Functions and Diseases

RBP Type Canonical_RBPs
Diseases Cancer Disease
Drug N.A.
Main interacting RNAs N.A.
Moonlighting functions Metabolic enzyme
Localizations N.A.
BulkPerturb-seq N.A.

Description

Ensembl ID ENSG00000152700 Gene ID 51128 Accession 10535
Symbol SAR1B Alias ANDD;CMRD;GTBPB;SARA2 Full Name secretion associated Ras related GTPase 1B
Status Confidence Length 48123 bases Strand Minus strand
Position 5 : 134601149 - 134649271 RNA binding domain MMR_HSR1
Summary The protein encoded by this gene is a small GTPase that acts as a homodimer. The encoded protein is activated by the guanine nucleotide exchange factor PREB and is involved in protein transport from the endoplasmic reticulum to the Golgi. This protein is part of the COPII coat complex. Defects in this gene are a cause of chylomicron retention disease (CMRD), also known as Anderson disease (ANDD). Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Mar 2010]

RNA binding domains (RBDs)

Protein Domain Pfam ID E-value Domain number
ENSP00000425466 MMR_HSR1 PF01926 1.4e-05 1
ENSP00000385432 MMR_HSR1 PF01926 2.1e-05 1
ENSP00000404997 MMR_HSR1 PF01926 2.1e-05 1
ENSP00000425367 MMR_HSR1 PF01926 0.0001 1
ENSP00000423005 MMR_HSR1 PF01926 0.00063 1

RNA binding proteomes (RBPomes)

Pubmed ID Full Name Cell Author Time Doi

Literatures on RNA binding capacity

Pubmed ID Title Author Time Journal

Transcripts

Name Transcript ID bp Protein Translation ID
SAR1B-201 ENST00000402673 6517 198aa ENSP00000385432
SAR1B-208 ENST00000507419 2287 130aa ENSP00000425339
SAR1B-209 ENST00000508363 3086 No protein -
SAR1B-204 ENST00000502539 708 130aa ENSP00000426335
SAR1B-202 ENST00000439578 929 198aa ENSP00000404997
SAR1B-211 ENST00000509937 455 130aa ENSP00000424673
SAR1B-210 ENST00000509730 506 118aa ENSP00000423197
SAR1B-205 ENST00000503318 733 144aa ENSP00000425367
SAR1B-207 ENST00000505758 670 170aa ENSP00000425466
SAR1B-203 ENST00000502286 548 103aa ENSP00000423005
SAR1B-206 ENST00000504242 676 No protein -

Pathways

Pathway ID Pathway Name Source

Phenotypes

ensgID Trait pValue Pubmed ID
49081Child Development Disorders, Pervasive2.1897300E-006-
49804Child Development Disorders, Pervasive2.0278300E-006-
51255Child Development Disorders, Pervasive4.0673100E-005-

GWAS

ensgIDSNPChromosomePosition TraitPubmedIDOr or BEAT EFO ID

Protein-Protein Interaction (PPI)

Paralogs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id
ENSG00000152700homo_sapiensENSP0000032262847.263730.8458homo_sapiensENSP0000038543247.979831.3131
ENSG00000152700homo_sapiensENSP0000033975449.751228.8557homo_sapiensENSP0000038543250.505129.2929
ENSG00000152700homo_sapiensENSP0000032384749.479231.25homo_sapiensENSP0000038543247.979830.303
ENSG00000152700homo_sapiensENSP0000023152418.118510.9756homo_sapiensENSP0000038543252.525331.8182
ENSG00000152700homo_sapiensENSP0000048318342.774626.0116homo_sapiensENSP0000038543237.373722.7273
ENSG00000152700homo_sapiensENSP0000028202648.469431.6327homo_sapiensENSP0000038543247.979831.3131
ENSG00000152700homo_sapiensENSP0000029508748.603429.6089homo_sapiensENSP0000038543243.939426.7677
ENSG00000152700homo_sapiensENSP0000029831659.428638.2857homo_sapiensENSP0000038543252.525333.8384
ENSG00000152700homo_sapiensENSP0000036233897.979889.899homo_sapiensENSP0000038543297.979889.899
ENSG00000152700homo_sapiensENSP000000002336038.3333homo_sapiensENSP0000038543254.545534.8485
ENSG00000152700homo_sapiensENSP0000024674745.652227.7174homo_sapiensENSP0000038543242.424225.7576
ENSG00000152700homo_sapiensENSP0000030601059.444441.1111homo_sapiensENSP0000038543254.040437.3737
ENSG00000152700homo_sapiensENSP0000026074650.549431.3187homo_sapiensENSP0000038543246.464628.7879
ENSG00000152700homo_sapiensENSP0000036648747.48631.8436homo_sapiensENSP0000038543242.929328.7879
ENSG00000152700homo_sapiensENSP0000026958643.016825.6983homo_sapiensENSP0000038543238.888923.2323
ENSG00000152700homo_sapiensENSP0000049267129.811318.8679homo_sapiensENSP0000038543239.89925.2525
ENSG00000152700homo_sapiensENSP000002564965028.4946homo_sapiensENSP0000038543246.969726.7677
ENSG00000152700homo_sapiensENSP0000043342739.215721.0784homo_sapiensENSP0000038543240.40421.7172
ENSG00000152700homo_sapiensENSP0000041961952.688234.4086homo_sapiensENSP0000038543249.494932.3232
ENSG00000152700homo_sapiensENSP0000027221751.075331.1828homo_sapiensENSP0000038543247.979829.2929
ENSG00000152700homo_sapiensENSP0000049835049.531.5homo_sapiensENSP000003854325031.8182
ENSG00000152700homo_sapiensENSP0000048348643.283627.3632homo_sapiensENSP0000038543243.939427.7778
ENSG00000152700homo_sapiensENSP0000037776922.196313.785homo_sapiensENSP0000038543247.979829.798
ENSG00000152700homo_sapiensENSP0000030849634.016421.3115homo_sapiensENSP0000038543241.919226.2626
ENSG00000152700homo_sapiensENSP0000039863734.37522.6562homo_sapiensENSP0000038543244.444429.2929
ENSG00000152700homo_sapiensENSP0000026163655.801135.3591homo_sapiensENSP0000038543251.010132.3232
ENSG00000152700homo_sapiensENSP0000025668260.22138.1215homo_sapiensENSP0000038543255.050534.8485
ENSG00000152700homo_sapiensENSP0000033747831.073421.4689homo_sapiensENSP0000038543227.777819.1919
ENSG00000152700homo_sapiensENSP0000040424731.073421.4689homo_sapiensENSP0000038543227.777819.1919
ENSG00000152700homo_sapiensENSP0000027210260.773538.1215homo_sapiensENSP0000038543255.555634.8485

Orthologs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id
ENSG00000152700homo_sapiensENSP0000038543210099.4949nomascus_leucogenysENSNLEP0000000990910099.4949
ENSG00000152700homo_sapiensENSP0000038543210099.4949pan_paniscusENSPPAP0000001992310099.4949
ENSG00000152700homo_sapiensENSP0000038543210098.9899pongo_abeliiENSPPYP0000001765510098.9899
ENSG00000152700homo_sapiensENSP0000038543210099.4949pan_troglodytesENSPTRP0000002950110099.4949
ENSG00000152700homo_sapiensENSP0000038543265.656665.1515gorilla_gorillaENSGGOP0000002025710099.2308
ENSG00000152700homo_sapiensENSP0000038543292.424285.8586ornithorhynchus_anatinusENSOANP0000000198158.842454.6624
ENSG00000152700homo_sapiensENSP0000038543299.494996.9697sarcophilus_harrisiiENSSHAP0000001765899.494996.9697
ENSG00000152700homo_sapiensENSP0000038543284.848583.8384choloepus_hoffmanniENSCHOP0000001141585.714384.6939
ENSG00000152700homo_sapiensENSP0000038543210098.9899dasypus_novemcinctusENSDNOP0000002341910098.9899
ENSG00000152700homo_sapiensENSP0000038543298.484897.9798echinops_telfairiENSETEP0000001311710099.4872
ENSG00000152700homo_sapiensENSP0000038543210099.4949callithrix_jacchusENSCJAP0000000883810099.4949
ENSG00000152700homo_sapiensENSP0000038543210099.4949cercocebus_atysENSCATP0000000762210099.4949
ENSG00000152700homo_sapiensENSP0000038543292.929390.9091macaca_mulattaENSMMUP0000007325972.727371.1462
ENSG00000152700homo_sapiensENSP0000038543210099.4949macaca_nemestrinaENSMNEP0000004578810099.4949
ENSG00000152700homo_sapiensENSP0000038543292.929390.9091papio_anubisENSPANP0000000264187.203885.3081
ENSG00000152700homo_sapiensENSP0000038543210099.4949mandrillus_leucophaeusENSMLEP0000002877510099.4949
ENSG00000152700homo_sapiensENSP0000038543210098.9899tursiops_truncatusENSTTRP0000001598810098.9899
ENSG00000152700homo_sapiensENSP0000038543210098.9899vulpes_vulpesENSVVUP0000002914510098.9899
ENSG00000152700homo_sapiensENSP0000038543210098.9899mus_spretusMGP_SPRETEiJ_P002792610098.9899
ENSG00000152700homo_sapiensENSP0000038543286.363684.3434equus_asinusENSEASP0000506228583.823581.8627
ENSG00000152700homo_sapiensENSP0000038543210098.4848capra_hircusENSCHIP0000002596210098.4848
ENSG00000152700homo_sapiensENSP0000038543299.494998.4848loxodonta_africanaENSLAFP0000000085699.494998.4848
ENSG00000152700homo_sapiensENSP0000038543210099.4949panthera_leoENSPLOP0000000112210099.4949
ENSG00000152700homo_sapiensENSP0000038543210098.9899ailuropoda_melanoleucaENSAMEP0000001886110098.9899
ENSG00000152700homo_sapiensENSP0000038543210098.4848bos_indicus_hybridENSBIXP0000500479310098.4848
ENSG00000152700homo_sapiensENSP0000038543287.878885.8586oryctolagus_cuniculusENSOCUP0000004329758.983157.6271
ENSG00000152700homo_sapiensENSP0000038543298.989996.9697equus_caballusENSECAP0000001015993.779991.866
ENSG00000152700homo_sapiensENSP0000038543210098.9899canis_lupus_familiarisENSCAFP0084501859610098.9899
ENSG00000152700homo_sapiensENSP0000038543210099.4949panthera_pardusENSPPRP0000001589310099.4949
ENSG00000152700homo_sapiensENSP0000038543210098.9899marmota_marmota_marmotaENSMMMP0000000042810098.9899
ENSG00000152700homo_sapiensENSP0000038543210098.4848balaenoptera_musculusENSBMSP0001000102810098.4848
ENSG00000152700homo_sapiensENSP0000038543210097.9798cavia_porcellusENSCPOP0000002174510097.9798
ENSG00000152700homo_sapiensENSP0000038543210099.4949felis_catusENSFCAP0000000031010099.4949
ENSG00000152700homo_sapiensENSP0000038543210098.4848ursus_americanusENSUAMP0000002240410098.4848
ENSG00000152700homo_sapiensENSP0000038543288.383883.3333monodelphis_domesticaENSMODP0000001778791.145885.9375
ENSG00000152700homo_sapiensENSP0000038543210098.4848bison_bison_bisonENSBBBP0000002435010098.4848
ENSG00000152700homo_sapiensENSP0000038543210098.9899monodon_monocerosENSMMNP0001500330610098.9899
ENSG00000152700homo_sapiensENSP0000038543210098.9899sus_scrofaENSSSCP0000004229210098.9899
ENSG00000152700homo_sapiensENSP0000038543297.979896.4646microcebus_murinusENSMICP0000001058798.477296.9543
ENSG00000152700homo_sapiensENSP0000038543210096.9697octodon_degusENSODEP0000001318610096.9697
ENSG00000152700homo_sapiensENSP0000038543299.494998.4848jaculus_jaculusENSJJAP0000000027399.494998.4848
ENSG00000152700homo_sapiensENSP0000038543279.292972.7273jaculus_jaculusENSJJAP0000001544687.222280
ENSG00000152700homo_sapiensENSP0000038543210098.4848ovis_aries_rambouilletENSOARP0002001028910098.4848
ENSG00000152700homo_sapiensENSP0000038543210098.4848ursus_maritimusENSUMAP0000002428310098.4848
ENSG00000152700homo_sapiensENSP0000038543210098.9899delphinapterus_leucasENSDLEP0000000556610098.9899
ENSG00000152700homo_sapiensENSP0000038543210098.9899physeter_catodonENSPCTP0000501570010098.9899
ENSG00000152700homo_sapiensENSP0000038543210098.9899mus_caroliMGP_CAROLIEiJ_P002655110098.9899
ENSG00000152700homo_sapiensENSP0000038543210098.9899mus_musculusENSMUSP0000002065310098.9899
ENSG00000152700homo_sapiensENSP0000038543210099.4949dipodomys_ordiiENSDORP0000002468510099.4949
ENSG00000152700homo_sapiensENSP0000038543210098.9899mustela_putorius_furoENSMPUP0000001001210098.9899
ENSG00000152700homo_sapiensENSP0000038543277.777876.7677aotus_nancymaaeENSANAP0000003013993.333392.1212
ENSG00000152700homo_sapiensENSP0000038543276.767773.7374saimiri_boliviensis_boliviensisENSSBOP0000001226991.01887.4251
ENSG00000152700homo_sapiensENSP0000038543255.555652.5253vicugna_pacosENSVPAP0000001000196.491291.2281
ENSG00000152700homo_sapiensENSP0000038543277.777877.2727vicugna_pacosENSVPAP0000000146977.777877.2727
ENSG00000152700homo_sapiensENSP0000038543210098.9899chlorocebus_sabaeusENSCSAP0000000974210098.9899
ENSG00000152700homo_sapiensENSP0000038543247.979846.4646tupaia_belangeriENSTBEP0000000161490.476287.619
ENSG00000152700homo_sapiensENSP0000038543268.181867.1717tupaia_belangeriENSTBEP0000000350598.540197.0803
ENSG00000152700homo_sapiensENSP0000038543210098.9899mesocricetus_auratusENSMAUP0000001511110098.9899
ENSG00000152700homo_sapiensENSP0000038543210098.9899phocoena_sinusENSPSNP0000002706610098.9899
ENSG00000152700homo_sapiensENSP0000038543210099.4949camelus_dromedariusENSCDRP0000500389310099.4949
ENSG00000152700homo_sapiensENSP0000038543299.494998.9899carlito_syrichtaENSTSYP0000001088399.494998.9899
ENSG00000152700homo_sapiensENSP0000038543210099.4949panthera_tigris_altaicaENSPTIP0000000043810099.4949
ENSG00000152700homo_sapiensENSP0000038543210098.4848prolemur_simusENSPSMP0000002991210098.4848
ENSG00000152700homo_sapiensENSP0000038543285.858682.3232microtus_ochrogasterENSMOCP0000001625193.406689.5604
ENSG00000152700homo_sapiensENSP0000038543210099.4949sorex_araneusENSSARP0000000194710099.4949
ENSG00000152700homo_sapiensENSP0000038543210098.9899peromyscus_maniculatus_bairdiiENSPEMP0000002794610098.9899
ENSG00000152700homo_sapiensENSP0000038543210098.4848bos_mutusENSBMUP0000000212699.497597.99
ENSG00000152700homo_sapiensENSP0000038543210098.9899mus_spicilegusENSMSIP0000002606310098.9899
ENSG00000152700homo_sapiensENSP0000038543210098.9899cricetulus_griseus_chok1gshdENSCGRP0000101582610098.9899
ENSG00000152700homo_sapiensENSP0000038543210099.4949pteropus_vampyrusENSPVAP0000001172210099.4949
ENSG00000152700homo_sapiensENSP0000038543299.494998.4848myotis_lucifugusENSMLUP0000001488699.494998.4848
ENSG00000152700homo_sapiensENSP0000038543299.494996.9697vombatus_ursinusENSVURP0001000979799.494996.9697
ENSG00000152700homo_sapiensENSP0000038543299.494998.4848rhinolophus_ferrumequinumENSRFEP0001002951499.494998.4848
ENSG00000152700homo_sapiensENSP0000038543210098.9899neovison_visonENSNVIP0000002114810098.9899
ENSG00000152700homo_sapiensENSP0000038543210098.4848bos_taurusENSBTAP0000002828010098.4848
ENSG00000152700homo_sapiensENSP0000038543299.494997.9798heterocephalus_glaber_femaleENSHGLP0000004472899.494997.9798
ENSG00000152700homo_sapiensENSP0000038543210099.4949rhinopithecus_bietiENSRBIP0000002606810099.4949
ENSG00000152700homo_sapiensENSP0000038543210098.9899canis_lupus_dingoENSCAFP0002000165810098.9899
ENSG00000152700homo_sapiensENSP0000038543210099.4949sciurus_vulgarisENSSVLP0000503098410099.4949
ENSG00000152700homo_sapiensENSP0000038543299.494996.9697phascolarctos_cinereusENSPCIP0000001842599.494996.9697
ENSG00000152700homo_sapiensENSP0000038543298.989997.4747procavia_capensisENSPCAP0000000244398.989997.4747
ENSG00000152700homo_sapiensENSP0000038543210098.9899nannospalax_galiliENSNGAP0000001504410098.9899
ENSG00000152700homo_sapiensENSP0000038543210098.4848bos_grunniensENSBGRP0000000255710098.4848
ENSG00000152700homo_sapiensENSP0000038543210098.9899chinchilla_lanigeraENSCLAP0000002300810098.9899
ENSG00000152700homo_sapiensENSP0000038543263.636460.6061chinchilla_lanigeraENSCLAP0000000854494.736890.2256
ENSG00000152700homo_sapiensENSP0000038543280.30376.7677chinchilla_lanigeraENSCLAP0000000161593.529489.4118
ENSG00000152700homo_sapiensENSP0000038543210098.4848cervus_hanglu_yarkandensisENSCHYP0000002464210098.4848
ENSG00000152700homo_sapiensENSP0000038543210098.9899catagonus_wagneriENSCWAP0000000176310098.9899
ENSG00000152700homo_sapiensENSP0000038543299.494998.9899ictidomys_tridecemlineatusENSSTOP0000001015999.494998.9899
ENSG00000152700homo_sapiensENSP0000038543272.727367.6768ictidomys_tridecemlineatusENSSTOP000000301339083.75
ENSG00000152700homo_sapiensENSP0000038543290.40490.404otolemur_garnettiiENSOGAP00000011962100100
ENSG00000152700homo_sapiensENSP0000038543210098.9899cebus_imitatorENSCCAP0000003887910098.9899
ENSG00000152700homo_sapiensENSP0000038543210098.9899urocitellus_parryiiENSUPAP0001002125610098.9899
ENSG00000152700homo_sapiensENSP0000038543210098.4848moschus_moschiferusENSMMSP0000001883410098.4848
ENSG00000152700homo_sapiensENSP0000038543210099.4949rhinopithecus_roxellanaENSRROP0000000881410099.4949
ENSG00000152700homo_sapiensENSP0000038543210099.4949mus_pahariMGP_PahariEiJ_P003332210099.4949
ENSG00000152700homo_sapiensENSP0000038543298.989996.9697propithecus_coquereliENSPCOP0000002664198.989996.9697
ENSG00000152700homo_sapiensENSP0000038543288.888987.8788propithecus_coquereliENSPCOP0000000484210098.8636
ENSG00000152700homo_sapiensENSP0000038543291.414184.3434xenopus_tropicalisENSXETP0000002286191.414184.3434
ENSG00000152700homo_sapiensENSP0000038543298.989996.9697chrysemys_picta_belliiENSCPBP0000001070498.989996.9697
ENSG00000152700homo_sapiensENSP0000038543298.989997.4747sphenodon_punctatusENSSPUP0000001228698.989997.4747
ENSG00000152700homo_sapiensENSP0000038543298.989997.9798anas_platyrhynchos_platyrhynchosENSAPLP0000000699698.989997.9798
ENSG00000152700homo_sapiensENSP0000038543298.989997.4747gallus_gallusENSGALP0001001866289.908388.5321
ENSG00000152700homo_sapiensENSP0000038543298.484897.4747meleagris_gallopavoENSMGAP0000002191490.277889.3519
ENSG00000152700homo_sapiensENSP0000038543297.474794.9495serinus_canariaENSSCAP0000001486097.969595.4315
ENSG00000152700homo_sapiensENSP0000038543297.474794.4444parus_majorENSPMJP0000001253797.969594.9239
ENSG00000152700homo_sapiensENSP0000038543297.474793.4343anolis_carolinensisENSACAP0000000178097.474793.4343
ENSG00000152700homo_sapiensENSP0000038543297.474794.9495geospiza_fortisENSGFOP0000000344697.969595.4315
ENSG00000152700homo_sapiensENSP0000038543297.474795.4545taeniopygia_guttataENSTGUP0000003400597.969595.9391
ENSG00000152700homo_sapiensENSP0000038543298.989996.9697pelodiscus_sinensisENSPSIP0000000515598.989996.9697
ENSG00000152700homo_sapiensENSP0000038543298.484895.9596gopherus_evgoodeiENSGEVP0000501125798.484895.9596
ENSG00000152700homo_sapiensENSP0000038543298.484896.4646chelonoidis_abingdoniiENSCABP0000000614098.484896.4646
ENSG00000152700homo_sapiensENSP0000038543298.484897.4747struthio_camelus_australisENSSCUP0000002201798.484897.4747
ENSG00000152700homo_sapiensENSP0000038543298.989998.4848anser_brachyrhynchusENSABRP0000001319398.989998.4848
ENSG00000152700homo_sapiensENSP0000038543298.989997.9798strigops_habroptilaENSSHBP0000500794498.989997.9798
ENSG00000152700homo_sapiensENSP0000038543298.989996.9697terrapene_carolina_triunguisENSTMTP0000002909798.989996.9697
ENSG00000152700homo_sapiensENSP0000038543298.989998.4848aquila_chrysaetos_chrysaetosENSACCP0002001396498.989998.4848
ENSG00000152700homo_sapiensENSP0000038543297.474794.9495ficedula_albicollisENSFALP0000000827597.969595.4315
ENSG00000152700homo_sapiensENSP0000038543298.989998.4848coturnix_japonicaENSCJPP0000500534198.989998.4848

Gene Ontology

Go ID Go term No. evidence Entries Species Category
GO:0002474involved_in antigen processing and presentation of peptide antigen via MHC class I1TASHomo_sapiens(9606)Process
GO:0003400involved_in regulation of COPII vesicle coating1IBAHomo_sapiens(9606)Process
GO:0003924enables GTPase activity2IBA,TASHomo_sapiens(9606)Function
GO:0005515enables protein binding1IPIHomo_sapiens(9606)Function
GO:0005525enables GTP binding1IEAHomo_sapiens(9606)Function
GO:0005789located_in endoplasmic reticulum membrane1TASHomo_sapiens(9606)Component
GO:0005829located_in cytosol1TASHomo_sapiens(9606)Component
GO:0006886involved_in intracellular protein transport1IBAHomo_sapiens(9606)Process
GO:0006888involved_in endoplasmic reticulum to Golgi vesicle-mediated transport1IBAHomo_sapiens(9606)Process
GO:0012507located_in ER to Golgi transport vesicle membrane1TASHomo_sapiens(9606)Component
GO:0016050involved_in vesicle organization1IBAHomo_sapiens(9606)Process
GO:0030127part_of COPII vesicle coat1IBAHomo_sapiens(9606)Component
GO:0032368involved_in regulation of lipid transport1IDAHomo_sapiens(9606)Process
GO:0032580located_in Golgi cisterna membrane1IEAHomo_sapiens(9606)Component
GO:0042953involved_in lipoprotein transport1IDAHomo_sapiens(9606)Process
GO:0046872enables metal ion binding1IEAHomo_sapiens(9606)Function
GO:0055088involved_in lipid homeostasis1IDAHomo_sapiens(9606)Process
GO:0061024involved_in membrane organization1IBAHomo_sapiens(9606)Process
GO:0070863involved_in positive regulation of protein exit from endoplasmic reticulum1IBAHomo_sapiens(9606)Process
GO:0070971is_active_in endoplasmic reticulum exit site1IBAHomo_sapiens(9606)Component

Expression