Functions and Diseases

RBP Type Canonical_RBPs
Diseases CancerCHIKVSARS-COV-OC43FlavivirusesHIVSARS-COV-2SINVDengueZika
Drug N.A.
Main interacting RNAs tRNA
Moonlighting functions N.A.
Localizations Stress granule or P-body
BulkPerturb-seq N.A.

Description

Ensembl ID ENSG00000158417 Gene ID 9669 Accession 30793
Symbol EIF5B Alias IF2 Full Name eukaryotic translation initiation factor 5B
Status Confidence Length 63956 bases Strand Plus strand
Position 2 : 99337371 - 99401326 RNA binding domain GTP_EFTU , MMR_HSR1 , IF-2 , GTP_EFTU_D2
Summary Accurate initiation of translation in eukaryotes is complex and requires many factors, some of which are composed of multiple subunits. The process is simpler in prokaryotes which have only three initiation factors (IF1, IF2, IF3). Two of these factors are conserved in eukaryotes: the homolog of IF1 is eIF1A and the homolog of IF2 is eIF5B. This gene encodes eIF5B. Factors eIF1A and eIF5B interact on the ribosome along with other initiation factors and GTP to position the initiation methionine tRNA on the start codon of the mRNA so that translation initiates accurately. [provided by RefSeq, Jul 2008]

RNA binding domains (RBDs)

Protein Domain Pfam ID E-value Domain number
ENSP00000478914 GTP_EFTU_D2 PF03144 5.7e-09 1
ENSP00000478914 GTP_EFTU PF00009 7.6e-35 2
ENSP00000478914 MMR_HSR1 PF01926 3.5e-05 3
ENSP00000478914 IF-2 PF11987 1.1e-19 4
ENSP00000289371 GTP_EFTU_D2 PF03144 7e-09 1
ENSP00000289371 GTP_EFTU PF00009 7.6e-35 2
ENSP00000289371 MMR_HSR1 PF01926 3.5e-05 3
ENSP00000289371 IF-2 PF11987 1.1e-19 4

RNA binding proteomes (RBPomes)

Pubmed ID Full Name Cell Author Time Doi

Literatures on RNA binding capacity

Pubmed ID Title Author Time Journal
37305324 IGF2BP3-induced activation of EIF5B contributes to progression of hepatocellular carcinoma cells. Xiaoyin Li 2022-01-01 Oncology research
33921849 The Nuclear Pore Complex Is a Key Target of Viral Proteases to Promote Viral Replication. Adrián Luis LA De 2021-04-19 Viruses
28138064 Human eIF3: from 'blobology' to biological insight. D H Jamie Cate 2017-03-19 Philosophical transactions of the Royal Society of London. Series B, Biological sciences
24189219 RNA-binding proteins impacting on internal initiation of translation. Encarnación Martínez-Salas 2013-11-01 International journal of molecular sciences
27278278 Proteomic analysis of mTOR inhibition-mediated phosphorylation changes in ribosomal proteins and eukaryotic translation initiation factors. Xu Jiang 2016-07-01 Protein & cell
34499219 A network of core and subtype-specific gene expression programs in myositis. R David Amici 2021-11-01 Acta neuropathologica
25350701 Structural insight into the recognition of amino-acylated initiator tRNA by eIF5B in the 80S initiation complex. Bernhard Kuhle 2014-09-17 BMC structural biology

Transcripts

Name Transcript ID bp Protein Translation ID
EIF5B-205 ENST00000617677 4698 1220aa ENSP00000478914
EIF5B-201 ENST00000289371 5741 1220aa ENSP00000289371
EIF5B-203 ENST00000470868 573 No protein -
EIF5B-204 ENST00000494190 664 No protein -
EIF5B-202 ENST00000470023 2331 No protein -

Gene Model

Pathways

Pathway ID Pathway Name Source

Phenotypes

ensgID Trait pValue Pubmed ID

GWAS

ensgIDSNPChromosomePosition TraitPubmedIDOr or BEAT EFO ID

Protein-Protein Interaction (PPI)

Paralogs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id
ENSG00000158417homo_sapiensENSP0000030794022.0289.09091homo_sapiensENSP0000028937115.49186.39344
ENSG00000158417homo_sapiensENSP0000041903825.832212.1172homo_sapiensENSP0000028937115.90167.45902
ENSG00000158417homo_sapiensENSP0000032243932.087915.6044homo_sapiensENSP0000028937111.96725.81967
ENSG00000158417homo_sapiensENSP0000034124741.24222.6115homo_sapiensENSP0000028937121.229511.6393
ENSG00000158417homo_sapiensENSP0000025303936.440719.0678homo_sapiensENSP0000028937114.09847.37705
ENSG00000158417homo_sapiensENSP0000044507736.016919.0678homo_sapiensENSP0000028937113.93447.37705
ENSG00000158417homo_sapiensENSP0000035681141.520521.1988homo_sapiensENSP0000028937123.278711.8852
ENSG00000158417homo_sapiensENSP0000025473029.026812.0805homo_sapiensENSP0000028937114.18035.90164
ENSG00000158417homo_sapiensENSP0000026820618.758.39286homo_sapiensENSP0000028937117.21317.70492
ENSG00000158417homo_sapiensENSP0000028154320.926810.1644homo_sapiensENSP0000028937111.47545.57377
ENSG00000158417homo_sapiensENSP0000026362929.023414.3054homo_sapiensENSP0000028937117.29518.52459
ENSG00000158417homo_sapiensENSP0000039813140.188421.3501homo_sapiensENSP0000028937120.983611.1475
ENSG00000158417homo_sapiensENSP0000039209420.16468.53909homo_sapiensENSP0000028937116.06566.80328
ENSG00000158417homo_sapiensENSP0000021718250.755929.8056homo_sapiensENSP0000028937119.262311.3115
ENSG00000158417homo_sapiensENSP0000033905351.731631.3853homo_sapiensENSP0000028937119.590211.8852
ENSG00000158417homo_sapiensENSP0000030399729.568112.7907homo_sapiensENSP0000028937114.59026.31148
ENSG00000158417homo_sapiensENSP0000021604427.354312.2571homo_sapiensENSP00000289371156.72131
ENSG00000158417homo_sapiensENSP0000029680525.802311.6816homo_sapiensENSP0000028937116.47547.45902

Orthologs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id
ENSG00000158417homo_sapiensENSP0000028937199.590299.0984nomascus_leucogenysENSNLEP0000001728799.590299.0984
ENSG00000158417homo_sapiensENSP0000028937196.147595.9016pan_paniscusENSPPAP0000001347099.406899.1525
ENSG00000158417homo_sapiensENSP0000028937199.508298.9344pongo_abeliiENSPPYP0000002520399.10298.5306
ENSG00000158417homo_sapiensENSP0000028937199.754199.6721pan_troglodytesENSPTRP0000005180699.754199.6721
ENSG00000158417homo_sapiensENSP0000028937199.426299.0164gorilla_gorillaENSGGOP0000002477799.020498.6122
ENSG00000158417homo_sapiensENSP0000028937190.409883.9344ornithorhynchus_anatinusENSOANP0000005249986.239380.0625
ENSG00000158417homo_sapiensENSP0000028937194.180388.5246sarcophilus_harrisiiENSSHAP0000001181994.412588.7428
ENSG00000158417homo_sapiensENSP0000028937190.983688.6066dasypus_novemcinctusENSDNOP0000000388696.943294.4105
ENSG00000158417homo_sapiensENSP0000028937193.770590.082echinops_telfairiENSETEP0000000118494.233990.5272
ENSG00000158417homo_sapiensENSP0000028937198.360797.7049callithrix_jacchusENSCJAP0000001844298.765498.107
ENSG00000158417homo_sapiensENSP0000028937199.590298.9344cercocebus_atysENSCATP0000003024699.508698.8534
ENSG00000158417homo_sapiensENSP0000028937197.786996.7213macaca_fascicularisENSMFAP0000003788996.991995.935
ENSG00000158417homo_sapiensENSP0000028937199.672199.0164macaca_mulattaENSMMUP0000006888399.590598.9353
ENSG00000158417homo_sapiensENSP0000028937199.508298.8525macaca_nemestrinaENSMNEP0000003369699.426798.7715
ENSG00000158417homo_sapiensENSP0000028937199.508298.7705papio_anubisENSPANP0000000659299.426798.6896
ENSG00000158417homo_sapiensENSP0000028937198.688597.9508mandrillus_leucophaeusENSMLEP0000001494399.504198.7603
ENSG00000158417homo_sapiensENSP0000028937195.901693.2787tursiops_truncatusENSTTRP0000000984795.901693.2787
ENSG00000158417homo_sapiensENSP0000028937197.868996.0656vulpes_vulpesENSVVUP0000004019697.949196.1444
ENSG00000158417homo_sapiensENSP0000028937194.91891.3115mus_spretusMGP_SPRETEiJ_P001825795.230391.6118
ENSG00000158417homo_sapiensENSP0000028937197.868995.7377equus_asinusENSEASP0000505212697.949195.8162
ENSG00000158417homo_sapiensENSP0000028937196.885294.0984capra_hircusENSCHIP0000003365596.885294.0984
ENSG00000158417homo_sapiensENSP0000028937196.803393.6885loxodonta_africanaENSLAFP0000000521496.962293.8424
ENSG00000158417homo_sapiensENSP0000028937197.950895.7377panthera_leoENSPLOP0000001873198.111795.8949
ENSG00000158417homo_sapiensENSP0000028937196.967293.9344bos_indicus_hybridENSBIXP0000500851797.046894.0115
ENSG00000158417homo_sapiensENSP0000028937196.639394.2623oryctolagus_cuniculusENSOCUP0000002619393.275390.981
ENSG00000158417homo_sapiensENSP0000028937197.377195.2459equus_caballusENSECAP0000007929896.038893.9369
ENSG00000158417homo_sapiensENSP0000028937197.786995.9836canis_lupus_familiarisENSCAFP0084502425997.786995.9836
ENSG00000158417homo_sapiensENSP0000028937197.377195.082panthera_pardusENSPPRP0000001939297.697495.3947
ENSG00000158417homo_sapiensENSP0000028937197.622995.7377marmota_marmota_marmotaENSMMMP0000002254897.783295.8949
ENSG00000158417homo_sapiensENSP0000028937197.213194.8361balaenoptera_musculusENSBMSP0001001900497.372794.9918
ENSG00000158417homo_sapiensENSP0000028937197.868995.7377felis_catusENSFCAP0000005198697.868995.7377
ENSG00000158417homo_sapiensENSP0000028937191.803386.1475monodelphis_domesticaENSMODP0000005231392.86987.1476
ENSG00000158417homo_sapiensENSP0000028937197.049293.9344bison_bison_bisonENSBBBP0000001540297.049293.9344
ENSG00000158417homo_sapiensENSP0000028937197.377194.918monodon_monocerosENSMMNP0001502623297.377194.918
ENSG00000158417homo_sapiensENSP0000028937190.655787.7869sus_scrofaENSSSCP0000000873395.509592.487
ENSG00000158417homo_sapiensENSP0000028937197.377195.9836microcebus_murinusENSMICP0000001455397.93996.5375
ENSG00000158417homo_sapiensENSP0000028937196.803393.9344ovis_aries_rambouilletENSOARP0002001570896.803393.9344
ENSG00000158417homo_sapiensENSP0000028937196.967294.8361ursus_maritimusENSUMAP0000001184097.126494.9918
ENSG00000158417homo_sapiensENSP0000028937188.770585.2459ochotona_princepsENSOPRP0000000675289.356485.8086
ENSG00000158417homo_sapiensENSP0000028937197.377194.8361delphinapterus_leucasENSDLEP0000000159497.456994.9139
ENSG00000158417homo_sapiensENSP0000028937197.377194.6721physeter_catodonENSPCTP0000501481297.377194.6721
ENSG00000158417homo_sapiensENSP0000028937194.590291.0656mus_caroliMGP_CAROLIEiJ_P001725594.901391.3651
ENSG00000158417homo_sapiensENSP000002893719591.3934mus_musculusENSMUSP0000002725295.312591.6941
ENSG00000158417homo_sapiensENSP0000028937197.45995.2459mustela_putorius_furoENSMPUP0000001197697.53995.324
ENSG00000158417homo_sapiensENSP0000028937199.426298.6066aotus_nancymaaeENSANAP0000000266099.426298.6066
ENSG00000158417homo_sapiensENSP0000028937198.606697.459saimiri_boliviensis_boliviensisENSSBOP0000003526698.364797.2199
ENSG00000158417homo_sapiensENSP0000028937185.245982.7049vicugna_pacosENSVPAP0000000718497.105594.211
ENSG00000158417homo_sapiensENSP0000028937199.590298.9344chlorocebus_sabaeusENSCSAP0000001324399.427298.7725
ENSG00000158417homo_sapiensENSP0000028937197.377194.5902phocoena_sinusENSPSNP0000001024897.377194.5902
ENSG00000158417homo_sapiensENSP0000028937197.45994.6721camelus_dromedariusENSCDRP0000502585797.45994.6721
ENSG00000158417homo_sapiensENSP0000028937196.967295.1639carlito_syrichtaENSTSYP0000001091897.930596.1093
ENSG00000158417homo_sapiensENSP0000028937196.065693.4426panthera_tigris_altaicaENSPTIP0000002545995.908393.2897
ENSG00000158417homo_sapiensENSP0000028937194.344390.082rattus_norvegicusENSRNOP0000007908894.654690.3783
ENSG00000158417homo_sapiensENSP0000028937197.622996.0656prolemur_simusENSPSMP0000002769898.267396.6997
ENSG00000158417homo_sapiensENSP0000028937196.065693.2787sorex_araneusENSSARP0000000193197.100394.2833
ENSG00000158417homo_sapiensENSP0000028937183.278779.918peromyscus_maniculatus_bairdiiENSPEMP0000003645292.112488.3953
ENSG00000158417homo_sapiensENSP000002893719591.2295mus_spicilegusENSMSIP0000000750895.312591.5296
ENSG00000158417homo_sapiensENSP0000028937195.983692.9508cricetulus_griseus_chok1gshdENSCGRP0000100870996.220293.1799
ENSG00000158417homo_sapiensENSP0000028937195.901693.1967myotis_lucifugusENSMLUP0000000744496.934594.2005
ENSG00000158417homo_sapiensENSP0000028937194.098488.2787vombatus_ursinusENSVURP0001000318593.944488.1342
ENSG00000158417homo_sapiensENSP0000028937197.295194.918rhinolophus_ferrumequinumENSRFEP0001003343897.295194.918
ENSG00000158417homo_sapiensENSP0000028937197.704995.3279neovison_visonENSNVIP0000002418197.624995.2498
ENSG00000158417homo_sapiensENSP0000028937196.475493.1148bos_taurusENSBTAP0000003452296.554693.1911
ENSG00000158417homo_sapiensENSP0000028937189.672186.2295heterocephalus_glaber_femaleENSHGLP0000002294792.711989.1525
ENSG00000158417homo_sapiensENSP0000028937197.213196.0656rhinopithecus_bietiENSRBIP0000000860098.097696.9396
ENSG00000158417homo_sapiensENSP0000028937195.573892.7049canis_lupus_dingoENSCAFP0002003198196.523293.6258
ENSG00000158417homo_sapiensENSP0000028937197.377195.4918sciurus_vulgarisENSSVLP0000501624397.377195.4918
ENSG00000158417homo_sapiensENSP0000028937185.245980.082phascolarctos_cinereusENSPCIP0000001767093.862888.1769
ENSG00000158417homo_sapiensENSP0000028937196.885293.8525bos_grunniensENSBGRP0000004294396.964793.9295
ENSG00000158417homo_sapiensENSP0000028937196.311592.2131chinchilla_lanigeraENSCLAP0000001111196.947292.8218
ENSG00000158417homo_sapiensENSP0000028937197.213194.5082cervus_hanglu_yarkandensisENSCHYP0000001612597.213194.5082
ENSG00000158417homo_sapiensENSP0000028937197.377194.2623catagonus_wagneriENSCWAP0000000142197.456994.3396
ENSG00000158417homo_sapiensENSP0000028937197.54195.5738ictidomys_tridecemlineatusENSSTOP0000001281797.54195.5738
ENSG00000158417homo_sapiensENSP0000028937197.786996.0656otolemur_garnettiiENSOGAP0000001707897.54795.8299
ENSG00000158417homo_sapiensENSP0000028937198.524697.541cebus_imitatorENSCCAP0000001894499.011598.0231
ENSG00000158417homo_sapiensENSP0000028937197.377195.2459urocitellus_parryiiENSUPAP0001000616597.377195.2459
ENSG00000158417homo_sapiensENSP0000028937197.213194.0984moschus_moschiferusENSMMSP0000000252497.213194.0984
ENSG00000158417homo_sapiensENSP0000028937199.508298.9344rhinopithecus_roxellanaENSRROP0000003013599.426798.8534
ENSG00000158417homo_sapiensENSP0000028937194.672190.7377mus_pahariMGP_PahariEiJ_P007260495.612691.6391
ENSG00000158417homo_sapiensENSP0000028937125.08213.1148caenorhabditis_elegansF46B6.6a.143.589722.792
ENSG00000158417homo_sapiensENSP0000028937181.639370.4918lepisosteus_oculatusENSLOCP0000000161981.239870.1468
ENSG00000158417homo_sapiensENSP0000028937114.34436.55738danio_rerioENSDARP0000011337320.51589.37866
ENSG00000158417homo_sapiensENSP0000028937114.83616.47541danio_rerioENSDARP0000011806821.19449.25059
ENSG00000158417homo_sapiensENSP0000028937185.819777.2131xenopus_tropicalisENSXETP0000006518186.600577.9156
ENSG00000158417homo_sapiensENSP0000028937190.655784.6721chrysemys_picta_belliiENSCPBP0000000672290.879284.8809
ENSG00000158417homo_sapiensENSP0000028937188.852581.3934sphenodon_punctatusENSSPUP0000001238090.484182.8881
ENSG00000158417homo_sapiensENSP0000028937190.163983.6885crocodylus_porosusENSCPRP0000501737090.609684.1021
ENSG00000158417homo_sapiensENSP0000028937183.360776.3115notechis_scutatusENSNSUP0000000312388.511781.027
ENSG00000158417homo_sapiensENSP0000028937189.508282.8689pseudonaja_textilisENSPTXP0000000276889.950683.2784
ENSG00000158417homo_sapiensENSP0000028937182.049276.8033anas_platyrhynchos_platyrhynchosENSAPLP0000001968792.003786.1213
ENSG00000158417homo_sapiensENSP0000028937189.836183.7705gallus_gallusENSGALP0001002207788.601582.6192
ENSG00000158417homo_sapiensENSP0000028937190.08284.1803meleagris_gallopavoENSMGAP0000001567787.430481.7025
ENSG00000158417homo_sapiensENSP0000028937190.163984.1803serinus_canariaENSSCAP0000002342190.759184.736
ENSG00000158417homo_sapiensENSP0000028937190.327984.0984parus_majorENSPMJP0000002045590.327984.0984
ENSG00000158417homo_sapiensENSP0000028937180.819774.1803naja_najaENSNNAP0000002709087.566680.373
ENSG00000158417homo_sapiensENSP0000028937190.409884.0164taeniopygia_guttataENSTGUP0000003226290.558384.1544
ENSG00000158417homo_sapiensENSP0000028937184.180373.7705erpetoichthys_calabaricusENSECRP0000000758482.225872.0576
ENSG00000158417homo_sapiensENSP0000028937180.655774.0984salvator_merianaeENSSMRP0000002804592.307784.803
ENSG00000158417homo_sapiensENSP0000028937190.737784.5082gopherus_evgoodeiENSGEVP0000502810491.036284.7862
ENSG00000158417homo_sapiensENSP0000028937187.622981.7213chelonoidis_abingdoniiENSCABP0000000476390.134984.0641
ENSG00000158417homo_sapiensENSP0000028937190.327984.4262strigops_habroptilaENSSHBP0000501651790.849184.9134
ENSG00000158417homo_sapiensENSP0000028937190.655784.7541terrapene_carolina_triunguisENSTMTP0000000830990.879284.963
ENSG00000158417homo_sapiensENSP0000028937125.163912.8689saccharomyces_cerevisiaeYOL023W45.414223.2249
ENSG00000158417homo_sapiensENSP000002893711.967210.819672seriola_lalandi_dorsalisENSSLDP00000001964125
ENSG00000158417homo_sapiensENSP0000028937115.81979.7541oncorhynchus_tshawytschaENSOTSP0000504419247.536929.3103
ENSG00000158417homo_sapiensENSP0000028937118.934410.9016oncorhynchus_tshawytschaENSOTSP0000504377049.570828.5408
ENSG00000158417homo_sapiensENSP0000028937190.819785aquila_chrysaetos_chrysaetosENSACCP0002002178690.894285.0697
ENSG00000158417homo_sapiensENSP0000028937183.770574.3443leptobrachium_leishanenseENSLLEP0000000096686.244776.5401

Gene Ontology

Go ID Go term No. evidence Entries Species Category
GO:0000049enables tRNA binding1IDAHomo_sapiens(9606)Function
GO:0003723enables RNA binding1HDAHomo_sapiens(9606)Function
GO:0003743enables translation initiation factor activity3IBA,IDA,NASHomo_sapiens(9606)Function
GO:0003924enables GTPase activity2IDA,IMPHomo_sapiens(9606)Function
GO:0005515enables protein binding1IPIHomo_sapiens(9606)Function
GO:0005525enables GTP binding1IDAHomo_sapiens(9606)Function
GO:0005634NOT located_in nucleus1IDAHomo_sapiens(9606)Component
GO:0005737is_active_in cytoplasm2IBA,IDAHomo_sapiens(9606)Component
GO:0005829located_in cytosol1TASHomo_sapiens(9606)Component
GO:0006413involved_in translational initiation1IBAHomo_sapiens(9606)Process
GO:0006446involved_in regulation of translational initiation2IDA,NASHomo_sapiens(9606)Process
GO:0042255involved_in ribosome assembly1IDAHomo_sapiens(9606)Process
GO:0045202located_in synapse1IEAHomo_sapiens(9606)Component
GO:0046872enables metal ion binding1IEAHomo_sapiens(9606)Function

Expression