31766606
ENSG00000161547 SRSF2 tumor 31838573
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
ENSG00000161547 SRSF2 chronic myelomonocytic leukemia missense_variant 40.88% (419/1025) 17 entries
ENSG00000161547 SRSF2 acute myeloid leukemia amino_acid_insertion 4.468% (234/5237) 4 entries
ENSG00000161547 SRSF2 chronic myelomonocytic leukemia sequence_alteration 40.88% (419/1025) 3 entries
ENSG00000161547 SRSF2 acute myeloid leukemia missense_variant 4.468% (234/5237) 12 entries
ENSG00000161547 SRSF2 acute myeloid leukemia conservative_inframe_deletion 4.468% (234/5237) 5 entries
ENSG00000161547 SRSF2 chronic myelomonocytic leukemia frameshift_variant 40.88% (419/1025) 1 entry
ENSG00000161547 SRSF2 myelodysplastic syndrome transcript_ablation 7.433% (236/3175) 1 entry
ENSG00000161547 SRSF2 acute myeloid leukemia sequence_alteration 4.468% (234/5237) 2 entries
ENSG00000161547 SRSF2 chronic myelomonocytic leukemia amino_acid_insertion 40.88% (419/1025) 4 entries
ENSG00000161547 SRSF2 chronic myelomonocytic leukemia conservative_inframe_deletion 40.88% (419/1025) 3 entries
ENSG00000161547 SRSF2 myelodysplastic syndrome frameshift_variant 7.433% (236/3175) 2 entries
ENSG00000161547 SRSF2 myelodysplastic syndrome conservative_inframe_deletion 7.433% (236/3175) 6 entries
ENSG00000161547 SRSF2 acute myeloid leukemia frameshift_variant 4.468% (234/5237) 2 entries
ENSG00000161547 SRSF2 myelodysplastic syndrome missense_variant 7.433% (236/3175) 18 entries
ENSG00000161547 SRSF2 chronic myelogenous leukemia missense_variant 24.49% (12/49) 5 entries
ENSG00000161547 SRSF2 myelodysplastic syndrome sequence_alteration 7.433% (236/3175) 4 entries
ENSG00000161547 SRSF2 Mast Cell Neoplasm missense_variant 20.95% (31/148) 2 entries
ENSG00000161547 SRSF2 chronic myelogenous leukemia conservative_inframe_deletion 24.49% (12/49) 1 entry
ENSG00000161547 SRSF2 skin melanoma missense_variant 0.6897% (8/1160) 2 entries
ENSG00000161547 SRSF2 colorectal adenocarcinoma missense_variant 0.4496% (7/1557) 1 entry
ENSG00000161547 SRSF2 marginal zone B-cell lymphoma missense_variant 6.25% (2/32) 1 entry
ENSG00000161547 SRSF2 prostate adenocarcinoma missense_variant 0.2475% (6/2424) 1 entry
ENSG00000161547 SRSF2 testicular seminoma missense_variant 2.564% (2/78) 2 entries
ENSG00000161547 SRSF2 acute lymphoblastic leukemia sequence_alteration 0.3384% (2/591) 1 entry
ENSG00000161547 SRSF2 colorectal adenocarcinoma conservative_inframe_deletion 0.4496% (7/1557) 1 entry
ENSG00000161547 SRSF2 Juvenile Myelomonocytic Leukemia missense_variant 1.198% (2/167) 1 entry
ENSG00000161547 SRSF2 esophageal adenocarcinoma sequence_alteration 0.5484% (3/547) 1 entry
ENSG00000161547 SRSF2 bladder transitional cell carcinoma missense_variant 0.8791% (4/455) 1 entry
ENSG00000161547 SRSF2 pancreatic neuroendocrine tumor missense_variant 1.271% (3/236) 1 entry
ENSG00000161547 SRSF2 Granulocytic Sarcoma missense_variant 8.0% (2/25) 1 entry
ENSG00000161547 SRSF2 breast ductal adenocarcinoma missense_variant 0.6266% (10/1596) 1 entry
ENSG00000161547 SRSF2 Myelodysplastic/Myeloproliferative Neoplasm missense_variant 11.59% (8/69) 6 entries
ENSG00000161547 SRSF2 myelodysplastic syndrome amino_acid_insertion 7.433% (236/3175) 1 entry
ENSG00000161547 SRSF2 B-cell acute lymphoblastic leukemia missense_variant 1.77% (2/113) 1 entry
ENSG00000161547 SRSF2 prostate adenocarcinoma sequence_alteration 0.2475% (6/2424) 1 entry
ENSG00000161547 SRSF2 colon adenocarcinoma frameshift_variant 0.4013% (5/1246) 2 entries
ENSG00000161547 SRSF2 breast ductal adenocarcinoma sequence_alteration 0.6266% (10/1596) 1 entry
ENSG00000161547 SRSF2 hepatocellular carcinoma missense_variant 0.1953% (2/1024) 1 entry
ENSG00000161547 SRSF2 polycythemia vera missense_variant 1.754% (2/114) 1 entry
ENSG00000161547 SRSF2 lung adenocarcinoma missense_variant 0.394% (10/2538) 2 entries
ENSG00000161547 SRSF2 squamous cell lung carcinoma missense_variant 0.8584% (8/932) 2 entries
ENSG00000161547 SRSF2 squamous cell lung carcinoma frameshift_variant 0.8584% (8/932) 1 entry
ENSG00000161547 SRSF2 rectal adenocarcinoma missense_variant 0.1832% (1/546) 1 entry
ENSG00000161547 SRSF2 Mixed Lobular and Ductal Breast Carcinoma missense_variant 1.587% (1/63) 1 entry
ENSG00000161547 SRSF2 Kidney Oncocytoma missense_variant 2.857% (1/35) 1 entry
ENSG00000161547 SRSF2 small cell lung carcinoma sequence_alteration 0.2268% (1/441) 1 entry
ENSG00000161547 SRSF2 pharyngeal squamous cell carcinoma missense_variant 1.235% (1/81) 1 entry
ENSG00000161547 SRSF2 HER2 Positive Breast Carcinoma stop_gained 0.8772% (1/114) 1 entry
ENSG00000161547 SRSF2 Uterine Carcinosarcoma missense_variant 0.6757% (1/148) 1 entry
ENSG00000161547 SRSF2 nasal cavity and paranasal sinus carcinoma missense_variant 4.348% (1/23) 1 entry
ENSG00000161547 SRSF2 diffuse large B-cell lymphoma conservative_inframe_deletion 0.4751% (2/421) 1 entry
ENSG00000161547 SRSF2 Brain Stem Glioblastoma sequence_alteration 1.786% (1/56) 1 entry
ENSG00000161547 SRSF2 metaplastic breast carcinoma missense_variant 1.042% (1/96) 1 entry
ENSG00000161547 SRSF2 urothelial carcinoma missense_variant 1.163% (1/86) 1 entry
ENSG00000161547 SRSF2 carcinoid tumor missense_variant 25.0% (1/4) 1 entry
ENSG00000161547 SRSF2 Splenic Diffuse Large B-Cell Lymphoma sequence_alteration 25.0% (1/4) 1 entry
ENSG00000161547 SRSF2 papillary renal cell carcinoma missense_variant 0.2725% (1/367) 1 entry
ENSG00000161547 SRSF2 colon adenocarcinoma conservative_inframe_deletion 0.4013% (5/1246) 1 entry
ENSG00000161547 SRSF2 neoplasm of mature B-cells missense_variant 1.562% (1/64) 1 entry
ENSG00000161547 SRSF2 Splenic Diffuse Large B-Cell Lymphoma conservative_inframe_deletion 25.0% (1/4) 1 entry
ENSG00000161547 SRSF2 diffuse large B-cell lymphoma missense_variant 0.4751% (2/421) 1 entry
ENSG00000161547 SRSF2 leiomyosarcoma frameshift_variant 1.0% (1/100) 1 entry
ENSG00000161547 SRSF2 basal cell carcinoma missense_variant 1.471% (1/68) 1 entry
ENSG00000161547 SRSF2 Anal Squamous Cell Carcinoma stop_gained 1.22% (1/82) 1 entry
ENSG00000161547 SRSF2 colon adenocarcinoma missense_variant 0.4013% (5/1246) 1 entry
ENSG00000161547 SRSF2 Chronic Neutrophilic Leukemia missense_variant 20.0% (1/5) 1 entry
ENSG00000161547 SRSF2 gastric adenocarcinoma missense_variant 0.1119% (1/894) 1 entry
ENSG00000161547 SRSF2 gastric intestinal type adenocarcinoma missense_variant 1.176% (1/85) 1 entry
ENSG00000161547 SRSF2 embryonal rhabdomyosarcoma sequence_alteration 1.163% (1/86) 1 entry
ENSG00000161547 SRSF2 anaplastic oligodendroglioma missense_variant 1.124% (1/89) 1 entry
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000161547 SRSF2 SARC 0.00022 high
ENSG00000161547 SRSF2 STAD 0.039 low
ENSG00000161547 SRSF2 UVM 0.00053 high
ENSG00000161547 SRSF2 UCEC 7e-04 high
ENSG00000161547 SRSF2 LUSC 0.013 low
ENSG00000161547 SRSF2 READ 0.011 low
ENSG00000161547 SRSF2 KIRP 0.0055 high
ENSG00000161547 SRSF2 KICH 0.0033 high
ENSG00000161547 SRSF2 PCPG 0.0011 high
ENSG00000161547 SRSF2 THYM 0.0045 low
ENSG00000161547 SRSF2 COAD 0.034 low
ENSG00000161547 SRSF2 UCS 0.032 low
ENSG00000161547 SRSF2 ESCA 0.0023 high
ENSG00000161547 SRSF2 OV 0.011 low
ENSG00000161547 SRSF2 PRAD 0.0065 high
ENSG00000161547 SRSF2 BLCA 0.00024 low
ENSG00000161547 SRSF2 LAML 0.025 low
ENSG00000161547 SRSF2 GBM 0.0075 low
ENSG00000161547 SRSF2 SKCM 0.0084 low
ENSG00000161547 SRSF2 CESC 0.0033 low
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000161547 SRSF2 LUAD Amp 2.226975 0.154086 0.392055 0.503876
ENSG00000161547 SRSF2 LGG Amp 2.613928 0.071324 0.565841 0.079922
ENSG00000161547 SRSF2 CESC Amp 1.796306 0.172054 0.608381 0.227119
ENSG00000161547 SRSF2 PAAD Del 3.747687 0.098262 0.356137 0.228261
ENSG00000161547 SRSF2 SKCM Amp 5.973099 0.266244 0.571806 0.343324
ENSG00000161547 SRSF2 LIHC Amp 8.142084 0.260572 0.662772 0.381081
ENSG00000161547 SRSF2 BLCA Amp 1.415603 0.190711 0.453351 0.468137
ENSG00000161547 SRSF2 PRAD Amp 0.840292 0.047803 0.486165 0.046748
ENSG00000161547 SRSF2 OV Amp 1.059206 0.341892 0.531066 0.336788