Functions and Diseases

RBP Type Canonical_RBPs
Diseases CancerSARS-COV-OC43FlavivirusesSARS-COV-2DengueZika
Drug N.A.
Main interacting RNAs mRNA
Moonlighting functions TF
Localizations N.A.
BulkPerturb-seq N.A.

Description

Ensembl ID ENSG00000160633 Gene ID 6294 Accession 10520
Symbol SAFB Alias HAP;HET;SAF-B;SAFB1;SAB-B1;SAF-B1 Full Name scaffold attachment factor B
Status Confidence Length 45444 bases Strand Plus strand
Position 19 : 5623035 - 5668478 RNA binding domain SAP , RRM_5 , RRM_1
Summary This gene encodes a DNA-binding protein which has high specificity for scaffold or matrix attachment region DNA elements (S/MAR DNA). This protein is thought to be involved in attaching the base of chromatin loops to the nuclear matrix but there is conflicting evidence as to whether this protein is a component of chromatin or a nuclear matrix protein. Scaffold attachment factors are a specific subset of nuclear matrix proteins (NMP) that specifically bind to S/MAR. The encoded protein is thought to serve as a molecular base to assemble a 'transcriptosome complex' in the vicinity of actively transcribed genes. It is involved in the regulation of heat shock protein 27 transcription, can act as an estrogen receptor co-repressor and is a candidate for breast tumorigenesis. This gene is arranged head-to-head with a similar gene whose product has the same functions. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jan 2011]

RNA binding domains (RBDs)

RNA binding proteomes (RBPomes)

Transcripts

Phenotypes

Protein-Protein Interaction (PPI)

Paralogs

Orthologs

Gene Ontology

Expression