Functions and Diseases

RBP Type Canonical_RBPs
Diseases CancerSARS-COV-OC43FlavivirusesHIVRVSARS-COV-2SINVDengueZika
Drug Drug
Main interacting RNAs rRNA
Moonlighting functions Metabolic enzyme
Localizations Stress granucleP-body
BulkPerturb-seq DataSet_02_106

Description

Ensembl ID ENSG00000149273 Gene ID 6188 Accession 10420
Symbol RPS3 Alias S3;uS3 Full Name ribosomal protein S3
Status Confidence Length 22763 bases Strand Plus strand
Position 11 : 75399518 - 75422280 RNA binding domain KH_2 , Ribosomal_S3_C
Summary Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit, where it forms part of the domain where translation is initiated. The protein belongs to the S3P family of ribosomal proteins. Studies of the mouse and rat proteins have demonstrated that the protein has an extraribosomal role as an endonuclease involved in the repair of UV-induced DNA damage. The protein appears to be located in both the cytoplasm and nucleus but not in the nucleolus. Higher levels of expression of this gene in colon adenocarcinomas and adenomatous polyps compared to adjacent normal colonic mucosa have been observed. This gene is co-transcribed with the small nucleolar RNA genes U15A and U15B, which are located in its first and fifth introns, respectively. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2012]

RNA binding domains (RBDs)

Protein Domain Pfam ID E-value Domain number
ENSP00000433155 KH_2 PF07650 1.9e-11 1
ENSP00000437105 KH_2 PF07650 2.2e-11 1
ENSP00000431737 KH_2 PF07650 2.7e-11 1
ENSP00000436335 KH_2 PF07650 4.4e-11 1
ENSP00000433821 KH_2 PF07650 8.8e-11 1
ENSP00000433821 Ribosomal_S3_C PF00189 5.8e-23 2
ENSP00000434643 KH_2 PF07650 8.8e-11 1
ENSP00000434643 Ribosomal_S3_C PF00189 5.8e-23 2
ENSP00000436971 KH_2 PF07650 8.8e-11 1
ENSP00000436971 Ribosomal_S3_C PF00189 5.8e-23 2
ENSP00000278572 KH_2 PF07650 4.2e-10 1
ENSP00000278572 Ribosomal_S3_C PF00189 6.8e-23 2
ENSP00000432542 KH_2 PF07650 6.7e-10 1
ENSP00000431834 KH_2 PF07650 1.2e-09 1
ENSP00000433421 KH_2 PF07650 3.9e-09 1
ENSP00000433421 Ribosomal_S3_C PF00189 5.5e-23 2
ENSP00000435457 KH_2 PF07650 1.1e-08 1
ENSP00000436556 Ribosomal_S3_C PF00189 3e-20 1
ENSP00000416745 Ribosomal_S3_C PF00189 6.2e-17 1
ENSP00000435566 Ribosomal_S3_C PF00189 2e-08 1

RNA binding proteomes (RBPomes)

Pubmed ID Full Name Cell Author Time Doi

Literatures on RNA binding capacity

Pubmed ID Title Author Time Journal

Transcripts

Name Transcript ID bp Protein Translation ID
RPS3-212 ENST00000529173 1373 No protein -
RPS3-210 ENST00000528439 473 91aa ENSP00000432542
RPS3-217 ENST00000531188 2059 243aa ENSP00000434643
RPS3-214 ENST00000530164 1878 117aa ENSP00000433155
RPS3-216 ENST00000530721 796 44aa ENSP00000432458
RPS3-202 ENST00000422465 903 103aa ENSP00000416745
RPS3-201 ENST00000278572 907 259aa ENSP00000278572
RPS3-218 ENST00000532872 737 115aa ENSP00000431834
RPS3-219 ENST00000534440 564 158aa ENSP00000436335
RPS3-209 ENST00000527446 1306 243aa ENSP00000436971
RPS3-207 ENST00000526608 710 231aa ENSP00000433421
RPS3-208 ENST00000527273 390 128aa ENSP00000435457
RPS3-203 ENST00000524851 866 243aa ENSP00000433821
RPS3-206 ENST00000526248 771 135aa ENSP00000431737
RPS3-213 ENST00000529285 550 No protein -
RPS3-220 ENST00000534555 387 No protein -
RPS3-211 ENST00000528847 639 36aa ENSP00000435566
RPS3-205 ENST00000525933 1307 171aa ENSP00000436556
RPS3-204 ENST00000525690 421 33aa ENSP00000436476
RPS3-215 ENST00000530170 531 123aa ENSP00000437105

Pathways

Pathway ID Pathway Name Source

Phenotypes

ensgID Trait pValue Pubmed ID

GWAS

ensgIDSNPChromosomePosition TraitPubmedIDOr or BEAT EFO ID

Protein-Protein Interaction (PPI)

Paralogs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id
ENSG00000149273homo_sapiensENSP0000049681338.505724.1379homo_sapiensENSP0000043464327.57217.284

Orthologs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id
ENSG00000149273homo_sapiensENSP00000434643100100pan_paniscusENSPPAP00000012063100100
ENSG00000149273homo_sapiensENSP0000043464397.942497.1193pongo_abeliiENSPPYP0000000421590.839790.0763
ENSG00000149273homo_sapiensENSP00000434643100100pan_troglodytesENSPTRP00000062955100100
ENSG00000149273homo_sapiensENSP00000434643100100gorilla_gorillaENSGGOP00000006379100100
ENSG00000149273homo_sapiensENSP0000043464398.765498.3539notamacropus_eugeniiENSMEUP0000001055898.765498.3539
ENSG00000149273homo_sapiensENSP0000043464383.950681.07choloepus_hoffmanniENSCHOP0000000472093.150789.9543
ENSG00000149273homo_sapiensENSP0000043464310099.5885dasypus_novemcinctusENSDNOP0000001153891.353490.9774
ENSG00000149273homo_sapiensENSP0000043464398.353997.5309erinaceus_europaeusENSEEUP0000001326898.353997.5309
ENSG00000149273homo_sapiensENSP0000043464382.71682.716echinops_telfairiENSETEP0000001256682.71682.716
ENSG00000149273homo_sapiensENSP0000043464399.588599.5885callithrix_jacchusENSCJAP0000002846185.815685.8156
ENSG00000149273homo_sapiensENSP00000434643100100cercocebus_atysENSCATP0000002362090.671690.6716
ENSG00000149273homo_sapiensENSP0000043464329.629629.6296macaca_fascicularisENSMFAP0000003961293.506593.5065
ENSG00000149273homo_sapiensENSP00000434643100100macaca_mulattaENSMMUP00000036826100100
ENSG00000149273homo_sapiensENSP0000043464363.78662.5514macaca_nemestrinaENSMNEP0000004070194.512292.6829
ENSG00000149273homo_sapiensENSP0000043464378.600876.5432macaca_nemestrinaENSMNEP0000001316884.888982.6667
ENSG00000149273homo_sapiensENSP00000434643100100papio_anubisENSPANP0000000073393.822493.8224
ENSG00000149273homo_sapiensENSP00000434643100100mandrillus_leucophaeusENSMLEP0000000671793.822493.8224
ENSG00000149273homo_sapiensENSP00000434643100100tursiops_truncatusENSTTRP00000005538100100
ENSG00000149273homo_sapiensENSP0000043464310099.5885vulpes_vulpesENSVVUP0000003370210099.5885
ENSG00000149273homo_sapiensENSP0000043464310099.5885mus_spretusMGP_SPRETEiJ_P008420710099.5885
ENSG00000149273homo_sapiensENSP0000043464310099.5885equus_asinusENSEASP0000502072586.476986.121
ENSG00000149273homo_sapiensENSP00000434643100100capra_hircusENSCHIP00000009520100100
ENSG00000149273homo_sapiensENSP0000043464310099.5885loxodonta_africanaENSLAFP0000000358210099.5885
ENSG00000149273homo_sapiensENSP0000043464310099.5885panthera_leoENSPLOP0000000866810099.5885
ENSG00000149273homo_sapiensENSP00000434643100100bos_indicus_hybridENSBIXP0000504543486.476986.4769
ENSG00000149273homo_sapiensENSP0000043464310099.5885oryctolagus_cuniculusENSOCUP0000001859886.476986.121
ENSG00000149273homo_sapiensENSP0000043464310099.5885equus_caballusENSECAP0000001178986.476986.121
ENSG00000149273homo_sapiensENSP0000043464310099.5885canis_lupus_familiarisENSCAFP0084501655910099.5885
ENSG00000149273homo_sapiensENSP0000043464310099.5885panthera_pardusENSPPRP0000002883310099.5885
ENSG00000149273homo_sapiensENSP0000043464310099.5885marmota_marmota_marmotaENSMMMP0000001102610099.5885
ENSG00000149273homo_sapiensENSP00000434643100100balaenoptera_musculusENSBMSP00010009113100100
ENSG00000149273homo_sapiensENSP0000043464310099.5885cavia_porcellusENSCPOP0000002876610099.5885
ENSG00000149273homo_sapiensENSP0000043464310099.5885felis_catusENSFCAP0000001108010099.5885
ENSG00000149273homo_sapiensENSP0000043464310099.5885ursus_americanusENSUAMP0000002787110099.5885
ENSG00000149273homo_sapiensENSP0000043464399.588599.177monodelphis_domesticaENSMODP0000000861199.588599.177
ENSG00000149273homo_sapiensENSP00000434643100100bison_bison_bisonENSBBBP0000002676794.18694.186
ENSG00000149273homo_sapiensENSP00000434643100100monodon_monocerosENSMMNP00015027057100100
ENSG00000149273homo_sapiensENSP00000434643100100sus_scrofaENSSSCP0000001577492.748192.7481
ENSG00000149273homo_sapiensENSP00000434643100100microcebus_murinusENSMICP00000020936100100
ENSG00000149273homo_sapiensENSP0000043464389.300488.0658octodon_degusENSODEP0000000329895.594794.2731
ENSG00000149273homo_sapiensENSP0000043464357.201653.4979octodon_degusENSODEP0000000230090.259784.4156
ENSG00000149273homo_sapiensENSP0000043464389.300487.6543octodon_degusENSODEP0000000078195.175493.4211
ENSG00000149273homo_sapiensENSP0000043464380.658475.3086octodon_degusENSODEP0000000165387.892482.0628
ENSG00000149273homo_sapiensENSP0000043464344.032941.5638octodon_degusENSODEP0000000493289.166784.1667
ENSG00000149273homo_sapiensENSP0000043464365.843664.6091octodon_degusENSODEP0000000910999.378997.5155
ENSG00000149273homo_sapiensENSP0000043464310099.5885jaculus_jaculusENSJJAP0000001741810099.5885
ENSG00000149273homo_sapiensENSP00000434643100100ovis_aries_rambouilletENSOARP0002000609093.461593.4615
ENSG00000149273homo_sapiensENSP0000043464373.25172.8395ochotona_princepsENSOPRP0000000867873.25172.8395
ENSG00000149273homo_sapiensENSP00000434643100100delphinapterus_leucasENSDLEP00000003876100100
ENSG00000149273homo_sapiensENSP00000434643100100physeter_catodonENSPCTP00005017935100100
ENSG00000149273homo_sapiensENSP0000043464310099.5885mus_caroliMGP_CAROLIEiJ_P008083710099.5885
ENSG00000149273homo_sapiensENSP0000043464310099.5885mus_musculusENSMUSP0000003299810099.5885
ENSG00000149273homo_sapiensENSP0000043464310099.5885dipodomys_ordiiENSDORP0000000279410099.5885
ENSG00000149273homo_sapiensENSP0000043464310099.5885mustela_putorius_furoENSMPUP0000000912010099.5885
ENSG00000149273homo_sapiensENSP00000434643100100aotus_nancymaaeENSANAP0000001986293.822493.8224
ENSG00000149273homo_sapiensENSP00000434643100100saimiri_boliviensis_boliviensisENSSBOP0000001007793.822493.8224
ENSG00000149273homo_sapiensENSP00000434643100100vicugna_pacosENSVPAP00000010808100100
ENSG00000149273homo_sapiensENSP00000434643100100chlorocebus_sabaeusENSCSAP00000000282100100
ENSG00000149273homo_sapiensENSP0000043464310099.5885tupaia_belangeriENSTBEP0000000609110099.5885
ENSG00000149273homo_sapiensENSP0000043464394.238793.0041mesocricetus_auratusENSMAUP0000000472298.706997.4138
ENSG00000149273homo_sapiensENSP00000434643100100phocoena_sinusENSPSNP00000008404100100
ENSG00000149273homo_sapiensENSP0000043464394.238792.5926carlito_syrichtaENSTSYP0000001861584.814883.3333
ENSG00000149273homo_sapiensENSP0000043464310099.5885panthera_tigris_altaicaENSPTIP0000001285310099.5885
ENSG00000149273homo_sapiensENSP0000043464397.530995.8848rattus_norvegicusENSRNOP0000000998897.530995.8848
ENSG00000149273homo_sapiensENSP0000043464361.728461.7284prolemur_simusENSPSMP0000002664999.337799.3377
ENSG00000149273homo_sapiensENSP00000434643100100prolemur_simusENSPSMP00000003736100100
ENSG00000149273homo_sapiensENSP0000043464310099.5885microtus_ochrogasterENSMOCP0000000781810099.5885
ENSG00000149273homo_sapiensENSP0000043464395.061794.6502sorex_araneusENSSARP0000000634395.850695.4357
ENSG00000149273homo_sapiensENSP0000043464310099.5885peromyscus_maniculatus_bairdiiENSPEMP0000002526210099.5885
ENSG00000149273homo_sapiensENSP00000434643100100bos_mutusENSBMUP0000000481594.18694.186
ENSG00000149273homo_sapiensENSP0000043464310099.5885mus_spicilegusENSMSIP0000003266310099.5885
ENSG00000149273homo_sapiensENSP0000043464376.954773.6626cricetulus_griseus_chok1gshdENSCGRP0000100315690.776786.8932
ENSG00000149273homo_sapiensENSP0000043464310099.5885cricetulus_griseus_chok1gshdENSCGRP0000101220786.476986.121
ENSG00000149273homo_sapiensENSP0000043464394.238793.8272pteropus_vampyrusENSPVAP0000001062694.628194.2149
ENSG00000149273homo_sapiensENSP0000043464399.588599.177myotis_lucifugusENSMLUP0000000371499.588599.177
ENSG00000149273homo_sapiensENSP0000043464360.082356.7901vombatus_ursinusENSVURP0001000792890.683285.7143
ENSG00000149273homo_sapiensENSP0000043464359.259357.2016vombatus_ursinusENSVURP0001000361796.644393.2886
ENSG00000149273homo_sapiensENSP0000043464398.765498.3539vombatus_ursinusENSVURP0001002223298.765498.3539
ENSG00000149273homo_sapiensENSP0000043464310099.5885rhinolophus_ferrumequinumENSRFEP0001002739986.476986.121
ENSG00000149273homo_sapiensENSP0000043464310099.5885neovison_visonENSNVIP0000002922310099.5885
ENSG00000149273homo_sapiensENSP00000434643100100bos_taurusENSBTAP00000003962100100
ENSG00000149273homo_sapiensENSP0000043464399.588599.177heterocephalus_glaber_femaleENSHGLP0000002719199.588599.177
ENSG00000149273homo_sapiensENSP00000434643100100rhinopithecus_bietiENSRBIP00000043513100100
ENSG00000149273homo_sapiensENSP0000043464310099.5885canis_lupus_dingoENSCAFP0002000248310099.5885
ENSG00000149273homo_sapiensENSP0000043464366.255165.8436sciurus_vulgarisENSSVLP0000502057310099.3789
ENSG00000149273homo_sapiensENSP0000043464310099.5885sciurus_vulgarisENSSVLP0000502803094.18693.7984
ENSG00000149273homo_sapiensENSP0000043464356.378653.0864phascolarctos_cinereusENSPCIP0000002525480.588275.8824
ENSG00000149273homo_sapiensENSP0000043464398.765498.3539phascolarctos_cinereusENSPCIP0000003253098.765498.3539
ENSG00000149273homo_sapiensENSP0000043464330.864228.8066phascolarctos_cinereusENSPCIP0000005128089.285783.3333
ENSG00000149273homo_sapiensENSP0000043464360.082357.2016phascolarctos_cinereusENSPCIP0000003028796.688792.053
ENSG00000149273homo_sapiensENSP0000043464381.89381.07procavia_capensisENSPCAP0000000283081.89381.07
ENSG00000149273homo_sapiensENSP0000043464310099.5885nannospalax_galiliENSNGAP0000001411410099.5885
ENSG00000149273homo_sapiensENSP00000434643100100bos_grunniensENSBGRP0000003721186.476986.4769
ENSG00000149273homo_sapiensENSP0000043464310099.5885chinchilla_lanigeraENSCLAP0000002017210099.5885
ENSG00000149273homo_sapiensENSP00000434643100100cervus_hanglu_yarkandensisENSCHYP0000000705762.628962.6289
ENSG00000149273homo_sapiensENSP00000434643100100catagonus_wagneriENSCWAP0000000241992.748192.7481
ENSG00000149273homo_sapiensENSP00000434643100100otolemur_garnettiiENSOGAP0000000475899.590299.5902
ENSG00000149273homo_sapiensENSP00000434643100100cebus_imitatorENSCCAP000000088389090
ENSG00000149273homo_sapiensENSP0000043464399.588599.177urocitellus_parryiiENSUPAP0001001692599.588599.177
ENSG00000149273homo_sapiensENSP00000434643100100moschus_moschiferusENSMMSP0000001376694.18694.186
ENSG00000149273homo_sapiensENSP00000434643100100rhinopithecus_roxellanaENSRROP00000002484100100
ENSG00000149273homo_sapiensENSP0000043464310099.5885mus_pahariMGP_PahariEiJ_P001767610099.5885
ENSG00000149273homo_sapiensENSP00000434643100100propithecus_coquereliENSPCOP00000031940100100
ENSG00000149273homo_sapiensENSP0000043464385.185274.4856caenorhabditis_elegansC23G10.3.183.805773.2794
ENSG00000149273homo_sapiensENSP0000043464387.654380.2469drosophila_melanogasterFBpp031206686.585479.2683
ENSG00000149273homo_sapiensENSP0000043464388.477485.5967ciona_intestinalisENSCINP0000001031381.74979.0875
ENSG00000149273homo_sapiensENSP0000043464378.600874.0741petromyzon_marinusENSPMAP0000000859695.590
ENSG00000149273homo_sapiensENSP0000043464359.259353.0864eptatretus_burgeriENSEBUP0000000541579.55871.2707
ENSG00000149273homo_sapiensENSP0000043464398.353997.5309callorhinchus_miliiENSCMIP0000004384395.694.8
ENSG00000149273homo_sapiensENSP0000043464398.353995.4733fundulus_heteroclitusENSFHEP0000003443297.55194.6939
ENSG00000149273homo_sapiensENSP0000043464398.353997.5309notechis_scutatusENSNSUP0000002382198.353997.5309
ENSG00000149273homo_sapiensENSP0000043464398.353997.5309pseudonaja_textilisENSPTXP0000002146398.353997.5309
ENSG00000149273homo_sapiensENSP0000043464386.831384.3621naja_najaENSNNAP0000001202484.482
ENSG00000149273homo_sapiensENSP0000043464388.477484.7737ciona_savignyiENSCSAVP0000000584383.657680.1556
ENSG00000149273homo_sapiensENSP0000043464377.777865.8436saccharomyces_cerevisiaeYNL178W78.7566.6667
ENSG00000149273homo_sapiensENSP0000043464397.942497.1193nothobranchius_furzeriENSNFUP0001503203894.444493.6508

Gene Ontology

Go ID Go term No. evidence Entries Species Category
GO:0000977contributes_to RNA polymerase II transcription regulatory region sequence-specific DNA binding1IMPHomo_sapiens(9606)Function
GO:0002181involved_in cytoplasmic translation2IC,NASHomo_sapiens(9606)Process
GO:0003677enables DNA binding1IDAHomo_sapiens(9606)Function
GO:0003684enables damaged DNA binding1IDAHomo_sapiens(9606)Function
GO:0003723enables RNA binding2HDA,IDAHomo_sapiens(9606)Function
GO:0003729enables mRNA binding1IDAHomo_sapiens(9606)Function
GO:0003735enables structural constituent of ribosome4HDA,IBA,IDA,NASHomo_sapiens(9606)Function
GO:0003906enables DNA-(apurinic or apyrimidinic site) endonuclease activity1IDAHomo_sapiens(9606)Function
GO:0004520enables DNA endonuclease activity1IDAHomo_sapiens(9606)Function
GO:0005515enables protein binding1IPIHomo_sapiens(9606)Function
GO:0005634is_active_in nucleus3IBA,IDA,IMPHomo_sapiens(9606)Component
GO:0005654located_in nucleoplasm1TASHomo_sapiens(9606)Component
GO:0005730located_in nucleolus1IDAHomo_sapiens(9606)Component
GO:0005737located_in cytoplasm3IDA,IMP,NASHomo_sapiens(9606)Component
GO:0005743located_in mitochondrial inner membrane1IDAHomo_sapiens(9606)Component
GO:0005759located_in mitochondrial matrix1IDAHomo_sapiens(9606)Component
GO:0005783located_in endoplasmic reticulum1IDAHomo_sapiens(9606)Component
GO:0005829located_in cytosol2IDA,TASHomo_sapiens(9606)Component
GO:0005840located_in ribosome1IDAHomo_sapiens(9606)Component
GO:0005844part_of polysome1IDAHomo_sapiens(9606)Component
GO:0005886located_in plasma membrane1IDAHomo_sapiens(9606)Component
GO:0005925located_in focal adhesion1HDAHomo_sapiens(9606)Component
GO:0006281involved_in DNA repair1IMPHomo_sapiens(9606)Process
GO:0006284involved_in base-excision repair1IDAHomo_sapiens(9606)Process
GO:0006412involved_in translation2IC,NASHomo_sapiens(9606)Process
GO:0006413involved_in translational initiation1NASHomo_sapiens(9606)Process
GO:0006915involved_in apoptotic process1IEAHomo_sapiens(9606)Process
GO:0006974involved_in DNA damage response1IEPHomo_sapiens(9606)Process
GO:0007059involved_in chromosome segregation1IMPHomo_sapiens(9606)Process
GO:0008017enables microtubule binding1IDAHomo_sapiens(9606)Function
GO:0010628involved_in positive regulation of gene expression1IMPHomo_sapiens(9606)Process
GO:0014069is_active_in postsynaptic density2EXP,IDAHomo_sapiens(9606)Component
GO:0015631enables tubulin binding1IDAHomo_sapiens(9606)Function
GO:0016020located_in membrane1HDAHomo_sapiens(9606)Component
GO:0017148involved_in negative regulation of translation1IDAHomo_sapiens(9606)Process
GO:0019104NOT enables DNA N-glycosylase activity2IDA,TASHomo_sapiens(9606)Function
GO:0019899enables enzyme binding1IPIHomo_sapiens(9606)Function
GO:0019900enables kinase binding1IPIHomo_sapiens(9606)Function
GO:0019901enables protein kinase binding1IPIHomo_sapiens(9606)Function
GO:0022626located_in cytosolic ribosome1IDAHomo_sapiens(9606)Component
GO:0022627part_of cytosolic small ribosomal subunit4HDA,IBA,IDA,NASHomo_sapiens(9606)Component
GO:0030544enables Hsp70 protein binding1IDAHomo_sapiens(9606)Function
GO:0031116involved_in positive regulation of microtubule polymerization1IMPHomo_sapiens(9606)Process
GO:0031334involved_in positive regulation of protein-containing complex assembly1IMPHomo_sapiens(9606)Process
GO:0031397involved_in negative regulation of protein ubiquitination1IDAHomo_sapiens(9606)Process
GO:0032079involved_in positive regulation of endodeoxyribonuclease activity1IDAHomo_sapiens(9606)Process
GO:0032357enables oxidized purine DNA binding1IDAHomo_sapiens(9606)Function
GO:0032358enables oxidized pyrimidine DNA binding1IDAHomo_sapiens(9606)Function
GO:0032587located_in ruffle membrane1IDAHomo_sapiens(9606)Component
GO:0032743involved_in positive regulation of interleukin-2 production1IMPHomo_sapiens(9606)Process
GO:0034614involved_in cellular response to reactive oxygen species1IDAHomo_sapiens(9606)Process
GO:0042104involved_in positive regulation of activated T cell proliferation1IMPHomo_sapiens(9606)Process
GO:0042981involved_in regulation of apoptotic process1IMPHomo_sapiens(9606)Process
GO:0043507involved_in positive regulation of JUN kinase activity1IMPHomo_sapiens(9606)Process
GO:0044390enables ubiquitin-like protein conjugating enzyme binding1IPIHomo_sapiens(9606)Function
GO:0044877enables protein-containing complex binding1IMPHomo_sapiens(9606)Function
GO:0045738involved_in negative regulation of DNA repair1IMPHomo_sapiens(9606)Process
GO:0045739involved_in positive regulation of DNA repair1IDAHomo_sapiens(9606)Process
GO:0050862involved_in positive regulation of T cell receptor signaling pathway1IMPHomo_sapiens(9606)Process
GO:0051018enables protein kinase A binding1IPIHomo_sapiens(9606)Function
GO:0051092involved_in positive regulation of NF-kappaB transcription factor activity2IGI,IMPHomo_sapiens(9606)Process
GO:0051225involved_in spindle assembly1IMPHomo_sapiens(9606)Process
GO:0051301involved_in cell division1IEAHomo_sapiens(9606)Process
GO:0051536enables iron-sulfur cluster binding1NASHomo_sapiens(9606)Function
GO:0051879enables Hsp90 protein binding1IDAHomo_sapiens(9606)Function
GO:0061481involved_in response to TNF agonist1IDAHomo_sapiens(9606)Process
GO:0070062located_in extracellular exosome1HDAHomo_sapiens(9606)Component
GO:0070181enables small ribosomal subunit rRNA binding1IDAHomo_sapiens(9606)Function
GO:0070301involved_in cellular response to hydrogen peroxide1IDAHomo_sapiens(9606)Process
GO:0071159part_of NF-kappaB complex1IDAHomo_sapiens(9606)Component
GO:0071356involved_in cellular response to tumor necrosis factor1IMPHomo_sapiens(9606)Process
GO:0072686located_in mitotic spindle1IDAHomo_sapiens(9606)Component
GO:0097100enables supercoiled DNA binding1IDAHomo_sapiens(9606)Function
GO:0140078enables class I DNA-(apurinic or apyrimidinic site) endonuclease activity1IEAHomo_sapiens(9606)Function
GO:0140297enables DNA-binding transcription factor binding1IPIHomo_sapiens(9606)Function
GO:1901224involved_in positive regulation of NIK/NF-kappaB signaling1IDAHomo_sapiens(9606)Process
GO:1902231involved_in positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage1IMPHomo_sapiens(9606)Process
GO:1905053involved_in positive regulation of base-excision repair1IDAHomo_sapiens(9606)Process
GO:1990904part_of ribonucleoprotein complex1IDAHomo_sapiens(9606)Component
GO:2001235involved_in positive regulation of apoptotic signaling pathway2IBA,IDAHomo_sapiens(9606)Process
GO:2001272involved_in positive regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis1IMPHomo_sapiens(9606)Process

Expression