RBP Type
Non-canonical_RBPs
Diseases
SARS-COV-OC43 Flaviviruses HIV IAV SARS-COV-2 SINV Dengue
Drug
N.A.
Main interacting RNAs
N.A.
Moonlighting functions
N.A.
Localizations
Stress granucle Nucleoli rim
BulkPerturb-seq
N.A.
Ensembl ID ENSG00000148773 Gene ID
4288 Accession
7107
Symbol
MKI67
Alias
KIA;MIB-;MIB-1;PPP1R105
Full Name
marker of proliferation Ki-67
Status
Confidence
Length
29765 bases
Strand
Minus strand
Position
10 : 128096659 - 128126423
RNA binding domain
N.A.
Summary
Enables protein C-terminus binding activity. Involved in regulation of chromosome segregation and regulation of mitotic nuclear division. Located in chromosome; nuclear body; and nucleolus. Colocalizes with condensed chromosome. Implicated in Crohn's disease; breast cancer; human immunodeficiency virus infectious disease; and pancreatic cancer. Biomarker of several diseases, including Barrett's esophagus; autoimmune disease of musculoskeletal system (multiple); endocrine gland cancer (multiple); gastrointestinal system cancer (multiple); and interstitial cystitis. [provided by Alliance of Genome Resources, Apr 2022]
RNA binding domains (RBDs)
Protein
Domain
Pfam ID
E-value
Domain number
RNA binding proteomes (RBPomes)
Pubmed ID
Full Name
Cell
Author
Time
Doi
Literatures on RNA binding capacity
Pubmed ID
Title
Author
Time
Journal
30308971 A Protein Intrinsic Disorder Approach for Characterising Differentially Expressed Genes in Transcriptome Data: Analysis of Cell-Adhesion Regulated Gene Expression in Lymphoma Cells.
Gustav Arvidsson
2018-10-10
International journal of molecular sciences
Name
Transcript ID
bp
Protein
Translation ID
MKI67-201
ENST00000368653
11417
2896aa
ENSP00000357642
MKI67-202
ENST00000368654
12716
3256aa
ENSP00000357643
MKI67-203
ENST00000464771
692
No protein
-
MKI67-205
ENST00000484853
733
No protein
-
MKI67-204
ENST00000478293
654
No protein
-
Pathway ID
Pathway Name
Source
ensgID
Trait
pValue
Pubmed ID
7377 Vitamin K 1.13725702176814E-6 17903293 37084 Platelet Function Tests 1.1440300E-005 - 37344 Platelet Function Tests 3.3071000E-005 - 37376 Platelet Function Tests 3.3071000E-005 - 37436 Platelet Function Tests 2.3753600E-005 - 39687 Platelet Function Tests 1.7308900E-005 - 39723 Platelet Function Tests 2.1507700E-005 - 39788 Platelet Function Tests 1.5646600E-005 - 42901 Platelet Function Tests 9.0334713E-006 - 42909 Platelet Function Tests 7.7609098E-006 - 42918 Platelet Function Tests 9.0334713E-006 - 42919 Platelet Function Tests 9.0334713E-006 - 42921 Platelet Function Tests 9.0334713E-006 - 42924 Platelet Function Tests 9.0334713E-006 - 53028 Interleukin-8 4.1190000E-005 - 53048 Interleukin-8 4.1190000E-005 - 53049 Interleukin-8 4.1480000E-005 - 53053 Interleukin-8 4.1190000E-005 - 74079 Linoleic Acid 3E-6 26584805 95072 Vitamin K 1E-6 17903293 96458 Orofacial Cleft 1 5E-6 22419666
ensgID SNP Chromosome Position
Trait PubmedID Or or BEAT
EFO ID
Protein-Protein Interaction (PPI)
Ensembl ID
Source
Target
Species
Protein ID
Perc_pos
Perc_id
Species
Protein ID
Perc_pos
Perc_id
ENSG00000148773 homo_sapiens ENSP00000328228 33.8221 17.6931 homo_sapiens ENSP00000357643 10.6265 5.55897
Ensembl ID
Source
Target
Species
Protein ID
Perc_pos
Perc_id
Species
Protein ID
Perc_pos
Perc_id
ENSG00000148773 homo_sapiens ENSP00000357643 95.6388 93.1511 nomascus_leucogenys ENSNLEP00000001760 95.6682 93.1797 ENSG00000148773 homo_sapiens ENSP00000357643 96.3759 95.5774 pan_paniscus ENSPPAP00000029253 97.5443 96.7361 ENSG00000148773 homo_sapiens ENSP00000357643 96.3145 93.6732 pongo_abelii ENSPPYP00000003227 96.4033 93.7596 ENSG00000148773 homo_sapiens ENSP00000357643 95.0553 94.3489 pan_troglodytes ENSPTRP00000005380 95.0261 94.3199 ENSG00000148773 homo_sapiens ENSP00000357643 98.0037 97.0823 gorilla_gorilla ENSGGOP00000004112 98.0941 97.1718 ENSG00000148773 homo_sapiens ENSP00000357643 23.0037 12.3464 sarcophilus_harrisii ENSSHAP00000042790 23.232 12.469 ENSG00000148773 homo_sapiens ENSP00000357643 18.7039 11.3636 choloepus_hoffmanni ENSCHOP00000008272 36.2284 22.0107 ENSG00000148773 homo_sapiens ENSP00000357643 12.1929 8.20025 dasypus_novemcinctus ENSDNOP00000028363 41.7017 28.0462 ENSG00000148773 homo_sapiens ENSP00000357643 86.4865 80.4361 callithrix_jacchus ENSCJAP00000082005 86.4599 80.4114 ENSG00000148773 homo_sapiens ENSP00000357643 85.7801 82.8931 cercocebus_atys ENSCATP00000016120 93.4426 90.2978 ENSG00000148773 homo_sapiens ENSP00000357643 93.2432 90.1106 macaca_fascicularis ENSMFAP00000032069 93.4441 90.3047 ENSG00000148773 homo_sapiens ENSP00000357643 93.3968 90.2027 macaca_mulatta ENSMMUP00000058805 93.598 90.397 ENSG00000148773 homo_sapiens ENSP00000357643 92.9668 89.8649 macaca_nemestrina ENSMNEP00000017552 93.3683 90.2529 ENSG00000148773 homo_sapiens ENSP00000357643 84.2752 81.2654 papio_anubis ENSPANP00000016111 85.1117 82.072 ENSG00000148773 homo_sapiens ENSP00000357643 93.4889 90.3563 mandrillus_leucophaeus ENSMLEP00000003629 93.6327 90.4952 ENSG00000148773 homo_sapiens ENSP00000357643 40.2948 31.8182 tursiops_truncatus ENSTTRP00000004613 62.2096 49.1228 ENSG00000148773 homo_sapiens ENSP00000357643 56.8796 43.4275 vulpes_vulpes ENSVVUP00000007247 59.0938 45.1181 ENSG00000148773 homo_sapiens ENSP00000357643 53.7162 42.6597 equus_asinus ENSEASP00005036283 66.4514 52.7736 ENSG00000148773 homo_sapiens ENSP00000357643 59.9509 45.3624 capra_hircus ENSCHIP00000028208 60.1541 45.5162 ENSG00000148773 homo_sapiens ENSP00000357643 3.28624 2.457 loxodonta_africana ENSLAFP00000022877 74.8252 55.9441 ENSG00000148773 homo_sapiens ENSP00000357643 44.4103 34.1523 panthera_leo ENSPLOP00000017242 62.6516 48.1802 ENSG00000148773 homo_sapiens ENSP00000357643 54.2998 41.1241 ailuropoda_melanoleuca ENSAMEP00000000219 64.2208 48.6378 ENSG00000148773 homo_sapiens ENSP00000357643 59.8587 45.2396 bos_indicus_hybrid ENSBIXP00005020965 58.1097 43.9177 ENSG00000148773 homo_sapiens ENSP00000357643 61.9165 48.9865 oryctolagus_cuniculus ENSOCUP00000004451 65.0742 51.4848 ENSG00000148773 homo_sapiens ENSP00000357643 56.0504 44.8403 equus_caballus ENSECAP00000036010 66.0753 52.8602 ENSG00000148773 homo_sapiens ENSP00000357643 56.5418 42.9668 canis_lupus_familiaris ENSCAFP00845038942 61.285 46.5712 ENSG00000148773 homo_sapiens ENSP00000357643 2.79484 2.18059 marmota_marmota_marmota ENSMMMP00000003626 65.942 51.4493 ENSG00000148773 homo_sapiens ENSP00000357643 53.1327 40.5405 felis_catus ENSFCAP00000059248 60.3839 46.0733 ENSG00000148773 homo_sapiens ENSP00000357643 24.7543 13.8514 monodelphis_domestica ENSMODP00000052275 28.2708 15.819 ENSG00000148773 homo_sapiens ENSP00000357643 52.672 39.742 bison_bison_bison ENSBBBP00000018666 55.0739 41.5543 ENSG00000148773 homo_sapiens ENSP00000357643 45.301 35.5037 monodon_monoceros ENSMMNP00015019282 56.6654 44.4103 ENSG00000148773 homo_sapiens ENSP00000357643 55.4975 41.2776 sus_scrofa ENSSSCP00000022710 56.3104 41.8822 ENSG00000148773 homo_sapiens ENSP00000357643 63.2985 51.5049 microcebus_murinus ENSMICP00000041892 70.0068 56.9633 ENSG00000148773 homo_sapiens ENSP00000357643 31.3268 23.2801 ochotona_princeps ENSOPRP00000014145 55.6465 41.353 ENSG00000148773 homo_sapiens ENSP00000357643 42.9054 33.3538 delphinapterus_leucas ENSDLEP00000013898 62.3382 48.4605 ENSG00000148773 homo_sapiens ENSP00000357643 48.7101 38.0528 physeter_catodon ENSPCTP00005019392 51.2108 40.0065 ENSG00000148773 homo_sapiens ENSP00000357643 19.5332 13.6057 mus_caroli MGP_CAROLIEiJ_P0082910 39.2593 27.3457 ENSG00000148773 homo_sapiens ENSP00000357643 34.1523 22.9423 mus_musculus ENSMUSP00000033310 35.0016 23.5127 ENSG00000148773 homo_sapiens ENSP00000357643 45.7617 34.8894 mustela_putorius_furo ENSMPUP00000002447 62.8957 47.9527 ENSG00000148773 homo_sapiens ENSP00000357643 86.8857 80.774 aotus_nancymaae ENSANAP00000026602 87.0729 80.948 ENSG00000148773 homo_sapiens ENSP00000357643 86.0258 80.0061 saimiri_boliviensis_boliviensis ENSSBOP00000017755 86.1846 80.1538 ENSG00000148773 homo_sapiens ENSP00000357643 93.3968 90.1413 chlorocebus_sabaeus ENSCSAP00000000780 93.5405 90.2799 ENSG00000148773 homo_sapiens ENSP00000357643 43.9189 35.1044 tupaia_belangeri ENSTBEP00000012461 50.1403 40.0771 ENSG00000148773 homo_sapiens ENSP00000357643 30.0061 20.4545 mesocricetus_auratus ENSMAUP00000003701 36.0783 24.5938 ENSG00000148773 homo_sapiens ENSP00000357643 44.9017 35.043 phocoena_sinus ENSPSNP00000012119 58.6677 45.7865 ENSG00000148773 homo_sapiens ENSP00000357643 69.9017 57.9238 carlito_syrichta ENSTSYP00000016651 70.0092 58.0129 ENSG00000148773 homo_sapiens ENSP00000357643 33.4459 23.2187 rattus_norvegicus ENSRNOP00000038727 34.8927 24.223 ENSG00000148773 homo_sapiens ENSP00000357643 30.8354 21.2838 microtus_ochrogaster ENSMOCP00000004643 38.7047 26.7155 ENSG00000148773 homo_sapiens ENSP00000357643 54.4226 41.3391 bos_mutus ENSBMUP00000019648 55.3231 42.0231 ENSG00000148773 homo_sapiens ENSP00000357643 33.9373 22.8808 mus_spicilegus ENSMSIP00000029707 36.1111 24.3464 ENSG00000148773 homo_sapiens ENSP00000357643 34.2445 23.5872 cricetulus_griseus_chok1gshd ENSCGRP00001017417 35.0409 24.1358 ENSG00000148773 homo_sapiens ENSP00000357643 49.2629 38.36 myotis_lucifugus ENSMLUP00000021866 64.5473 50.2616 ENSG00000148773 homo_sapiens ENSP00000357643 48.7101 38.2985 rhinolophus_ferrumequinum ENSRFEP00010010004 65.2944 51.338 ENSG00000148773 homo_sapiens ENSP00000357643 59.8587 45.2396 bos_taurus ENSBTAP00000003173 58.1097 43.9177 ENSG00000148773 homo_sapiens ENSP00000357643 60.5651 48.0344 heterocephalus_glaber_female ENSHGLP00000044130 65.5803 52.012 ENSG00000148773 homo_sapiens ENSP00000357643 84.5823 81.2346 rhinopithecus_bieti ENSRBIP00000018675 93.5144 89.8132 ENSG00000148773 homo_sapiens ENSP00000357643 55.9582 42.4447 canis_lupus_dingo ENSCAFP00020024895 61.059 46.3137 ENSG00000148773 homo_sapiens ENSP00000357643 60.2887 45.8845 cervus_hanglu_yarkandensis ENSCHYP00000029006 60.1963 45.8142 ENSG00000148773 homo_sapiens ENSP00000357643 3.83907 2.82555 otolemur_garnettii ENSOGAP00000017473 67.2043 49.4624 ENSG00000148773 homo_sapiens ENSP00000357643 13.4521 10.2273 otolemur_garnettii ENSOGAP00000016249 68.0124 51.7081 ENSG00000148773 homo_sapiens ENSP00000357643 87.5614 81.3882 cebus_imitator ENSCCAP00000031175 87.5077 81.3382 ENSG00000148773 homo_sapiens ENSP00000357643 58.5074 44.2875 moschus_moschiferus ENSMMSP00000015251 58.8144 44.5199 ENSG00000148773 homo_sapiens ENSP00000357643 93.1818 89.6806 rhinopithecus_roxellana ENSRROP00000009006 93.4689 89.9569 ENSG00000148773 homo_sapiens ENSP00000357643 29.1155 20.1474 mus_pahari MGP_PahariEiJ_P0019692 35.8548 24.8109 ENSG00000148773 homo_sapiens ENSP00000357643 2.14988 1.35135 ciona_intestinalis ENSCINP00000031807 43.2099 27.1605
Go ID
Go term
No. evidence
Entries
Species
Category
GO:0000793 colocalizes_with condensed chromosome 1 IDA Homo_sapiens(9606) Component GO:0003677 enables DNA binding 1 IEA Homo_sapiens(9606) Function GO:0003723 enables RNA binding 1 HDA Homo_sapiens(9606) Function GO:0005515 enables protein binding 1 IPI Homo_sapiens(9606) Function GO:0005524 enables ATP binding 1 IEA Homo_sapiens(9606) Function GO:0005634 is_active_in nucleus 2 IBA,IDA Homo_sapiens(9606) Component GO:0005654 located_in nucleoplasm 1 IDA Homo_sapiens(9606) Component GO:0005694 is_active_in chromosome 2 IBA,IDA Homo_sapiens(9606) Component GO:0005730 located_in nucleolus 1 IDA Homo_sapiens(9606) Component GO:0007049 involved_in cell cycle 1 IEA Homo_sapiens(9606) Process GO:0007088 involved_in regulation of mitotic nuclear division 2 IBA,IDA Homo_sapiens(9606) Process GO:0008283 NOT involved_in cell population proliferation 1 ISS Homo_sapiens(9606) Process GO:0016020 located_in membrane 1 HDA Homo_sapiens(9606) Component GO:0016604 located_in nuclear body 1 IDA Homo_sapiens(9606) Component GO:0051983 involved_in regulation of chromosome segregation 2 IBA,IDA Homo_sapiens(9606) Process GO:1902275 involved_in regulation of chromatin organization 1 ISS Homo_sapiens(9606) Process
Copyright © 2023, Bioinformatics Center, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, China. All Rights Reserved.
