Ensembl ID ENSG00000160633 Gene ID 6294 Accession 10520
Gene Symbol SAFB Alias HAP;HET;SAF-B;SAFB1;SAB-B1;SAF-B1 Full Name scaffold attachment factor B
Position 19 : 5623035 - 5668478 Length 45444 bases Strand Plus strand
Status Confidence Main interacting RNAsmRNARBP type Canonical_RBPs
Summary This gene encodes a DNA-binding protein which has high specificity for scaffold or matrix attachment region DNA elements (S/MAR DNA). This protein is thought to be involved in attaching the base of chromatin loops to the nuclear matrix but there is conflicting evidence as to whether this protein is a component of chromatin or a nuclear matrix protein. Scaffold attachment factors are a specific subset of nuclear matrix proteins (NMP) that specifically bind to S/MAR. The encoded protein is thought to serve as a molecular base to assemble a 'transcriptosome complex' in the vicinity of actively transcribed genes. It is involved in the regulation of heat shock protein 27 transcription, can act as an estrogen receptor co-repressor and is a candidate for breast tumorigenesis. This gene is arranged head-to-head with a similar gene whose product has the same functions. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jan 2011]

ENSG00000160633 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000160633 SAFB 0.29 2.31e-11 KIRC
ENSG00000160633 SAFB 0.33 2.74e-15 BRCA
ENSG00000160633 SAFB 0.30 9.70e-11 PRAD
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000160633 SAFB breast cancer 10999774
ENSG00000160633 SAFB breast cancer 11207044
ENSG00000160633 SAFB breast cancer 12660241
ENSG00000160633 SAFB breast cancer 14587024
ENSG00000160633 SAFB breast cancer 16195251
ENSG00000160633 SAFB breast cancer 16912158
ENSG00000160633 SAFB tumor 18772145
ENSG00000160633 SAFB tumour 19077293
ENSG00000160633 SAFB breast cancer 19137425
ENSG00000160633 SAFB tumor 19267898
ENSG00000160633 SAFB breast cancer 19901029
ENSG00000160633 SAFB cancer 20014070
ENSG00000160633 SAFB breast cancer 20224657
ENSG00000160633 SAFB tumors 21464516
ENSG00000160633 SAFB cancer 22817742
ENSG00000160633 SAFB metastatic tumors 23893242
ENSG00000160633 SAFB prostate cancer 24077602
ENSG00000160633 SAFB Breast Cancer 26273616
ENSG00000160633 SAFB cancer 26482227
ENSG00000160633 SAFB Colorectal Cancer 28912140
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000160633 SAFB MESO 0.035 high
ENSG00000160633 SAFB STAD 0.01 low
ENSG00000160633 SAFB UVM 0.027 low
ENSG00000160633 SAFB PAAD 0.00043 low
ENSG00000160633 SAFB UCEC 0.0046 low
ENSG00000160633 SAFB ACC 0.00015 high
ENSG00000160633 SAFB HNSC 0.034 low
ENSG00000160633 SAFB KIRP 0.00089 high
ENSG00000160633 SAFB KICH 0.00023 low
ENSG00000160633 SAFB LUAD 0.0043 high
ENSG00000160633 SAFB PCPG 0.0063 high
ENSG00000160633 SAFB THYM 0.00027 low
ENSG00000160633 SAFB BRCA 0.024 low
ENSG00000160633 SAFB COAD 0.0091 high
ENSG00000160633 SAFB KIRC 0.05 high
ENSG00000160633 SAFB TGCT 0.017 low
ENSG00000160633 SAFB LAML 0.011 low
ENSG00000160633 SAFB GBM 0.039 low
ENSG00000160633 SAFB SKCM 0.015 high
ENSG00000160633 SAFB CESC 0.016 low
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000160633 SAFB LUSC Del 2.853124 0.092706 0.342755 0.405190
ENSG00000160633 SAFB LUAD Del 1.821486 0.065463 0.345319 0.538760
ENSG00000160633 SAFB CESC Del 9.935663 0.175793 0.461164 0.342373
ENSG00000160633 SAFB UCS Del 6.226609 0.529725 0.601077 0.678571
ENSG00000160633 SAFB PAAD Del 1.297100 0.057663 0.350991 0.179348
ENSG00000160633 SAFB ESCA Del 1.659851 0.123563 0.333373 0.478261
ENSG00000160633 SAFB HNSC Del 5.927968 0.098310 0.335378 0.285441
ENSG00000160633 SAFB LIHC Del 4.642711 0.117628 0.460717 0.232432
ENSG00000160633 SAFB BLCA Del 2.396345 0.104019 0.323708 0.338235
ENSG00000160633 SAFB BRCA Del 3.497756 0.084407 0.362364 0.262037
ENSG00000160633 SAFB STAD Del 1.700571 0.074877 0.355580 0.349206
ENSG00000160633 SAFB UCEC Del 34.773491 0.227577 0.586737 0.257885
ENSG00000160633 SAFB OV Del 70.084420 0.663801 0.636410 0.716753