Functions and Diseases

RBP Type Canonical_RBPs
Diseases CancerSARS-COV-OC43FlavivirusesHIVRVSARS-COV-2SINVDengueZika
Drug N.A.
Main interacting RNAs mRNA
Moonlighting functions N.A.
Localizations Stress granucle
BulkPerturb-seq DataSet_01_149 DataSet_01_237

Description

Ensembl ID ENSG00000145907 Gene ID 10146 Accession 30292
Symbol G3BP1 Alias G3BP;HDH-VIII Full Name G3BP stress granule assembly factor 1
Status Confidence Length 41867 bases Strand Plus strand
Position 5 : 151771045 - 151812911 RNA binding domain NTF2 , RRM_1
Summary This gene encodes one of the DNA-unwinding enzymes which prefers partially unwound 3'-tailed substrates and can also unwind partial RNA/DNA and RNA/RNA duplexes in an ATP-dependent fashion. This enzyme is a member of the heterogeneous nuclear RNA-binding proteins and is also an element of the Ras signal transduction pathway. It binds specifically to the Ras-GTPase-activating protein by associating with its SH3 domain. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Jul 2008]

RNA binding domains (RBDs)

Protein Domain Pfam ID E-value Domain number
ENSP00000503654 RRM_1 PF00076 1.9e-13 1
ENSP00000503385 RRM_1 PF00076 7.8e-13 1
ENSP00000503385 NTF2 PF02136 4.9e-32 2
ENSP00000504156 RRM_1 PF00076 7.8e-13 1
ENSP00000504156 NTF2 PF02136 4.9e-32 2
ENSP00000348578 RRM_1 PF00076 1.4e-12 1
ENSP00000348578 NTF2 PF02136 5.6e-32 2
ENSP00000377681 RRM_1 PF00076 1.4e-12 1
ENSP00000377681 NTF2 PF02136 5.6e-32 2
ENSP00000430480 RRM_1 PF00076 1.4e-12 1
ENSP00000430480 NTF2 PF02136 5.6e-32 2
ENSP00000502880 RRM_1 PF00076 1.4e-12 1
ENSP00000502880 NTF2 PF02136 5.6e-32 2
ENSP00000503039 RRM_1 PF00076 1.4e-12 1
ENSP00000503039 NTF2 PF02136 5.6e-32 2
ENSP00000503699 RRM_1 PF00076 1.4e-12 1
ENSP00000503699 NTF2 PF02136 5.6e-32 2
ENSP00000503939 RRM_1 PF00076 1.4e-12 1
ENSP00000503939 NTF2 PF02136 5.6e-32 2
ENSP00000504140 RRM_1 PF00076 1.4e-12 1
ENSP00000504140 NTF2 PF02136 5.6e-32 2
ENSP00000504627 RRM_1 PF00076 1.4e-12 1
ENSP00000504627 NTF2 PF02136 5.6e-32 2
ENSP00000504525 RRM_1 PF00076 1.4e-12 1
ENSP00000504525 NTF2 PF02136 5.7e-28 2
ENSP00000504722 RRM_1 PF00076 1.4e-12 1
ENSP00000504722 NTF2 PF02136 5.7e-28 2
ENSP00000503184 RRM_1 PF00076 0.00039 1
ENSP00000504786 NTF2 PF02136 2.5e-32 1
ENSP00000504573 NTF2 PF02136 3.2e-32 1
ENSP00000427810 NTF2 PF02136 3.6e-32 1
ENSP00000428926 NTF2 PF02136 5.8e-28 1
ENSP00000504403 NTF2 PF02136 5.8e-28 1
ENSP00000504039 NTF2 PF02136 3e-27 1
ENSP00000429920 NTF2 PF02136 3.7e-27 1
ENSP00000430738 NTF2 PF02136 2.6e-21 1
ENSP00000503080 NTF2 PF02136 2.4e-17 1
ENSP00000503180 NTF2 PF02136 1.5e-13 1
ENSP00000504281 NTF2 PF02136 6.2e-08 1
ENSP00000503142 NTF2 PF02136 1.6e-07 1
ENSP00000504056 NTF2 PF02136 0.00014 1

RNA binding proteomes (RBPomes)

Pubmed ID Full Name Cell Author Time Doi

Literatures on RNA binding capacity

Pubmed ID Title Author Time Journal
31501480 G3BP1 inhibits ubiquitinated protein aggregations induced by p62 and USP10. Sergei Anisimov 2019-09-09 Scientific reports
23826389 Identification of Novel Stress Granule Components That Are Involved in Nuclear Transport. Hicham Mahboubi 2013-01-01 PloS one
24260247 Production of a dominant-negative fragment due to G3BP1 cleavage contributes to the disruption of mitochondria-associated protective stress granules during CVB3 infection. Gabriel Fung 2013-01-01 PloS one
37219408 Stress granules sequester Alzheimer's disease-associated gene transcripts and regulate disease-related neuronal proteostasis. Kaoru Sato 2023-05-22 Aging
37107644 Cellular Functions of Deubiquitinating Enzymes in Ovarian Adenocarcinoma. Yosuk Min 2023-04-09 Genes
27043612 Enterovirus Control of Translation and RNA Granule Stress Responses. E Richard Lloyd 2016-03-30 Viruses
27610098 Interplay between Inflammation and Cellular Stress Triggered by Flaviviridae Viruses. C L Ana Valadão 2016-01-01 Frontiers in microbiology
24321297 Regulation of PMP22 mRNA by G3BP1 affects cell proliferation in breast cancer cells. Sofia Winslow 2013-12-09 Molecular cancer
33450233 Age-related loss of axonal regeneration is reflected by the level of local translation. Susan S van 2021-05-01 Experimental neurology
29463567 Single-molecule imaging reveals dynamic biphasic partition of RNA-binding proteins in stress granules. Benedikt Niewidok 2018-04-02 The Journal of cell biology
34901782 SARS-CoV-2 nucleocapsid protein binds host mRNAs and attenuates stress granules to impair host stress response. Syed Nabeel-Shah 2022-01-21 iScience
30091651 The leucine-rich region of Flightless I interacts with R-ras to regulate cell extension formation. D P Arora 2018-10-01 Molecular biology of the cell
34237110 The multi-functional reovirus σ3 protein is a virulence factor that suppresses stress granule formation and is associated with myocardial injury. Yingying Guo 2021-07-01 PLoS pathogens
34526993 Research Progress on the Structure and Function of G3BP. Weifang Kang 2021-01-01 Frontiers in immunology
27165399 The cis-acting replication element of the Hepatitis C virus genome recruits host factors that influence viral replication and translation. Pablo Ríos-Marco 2016-05-11 Scientific reports
34297914 RNA modulates physiological and neuropathological protein phase transitions. R Jacob Mann 2021-09-01 Neuron
28869609 N6-methyladenosine (m6A) recruits and repels proteins to regulate mRNA homeostasis. R Raghu Edupuganti 2017-10-01 Nature structural & molecular biology
34400613 Molecular determinants for regulation of G3BP1/2 phase separation by the SARS-CoV-2 nucleocapsid protein. Wenjie Huang 2021-08-17 Cell discovery
32978516 Aberrant NSUN2-mediated m5C modification of H19 lncRNA is associated with poor differentiation of hepatocellular carcinoma. Zhen Sun 2020-11-01 Oncogene
37425880 Interaction between host G3BP and viral nucleocapsid protein regulates SARS-CoV-2 replication. Zemin Yang 2023-06-30 bioRxiv : the preprint server for biology

Transcripts

Name Transcript ID bp Protein Translation ID
G3BP1-213 ENST00000523519 535 106aa ENSP00000430738
G3BP1-209 ENST00000520578 529 117aa ENSP00000429920
G3BP1-214 ENST00000627077 173 31aa ENSP00000486887
G3BP1-272 ENST00000678976 206 31aa ENSP00000504139
G3BP1-238 ENST00000677408 194 31aa ENSP00000503087
G3BP1-250 ENST00000678070 1565 466aa ENSP00000503039
G3BP1-271 ENST00000678964 10622 426aa ENSP00000503385
G3BP1-270 ENST00000678925 10011 466aa ENSP00000503699
G3BP1-202 ENST00000394123 10240 466aa ENSP00000377681
G3BP1-227 ENST00000676978 9997 466aa ENSP00000503939
G3BP1-278 ENST00000679289 10323 153aa ENSP00000504039
G3BP1-240 ENST00000677493 10243 304aa ENSP00000504786
G3BP1-218 ENST00000676644 10372 56aa ENSP00000504249
G3BP1-245 ENST00000677757 11945 No protein -
G3BP1-247 ENST00000677909 177 No protein -
G3BP1-212 ENST00000522761 1691 466aa ENSP00000430480
G3BP1-222 ENST00000676827 1768 466aa ENSP00000504627
G3BP1-208 ENST00000520177 2654 367aa ENSP00000427810
G3BP1-217 ENST00000676634 1000 No protein -
G3BP1-205 ENST00000518726 869 No protein -
G3BP1-206 ENST00000519832 1173 No protein -
G3BP1-241 ENST00000677602 3216 No protein -
G3BP1-267 ENST00000678854 1326 170aa ENSP00000503080
G3BP1-226 ENST00000676911 998 No protein -
G3BP1-207 ENST00000520006 229 31aa ENSP00000428469
G3BP1-203 ENST00000507878 581 No protein -
G3BP1-204 ENST00000517947 558 37aa ENSP00000430045
G3BP1-210 ENST00000522367 782 122aa ENSP00000428926
G3BP1-221 ENST00000676813 1046 37aa ENSP00000502929
G3BP1-228 ENST00000677105 1532 476aa ENSP00000504722
G3BP1-252 ENST00000678101 1794 466aa ENSP00000504140
G3BP1-269 ENST00000678910 1737 134aa ENSP00000503654
G3BP1-201 ENST00000356245 10227 466aa ENSP00000348578
G3BP1-262 ENST00000678646 10257 476aa ENSP00000504525
G3BP1-237 ENST00000677381 10136 122aa ENSP00000504403
G3BP1-268 ENST00000678904 10474 No protein -
G3BP1-239 ENST00000677433 583 151aa ENSP00000503142
G3BP1-257 ENST00000678369 3086 No protein -
G3BP1-236 ENST00000677369 284 31aa ENSP00000502976
G3BP1-234 ENST00000677284 299 31aa ENSP00000504125
G3BP1-233 ENST00000677252 148 No protein -
G3BP1-260 ENST00000678564 1737 426aa ENSP00000504156
G3BP1-224 ENST00000676894 1207 No protein -
G3BP1-248 ENST00000677923 10583 334aa ENSP00000504573
G3BP1-235 ENST00000677323 10540 466aa ENSP00000502880
G3BP1-211 ENST00000522666 783 37aa ENSP00000429316
G3BP1-253 ENST00000678153 125 No protein -
G3BP1-255 ENST00000678209 125 No protein -
G3BP1-249 ENST00000678027 125 No protein -
G3BP1-229 ENST00000677126 125 No protein -
G3BP1-230 ENST00000677146 503 66aa ENSP00000503388
G3BP1-274 ENST00000679057 192 No protein -
G3BP1-251 ENST00000678086 114 No protein -
G3BP1-265 ENST00000678750 1898 No protein -
G3BP1-258 ENST00000678372 448 37aa ENSP00000504056
G3BP1-231 ENST00000677211 520 61aa ENSP00000503180
G3BP1-244 ENST00000677687 222 63aa ENSP00000504281
G3BP1-216 ENST00000676590 345 36aa ENSP00000504178
G3BP1-259 ENST00000678500 531 59aa ENSP00000503647
G3BP1-275 ENST00000679135 329 110aa ENSP00000503223
G3BP1-273 ENST00000679004 354 17aa ENSP00000503296
G3BP1-264 ENST00000678726 339 40aa ENSP00000502848
G3BP1-254 ENST00000678194 311 39aa ENSP00000503653
G3BP1-277 ENST00000679207 782 No protein -
G3BP1-276 ENST00000679193 2304 No protein -
G3BP1-246 ENST00000677854 341 49aa ENSP00000503694
G3BP1-266 ENST00000678825 436 102aa ENSP00000504001
G3BP1-263 ENST00000678657 1187 158aa ENSP00000504393
G3BP1-232 ENST00000677241 378 No protein -
G3BP1-242 ENST00000677608 222 74aa ENSP00000504384
G3BP1-215 ENST00000676507 386 49aa ENSP00000503184
G3BP1-261 ENST00000678612 411 61aa ENSP00000503802
G3BP1-243 ENST00000677658 390 54aa ENSP00000503905
G3BP1-225 ENST00000676899 1054 114aa ENSP00000504490
G3BP1-219 ENST00000676715 8602 85aa ENSP00000503528
G3BP1-256 ENST00000678295 1233 68aa ENSP00000503775
G3BP1-223 ENST00000676878 593 68aa ENSP00000504118
G3BP1-220 ENST00000676734 590 68aa ENSP00000504327

Pathways

Pathway ID Pathway Name Source

Phenotypes

ensgID Trait pValue Pubmed ID
37015Platelet Function Tests3.0900000E-006-
37021Platelet Function Tests3.3200000E-006-
64484Child Behavior8E-624839885
93771Alzheimer Disease2E-726830138
93772Age of Onset2E-726830138

GWAS

ensgIDSNPChromosomePosition TraitPubmedIDOr or BEAT EFO ID

Protein-Protein Interaction (PPI)

Paralogs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id
ENSG00000145907homo_sapiensENSP0000035273876.55664.3154homo_sapiensENSP0000034857879.184566.5236

Orthologs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id
ENSG00000145907homo_sapiensENSP0000034857894.635294.6352nomascus_leucogenysENSNLEP0000004437994.635294.6352
ENSG00000145907homo_sapiensENSP00000348578100100pan_paniscusENSPPAP00000008661100100
ENSG00000145907homo_sapiensENSP0000034857899.785499.7854pongo_abeliiENSPPYP0000001786999.785499.7854
ENSG00000145907homo_sapiensENSP0000034857895.064494.4206pan_troglodytesENSPTRP0000007754889.314588.7097
ENSG00000145907homo_sapiensENSP00000348578100100gorilla_gorillaENSGGOP00000024789100100
ENSG00000145907homo_sapiensENSP0000034857890.987186.0515ornithorhynchus_anatinusENSOANP0000000811391.97486.9848
ENSG00000145907homo_sapiensENSP0000034857892.918589.6996sarcophilus_harrisiiENSSHAP0000000965791.737388.5593
ENSG00000145907homo_sapiensENSP0000034857857.081556.2232choloepus_hoffmanniENSCHOP0000000956161.290360.3687
ENSG00000145907homo_sapiensENSP0000034857897.639595.4936dasypus_novemcinctusENSDNOP0000002772097.849595.6989
ENSG00000145907homo_sapiensENSP0000034857889.699687.1245erinaceus_europaeusENSEEUP0000001120890.280887.689
ENSG00000145907homo_sapiensENSP0000034857890.557988.6266echinops_telfairiENSETEP0000001416897.459695.3811
ENSG00000145907homo_sapiensENSP0000034857810099.3562callithrix_jacchusENSCJAP0000002853810099.3562
ENSG00000145907homo_sapiensENSP0000034857890.772589.485cercocebus_atysENSCATP0000000577385.110783.9034
ENSG00000145907homo_sapiensENSP0000034857899.785499.5708macaca_fascicularisENSMFAP0000003183983.93583.7545
ENSG00000145907homo_sapiensENSP0000034857894.20693.3476macaca_mulattaENSMMUP0000001928680.402979.6703
ENSG00000145907homo_sapiensENSP0000034857899.785499.5708macaca_nemestrinaENSMNEP0000000465299.785499.5708
ENSG00000145907homo_sapiensENSP0000034857899.141698.927papio_anubisENSPANP0000004385894.478594.274
ENSG00000145907homo_sapiensENSP0000034857894.635293.7768mandrillus_leucophaeusENSMLEP0000001580098.657797.7629
ENSG00000145907homo_sapiensENSP0000034857891.416389.9142tursiops_truncatusENSTTRP0000000861691.612990.1075
ENSG00000145907homo_sapiensENSP0000034857898.92797.8541vulpes_vulpesENSVVUP0000000731299.139898.0645
ENSG00000145907homo_sapiensENSP0000034857893.776890.7725mus_spretusMGP_SPRETEiJ_P002814988.104885.2823
ENSG00000145907homo_sapiensENSP0000034857898.92797.8541equus_asinusENSEASP0000506045389.514688.5437
ENSG00000145907homo_sapiensENSP0000034857898.497996.3519capra_hircusENSCHIP0000001524498.709796.5591
ENSG00000145907homo_sapiensENSP0000034857898.497997.2103loxodonta_africanaENSLAFP0000000769798.709797.4194
ENSG00000145907homo_sapiensENSP0000034857899.356298.2833panthera_leoENSPLOP0000000063699.569998.4946
ENSG00000145907homo_sapiensENSP0000034857898.712497.6395ailuropoda_melanoleucaENSAMEP0000000831098.924797.8495
ENSG00000145907homo_sapiensENSP0000034857898.712496.5665bos_indicus_hybridENSBIXP0000501880091.269889.2857
ENSG00000145907homo_sapiensENSP0000034857881.330579.8283oryctolagus_cuniculusENSOCUP0000004582089.386887.7358
ENSG00000145907homo_sapiensENSP0000034857890.987189.9142oryctolagus_cuniculusENSOCUP0000001545088.702987.6569
ENSG00000145907homo_sapiensENSP0000034857873.819772.103oryctolagus_cuniculusENSOCUP0000003638594.505592.3077
ENSG00000145907homo_sapiensENSP0000034857898.283396.9957oryctolagus_cuniculusENSOCUP0000004921398.494697.2043
ENSG00000145907homo_sapiensENSP0000034857898.92797.8541equus_caballusENSECAP0000006628090.215389.2368
ENSG00000145907homo_sapiensENSP0000034857898.068796.9957canis_lupus_familiarisENSCAFP0084500722796.210595.1579
ENSG00000145907homo_sapiensENSP0000034857899.141698.0687panthera_pardusENSPPRP0000000801699.354898.2796
ENSG00000145907homo_sapiensENSP0000034857898.497997.6395marmota_marmota_marmotaENSMMMP0000000641798.709797.8495
ENSG00000145907homo_sapiensENSP0000034857898.712497.8541marmota_marmota_marmotaENSMMMP0000001574598.924798.0645
ENSG00000145907homo_sapiensENSP0000034857876.180373.3906balaenoptera_musculusENSBMSP0001002774790.330887.0229
ENSG00000145907homo_sapiensENSP0000034857897.854196.1373balaenoptera_musculusENSBMSP0001001966298.915497.18
ENSG00000145907homo_sapiensENSP0000034857892.918591.4163balaenoptera_musculusENSBMSP0001000389596.651895.0893
ENSG00000145907homo_sapiensENSP0000034857897.854196.3519cavia_porcellusENSCPOP0000003204698.064596.5591
ENSG00000145907homo_sapiensENSP0000034857899.356298.2833felis_catusENSFCAP0000004567499.569998.4946
ENSG00000145907homo_sapiensENSP0000034857898.92797.8541ursus_americanusENSUAMP0000000984799.139898.0645
ENSG00000145907homo_sapiensENSP0000034857866.30959.8712monodelphis_domesticaENSMODP0000003026085.833377.5
ENSG00000145907homo_sapiensENSP0000034857881.974377.897monodelphis_domesticaENSMODP0000001739180.252176.2605
ENSG00000145907homo_sapiensENSP0000034857892.918589.2704monodelphis_domesticaENSMODP0000001121892.918589.2704
ENSG00000145907homo_sapiensENSP0000034857898.712496.5665bison_bison_bisonENSBBBP0000002654998.924796.7742
ENSG00000145907homo_sapiensENSP0000034857881.545179.3991monodon_monocerosENSMMNP0001501895597.186794.6292
ENSG00000145907homo_sapiensENSP0000034857889.270484.9785monodon_monocerosENSMMNP0001500099888.135683.8983
ENSG00000145907homo_sapiensENSP0000034857899.356297.6395monodon_monocerosENSMMNP0001500437199.569997.8495
ENSG00000145907homo_sapiensENSP0000034857898.497996.5665sus_scrofaENSSSCP0000003484092.727390.9091
ENSG00000145907homo_sapiensENSP0000034857894.635293.133microcebus_murinusENSMICP0000001113196.288294.7598
ENSG00000145907homo_sapiensENSP0000034857889.914289.2704microcebus_murinusENSMICP0000004160199.054498.3452
ENSG00000145907homo_sapiensENSP0000034857892.060190.3433octodon_degusENSODEP0000002215695.121993.3481
ENSG00000145907homo_sapiensENSP0000034857897.639595.279jaculus_jaculusENSJJAP0000001460697.849595.4839
ENSG00000145907homo_sapiensENSP0000034857898.497996.3519ovis_aries_rambouilletENSOARP0002002210298.709796.5591
ENSG00000145907homo_sapiensENSP0000034857896.781194.8498ovis_aries_rambouilletENSOARP0002002759691.666789.8374
ENSG00000145907homo_sapiensENSP0000034857888.41286.6953ursus_maritimusENSUMAP0000000403588.41286.6953
ENSG00000145907homo_sapiensENSP0000034857890.772589.0558ochotona_princepsENSOPRP0000000965290.967789.2473
ENSG00000145907homo_sapiensENSP0000034857889.270485.6223delphinapterus_leucasENSDLEP0000000300094.545590.6818
ENSG00000145907homo_sapiensENSP0000034857899.356297.6395delphinapterus_leucasENSDLEP0000000700999.569997.8495
ENSG00000145907homo_sapiensENSP0000034857875.107369.9571physeter_catodonENSPCTP0000501596382.547276.8868
ENSG00000145907homo_sapiensENSP0000034857899.356297.6395physeter_catodonENSPCTP0000500170499.569997.8495
ENSG00000145907homo_sapiensENSP0000034857895.922793.3476mus_caroliMGP_CAROLIEiJ_P002677896.12993.5484
ENSG00000145907homo_sapiensENSP0000034857895.922793.5622mus_musculusENSMUSP0000001872796.12993.7634
ENSG00000145907homo_sapiensENSP0000034857888.197484.9785dipodomys_ordiiENSDORP0000001773094.482891.0345
ENSG00000145907homo_sapiensENSP0000034857898.283397.4249mustela_putorius_furoENSMPUP0000001355898.494697.6344
ENSG00000145907homo_sapiensENSP0000034857878.755475.5365aotus_nancymaaeENSANAP0000003675489.95186.2745
ENSG00000145907homo_sapiensENSP0000034857810099.5708aotus_nancymaaeENSANAP0000000888510099.5708
ENSG00000145907homo_sapiensENSP0000034857856.652456.2232saimiri_boliviensis_boliviensisENSSBOP0000002708710099.2424
ENSG00000145907homo_sapiensENSP0000034857898.92796.7811vicugna_pacosENSVPAP0000000414399.139896.9893
ENSG00000145907homo_sapiensENSP0000034857899.785499.5708chlorocebus_sabaeusENSCSAP0000000709599.785499.5708
ENSG00000145907homo_sapiensENSP0000034857872.961471.6738tupaia_belangeriENSTBEP0000000378997.701195.977
ENSG00000145907homo_sapiensENSP0000034857895.493692.7039mesocricetus_auratusENSMAUP0000000681095.698992.9032
ENSG00000145907homo_sapiensENSP0000034857889.270485.4077phocoena_sinusENSPSNP0000003020394.760890.6606
ENSG00000145907homo_sapiensENSP0000034857899.356297.6395phocoena_sinusENSPSNP0000001897599.569997.8495
ENSG00000145907homo_sapiensENSP0000034857893.347691.2017camelus_dromedariusENSCDRP0000500205096.666794.4444
ENSG00000145907homo_sapiensENSP0000034857899.356297.8541carlito_syrichtaENSTSYP0000000419499.356297.8541
ENSG00000145907homo_sapiensENSP0000034857899.356298.0687panthera_tigris_altaicaENSPTIP0000001447599.569998.2796
ENSG00000145907homo_sapiensENSP0000034857895.708293.5622rattus_norvegicusENSRNOP0000001814995.91493.7634
ENSG00000145907homo_sapiensENSP0000034857899.356298.4979prolemur_simusENSPSMP0000003280999.356298.4979
ENSG00000145907homo_sapiensENSP0000034857894.635292.4893microtus_ochrogasterENSMOCP0000000613194.838792.6882
ENSG00000145907homo_sapiensENSP0000034857895.493693.5622peromyscus_maniculatus_bairdiiENSPEMP0000002351295.698993.7634
ENSG00000145907homo_sapiensENSP0000034857898.712496.5665bos_mutusENSBMUP0000001555098.924796.7742
ENSG00000145907homo_sapiensENSP0000034857865.879863.7339mus_spicilegusENSMSIP0000001809587.965685.1003
ENSG00000145907homo_sapiensENSP0000034857895.708292.9185mus_spicilegusENSMSIP0000001018895.91493.1183
ENSG00000145907homo_sapiensENSP0000034857886.695382.618cricetulus_griseus_chok1gshdENSCGRP0000102679990.786586.5169
ENSG00000145907homo_sapiensENSP0000034857876.609474.0343cricetulus_griseus_chok1gshdENSCGRP0000101484994.444491.2698
ENSG00000145907homo_sapiensENSP0000034857889.055884.5494cricetulus_griseus_chok1gshdENSCGRP0000102431392.427687.7506
ENSG00000145907homo_sapiensENSP0000034857898.497997.4249pteropus_vampyrusENSPVAP0000001627397.659696.5957
ENSG00000145907homo_sapiensENSP0000034857897.639596.3519myotis_lucifugusENSMLUP0000000145497.430496.1456
ENSG00000145907homo_sapiensENSP0000034857856.652452.5751vombatus_ursinusENSVURP0001000786787.128780.8581
ENSG00000145907homo_sapiensENSP0000034857893.13391.6309rhinolophus_ferrumequinumENSRFEP0001002187496.659295.1002
ENSG00000145907homo_sapiensENSP0000034857898.283397.4249neovison_visonENSNVIP0000002633198.494697.6344
ENSG00000145907homo_sapiensENSP0000034857898.712496.5665bos_taurusENSBTAP0000002706798.924796.7742
ENSG00000145907homo_sapiensENSP0000034857898.497997.4249heterocephalus_glaber_femaleENSHGLP0000002087498.709797.6344
ENSG00000145907homo_sapiensENSP0000034857899.785499.5708rhinopithecus_bietiENSRBIP0000003737999.785499.5708
ENSG00000145907homo_sapiensENSP0000034857898.92797.8541canis_lupus_dingoENSCAFP0002003046899.139898.0645
ENSG00000145907homo_sapiensENSP0000034857898.712497.6395sciurus_vulgarisENSSVLP0000502064198.924797.8495
ENSG00000145907homo_sapiensENSP0000034857822.961419.7425phascolarctos_cinereusENSPCIP0000005331467.721558.2278
ENSG00000145907homo_sapiensENSP0000034857864.806962.8755procavia_capensisENSPCAP0000000137586.781684.1954
ENSG00000145907homo_sapiensENSP0000034857897.424994.8498nannospalax_galiliENSNGAP0000000748997.844895.2586
ENSG00000145907homo_sapiensENSP0000034857896.781194.6352bos_grunniensENSBGRP0000001486393.374791.3043
ENSG00000145907homo_sapiensENSP0000034857898.712497.8541chinchilla_lanigeraENSCLAP0000001842798.924798.0645
ENSG00000145907homo_sapiensENSP0000034857898.497996.3519cervus_hanglu_yarkandensisENSCHYP0000001667798.709796.5591
ENSG00000145907homo_sapiensENSP0000034857898.068796.5665catagonus_wagneriENSCWAP0000000126398.279696.7742
ENSG00000145907homo_sapiensENSP0000034857898.92798.0687ictidomys_tridecemlineatusENSSTOP0000001426099.139898.2796
ENSG00000145907homo_sapiensENSP0000034857899.141697.8541otolemur_garnettiiENSOGAP0000000153998.089296.8153
ENSG00000145907homo_sapiensENSP0000034857810099.5708cebus_imitatorENSCCAP0000002177310099.5708
ENSG00000145907homo_sapiensENSP0000034857898.92798.0687urocitellus_parryiiENSUPAP0001002258099.139898.2796
ENSG00000145907homo_sapiensENSP0000034857884.120278.97moschus_moschiferusENSMMSP0000002114093.333387.619
ENSG00000145907homo_sapiensENSP0000034857898.497996.3519moschus_moschiferusENSMMSP0000000403298.709796.5591
ENSG00000145907homo_sapiensENSP0000034857899.785499.5708rhinopithecus_roxellanaENSRROP0000001156299.785499.5708
ENSG00000145907homo_sapiensENSP0000034857895.493693.133mus_pahariMGP_PahariEiJ_P003355195.698993.3333
ENSG00000145907homo_sapiensENSP0000034857838.197421.8884caenorhabditis_elegansK08F4.2.137.632121.5645
ENSG00000145907homo_sapiensENSP0000034857857.725343.7768drosophila_melanogasterFBpp031206438.985529.5652
ENSG00000145907homo_sapiensENSP0000034857857.510743.5622ciona_intestinalisENSCINP0000000984557.142943.2836
ENSG00000145907homo_sapiensENSP0000034857822.746817.5966petromyzon_marinusENSPMAP0000000563270.198754.3046
ENSG00000145907homo_sapiensENSP0000034857881.330573.6051callorhinchus_miliiENSCMIP0000000082277.189469.8574
ENSG00000145907homo_sapiensENSP0000034857875.751165.6652latimeria_chalumnaeENSLACP0000002043773.388863.6175
ENSG00000145907homo_sapiensENSP0000034857881.115974.0343lepisosteus_oculatusENSLOCP0000001432678.7571.875
ENSG00000145907homo_sapiensENSP0000034857877.467867.8112clupea_harengusENSCHAP0000004551374.586865.2893
ENSG00000145907homo_sapiensENSP0000034857879.399170.1717danio_rerioENSDARP0000012121177.568168.5535
ENSG00000145907homo_sapiensENSP0000034857878.755469.5279carassius_auratusENSCARP0000011221575.359366.5298
ENSG00000145907homo_sapiensENSP0000034857877.89768.2403carassius_auratusENSCARP0000001230274.845465.567
ENSG00000145907homo_sapiensENSP0000034857879.184570.6009astyanax_mexicanusENSAMXP0000004771377.196768.8285
ENSG00000145907homo_sapiensENSP0000034857877.89768.8841ictalurus_punctatusENSIPUP0000000169876.421167.5789
ENSG00000145907homo_sapiensENSP0000034857877.89767.382esox_luciusENSELUP0000002331872.455162.6747
ENSG00000145907homo_sapiensENSP0000034857876.82469.3133electrophorus_electricusENSEEEP0000002984874.428367.1518
ENSG00000145907homo_sapiensENSP0000034857878.9768.8841oncorhynchus_kisutchENSOKIP0000503387774.949165.3768
ENSG00000145907homo_sapiensENSP0000034857879.184569.0987oncorhynchus_kisutchENSOKIP0000505115975.925966.2551
ENSG00000145907homo_sapiensENSP0000034857878.9768.8841oncorhynchus_mykissENSOMYP0000007804974.343464.8485
ENSG00000145907homo_sapiensENSP0000034857880.042969.7425oncorhynchus_mykissENSOMYP0000008032675.353565.6566
ENSG00000145907homo_sapiensENSP0000034857879.613769.3133salmo_salarENSSSAP0000017436271.760262.4758
ENSG00000145907homo_sapiensENSP0000034857878.755468.8841salmo_salarENSSSAP0000013613374.141464.8485
ENSG00000145907homo_sapiensENSP0000034857878.755468.8841salmo_truttaENSSTUP0000000234174.141464.8485
ENSG00000145907homo_sapiensENSP0000034857879.828369.5279salmo_truttaENSSTUP0000004988773.956364.4135
ENSG00000145907homo_sapiensENSP0000034857878.9770.1717gadus_morhuaENSGMOP0000002080274.949166.5988
ENSG00000145907homo_sapiensENSP0000034857880.042971.2446fundulus_heteroclitusENSFHEP0000001339276.74968.3128
ENSG00000145907homo_sapiensENSP0000034857879.828371.2446poecilia_reticulataENSPREP0000001232776.229568.0328
ENSG00000145907homo_sapiensENSP0000034857880.042971.4592xiphophorus_maculatusENSXMAP0000001929975.967467.8208
ENSG00000145907homo_sapiensENSP0000034857877.038665.8798oryzias_latipesENSORLP0000001430674.791763.9583
ENSG00000145907homo_sapiensENSP0000034857880.257570.8155cyclopterus_lumpusENSCLMP0000500761972.480663.9535
ENSG00000145907homo_sapiensENSP0000034857877.682468.6695oreochromis_niloticusENSONIP0000000536772.464
ENSG00000145907homo_sapiensENSP0000034857880.257571.2446haplochromis_burtoniENSHBUP0000001012875.251566.8008
ENSG00000145907homo_sapiensENSP0000034857880.472171.4592astatotilapia_callipteraENSACLP0000002556075.910967.4089
ENSG00000145907homo_sapiensENSP0000034857879.613771.2446sparus_aurataENSSAUP0001001535074.647966.8008
ENSG00000145907homo_sapiensENSP0000034857880.901372.103lates_calcariferENSLCAP0001001373375.702867.4699
ENSG00000145907homo_sapiensENSP0000034857886.695378.5408xenopus_tropicalisENSXETP0000002343979.684472.1893
ENSG00000145907homo_sapiensENSP0000034857871.459268.0257chrysemys_picta_belliiENSCPBP0000001373291.232986.8493
ENSG00000145907homo_sapiensENSP0000034857889.270484.3348sphenodon_punctatusENSSPUP0000000569891.228186.1842
ENSG00000145907homo_sapiensENSP0000034857891.845586.4807crocodylus_porosusENSCPRP0000501833588.796783.61
ENSG00000145907homo_sapiensENSP0000034857875.751170.1717laticauda_laticaudataENSLLTP0000002193785.679679.3689
ENSG00000145907homo_sapiensENSP0000034857889.270483.4764notechis_scutatusENSNSUP0000002286786.666781.0417
ENSG00000145907homo_sapiensENSP0000034857889.270483.4764pseudonaja_textilisENSPTXP0000002013186.666781.0417
ENSG00000145907homo_sapiensENSP0000034857891.416386.0515anas_platyrhynchos_platyrhynchosENSAPLP0000003179487.654382.5103
ENSG00000145907homo_sapiensENSP0000034857891.201785.8369gallus_gallusENSGALP0001002020991.397986.0215
ENSG00000145907homo_sapiensENSP0000034857891.201785.8369meleagris_gallopavoENSMGAP0000000590985.513180.4829
ENSG00000145907homo_sapiensENSP0000034857891.201786.0515serinus_canariaENSSCAP0000001639990.042484.9576
ENSG00000145907homo_sapiensENSP0000034857890.987185.8369parus_majorENSPMJP0000000988679.104574.6269
ENSG00000145907homo_sapiensENSP0000034857889.270483.691anolis_carolinensisENSACAP0000000967588.135682.6271
ENSG00000145907homo_sapiensENSP0000034857880.472171.4592neolamprologus_brichardiENSNBRP0000001829275.452767.002
ENSG00000145907homo_sapiensENSP0000034857889.270482.4034naja_najaENSNNAP0000001925788.135681.3559
ENSG00000145907homo_sapiensENSP0000034857889.270483.4764podarcis_muralisENSPMRP0000001127388.135682.4153
ENSG00000145907homo_sapiensENSP0000034857887.339181.3305geospiza_fortisENSGFOP0000000052781.237575.6487
ENSG00000145907homo_sapiensENSP0000034857884.763979.3991taeniopygia_guttataENSTGUP0000000077981.780576.6046
ENSG00000145907homo_sapiensENSP0000034857882.188874.2489erpetoichthys_calabaricusENSECRP0000001718579.625871.9335
ENSG00000145907homo_sapiensENSP0000034857880.901371.2446kryptolebias_marmoratusENSKMAP0000000335076.008166.9355
ENSG00000145907homo_sapiensENSP0000034857889.914284.5494salvator_merianaeENSSMRP0000001943490.107584.7312
ENSG00000145907homo_sapiensENSP0000034857878.111665.8798oryzias_javanicusENSOJAP0000000370975.206663.4298
ENSG00000145907homo_sapiensENSP0000034857880.042971.2446amphilophus_citrinellusENSACIP0000003143875.659267.3428
ENSG00000145907homo_sapiensENSP0000034857880.257570.8155dicentrarchus_labraxENSDLAP0000503844074.353965.6064
ENSG00000145907homo_sapiensENSP0000034857881.330572.103amphiprion_perculaENSAPEP0000000430276.565767.8788
ENSG00000145907homo_sapiensENSP0000034857877.038666.0944oryzias_sinensisENSOSIP0000002788574.791764.1667
ENSG00000145907homo_sapiensENSP0000034857891.845586.4807pelodiscus_sinensisENSPSIP0000001692390.105384.8421
ENSG00000145907homo_sapiensENSP0000034857890.772585.6223gopherus_evgoodeiENSGEVP0000501837687.03782.0988
ENSG00000145907homo_sapiensENSP0000034857890.772585.6223chelonoidis_abingdoniiENSCABP0000001708691.163885.9914
ENSG00000145907homo_sapiensENSP0000034857881.115971.8884seriola_dumeriliENSSDUP0000001208376.209767.5403
ENSG00000145907homo_sapiensENSP0000034857879.828370.8155cottoperca_gobioENSCGOP0000002101575.151566.6667
ENSG00000145907homo_sapiensENSP0000034857890.557984.5494struthio_camelus_australisENSSCUP0000001731682.745177.2549
ENSG00000145907homo_sapiensENSP0000034857891.416386.2661anser_brachyrhynchusENSABRP0000002020590.254285.1695
ENSG00000145907homo_sapiensENSP0000034857877.89768.4549gasterosteus_aculeatusENSGACP0000002225775.467866.3202
ENSG00000145907homo_sapiensENSP0000034857879.399168.8841cynoglossus_semilaevisENSCSEP0000001999975.356465.3768
ENSG00000145907homo_sapiensENSP0000034857880.472171.4592poecilia_formosaENSPFOP0000000806376.219567.6829
ENSG00000145907homo_sapiensENSP0000034857879.828370.1717myripristis_murdjanENSMMDP0000502759576.543267.284
ENSG00000145907homo_sapiensENSP0000034857877.89768.6695sander_luciopercaENSSLUP0000002411871.456762.9921
ENSG00000145907homo_sapiensENSP0000034857891.201785.6223strigops_habroptilaENSSHBP0000500939390.042484.5339
ENSG00000145907homo_sapiensENSP0000034857881.115971.6738amphiprion_ocellarisENSAOCP0000002506476.363667.4747
ENSG00000145907homo_sapiensENSP0000034857890.987185.8369terrapene_carolina_triunguisENSTMTP0000000626191.379386.2069
ENSG00000145907homo_sapiensENSP0000034857878.9768.8841hucho_huchoENSHHUP0000002165975.409865.7787
ENSG00000145907homo_sapiensENSP0000034857880.257569.7425hucho_huchoENSHHUP0000002749076.639366.5984
ENSG00000145907homo_sapiensENSP0000034857872.317662.6609betta_splendensENSBSLP0000003732572.162762.5268
ENSG00000145907homo_sapiensENSP0000034857878.755470.6009pygocentrus_nattereriENSPNAP0000003493877.754269.7034
ENSG00000145907homo_sapiensENSP0000034857880.472171.6738anabas_testudineusENSATEP0000002572275.452767.2032
ENSG00000145907homo_sapiensENSP0000034857857.081543.9914ciona_savignyiENSCSAVP0000001391857.575844.3723
ENSG00000145907homo_sapiensENSP0000034857838.197422.7468saccharomyces_cerevisiaeYNR051C34.563120.5825
ENSG00000145907homo_sapiensENSP0000034857874.892766.5236seriola_lalandi_dorsalisENSSLDP0000001812171.958863.9175
ENSG00000145907homo_sapiensENSP0000034857880.901370.6009labrus_bergyltaENSLBEP0000001674776.008166.3306
ENSG00000145907homo_sapiensENSP0000034857859.656750.4292labrus_bergyltaENSLBEP0000000701862.612652.9279
ENSG00000145907homo_sapiensENSP0000034857880.257571.2446pundamilia_nyerereiENSPNYP0000000401375.251566.8008
ENSG00000145907homo_sapiensENSP0000034857879.399170.3863mastacembelus_armatusENSMAMP0000001948774.747566.2626
ENSG00000145907homo_sapiensENSP0000034857881.330572.3176stegastes_partitusENSSPAP0000001872476.411367.9436
ENSG00000145907homo_sapiensENSP0000034857878.326268.2403oncorhynchus_tshawytschaENSOTSP0000503056462.607254.5455
ENSG00000145907homo_sapiensENSP0000034857879.399168.8841oncorhynchus_tshawytschaENSOTSP0000500447764.912356.3158
ENSG00000145907homo_sapiensENSP0000034857880.901371.6738acanthochromis_polyacanthusENSAPOP0000001621576.161667.4747
ENSG00000145907homo_sapiensENSP0000034857891.201785.4077aquila_chrysaetos_chrysaetosENSACCP0002001918790.042484.322
ENSG00000145907homo_sapiensENSP0000034857878.9769.7425nothobranchius_furzeriENSNFUP0001500077774.796766.0569
ENSG00000145907homo_sapiensENSP0000034857880.901371.4592cyprinodon_variegatusENSCVAP0000000488076.161667.2727
ENSG00000145907homo_sapiensENSP0000034857878.755468.8841denticeps_clupeoidesENSDCDP0000005768163.937355.9233
ENSG00000145907homo_sapiensENSP0000034857881.115971.03larimichthys_croceaENSLCRP0000503523676.056366.5996
ENSG00000145907homo_sapiensENSP0000034857828.111625.5365takifugu_rubripesENSTRUP0000006480886.184278.2895
ENSG00000145907homo_sapiensENSP0000034857887.553682.618ficedula_albicollisENSFALP0000002352585.894781.0526
ENSG00000145907homo_sapiensENSP0000034857877.038666.9528hippocampus_comesENSHCOP0000000237272.088462.6506
ENSG00000145907homo_sapiensENSP0000034857878.9769.9571cyprinus_carpio_carpioENSCCRP0000006763575.876367.2165
ENSG00000145907homo_sapiensENSP0000034857874.892766.0944cyprinus_carpio_carpioENSCCRP0000006752467.635759.6899
ENSG00000145907homo_sapiensENSP0000034857890.987185.8369coturnix_japonicaENSCJPP0000500775089.830584.7458
ENSG00000145907homo_sapiensENSP0000034857880.472171.4592poecilia_latipinnaENSPLAP0000002390869.832462.0112
ENSG00000145907homo_sapiensENSP0000034857868.240358.5837sinocyclocheilus_grahamiENSSGRP0000003695273.611163.1944
ENSG00000145907homo_sapiensENSP0000034857869.742561.588sinocyclocheilus_grahamiENSSGRP0000007295874.031965.3759
ENSG00000145907homo_sapiensENSP0000034857880.472171.4592maylandia_zebraENSMZEP0000502730975.452767.002
ENSG00000145907homo_sapiensENSP0000034857874.678165.0215tetraodon_nigroviridisENSTNIP0000001593374.678165.0215
ENSG00000145907homo_sapiensENSP0000034857877.682468.4549paramormyrops_kingsleyaeENSPKIP0000000617674.948266.0455
ENSG00000145907homo_sapiensENSP0000034857877.682469.0987scleropages_formosusENSSFOP0001500310075.259966.9439
ENSG00000145907homo_sapiensENSP0000034857885.836975.5365leptobrachium_leishanenseENSLLEP0000001740279.840370.2595
ENSG00000145907homo_sapiensENSP0000034857879.399170.3863scophthalmus_maximusENSSMAP0000001086770.208762.2391
ENSG00000145907homo_sapiensENSP0000034857877.467865.4506oryzias_melastigmaENSOMEP0000003486074.586863.0165

Gene Ontology

Go ID Go term No. evidence Entries Species Category
GO:0003677enables DNA binding1IEAHomo_sapiens(9606)Function
GO:0003678enables DNA helicase activity1IDAHomo_sapiens(9606)Function
GO:0003723enables RNA binding1HDAHomo_sapiens(9606)Function
GO:0003724enables RNA helicase activity1IDAHomo_sapiens(9606)Function
GO:0003729enables mRNA binding1IBAHomo_sapiens(9606)Function
GO:0004519enables endonuclease activity1IEAHomo_sapiens(9606)Function
GO:0005515enables protein binding1IPIHomo_sapiens(9606)Function
GO:0005524enables ATP binding1IEAHomo_sapiens(9606)Function
GO:0005634located_in nucleus1IEAHomo_sapiens(9606)Component
GO:0005737located_in cytoplasm1IDAHomo_sapiens(9606)Component
GO:0005829is_active_in cytosol3IBA,IDA,TASHomo_sapiens(9606)Component
GO:0005925located_in focal adhesion1HDAHomo_sapiens(9606)Component
GO:0007265involved_in Ras protein signal transduction1TASHomo_sapiens(9606)Process
GO:0010494is_active_in cytoplasmic stress granule3IDA,ISSHomo_sapiens(9606)Component
GO:0016887enables ATP hydrolysis activity1IEAHomo_sapiens(9606)Function
GO:0032481involved_in positive regulation of type I interferon production2IDA,IMPHomo_sapiens(9606)Process
GO:0032508involved_in DNA duplex unwinding1IEAHomo_sapiens(9606)Process
GO:0033677enables DNA/RNA helicase activity1IDAHomo_sapiens(9606)Function
GO:0034063involved_in stress granule assembly2IDA,IMPHomo_sapiens(9606)Process
GO:0043024enables ribosomal small subunit binding1IDAHomo_sapiens(9606)Function
GO:0043204located_in perikaryon1IEAHomo_sapiens(9606)Component
GO:0045087involved_in innate immune response1IEAHomo_sapiens(9606)Process
GO:0051607involved_in defense response to virus1IMPHomo_sapiens(9606)Process
GO:0062029involved_in positive regulation of stress granule assembly1IMPHomo_sapiens(9606)Process
GO:0090090involved_in negative regulation of canonical Wnt signaling pathway1IEAHomo_sapiens(9606)Process
GO:0140693enables molecular condensate scaffold activity1IDAHomo_sapiens(9606)Function
GO:1990904part_of ribonucleoprotein complex1IBAHomo_sapiens(9606)Component

Expression