Ensembl ID ENSG00000161011 Gene ID 8878 Accession 11280
Gene Symbol SQSTM1 Alias p60;p62;A170;DMRV;OSIL;PDB3;ZIP3;p62B;NADGP;FTDALS3 Full Name sequestosome 1
Position 5 : 179806408 - 179838078 Length 31671 bases Strand Plus strand
Status Confidence Main interacting RNAsN.A.RBP type Non-canonical_RBPs
Summary This gene encodes a multifunctional protein that binds ubiquitin and regulates activation of the nuclear factor kappa-B (NF-kB) signaling pathway. The protein functions as a scaffolding/adaptor protein in concert with TNF receptor-associated factor 6 to mediate activation of NF-kB in response to upstream signals. Alternatively spliced transcript variants encoding either the same or different isoforms have been identified for this gene. Mutations in this gene result in sporadic and familial Paget disease of bone. [provided by RefSeq, Mar 2009]

ENSG00000161011 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000161011 SQSTM1 0.56 1.27e-13 KIRC
ENSG00000161011 SQSTM1 1.05 4.73e-11 LIHC
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000161011 SQSTM1 breast cancers 17395976
ENSG00000161011 SQSTM1 tumors 19016598
ENSG00000161011 SQSTM1 breast cancer 19444933
ENSG00000161011 SQSTM1 tumor 19524509
ENSG00000161011 SQSTM1 cancer 19713972
ENSG00000161011 SQSTM1 tumors 19787053
ENSG00000161011 SQSTM1 cancer 20103647
ENSG00000161011 SQSTM1 giant cell tumor 20200946
ENSG00000161011 SQSTM1 tumor 20520551
ENSG00000161011 SQSTM1 Colon cancer 20930850
ENSG00000161011 SQSTM1 ovarian cancer 21371883
ENSG00000161011 SQSTM1 colon cancer 21461234
ENSG00000161011 SQSTM1 tumor 21498118
ENSG00000161011 SQSTM1 tumors 21746920
ENSG00000161011 SQSTM1 tumor 21764854
ENSG00000161011 SQSTM1 cancer 22074114
ENSG00000161011 SQSTM1 breast cancer 22296116
ENSG00000161011 SQSTM1 lung cancer 22412944
ENSG00000161011 SQSTM1 tumor 22441015
ENSG00000161011 SQSTM1 breast cancer 22457718
ENSG00000161011 SQSTM1 colon cancer 22652752
ENSG00000161011 SQSTM1 cancer 22860231
ENSG00000161011 SQSTM1 breast cancer 23026799
ENSG00000161011 SQSTM1 prostate cancer 23075929
ENSG00000161011 SQSTM1 breast cancer 23221969
ENSG00000161011 SQSTM1 Tumor 23965851
ENSG00000161011 SQSTM1 pancreatic cancer 24048269
ENSG00000161011 SQSTM1 colorectal cancer 24065390
ENSG00000161011 SQSTM1 tumor 24069557
ENSG00000161011 SQSTM1 Prostate Cancer 24073324
ENSG00000161011 SQSTM1 cancer 24086340
ENSG00000161011 SQSTM1 metastatic prostate cancer 24122957
ENSG00000161011 SQSTM1 cancer 24291777
ENSG00000161011 SQSTM1 kidney cancer 24332042
ENSG00000161011 SQSTM1 liver cancer 24401568
ENSG00000161011 SQSTM1 tumor 24492513
ENSG00000161011 SQSTM1 tumor 24553345
ENSG00000161011 SQSTM1 breast cancer 24599075
ENSG00000161011 SQSTM1 prostate cancer 24655592
ENSG00000161011 SQSTM1 cancer 24690104
ENSG00000161011 SQSTM1 tumor 24731006
ENSG00000161011 SQSTM1 cancer 24805111
ENSG00000161011 SQSTM1 bladder cancer 24815071
ENSG00000161011 SQSTM1 tumor 24888584
ENSG00000161011 SQSTM1 tumor 24888590
ENSG00000161011 SQSTM1 cancer 24922589
ENSG00000161011 SQSTM1 cancer 24991204
ENSG00000161011 SQSTM1 cancer 24991827
ENSG00000161011 SQSTM1 tumor 25026213
ENSG00000161011 SQSTM1 acute myeloid leukemia (AML) 25034783
ENSG00000161011 SQSTM1 breast cancers 25088198
ENSG00000161011 SQSTM1 breast cancer 25088800
ENSG00000161011 SQSTM1 prostate cancer 25103771
ENSG00000161011 SQSTM1 renal tumors 25126726
ENSG00000161011 SQSTM1 tumor 25126736
ENSG00000161011 SQSTM1 tumors 25159823
ENSG00000161011 SQSTM1 Mast Cell Tumors 25161207
ENSG00000161011 SQSTM1 tumor 25216025
ENSG00000161011 SQSTM1 ovarian cancer 25269472
ENSG00000161011 SQSTM1 Cancer 25277339
ENSG00000161011 SQSTM1 Tumor 25323883
ENSG00000161011 SQSTM1 cancer 25338734
ENSG00000161011 SQSTM1 colon cancer 25375374
ENSG00000161011 SQSTM1 tumor 25466963
ENSG00000161011 SQSTM1 tumor 25496309
ENSG00000161011 SQSTM1 breast cancer 25500539
ENSG00000161011 SQSTM1 HNSCC 25714028
ENSG00000161011 SQSTM1 Epithelial Ovarian Cancer 25859063
ENSG00000161011 SQSTM1 Prostate Cancer 25925890
ENSG00000161011 SQSTM1 tumor 26020424
ENSG00000161011 SQSTM1 breast cancer 26034986
ENSG00000161011 SQSTM1 tumor 26043024
ENSG00000161011 SQSTM1 cancers 26162509
ENSG00000161011 SQSTM1 cancer 26208877
ENSG00000161011 SQSTM1 cancer 26301314
ENSG00000161011 SQSTM1 prostate cancer 26423274
ENSG00000161011 SQSTM1 pancreatic cancer 26458814
ENSG00000161011 SQSTM1 cancer 26553068
ENSG00000161011 SQSTM1 tumors 26565381
ENSG00000161011 SQSTM1 GBM 26648842
ENSG00000161011 SQSTM1 tumors 26743088
ENSG00000161011 SQSTM1 breast cancer 26754771
ENSG00000161011 SQSTM1 GBM 26775697
ENSG00000161011 SQSTM1 colon cancer 26802026
ENSG00000161011 SQSTM1 tumor 26876213
ENSG00000161011 SQSTM1 cancer 26882440
ENSG00000161011 SQSTM1 gastric cancer 26910278
ENSG00000161011 SQSTM1 cancers 27038142
ENSG00000161011 SQSTM1 GBM 27163161
ENSG00000161011 SQSTM1 non-small cell lung cancer 27250032
ENSG00000161011 SQSTM1 esophageal cancer 27310928
ENSG00000161011 SQSTM1 breast cancer 27345399
ENSG00000161011 SQSTM1 tumor 27367669
ENSG00000161011 SQSTM1 colorectal cancer 27444698
ENSG00000161011 SQSTM1 lung cancer 27467530
ENSG00000161011 SQSTM1 cancers 27588471
ENSG00000161011 SQSTM1 cancers 27683183
ENSG00000161011 SQSTM1 Tumors 27708238
ENSG00000161011 SQSTM1 gastric cancer 27725863
ENSG00000161011 SQSTM1 Liver Cancer 27728806
ENSG00000161011 SQSTM1 cancer 27839920
ENSG00000161011 SQSTM1 AML 27864418
ENSG00000161011 SQSTM1 cancer 27929542
ENSG00000161011 SQSTM1 AML 28026112
ENSG00000161011 SQSTM1 tumors 28052027
ENSG00000161011 SQSTM1 AML 28118076
ENSG00000161011 SQSTM1 pancreatic cancer 28139733
ENSG00000161011 SQSTM1 pancreatic cancer 28176967
ENSG00000161011 SQSTM1 lung cancer 28183697
ENSG00000161011 SQSTM1 tumor 28348518
ENSG00000161011 SQSTM1 Thyroid Cancers 28351223
ENSG00000161011 SQSTM1 cancer 28358273
ENSG00000161011 SQSTM1 Tumor 28405513
ENSG00000161011 SQSTM1 breast cancer 28411887
ENSG00000161011 SQSTM1 cancers 28450176
ENSG00000161011 SQSTM1 Ovarian Cancer 28455291
ENSG00000161011 SQSTM1 ovarian cancer 28498503
ENSG00000161011 SQSTM1 tumor 28512249
ENSG00000161011 SQSTM1 breast cancer 28628113
ENSG00000161011 SQSTM1 cancers 28638475
ENSG00000161011 SQSTM1 breast cancer 28696138
ENSG00000161011 SQSTM1 GBM 28701921
ENSG00000161011 SQSTM1 tumor 28749466
ENSG00000161011 SQSTM1 breast cancer 28855742
ENSG00000161011 SQSTM1 tumor 28915569
ENSG00000161011 SQSTM1 tumors 28937603
ENSG00000161011 SQSTM1 breast cancer 28968743
ENSG00000161011 SQSTM1 liver cancer 28980855
ENSG00000161011 SQSTM1 ovarian cancer 29022892
ENSG00000161011 SQSTM1 breast cancer 29029506
ENSG00000161011 SQSTM1 GBM 29033794
ENSG00000161011 SQSTM1 tumor 29179443
ENSG00000161011 SQSTM1 non-small cell lung cancer 29190983
ENSG00000161011 SQSTM1 tumor 29328502
ENSG00000161011 SQSTM1 cancer 29344310
ENSG00000161011 SQSTM1 tumor 29592877
ENSG00000161011 SQSTM1 Tumor 29634950
ENSG00000161011 SQSTM1 Cancer 29656891
ENSG00000161011 SQSTM1 ovarian cancer 29699801
ENSG00000161011 SQSTM1 tumors 29707114
ENSG00000161011 SQSTM1 cancer 29789637
ENSG00000161011 SQSTM1 cancer 29928361
ENSG00000161011 SQSTM1 Cancer 29930914
ENSG00000161011 SQSTM1 tumour 29967346
ENSG00000161011 SQSTM1 gastric cancer 29989092
ENSG00000161011 SQSTM1 prostate cancer 29995557
ENSG00000161011 SQSTM1 lung cancer 30018090
ENSG00000161011 SQSTM1 cancer 30067838
ENSG00000161011 SQSTM1 ovarian cancer 30081720
ENSG00000161011 SQSTM1 cancer 30106434
ENSG00000161011 SQSTM1 non-small cell lung cancer 30145925
ENSG00000161011 SQSTM1 tumor 30198373
ENSG00000161011 SQSTM1 tumor 30204247
ENSG00000161011 SQSTM1 non-small cell lung cancer 30231667
ENSG00000161011 SQSTM1 TGCT 30245976
ENSG00000161011 SQSTM1 tumour 30247801
ENSG00000161011 SQSTM1 oral cancer 30272335
ENSG00000161011 SQSTM1 tumors 30289335
ENSG00000161011 SQSTM1 tumor 30302016
ENSG00000161011 SQSTM1 prostate cancer 30324661
ENSG00000161011 SQSTM1 colorectal cancer 30339814
ENSG00000161011 SQSTM1 breast cancer 30389135
ENSG00000161011 SQSTM1 cancer 30397181
ENSG00000161011 SQSTM1 Malignant Tumor 30410612
ENSG00000161011 SQSTM1 colon cancer 30451832
ENSG00000161011 SQSTM1 cancer 30477228
ENSG00000161011 SQSTM1 cancer 30483817
ENSG00000161011 SQSTM1 cancer 30499183
ENSG00000161011 SQSTM1 breast cancer 30563263
ENSG00000161011 SQSTM1 AML 30563411
ENSG00000161011 SQSTM1 tumors 30603055
ENSG00000161011 SQSTM1 tumors 30621754
ENSG00000161011 SQSTM1 liver tumors 30642133
ENSG00000161011 SQSTM1 breast cancer 30653426
ENSG00000161011 SQSTM1 cancer 30654687
ENSG00000161011 SQSTM1 tumor 30718520
ENSG00000161011 SQSTM1 cancer 30736337
ENSG00000161011 SQSTM1 triple-negative breast cancer 30773992
ENSG00000161011 SQSTM1 tumors 30782064
ENSG00000161011 SQSTM1 inflammatory myofibroblastic tumor 30790150
ENSG00000161011 SQSTM1 cancer 30806145
ENSG00000161011 SQSTM1 cancer 30875926
ENSG00000161011 SQSTM1 cancer 30894055
ENSG00000161011 SQSTM1 tumor 30896863
ENSG00000161011 SQSTM1 gastric cancer 30925913
ENSG00000161011 SQSTM1 cancer 30941888
ENSG00000161011 SQSTM1 tumor 31016112
ENSG00000161011 SQSTM1 laryngeal cancer 31050705
ENSG00000161011 SQSTM1 tumor 31159487
ENSG00000161011 SQSTM1 Cancer 31177911
ENSG00000161011 SQSTM1 cancer 31182922
ENSG00000161011 SQSTM1 tumor 31208298
ENSG00000161011 SQSTM1 NSCLC non-small cell lung cancer 31217023
ENSG00000161011 SQSTM1 lung cancer 31232177
ENSG00000161011 SQSTM1 tumor 31242129
ENSG00000161011 SQSTM1 tumor 31284710
ENSG00000161011 SQSTM1 tumours 31332942
ENSG00000161011 SQSTM1 cancer 31351198
ENSG00000161011 SQSTM1 tumor 31401659
ENSG00000161011 SQSTM1 breast cancer 31413316
ENSG00000161011 SQSTM1 tumor 31462126
ENSG00000161011 SQSTM1 tumour 31508470
ENSG00000161011 SQSTM1 cancer 31510897
ENSG00000161011 SQSTM1 tumour 31543384
ENSG00000161011 SQSTM1 cancer 31608105
ENSG00000161011 SQSTM1 tumor 31612776
ENSG00000161011 SQSTM1 tumors 31637005
ENSG00000161011 SQSTM1 brain tumors 31674265
ENSG00000161011 SQSTM1 tumor 31679460
ENSG00000161011 SQSTM1 bladder cancer 31685029
ENSG00000161011 SQSTM1 tumor 31695024
ENSG00000161011 SQSTM1 Cancer 31696776
ENSG00000161011 SQSTM1 cancer 31754084
ENSG00000161011 SQSTM1 cancer 31775562
ENSG00000161011 SQSTM1 pancreatic cancer 31785531
ENSG00000161011 SQSTM1 gastric cancer 31810936
ENSG00000161011 SQSTM1 kidney cancer 31810986
ENSG00000161011 SQSTM1 tumour 31880318
ENSG00000161011 SQSTM1 tumor 31889127
ENSG00000161011 SQSTM1 lung cancer 31931029
ENSG00000161011 SQSTM1 tumor 31931659
ENSG00000161011 SQSTM1 Tumor 31952347
ENSG00000161011 SQSTM1 cancer 31983282
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000161011 SQSTM1 SARC 0.00017 low
ENSG00000161011 SQSTM1 UVM 0.035 high
ENSG00000161011 SQSTM1 THCA 0.039 low
ENSG00000161011 SQSTM1 ACC 0.00053 low
ENSG00000161011 SQSTM1 LUSC 0.041 high
ENSG00000161011 SQSTM1 READ 0.0059 low
ENSG00000161011 SQSTM1 LUAD 0.047 high
ENSG00000161011 SQSTM1 PCPG 0.0028 high
ENSG00000161011 SQSTM1 THYM 0.0013 high
ENSG00000161011 SQSTM1 OV 0.015 high
ENSG00000161011 SQSTM1 DLBC 0.0046 low
ENSG00000161011 SQSTM1 KIRC 0.042 low
ENSG00000161011 SQSTM1 TGCT 0.0031 high
ENSG00000161011 SQSTM1 BLCA 0.042 high
ENSG00000161011 SQSTM1 LAML 0.01 high
ENSG00000161011 SQSTM1 GBM 0.012 high
ENSG00000161011 SQSTM1 SKCM 0.034 low
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000161011 SQSTM1 LGG Del 4.251480 0.069855 0.418049 0.111111
ENSG00000161011 SQSTM1 KIRP Amp 0.969852 0.061208 0.634107 0.125000
ENSG00000161011 SQSTM1 ACC Amp 1.636341 0.386685 1.222109 0.677778
ENSG00000161011 SQSTM1 GBM Del 0.885415 0.054414 0.464196 0.097054
ENSG00000161011 SQSTM1 SKCM Del 1.310934 0.076405 0.479879 0.291553
ENSG00000161011 SQSTM1 HNSC Del 1.768856 0.066162 0.395338 0.373563
ENSG00000161011 SQSTM1 LIHC Amp 2.907330 0.165898 0.582556 0.354054
ENSG00000161011 SQSTM1 BLCA Del 1.669719 0.093405 0.399768 0.477941
ENSG00000161011 SQSTM1 KIRC Amp 59.407579 0.324820 0.550725 0.625000