Ensembl ID ENSG00000158417 Gene ID 9669 Accession 30793
Gene Symbol EIF5B Alias IF2 Full Name eukaryotic translation initiation factor 5B
Position 2 : 99337371 - 99401326 Length 63956 bases Strand Plus strand
Status Confidence Main interacting RNAstRNARBP type Canonical_RBPs
Summary Accurate initiation of translation in eukaryotes is complex and requires many factors, some of which are composed of multiple subunits. The process is simpler in prokaryotes which have only three initiation factors (IF1, IF2, IF3). Two of these factors are conserved in eukaryotes: the homolog of IF1 is eIF1A and the homolog of IF2 is eIF5B. This gene encodes eIF5B. Factors eIF1A and eIF5B interact on the ribosome along with other initiation factors and GTP to position the initiation methionine tRNA on the start codon of the mRNA so that translation initiates accurately. [provided by RefSeq, Jul 2008]

ENSG00000158417 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000158417 EIF5B prostate cancer 10516606
ENSG00000158417 EIF5B tumors 10651023
ENSG00000158417 EIF5B bladder tumors 10719738
ENSG00000158417 EIF5B colon cancer 16075278
ENSG00000158417 EIF5B breast cancer 21180879
ENSG00000158417 EIF5B tumor 21594483
ENSG00000158417 EIF5B cancer 26636041
ENSG00000158417 EIF5B cancer 27053324
ENSG00000158417 EIF5B tumor 27694689
ENSG00000158417 EIF5B breast cancers 27773872
ENSG00000158417 EIF5B cancer 28649990
ENSG00000158417 EIF5B GBM 29687002
ENSG00000158417 EIF5B gastric cancer 30243023
ENSG00000158417 EIF5B cancer 30670698
ENSG00000158417 EIF5B brain tumor 31671279
ENSG00000158417 EIF5B tumors 8863671
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000158417 EIF5B CHOL 0.05 low
ENSG00000158417 EIF5B PAAD 0.019 high
ENSG00000158417 EIF5B UCEC 0.03 high
ENSG00000158417 EIF5B LGG 0.017 low
ENSG00000158417 EIF5B LUSC 0.0035 low
ENSG00000158417 EIF5B HNSC 0.0046 high
ENSG00000158417 EIF5B KIRP 0.00015 high
ENSG00000158417 EIF5B KICH 0.0036 high
ENSG00000158417 EIF5B LUAD 0.0089 high
ENSG00000158417 EIF5B PCPG 0.00047 high
ENSG00000158417 EIF5B THYM 0.024 high
ENSG00000158417 EIF5B COAD 0.0078 high
ENSG00000158417 EIF5B OV 0.0012 low
ENSG00000158417 EIF5B KIRC 0.0018 high
ENSG00000158417 EIF5B TGCT 0.014 high
ENSG00000158417 EIF5B BLCA 0.0097 high
ENSG00000158417 EIF5B GBM 0.016 low
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency