Functions and Diseases

RBP Type Non-canonical_RBPs
Diseases CancerSARS-COV-2
Drug N.A.
Main interacting RNAs N.A.
Moonlighting functions E3 ligase
Localizations Stress granucle
BulkPerturb-seq N.A.

Description

Ensembl ID ENSG00000161011 Gene ID 8878 Accession 11280
Symbol SQSTM1 Alias p60;p62;A170;DMRV;OSIL;PDB3;ZIP3;p62B;NADGP;FTDALS3 Full Name sequestosome 1
Status Confidence Length 31671 bases Strand Plus strand
Position 5 : 179806408 - 179838078 RNA binding domain N.A.
Summary This gene encodes a multifunctional protein that binds ubiquitin and regulates activation of the nuclear factor kappa-B (NF-kB) signaling pathway. The protein functions as a scaffolding/adaptor protein in concert with TNF receptor-associated factor 6 to mediate activation of NF-kB in response to upstream signals. Alternatively spliced transcript variants encoding either the same or different isoforms have been identified for this gene. Mutations in this gene result in sporadic and familial Paget disease of bone. [provided by RefSeq, Mar 2009]

RNA binding domains (RBDs)

Protein Domain Pfam ID E-value Domain number

RNA binding proteomes (RBPomes)

Pubmed ID Full Name Cell Author Time Doi

Literatures on RNA binding capacity

Pubmed ID Title Author Time Journal
31006338 Vault RNA emerges as a regulator of selective autophagy. Rastislav Horos 2019-08-01 Autophagy
31097692 Impaired autophagic degradation of lncRNA ARHGAP5-AS1 promotes chemoresistance in gastric cancer. Liyuan Zhu 2019-05-16 Cell death & disease
33662035 The CDT of Helicobacter hepaticus induces pro-survival autophagy and nucleoplasmic reticulum formation concentrating the RNA binding proteins UNR/CSDE1 and P62/SQSTM1. Wencan He 2021-03-01 PLoS pathogens
31753861 Autophagy and cancer: Modulation of cell death pathways and cancer cell adaptations. G Christina Towers 2020-01-06 The Journal of cell biology
22174682 IRGM is a common target of RNA viruses that subvert the autophagy network. Pombo Isabel Grégoire 2011-12-01 PLoS pathogens
23922739 Autophagy activation clears ELAVL1/HuR-mediated accumulation of SQSTM1/p62 during proteasomal inhibition in human retinal pigment epithelial cells. Johanna Viiri 2013-01-01 PloS one
30979586 ULK1 and ULK2 Regulate Stress Granule Disassembly Through Phosphorylation and Activation of VCP/p97. Bo Wang 2019-05-16 Molecular cell
35545049 The lactate-NAD+ axis activates cancer-associated fibroblasts by downregulating p62. F Juan Linares 2022-05-10 Cell reports

Transcripts

Name Transcript ID bp Protein Translation ID
SQSTM1-210 ENST00000506042 921 No protein -
SQSTM1-215 ENST00000514093 842 167aa ENSP00000427308
SQSTM1-211 ENST00000506690 2405 No protein -
SQSTM1-214 ENST00000512234 1722 No protein -
SQSTM1-203 ENST00000422245 628 140aa ENSP00000394534
SQSTM1-207 ENST00000481335 562 No protein -
SQSTM1-205 ENST00000464493 532 No protein -
SQSTM1-212 ENST00000508284 578 69aa ENSP00000424195
SQSTM1-216 ENST00000626660 274 73aa ENSP00000487071
SQSTM1-204 ENST00000453046 572 73aa ENSP00000405061
SQSTM1-209 ENST00000504627 602 190aa ENSP00000425957
SQSTM1-202 ENST00000389805 2840 440aa ENSP00000374455
SQSTM1-213 ENST00000510187 1714 378aa ENSP00000424477
SQSTM1-201 ENST00000360718 2253 356aa ENSP00000353944
SQSTM1-208 ENST00000485412 656 No protein -
SQSTM1-206 ENST00000466342 808 No protein -

Gene Model

Pathways

Pathway ID Pathway Name Source

Phenotypes

ensgID Trait pValue Pubmed ID
14766Hemoglobin A, Glycosylated6.0230000E-00519875614
52289Child Development Disorders, Pervasive7.3000000E-005-
73878Alzheimer Disease7E-724162737

GWAS

ensgIDSNPChromosomePosition TraitPubmedIDOr or BEAT EFO ID

Protein-Protein Interaction (PPI)

Paralogs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id
ENSG00000161011homo_sapiensENSP00000491834100100homo_sapiensENSP00000374455100100

Orthologs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id
ENSG00000161011homo_sapiensENSP0000037445544.318243.8636nomascus_leucogenysENSNLEP0000000215298.984897.9695
ENSG00000161011homo_sapiensENSP0000037445599.772799.7727pan_paniscusENSPPAP0000002224699.772799.7727
ENSG00000161011homo_sapiensENSP0000037445599.090998.1818pongo_abeliiENSPPYP0000003406599.090998.1818
ENSG00000161011homo_sapiensENSP0000037445599.772799.7727pan_troglodytesENSPTRP0000004779099.772799.7727
ENSG00000161011homo_sapiensENSP0000037445599.772799.3182gorilla_gorillaENSGGOP0000002018299.772799.3182
ENSG00000161011homo_sapiensENSP0000037445578.636467.5ornithorhynchus_anatinusENSOANP0000002338675.381364.7059
ENSG00000161011homo_sapiensENSP0000037445568.863658.8636sarcophilus_harrisiiENSSHAP0000002803673.01262.4096
ENSG00000161011homo_sapiensENSP0000037445556.363648.4091notamacropus_eugeniiENSMEUP0000001140772.09361.9186
ENSG00000161011homo_sapiensENSP0000037445537.045534.0909choloepus_hoffmanniENSCHOP0000001006648.36844.5104
ENSG00000161011homo_sapiensENSP0000037445593.636489.5455dasypus_novemcinctusENSDNOP0000002737893.212789.1403
ENSG00000161011homo_sapiensENSP0000037445577.045573.1818erinaceus_europaeusENSEEUP0000001453290.884786.3271
ENSG00000161011homo_sapiensENSP0000037445559.772751.8182echinops_telfairiENSETEP0000001597179.216968.6747
ENSG00000161011homo_sapiensENSP0000037445575.227369.7727echinops_telfairiENSETEP0000000441289.701983.1978
ENSG00000161011homo_sapiensENSP0000037445597.596.1364callithrix_jacchusENSCJAP0000001868597.722196.3554
ENSG00000161011homo_sapiensENSP0000037445598.863697.7273cercocebus_atysENSCATP0000002126098.863697.7273
ENSG00000161011homo_sapiensENSP0000037445598.863697.7273macaca_fascicularisENSMFAP0000005224693.347692.2747
ENSG00000161011homo_sapiensENSP0000037445598.636497.5macaca_mulattaENSMMUP0000003359898.636497.5
ENSG00000161011homo_sapiensENSP0000037445599.090997.9545macaca_nemestrinaENSMNEP0000000479299.090997.9545
ENSG00000161011homo_sapiensENSP0000037445574.090973.1818papio_anubisENSPANP0000000873999.390298.1707
ENSG00000161011homo_sapiensENSP0000037445583.863682.7273mandrillus_leucophaeusENSMLEP0000002669098.663197.3262
ENSG00000161011homo_sapiensENSP0000037445594.772792.2727tursiops_truncatusENSTTRP0000000417294.772792.2727
ENSG00000161011homo_sapiensENSP0000037445588.409184.0909vulpes_vulpesENSVVUP0000000203187.612683.3333
ENSG00000161011homo_sapiensENSP000003744559591.1364mus_spretusMGP_SPRETEiJ_P002779094.570190.724
ENSG00000161011homo_sapiensENSP0000037445595.909193.4091equus_asinusENSEASP0000501835195.909193.4091
ENSG00000161011homo_sapiensENSP0000037445594.545593.4091capra_hircusENSCHIP0000002670494.545593.4091
ENSG00000161011homo_sapiensENSP0000037445587.045583.8636loxodonta_africanaENSLAFP0000002715186.067482.9213
ENSG00000161011homo_sapiensENSP0000037445594.772792.5panthera_leoENSPLOP0000000264479.277677.3764
ENSG00000161011homo_sapiensENSP0000037445584.772781.1364ailuropoda_melanoleucaENSAMEP0000003499475.967472.7088
ENSG00000161011homo_sapiensENSP000003744558583.1818bos_indicus_hybridENSBIXP0000500088970.699469.1871
ENSG00000161011homo_sapiensENSP0000037445595.227392.7273oryctolagus_cuniculusENSOCUP0000001326380.88878.7645
ENSG00000161011homo_sapiensENSP0000037445595.681893.1818equus_caballusENSECAP0000001850278.398576.3501
ENSG00000161011homo_sapiensENSP0000037445592.954590.2273canis_lupus_familiarisENSCAFP0084501041888.336985.7451
ENSG00000161011homo_sapiensENSP0000037445594.772792.5panthera_pardusENSPPRP0000001117993.707991.4607
ENSG00000161011homo_sapiensENSP0000037445595.909192.7273marmota_marmota_marmotaENSMMMP0000001174595.909192.7273
ENSG00000161011homo_sapiensENSP0000037445594.772792.5balaenoptera_musculusENSBMSP0001001138094.772792.5
ENSG00000161011homo_sapiensENSP0000037445577.272772.2727cavia_porcellusENSCPOP0000002353781.927776.6265
ENSG00000161011homo_sapiensENSP0000037445594.545592.2727felis_catusENSFCAP0000001363793.905291.6479
ENSG00000161011homo_sapiensENSP0000037445584.772780.9091ursus_americanusENSUAMP0000003593375.967472.5051
ENSG00000161011homo_sapiensENSP0000037445576.590965.9091monodelphis_domesticaENSMODP0000004695375.900965.3153
ENSG00000161011homo_sapiensENSP0000037445575.227374.0909bison_bison_bisonENSBBBP0000000446692.977591.573
ENSG00000161011homo_sapiensENSP000003744559592.5monodon_monocerosENSMMNP000150037349592.5
ENSG00000161011homo_sapiensENSP0000037445595.454592.9545sus_scrofaENSSSCP0000005698595.454592.9545
ENSG00000161011homo_sapiensENSP0000037445595.454592.7273microcebus_murinusENSMICP0000000597695.454592.7273
ENSG00000161011homo_sapiensENSP0000037445587.727381.8182octodon_degusENSODEP0000001007987.330381.448
ENSG00000161011homo_sapiensENSP0000037445578.409173.8636jaculus_jaculusENSJJAP0000001567887.563582.4873
ENSG00000161011homo_sapiensENSP0000037445594.545590.6818jaculus_jaculusENSJJAP0000000771594.545590.6818
ENSG00000161011homo_sapiensENSP0000037445575.909170.6818jaculus_jaculusENSJJAP0000001119984.987379.1349
ENSG00000161011homo_sapiensENSP0000037445593.409192.2727ovis_aries_rambouilletENSOARP0002001817593.835692.6941
ENSG00000161011homo_sapiensENSP0000037445552.045546.3636ursus_maritimusENSUMAP0000003363358.567852.1739
ENSG00000161011homo_sapiensENSP0000037445562.045557.7273ochotona_princepsENSOPRP0000001419862.903258.5253
ENSG00000161011homo_sapiensENSP000003744559592.5delphinapterus_leucasENSDLEP000000234039592.5
ENSG00000161011homo_sapiensENSP0000037445594.545592.2727physeter_catodonENSPCTP0000500170594.545592.2727
ENSG00000161011homo_sapiensENSP0000037445594.545591.1364mus_caroliMGP_CAROLIEiJ_P002642494.117690.724
ENSG00000161011homo_sapiensENSP0000037445594.772791.1364mus_musculusENSMUSP0000009983594.343990.724
ENSG00000161011homo_sapiensENSP000003744558580.2273dipodomys_ordiiENSDORP0000001397286.374181.5242
ENSG00000161011homo_sapiensENSP0000037445577.954575.2273mustela_putorius_furoENSMPUP0000000064792.452889.2183
ENSG00000161011homo_sapiensENSP0000037445598.636496.5909aotus_nancymaaeENSANAP0000003766798.636496.5909
ENSG00000161011homo_sapiensENSP0000037445597.595.6818saimiri_boliviensis_boliviensisENSSBOP0000001515797.722195.8998
ENSG00000161011homo_sapiensENSP0000037445541.590940.4545vicugna_pacosENSVPAP0000000727664.893663.1206
ENSG00000161011homo_sapiensENSP0000037445598.409196.5909chlorocebus_sabaeusENSCSAP0000000459498.409196.5909
ENSG00000161011homo_sapiensENSP0000037445595.909192.2727mesocricetus_auratusENSMAUP0000001468395.475191.8552
ENSG00000161011homo_sapiensENSP0000037445594.772792.2727phocoena_sinusENSPSNP0000001250594.772792.2727
ENSG00000161011homo_sapiensENSP0000037445595.227393.4091camelus_dromedariusENSCDRP0000500772595.227393.4091
ENSG00000161011homo_sapiensENSP0000037445576.136473.1818carlito_syrichtaENSTSYP0000001372090.540587.027
ENSG00000161011homo_sapiensENSP0000037445576.136473.8636panthera_tigris_altaicaENSPTIP0000002569294.366291.5493
ENSG00000161011homo_sapiensENSP0000037445594.545591.3636rattus_norvegicusENSRNOP0000005602194.760891.5718
ENSG00000161011homo_sapiensENSP0000037445595.454593.4091prolemur_simusENSPSMP0000001573395.67293.6219
ENSG00000161011homo_sapiensENSP000003744559591.8182peromyscus_maniculatus_bairdiiENSPEMP0000002171994.570191.4027
ENSG00000161011homo_sapiensENSP000003744557573.8636bos_mutusENSBMUP0000001971692.696691.2921
ENSG00000161011homo_sapiensENSP000003744559591.1364mus_spicilegusENSMSIP0000001095293.72289.9103
ENSG00000161011homo_sapiensENSP0000037445595.909192.0455cricetulus_griseus_chok1gshdENSCGRP0000100725995.475191.629
ENSG00000161011homo_sapiensENSP0000037445583.863680.6818pteropus_vampyrusENSPVAP0000001461583.673580.4989
ENSG00000161011homo_sapiensENSP0000037445578.636475myotis_lucifugusENSMLUP0000000114793.261588.9488
ENSG00000161011homo_sapiensENSP0000037445577.567.0455vombatus_ursinusENSVURP0001002567976.629266.2921
ENSG00000161011homo_sapiensENSP0000037445594.772792.2727rhinolophus_ferrumequinumENSRFEP0001003219694.343991.8552
ENSG00000161011homo_sapiensENSP0000037445574.318271.5909neovison_visonENSNVIP0000001256092.634689.2351
ENSG00000161011homo_sapiensENSP0000037445581.136477.7273bos_taurusENSBTAP0000005926468.2665.392
ENSG00000161011homo_sapiensENSP0000037445582.578.4091heterocephalus_glaber_femaleENSHGLP0000005626171.316367.78
ENSG00000161011homo_sapiensENSP0000037445597.727396.3636rhinopithecus_bietiENSRBIP0000003334395.343794.0133
ENSG00000161011homo_sapiensENSP0000037445592.954590.2273canis_lupus_dingoENSCAFP0002000311092.325189.6162
ENSG00000161011homo_sapiensENSP0000037445596.590993.6364sciurus_vulgarisENSSVLP0000500578596.590993.6364
ENSG00000161011homo_sapiensENSP0000037445577.272766.3636phascolarctos_cinereusENSPCIP0000000475961.371852.7076
ENSG00000161011homo_sapiensENSP0000037445594.318292.0455procavia_capensisENSPCAP0000000227194.748992.4658
ENSG00000161011homo_sapiensENSP0000037445594.545591.1364nannospalax_galiliENSNGAP0000000012994.545591.1364
ENSG00000161011homo_sapiensENSP0000037445584.772782.9545bos_grunniensENSBGRP0000000748870.510468.9981
ENSG00000161011homo_sapiensENSP0000037445583.636478.8636chinchilla_lanigeraENSCLAP0000002171674.343470.101
ENSG00000161011homo_sapiensENSP0000037445594.545592.2727cervus_hanglu_yarkandensisENSCHYP0000003698594.545592.2727
ENSG00000161011homo_sapiensENSP0000037445595.454592.5catagonus_wagneriENSCWAP0000000027495.454592.5
ENSG00000161011homo_sapiensENSP0000037445596.363693.4091ictidomys_tridecemlineatusENSSTOP0000003245896.363693.4091
ENSG00000161011homo_sapiensENSP0000037445595.454593.1818otolemur_garnettiiENSOGAP0000000192494.170491.9283
ENSG00000161011homo_sapiensENSP0000037445597.596.3636cebus_imitatorENSCCAP0000003233697.722196.5831
ENSG00000161011homo_sapiensENSP0000037445596.136492.9545urocitellus_parryiiENSUPAP0001001628296.136492.9545
ENSG00000161011homo_sapiensENSP0000037445594.545592.5moschus_moschiferusENSMMSP0000001991994.545592.5
ENSG00000161011homo_sapiensENSP0000037445597.727396.3636rhinopithecus_roxellanaENSRROP0000002467795.343794.0133
ENSG00000161011homo_sapiensENSP0000037445594.772790.9091mus_pahariMGP_PahariEiJ_P003320094.343990.4977
ENSG00000161011homo_sapiensENSP0000037445593.181889.5455propithecus_coquereliENSPCOP0000001526993.181889.5455
ENSG00000161011homo_sapiensENSP0000037445518.409111.1364caenorhabditis_elegansY40C5A.1.133.471120.2479
ENSG00000161011homo_sapiensENSP0000037445531.363619.5455caenorhabditis_elegansC06G3.6.227.710817.2691
ENSG00000161011homo_sapiensENSP000003744554020.6818caenorhabditis_elegansT12G3.1a.125.396813.1313
ENSG00000161011homo_sapiensENSP0000037445513.63648.63636caenorhabditis_elegansY32B12A.1.133.898321.4689
ENSG00000161011homo_sapiensENSP0000037445515.454510.2273caenorhabditis_elegansT26H2.5.129.694319.6507
ENSG00000161011homo_sapiensENSP0000037445542.045524.3182drosophila_melanogasterFBpp009968330.884817.8631
ENSG00000161011homo_sapiensENSP0000037445520.227312.0455ciona_intestinalisENSCINP0000003389947.849528.4946
ENSG00000161011homo_sapiensENSP0000037445534.090924.3182ciona_intestinalisENSCINP0000002399145.592732.5228
ENSG00000161011homo_sapiensENSP0000037445522.954514.0909ciona_intestinalisENSCINP0000000256545.089327.6786
ENSG00000161011homo_sapiensENSP0000037445546.818234.7727petromyzon_marinusENSPMAP0000000365645.374533.7004
ENSG00000161011homo_sapiensENSP0000037445556.590944.3182callorhinchus_miliiENSCMIP0000001365457.110144.7248
ENSG00000161011homo_sapiensENSP0000037445563.181847.2727latimeria_chalumnaeENSLACP0000001383163.038547.1655
ENSG00000161011homo_sapiensENSP0000037445560.227346.1364lepisosteus_oculatusENSLOCP0000001408260.227346.1364
ENSG00000161011homo_sapiensENSP0000037445560.454547.5clupea_harengusENSCHAP0000004512757.826145.4348
ENSG00000161011homo_sapiensENSP0000037445560.909147.0455danio_rerioENSDARP0000011711359.29245.7965
ENSG00000161011homo_sapiensENSP0000037445558.636444.3182carassius_auratusENSCARP0000010182750.292438.0117
ENSG00000161011homo_sapiensENSP0000037445561.363647.5carassius_auratusENSCARP0000000445259.210545.8333
ENSG00000161011homo_sapiensENSP0000037445559.090945.9091astyanax_mexicanusENSAMXP0000001183660.889947.3068
ENSG00000161011homo_sapiensENSP0000037445560.681847.9545ictalurus_punctatusENSIPUP0000001922658.043545.8696
ENSG00000161011homo_sapiensENSP0000037445559.318245.9091esox_luciusENSELUP0000002266455.296642.7966
ENSG00000161011homo_sapiensENSP0000037445559.090947.7273electrophorus_electricusENSEEEP0000005066057.017546.0526
ENSG00000161011homo_sapiensENSP0000037445559.090945.9091oncorhynchus_kisutchENSOKIP0000501200155.437143.0704
ENSG00000161011homo_sapiensENSP0000037445558.409145.4545oncorhynchus_kisutchENSOKIP0000508776655.387943.1034
ENSG00000161011homo_sapiensENSP0000037445558.863645.6818oncorhynchus_mykissENSOMYP0000009905155.223942.8571
ENSG00000161011homo_sapiensENSP0000037445549.090937.7273oncorhynchus_mykissENSOMYP0000011158744.536134.2268
ENSG00000161011homo_sapiensENSP0000037445558.181845salmo_salarENSSSAP0000010484954.122641.8605
ENSG00000161011homo_sapiensENSP0000037445558.636445.4545salmo_salarENSSSAP0000009736856.08743.4783
ENSG00000161011homo_sapiensENSP0000037445558.181844.7727salmo_truttaENSSTUP0000008904455.291642.5486
ENSG00000161011homo_sapiensENSP0000037445558.863645.4545salmo_truttaENSSTUP0000006252155.223942.6439
ENSG00000161011homo_sapiensENSP0000037445558.409146.8182gadus_morhuaENSGMOP0000002560057.623346.1883
ENSG00000161011homo_sapiensENSP0000037445559.545548.1818fundulus_heteroclitusENSFHEP0000000904558.222247.1111
ENSG00000161011homo_sapiensENSP0000037445558.863647.2727poecilia_reticulataENSPREP0000001673351.841.6
ENSG00000161011homo_sapiensENSP0000037445557.045545.9091oryzias_latipesENSORLP0000002548357.568846.3303
ENSG00000161011homo_sapiensENSP0000037445557.727344.5455cyclopterus_lumpusENSCLMP0000500768060.765546.89
ENSG00000161011homo_sapiensENSP0000037445558.863646.5909oreochromis_niloticusENSONIP0000000012659.403747.0183
ENSG00000161011homo_sapiensENSP0000037445558.863646.5909haplochromis_burtoniENSHBUP0000001574560.798148.1221
ENSG00000161011homo_sapiensENSP0000037445559.090946.8182astatotilapia_callipteraENSACLP0000002764860.747748.1308
ENSG00000161011homo_sapiensENSP0000037445542.727331.8182lates_calcariferENSLCAP0001000092355.13241.0557
ENSG00000161011homo_sapiensENSP0000037445569.772755.9091xenopus_tropicalisENSXETP0000003472067.324653.9474
ENSG00000161011homo_sapiensENSP0000037445570.909159.3182chrysemys_picta_belliiENSCPBP0000001273369.026657.7434
ENSG00000161011homo_sapiensENSP0000037445571.590960sphenodon_punctatusENSSPUP0000001611666.596255.814
ENSG00000161011homo_sapiensENSP0000037445549.318237.7273crocodylus_porosusENSCPRP0000501685460.614546.3687
ENSG00000161011homo_sapiensENSP0000037445567.045555.9091laticauda_laticaudataENSLLTP0000001839958.300448.6166
ENSG00000161011homo_sapiensENSP0000037445567.045555.9091notechis_scutatusENSNSUP0000000008765.555654.6667
ENSG00000161011homo_sapiensENSP0000037445567.045555.6818pseudonaja_textilisENSPTXP0000001950865.555654.4444
ENSG00000161011homo_sapiensENSP0000037445572.272760.6818gallus_gallusENSGALP0001002377170.198758.9404
ENSG00000161011homo_sapiensENSP0000037445560.681850.6818meleagris_gallopavoENSMGAP0000000726770.634958.9947
ENSG00000161011homo_sapiensENSP0000037445571.136459.5455serinus_canariaENSSCAP0000001576969.094957.8366
ENSG00000161011homo_sapiensENSP0000037445571.818260.4545parus_majorENSPMJP0000001038452.754644.4073
ENSG00000161011homo_sapiensENSP0000037445558.636446.5909anolis_carolinensisENSACAP0000002125463.235350.2451
ENSG00000161011homo_sapiensENSP0000037445559.090946.5909neolamprologus_brichardiENSNBRP0000000128660.747747.8972
ENSG00000161011homo_sapiensENSP0000037445566.136455naja_najaENSNNAP0000002290164.096953.304
ENSG00000161011homo_sapiensENSP0000037445568.409157.2727podarcis_muralisENSPMRP0000000945167.187556.25
ENSG00000161011homo_sapiensENSP000003744556050.6818geospiza_fortisENSGFOP0000000001170.212859.3085
ENSG00000161011homo_sapiensENSP0000037445571.590960taeniopygia_guttataENSTGUP0000001417769.536458.2781
ENSG00000161011homo_sapiensENSP0000037445561.136448.1818erpetoichthys_calabaricusENSECRP0000001500063.593450.1182
ENSG00000161011homo_sapiensENSP0000037445558.636446.3636kryptolebias_marmoratusENSKMAP000000244096047.4419
ENSG00000161011homo_sapiensENSP0000037445568.409155.9091salvator_merianaeENSSMRP0000002215566.008853.9474
ENSG00000161011homo_sapiensENSP0000037445557.272745.4545oryzias_javanicusENSOJAP0000000356061.313948.6618
ENSG00000161011homo_sapiensENSP0000037445560.454547.5amphilophus_citrinellusENSACIP0000001262660.869647.8261
ENSG00000161011homo_sapiensENSP0000037445559.090946.1364dicentrarchus_labraxENSDLAP0000507923060.889947.541
ENSG00000161011homo_sapiensENSP0000037445539.772731.3636amphiprion_perculaENSAPEP0000000743259.32246.7797
ENSG00000161011homo_sapiensENSP0000037445516.590912.0455amphiprion_perculaENSAPEP0000000738964.601846.9027
ENSG00000161011homo_sapiensENSP0000037445567.727356.1364pelodiscus_sinensisENSPSIP0000001071468.192256.5217
ENSG00000161011homo_sapiensENSP0000037445571.363659.3182gopherus_evgoodeiENSGEVP0000500619468.70957.1116
ENSG00000161011homo_sapiensENSP0000037445571.590959.5455chelonoidis_abingdoniiENSCABP0000001787468.927857.3304
ENSG00000161011homo_sapiensENSP0000037445559.545546.5909seriola_dumeriliENSSDUP0000002235763.438349.6368
ENSG00000161011homo_sapiensENSP0000037445534.090926.8182cottoperca_gobioENSCGOP0000004836366.666752.4444
ENSG00000161011homo_sapiensENSP0000037445565.227355.2273struthio_camelus_australisENSSCUP0000000390772.110561.0553
ENSG00000161011homo_sapiensENSP0000037445572.045562.0455anser_brachyrhynchusENSABRP0000002151474.065463.785
ENSG00000161011homo_sapiensENSP0000037445558.636445.2273gasterosteus_aculeatusENSGACP0000002146861.282747.2684
ENSG00000161011homo_sapiensENSP0000037445554.318244.0909cynoglossus_semilaevisENSCSEP0000000839555.971945.4333
ENSG00000161011homo_sapiensENSP0000037445558.863647.5poecilia_formosaENSPFOP0000001721155.939545.1404
ENSG00000161011homo_sapiensENSP000003744556048.4091myripristis_murdjanENSMMDP0000503199354.209443.7372
ENSG00000161011homo_sapiensENSP0000037445558.636445.4545sander_luciopercaENSSLUP0000005044460.563446.9484
ENSG00000161011homo_sapiensENSP0000037445572.560.4545strigops_habroptilaENSSHBP0000500967870.575258.8496
ENSG00000161011homo_sapiensENSP0000037445559.545546.8182amphiprion_ocellarisENSAOCP0000003067461.938548.6998
ENSG00000161011homo_sapiensENSP0000037445570.909158.8636terrapene_carolina_triunguisENSTMTP0000003034368.874257.1744
ENSG00000161011homo_sapiensENSP0000037445558.181844.7727hucho_huchoENSHHUP0000002667054.935642.2747
ENSG00000161011homo_sapiensENSP0000037445559.318246.1364hucho_huchoENSHHUP0000000122957.615944.8124
ENSG00000161011homo_sapiensENSP0000037445556.818246.5909betta_splendensENSBSLP0000001685657.077646.8037
ENSG00000161011homo_sapiensENSP0000037445561.363648.6364pygocentrus_nattereriENSPNAP0000003192157.939945.9227
ENSG00000161011homo_sapiensENSP0000037445559.318248.1818anabas_testudineusENSATEP0000002809962.891651.0843
ENSG00000161011homo_sapiensENSP0000037445535.681822.9545ciona_savignyiENSCSAVP0000000850848.159530.9816
ENSG00000161011homo_sapiensENSP0000037445559.545546.3636seriola_lalandi_dorsalisENSSLDP0000002174260.788947.3318
ENSG00000161011homo_sapiensENSP0000037445517.272711.3636labrus_bergyltaENSLBEP0000003267370.370446.2963
ENSG00000161011homo_sapiensENSP0000037445538.409129.7727labrus_bergyltaENSLBEP0000003266162.132448.1618
ENSG00000161011homo_sapiensENSP0000037445559.090946.8182pundamilia_nyerereiENSPNYP0000000001060.747748.1308
ENSG00000161011homo_sapiensENSP0000037445558.409146.1364mastacembelus_armatusENSMAMP0000005028660.613247.8774
ENSG00000161011homo_sapiensENSP0000037445560.681848.1818stegastes_partitusENSSPAP0000002555664.337351.0843
ENSG00000161011homo_sapiensENSP0000037445554.318241.5909oncorhynchus_tshawytschaENSOTSP0000509485750.959539.0192
ENSG00000161011homo_sapiensENSP0000037445558.181845.4545oncorhynchus_tshawytschaENSOTSP0000509860656.387744.0529
ENSG00000161011homo_sapiensENSP0000037445557.954545.2273acanthochromis_polyacanthusENSAPOP0000001627362.653648.8943
ENSG00000161011homo_sapiensENSP0000037445573.409161.5909aquila_chrysaetos_chrysaetosENSACCP0002002184171.302459.8234
ENSG00000161011homo_sapiensENSP0000037445557.272746.1364nothobranchius_furzeriENSNFUP0001500501659.574547.9905
ENSG00000161011homo_sapiensENSP0000037445559.318247.7273cyprinodon_variegatusENSCVAP000000222016048.2759
ENSG00000161011homo_sapiensENSP0000037445561.590947.5denticeps_clupeoidesENSDCDP0000001910856.34143.4511
ENSG00000161011homo_sapiensENSP0000037445558.181846.1364larimichthys_croceaENSLCRP0000500930251.097840.519
ENSG00000161011homo_sapiensENSP0000037445557.727346.3636takifugu_rubripesENSTRUP0000008139555.458544.5415
ENSG00000161011homo_sapiensENSP0000037445567.045556.5909ficedula_albicollisENSFALP0000001653062.632752.8662
ENSG00000161011homo_sapiensENSP0000037445553.863642.9545hippocampus_comesENSHCOP0000001079358.23146.4373
ENSG00000161011homo_sapiensENSP0000037445558.636443.8636cyprinus_carpio_carpioENSCCRP0000001801253.862240.2923
ENSG00000161011homo_sapiensENSP0000037445560.909146.8182cyprinus_carpio_carpioENSCCRP0000012165158.008744.5887
ENSG00000161011homo_sapiensENSP0000037445568.863659.3182coturnix_japonicaENSCJPP0000500569068.397358.9165
ENSG00000161011homo_sapiensENSP0000037445544.318231.8182sinocyclocheilus_grahamiENSSGRP0000000497661.128543.8871
ENSG00000161011homo_sapiensENSP0000037445514.090910.4545sinocyclocheilus_grahamiENSSGRP0000000497268.888951.1111
ENSG00000161011homo_sapiensENSP0000037445514.090910.4545sinocyclocheilus_grahamiENSSGRP0000008624468.888951.1111
ENSG00000161011homo_sapiensENSP0000037445560.909146.5909sinocyclocheilus_grahamiENSSGRP0000001532256.302543.0672
ENSG00000161011homo_sapiensENSP0000037445559.090946.8182maylandia_zebraENSMZEP0000502959960.747748.1308
ENSG00000161011homo_sapiensENSP0000037445555.227345.6818tetraodon_nigroviridisENSTNIP0000000560657.719747.7435
ENSG00000161011homo_sapiensENSP0000037445558.409145paramormyrops_kingsleyaeENSPKIP0000003679061.045147.0309
ENSG00000161011homo_sapiensENSP0000037445559.545547.0455scleropages_formosusENSSFOP0001500434659.410446.9388
ENSG00000161011homo_sapiensENSP0000037445568.636455leptobrachium_leishanenseENSLLEP0000003106452.430642.0139
ENSG00000161011homo_sapiensENSP0000037445562.272749.5455leptobrachium_leishanenseENSLLEP0000002967565.550252.1531
ENSG00000161011homo_sapiensENSP0000037445556.590946.3636scophthalmus_maximusENSSMAP0000004607561.3350.2463
ENSG00000161011homo_sapiensENSP0000037445558.181846.5909oryzias_melastigmaENSOMEP0000000666357.918646.3801

Gene Ontology

Go ID Go term No. evidence Entries Species Category
GO:0000122involved_in negative regulation of transcription by RNA polymerase II1IEAHomo_sapiens(9606)Process
GO:0000407located_in phagophore assembly site1IEAHomo_sapiens(9606)Component
GO:0000422involved_in autophagy of mitochondrion1NASHomo_sapiens(9606)Process
GO:0000423involved_in mitophagy2IBA,IGIHomo_sapiens(9606)Process
GO:0000425involved_in pexophagy1IDAHomo_sapiens(9606)Process
GO:0000932located_in P-body1IDAHomo_sapiens(9606)Component
GO:0001659involved_in temperature homeostasis1IEAHomo_sapiens(9606)Process
GO:0001934involved_in positive regulation of protein phosphorylation1IEAHomo_sapiens(9606)Process
GO:0002376involved_in immune system process1IEAHomo_sapiens(9606)Process
GO:0002931involved_in response to ischemia1IEAHomo_sapiens(9606)Process
GO:0004674enables protein serine/threonine kinase activity1NASHomo_sapiens(9606)Function
GO:0005080enables protein kinase C binding2IBA,IPIHomo_sapiens(9606)Function
GO:0005515enables protein binding1IPIHomo_sapiens(9606)Function
GO:0005654located_in nucleoplasm1TASHomo_sapiens(9606)Component
GO:0005737located_in cytoplasm1IDAHomo_sapiens(9606)Component
GO:0005739located_in mitochondrion1IEAHomo_sapiens(9606)Component
GO:0005770located_in late endosome1IEAHomo_sapiens(9606)Component
GO:0005776is_active_in autophagosome2IDAHomo_sapiens(9606)Component
GO:0005783located_in endoplasmic reticulum1IEAHomo_sapiens(9606)Component
GO:0005829located_in cytosol2IDA,TASHomo_sapiens(9606)Component
GO:0006366involved_in transcription by RNA polymerase II1IEAHomo_sapiens(9606)Process
GO:0006468involved_in protein phosphorylation1IEAHomo_sapiens(9606)Process
GO:0006511involved_in ubiquitin-dependent protein catabolic process1TASHomo_sapiens(9606)Process
GO:0006606involved_in protein import into nucleus1IEAHomo_sapiens(9606)Process
GO:0006914involved_in autophagy3IDA,IMP,TASHomo_sapiens(9606)Process
GO:0006915involved_in apoptotic process1IEAHomo_sapiens(9606)Process
GO:0007032involved_in endosome organization2IBA,IDAHomo_sapiens(9606)Process
GO:0008104involved_in protein localization1TASHomo_sapiens(9606)Process
GO:0008270enables zinc ion binding1IEAHomo_sapiens(9606)Function
GO:0010508involved_in positive regulation of autophagy1IDAHomo_sapiens(9606)Process
GO:0010821involved_in regulation of mitochondrion organization1NASHomo_sapiens(9606)Process
GO:0016197involved_in endosomal transport1TASHomo_sapiens(9606)Process
GO:0016234located_in inclusion body1IDAHomo_sapiens(9606)Component
GO:0016235is_active_in aggresome1IBAHomo_sapiens(9606)Component
GO:0016236involved_in macroautophagy2IMP,ISSHomo_sapiens(9606)Process
GO:0016605located_in PML body1IDAHomo_sapiens(9606)Component
GO:0019899enables enzyme binding1IPIHomo_sapiens(9606)Function
GO:0019901enables protein kinase binding1IDAHomo_sapiens(9606)Function
GO:0030017located_in sarcomere1IEAHomo_sapiens(9606)Component
GO:0030154involved_in cell differentiation1IEAHomo_sapiens(9606)Process
GO:0030163involved_in protein catabolic process1IDAHomo_sapiens(9606)Process
GO:0030674enables protein-macromolecule adaptor activity1IDAHomo_sapiens(9606)Function
GO:0030971enables receptor tyrosine kinase binding1TASHomo_sapiens(9606)Function
GO:0031397involved_in negative regulation of protein ubiquitination1IDAHomo_sapiens(9606)Process
GO:0031625enables ubiquitin protein ligase binding2IDA,IPIHomo_sapiens(9606)Function
GO:0034614involved_in cellular response to reactive oxygen species1IDAHomo_sapiens(9606)Process
GO:0035255enables ionotropic glutamate receptor binding1ISSHomo_sapiens(9606)Function
GO:0035556involved_in intracellular signal transduction1TASHomo_sapiens(9606)Process
GO:0035591enables signaling adaptor activity1IDAHomo_sapiens(9606)Function
GO:0035973involved_in aggrephagy2IBA,IPIHomo_sapiens(9606)Process
GO:0038023enables signaling receptor activity1IDAHomo_sapiens(9606)Function
GO:0042169enables SH2 domain binding1IDAHomo_sapiens(9606)Function
GO:0042802enables identical protein binding1IPIHomo_sapiens(9606)Function
GO:0043065involved_in positive regulation of apoptotic process1TASHomo_sapiens(9606)Process
GO:0043122involved_in regulation of I-kappaB kinase/NF-kappaB signaling1IMPHomo_sapiens(9606)Process
GO:0043130enables ubiquitin binding2IDA,TASHomo_sapiens(9606)Function
GO:0043231located_in intracellular membrane-bounded organelle1IDAHomo_sapiens(9606)Component
GO:0044753is_active_in amphisome2IBA,IDAHomo_sapiens(9606)Component
GO:0044754located_in autolysosome1IDAHomo_sapiens(9606)Component
GO:0044877enables protein-containing complex binding1IEAHomo_sapiens(9606)Function
GO:0045944involved_in positive regulation of transcription by RNA polymerase II1TASHomo_sapiens(9606)Process
GO:0046578involved_in regulation of Ras protein signal transduction1NASHomo_sapiens(9606)Process
GO:0061635involved_in regulation of protein complex stability1IDAHomo_sapiens(9606)Process
GO:0061912involved_in selective autophagy2IDA,IMPHomo_sapiens(9606)Process
GO:0070062located_in extracellular exosome1HDAHomo_sapiens(9606)Component
GO:0070342involved_in brown fat cell proliferation1IEAHomo_sapiens(9606)Process
GO:0070530enables K63-linked polyubiquitin modification-dependent protein binding2IBA,IDAHomo_sapiens(9606)Function
GO:0071211involved_in protein targeting to vacuole involved in autophagy1IDAHomo_sapiens(9606)Process
GO:0097009involved_in energy homeostasis1IEAHomo_sapiens(9606)Process
GO:0097225located_in sperm midpiece1IEAHomo_sapiens(9606)Component
GO:0097413located_in Lewy body1IEAHomo_sapiens(9606)Component
GO:0098780involved_in response to mitochondrial depolarisation1IGIHomo_sapiens(9606)Process
GO:0140036enables ubiquitin-dependent protein binding1IDAHomo_sapiens(9606)Function
GO:1900273involved_in positive regulation of long-term synaptic potentiation1ISSHomo_sapiens(9606)Process
GO:1903078involved_in positive regulation of protein localization to plasma membrane1ISSHomo_sapiens(9606)Process
GO:1905719involved_in protein localization to perinuclear region of cytoplasm1IDAHomo_sapiens(9606)Process

Expression