RBP Type
Canonical_RBPs
Diseases
Flaviviruses SARS-COV-2 Dengue
Drug
N.A.
Main interacting RNAs
mRNA
Moonlighting functions
N.A.
Localizations
N.A.
BulkPerturb-seq
Ensembl ID ENSG00000145216 Gene ID
81608 Accession
19124
Symbol
FIP1L1
Alias
Rhe;FIP1;hFip1
Full Name
factor interacting with PAPOLA and CPSF1
Status
Confidence
Length
86813 bases
Strand
Plus strand
Position
4 : 53377569 - 53464381
RNA binding domain
Fip1
Summary
This gene encodes a subunit of the CPSF (cleavage and polyadenylation specificity factor) complex that polyadenylates the 3' end of mRNA precursors. This gene, the homolog of yeast Fip1 (factor interacting with PAP), binds to U-rich sequences of pre-mRNA and stimulates poly(A) polymerase activity. Its N-terminus contains a PAP-binding site and its C-terminus an RNA-binding domain. An interstitial chromosomal deletion on 4q12 creates an in-frame fusion of human genes FIP1L1 and PDGFRA (platelet-derived growth factor receptor, alpha). The FIP1L1-PDGFRA fusion gene encodes a constitutively activated tyrosine kinase that joins the first 233 amino acids of FIP1L1 to the last 523 amino acids of PDGFRA. This gene fusion and chromosomal deletion is the cause of some forms of idiopathic hypereosinophilic syndrome (HES). This syndrome, recently reclassified as chronic eosinophilic leukemia (CEL), is responsive to treatment with tyrosine kinase inhibitors. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Oct 2008]
RNA binding domains (RBDs)
Protein
Domain
Pfam ID
E-value
Domain number
ENSP00000515314
Fip1
PF05182 7.8e-25
1
ENSP00000515338
Fip1
PF05182 8.7e-25
1
ENSP00000515316
Fip1
PF05182 9.3e-25
1
ENSP00000515315
Fip1
PF05182 1e-24
1
ENSP00000425456
Fip1
PF05182 1.2e-24
1
ENSP00000515313
Fip1
PF05182 1.2e-24
1
ENSP00000515337
Fip1
PF05182 1.4e-24
1
ENSP00000515312
Fip1
PF05182 2e-24
1
ENSP00000515307
Fip1
PF05182 2e-24
1
ENSP00000515328
Fip1
PF05182 2e-24
1
ENSP00000515329
Fip1
PF05182 2.2e-24
1
ENSP00000515330
Fip1
PF05182 2.2e-24
1
ENSP00000515335
Fip1
PF05182 2.5e-24
1
ENSP00000302993
Fip1
PF05182 3.8e-24
1
ENSP00000515318
Fip1
PF05182 3.8e-24
1
ENSP00000515319
Fip1
PF05182 3.8e-24
1
ENSP00000515322
Fip1
PF05182 3.8e-24
1
ENSP00000515309
Fip1
PF05182 3.8e-24
1
ENSP00000421691
Fip1
PF05182 3.9e-24
1
ENSP00000515341
Fip1
PF05182 3.9e-24
1
ENSP00000515302
Fip1
PF05182 4e-24
1
ENSP00000515306
Fip1
PF05182 4e-24
1
ENSP00000515310
Fip1
PF05182 4e-24
1
ENSP00000515317
Fip1
PF05182 4.1e-24
1
ENSP00000515324
Fip1
PF05182 4.1e-24
1
ENSP00000515308
Fip1
PF05182 4.1e-24
1
ENSP00000515340
Fip1
PF05182 4.1e-24
1
ENSP00000515311
Fip1
PF05182 4.1e-24
1
ENSP00000515303
Fip1
PF05182 4.2e-24
1
ENSP00000515332
Fip1
PF05182 4.2e-24
1
ENSP00000515327
Fip1
PF05182 4.2e-24
1
ENSP00000515321
Fip1
PF05182 4.2e-24
1
ENSP00000515343
Fip1
PF05182 4.2e-24
1
ENSP00000515342
Fip1
PF05182 4.2e-24
1
ENSP00000515323
Fip1
PF05182 4.3e-24
1
ENSP00000515331
Fip1
PF05182 4.3e-24
1
ENSP00000515333
Fip1
PF05182 4.3e-24
1
ENSP00000515326
Fip1
PF05182 4.3e-24
1
ENSP00000515304
Fip1
PF05182 4.3e-24
1
ENSP00000515336
Fip1
PF05182 4.4e-24
1
ENSP00000351383
Fip1
PF05182 4.4e-24
1
ENSP00000515320
Fip1
PF05182 4.4e-24
1
ENSP00000515325
Fip1
PF05182 4.4e-24
1
ENSP00000336752
Fip1
PF05182 4.5e-24
1
ENSP00000515339
Fip1
PF05182 4.5e-24
1
ENSP00000515334
Fip1
PF05182 4.5e-24
1
ENSP00000515305
Fip1
PF05182 4.5e-24
1
ENSP00000515346
Fip1
PF05182 4.3e-14
1
RNA binding proteomes (RBPomes)
Pubmed ID
Full Name
Cell
Author
Time
Doi
Literatures on RNA binding capacity
Pubmed ID
Title
Author
Time
Journal
22400011 mRNA 3' end processing factors: a phylogenetic comparison.
K Sarah Darmon
2012-01-01
Comparative and functional genomics
23976869 Review of current classification, molecular alterations, and tyrosine kinase inhibitor therapies in myeloproliferative disorders with hypereosinophilia.
Violaine Havelange
2013-01-01
Journal of blood medicine
26700815 Insulator dysfunction and oncogene activation in IDH mutant gliomas.
A William Flavahan
2016-01-07
Nature
29166620 A Cell-Line-Specific Atlas of PARP-Mediated Protein Asp/Glu-ADP-Ribosylation in Breast Cancer.
Yuanli Zhen
2017-11-21
Cell reports
Name
Transcript ID
bp
Protein
Translation ID
FIP1L1-214
ENST00000703451
6829
543aa
ENSP00000515302
FIP1L1-215
ENST00000703452
6889
565aa
ENSP00000515303
FIP1L1-216
ENST00000703453
5420
580aa
ENSP00000515304
FIP1L1-217
ENST00000703454
5489
603aa
ENSP00000515305
FIP1L1-218
ENST00000703455
5234
544aa
ENSP00000515306
FIP1L1-219
ENST00000703456
4971
558aa
ENSP00000515307
FIP1L1-220
ENST00000703457
6819
556aa
ENSP00000515308
FIP1L1-221
ENST00000703458
6736
529aa
ENSP00000515309
FIP1L1-222
ENST00000703459
1880
550aa
ENSP00000515310
FIP1L1-223
ENST00000703460
3198
561aa
ENSP00000515311
FIP1L1-204
ENST00000504094
3219
532aa
ENSP00000421691
FIP1L1-224
ENST00000703461
4891
543aa
ENSP00000515312
FIP1L1-225
ENST00000703462
5253
379aa
ENSP00000515313
FIP1L1-226
ENST00000703463
5199
302aa
ENSP00000515314
FIP1L1-227
ENST00000703464
5223
348aa
ENSP00000515315
FIP1L1-228
ENST00000703465
5157
279aa
ENSP00000515316
FIP1L1-229
ENST00000703466
5212
552aa
ENSP00000515317
FIP1L1-230
ENST00000703467
6283
521aa
ENSP00000515318
FIP1L1-231
ENST00000703468
6289
523aa
ENSP00000515319
FIP1L1-232
ENST00000703469
6493
591aa
ENSP00000515320
FIP1L1-233
ENST00000703470
6424
568aa
ENSP00000515321
FIP1L1-234
ENST00000703471
6719
527aa
ENSP00000515322
FIP1L1-235
ENST00000703472
6869
577aa
ENSP00000515323
FIP1L1-236
ENST00000703473
6800
554aa
ENSP00000515324
FIP1L1-237
ENST00000703474
6914
592aa
ENSP00000515325
FIP1L1-238
ENST00000703475
6875
579aa
ENSP00000515326
FIP1L1-209
ENST00000511055
7433
No protein
-
FIP1L1-239
ENST00000703476
5249
567aa
ENSP00000515327
FIP1L1-240
ENST00000703477
3528
No protein
-
FIP1L1-202
ENST00000337488
3396
594aa
ENSP00000336752
FIP1L1-241
ENST00000703478
4749
499aa
ENSP00000515328
FIP1L1-242
ENST00000703479
4830
526aa
ENSP00000515329
FIP1L1-243
ENST00000703480
4857
535aa
ENSP00000515330
FIP1L1-244
ENST00000703481
5177
578aa
ENSP00000515331
FIP1L1-245
ENST00000703482
5241
565aa
ENSP00000515332
FIP1L1-246
ENST00000703483
5352
578aa
ENSP00000515333
FIP1L1-247
ENST00000703484
5421
601aa
ENSP00000515334
FIP1L1-248
ENST00000703485
6416
595aa
ENSP00000515335
FIP1L1-249
ENST00000703486
6459
583aa
ENSP00000515336
FIP1L1-250
ENST00000703487
7029
261aa
ENSP00000515337
FIP1L1-251
ENST00000703488
6822
277aa
ENSP00000515338
FIP1L1-252
ENST00000703489
6910
594aa
ENSP00000515339
FIP1L1-253
ENST00000703490
6802
558aa
ENSP00000515340
FIP1L1-254
ENST00000703491
6733
535aa
ENSP00000515341
FIP1L1-255
ENST00000703492
6841
571aa
ENSP00000515342
FIP1L1-256
ENST00000703493
8810
No protein
-
FIP1L1-257
ENST00000703494
8987
No protein
-
FIP1L1-258
ENST00000703495
8918
No protein
-
FIP1L1-210
ENST00000511376
582
No protein
-
FIP1L1-203
ENST00000358575
2180
588aa
ENSP00000351383
FIP1L1-259
ENST00000703496
6781
No protein
-
FIP1L1-207
ENST00000507922
1335
378aa
ENSP00000425456
FIP1L1-201
ENST00000306932
1878
520aa
ENSP00000302993
FIP1L1-260
ENST00000703497
6682
570aa
ENSP00000515343
FIP1L1-261
ENST00000703498
6599
49aa
ENSP00000515344
FIP1L1-205
ENST00000505125
3180
No protein
-
FIP1L1-262
ENST00000703499
4701
53aa
ENSP00000515345
FIP1L1-263
ENST00000703500
5052
544aa
ENSP00000515346
FIP1L1-212
ENST00000513975
1464
No protein
-
FIP1L1-208
ENST00000510668
599
No protein
-
FIP1L1-213
ENST00000514543
1465
26aa
ENSP00000421241
FIP1L1-264
ENST00000703501
5016
No protein
-
FIP1L1-265
ENST00000703502
4373
No protein
-
FIP1L1-266
ENST00000703503
4450
No protein
-
FIP1L1-211
ENST00000513008
1070
No protein
-
FIP1L1-206
ENST00000507206
341
No protein
-
Pathway ID
Pathway Name
Source
ensgID
Trait
pValue
Pubmed ID
30371 Potassium 5.5200000E-005 -
ensgID SNP Chromosome Position
Trait PubmedID Or or BEAT
EFO ID
Protein-Protein Interaction (PPI)
Ensembl ID
Source
Target
Species
Protein ID
Perc_pos
Perc_id
Species
Protein ID
Perc_pos
Perc_id
ENSG00000145216
Ensembl ID
Source
Target
Species
Protein ID
Perc_pos
Perc_id
Species
Protein ID
Perc_pos
Perc_id
ENSG00000145216 homo_sapiens ENSP00000336752 100 100 nomascus_leucogenys ENSNLEP00000010035 100 100 ENSG00000145216 homo_sapiens ENSP00000336752 99.6633 99.6633 pongo_abelii ENSPPYP00000045398 99.1625 99.1625 ENSG00000145216 homo_sapiens ENSP00000336752 100 100 gorilla_gorilla ENSGGOP00000028320 100 100 ENSG00000145216 homo_sapiens ENSP00000336752 33.5017 32.3232 choloepus_hoffmanni ENSCHOP00000003582 49.3797 47.6427 ENSG00000145216 homo_sapiens ENSP00000336752 99.8316 99.8316 macaca_fascicularis ENSMFAP00000031100 99.8316 99.8316 ENSG00000145216 homo_sapiens ENSP00000336752 99.8316 99.8316 mandrillus_leucophaeus ENSMLEP00000035256 99.8316 99.8316 ENSG00000145216 homo_sapiens ENSP00000336752 90.7407 89.7306 tursiops_truncatus ENSTTRP00000014966 98 96.9091 ENSG00000145216 homo_sapiens ENSP00000336752 99.1582 98.8215 loxodonta_africana ENSLAFP00000002180 99.1582 98.8215 ENSG00000145216 homo_sapiens ENSP00000336752 99.6633 99.3266 panthera_leo ENSPLOP00000004951 99.6633 99.3266 ENSG00000145216 homo_sapiens ENSP00000336752 100 99.6633 equus_caballus ENSECAP00000017077 100 99.6633 ENSG00000145216 homo_sapiens ENSP00000336752 99.6633 99.3266 canis_lupus_familiaris ENSCAFP00845016095 99.6633 99.3266 ENSG00000145216 homo_sapiens ENSP00000336752 99.6633 99.3266 panthera_pardus ENSPPRP00000006918 99.6633 99.3266 ENSG00000145216 homo_sapiens ENSP00000336752 99.6633 98.9899 balaenoptera_musculus ENSBMSP00010002733 97.2085 96.5517 ENSG00000145216 homo_sapiens ENSP00000336752 82.3232 80.8081 ursus_americanus ENSUAMP00000015250 94.7674 93.0233 ENSG00000145216 homo_sapiens ENSP00000336752 93.4343 92.7609 bison_bison_bison ENSBBBP00000024304 99.4624 98.7455 ENSG00000145216 homo_sapiens ENSP00000336752 92.2559 91.4141 microcebus_murinus ENSMICP00000007428 97.1631 96.2766 ENSG00000145216 homo_sapiens ENSP00000336752 51.8519 50.5051 ochotona_princeps ENSOPRP00000009181 54.5133 53.0973 ENSG00000145216 homo_sapiens ENSP00000336752 99.6633 98.9899 physeter_catodon ENSPCTP00005008311 99.6633 98.9899 ENSG00000145216 homo_sapiens ENSP00000336752 99.8316 99.8316 saimiri_boliviensis_boliviensis ENSSBOP00000034215 99.8316 99.8316 ENSG00000145216 homo_sapiens ENSP00000336752 99.6633 98.9899 phocoena_sinus ENSPSNP00000006899 99.6633 98.9899 ENSG00000145216 homo_sapiens ENSP00000336752 97.3064 95.7912 carlito_syrichta ENSTSYP00000002575 97.9661 96.4407 ENSG00000145216 homo_sapiens ENSP00000336752 94.7811 94.4444 panthera_tigris_altaica ENSPTIP00000009906 94.7811 94.4444 ENSG00000145216 homo_sapiens ENSP00000336752 99.6633 98.9899 prolemur_simus ENSPSMP00000030522 99.6633 98.9899 ENSG00000145216 homo_sapiens ENSP00000336752 99.3266 99.1582 sciurus_vulgaris ENSSVLP00005028742 99.3266 99.1582 ENSG00000145216 homo_sapiens ENSP00000336752 99.8316 99.3266 catagonus_wagneri ENSCWAP00000018710 99.8316 99.3266 ENSG00000145216 homo_sapiens ENSP00000336752 99.3266 98.9899 otolemur_garnettii ENSOGAP00000008544 99.1597 98.8235 ENSG00000145216 homo_sapiens ENSP00000336752 100 100 cebus_imitator ENSCCAP00000008579 100 100 ENSG00000145216 homo_sapiens ENSP00000336752 87.3737 87.037 propithecus_coquereli ENSPCOP00000018761 99.4253 99.0421 ENSG00000145216 homo_sapiens ENSP00000336752 88.7205 82.3232 salvator_merianae ENSSMRP00000006157 89.1709 82.7411 ENSG00000145216 homo_sapiens ENSP00000336752 87.2054 82.8283 terrapene_carolina_triunguis ENSTMTP00000018212 92.3351 87.7005
Go ID
Go term
No. evidence
Entries
Species
Category
GO:0003723 enables RNA binding 1 HDA Homo_sapiens(9606) Function GO:0005515 enables protein binding 1 IPI Homo_sapiens(9606) Function GO:0005654 located_in nucleoplasm 2 IDA,TAS Homo_sapiens(9606) Component GO:0005829 located_in cytosol 1 TAS Homo_sapiens(9606) Component GO:0005847 part_of mRNA cleavage and polyadenylation specificity factor complex 1 IBA Homo_sapiens(9606) Component GO:0006397 involved_in mRNA processing 1 IEA Homo_sapiens(9606) Process
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