Functions and Diseases

RBP Type Canonical_RBPs
Diseases Cancer Disease
Drug N.A.
Main interacting RNAs mRNA
Moonlighting functions N.A.
Localizations N.A.
BulkPerturb-seq N.A.

Description

Ensembl ID ENSG00000145191 Gene ID 8893 Accession 3261
Symbol EIF2B5 Alias CLE;CACH;LVWM;VWM5;EIF-2B;EIF2Bepsilon Full Name eukaryotic translation initiation factor 2B subunit epsilon
Status Confidence Length 9957 bases Strand Plus strand
Position 3 : 184135355 - 184145311 RNA binding domain W2
Summary This gene encodes one of five subunits of eukaryotic translation initiation factor 2B (EIF2B), a GTP exchange factor for eukaryotic initiation factor 2 and an essential regulator for protein synthesis. Mutations in this gene and the genes encoding other EIF2B subunits have been associated with leukoencephalopathy with vanishing white matter. [provided by RefSeq, Nov 2009]

RNA binding domains (RBDs)

Protein Domain Pfam ID E-value Domain number
ENSP00000497160 W2 PF02020 1.1e-18 1
ENSP00000498164 W2 PF02020 1.1e-18 1

RNA binding proteomes (RBPomes)

Pubmed ID Full Name Cell Author Time Doi

Literatures on RNA binding capacity

Pubmed ID Title Author Time Journal
28961236 Transcriptome analysis of hypoxic cancer cells uncovers intron retention in EIF2B5 as a mechanism to inhibit translation. K Lauren Brady 2017-09-01 PLoS biology

Transcripts

Name Transcript ID bp Protein Translation ID
EIF2B5-210 ENST00000491144 3038 No protein -
EIF2B5-229 ENST00000649814 3084 No protein -
EIF2B5-205 ENST00000471832 930 113aa ENSP00000497786
EIF2B5-220 ENST00000648314 2760 314aa ENSP00000496920
EIF2B5-226 ENST00000648915 2562 721aa ENSP00000497160
EIF2B5-203 ENST00000465218 2850 No protein -
EIF2B5-201 ENST00000432569 585 107aa ENSP00000414775
EIF2B5-215 ENST00000647636 2596 402aa ENSP00000497505
EIF2B5-225 ENST00000648890 2552 530aa ENSP00000497503
EIF2B5-223 ENST00000648682 2665 389aa ENSP00000498185
EIF2B5-216 ENST00000647909 2222 729aa ENSP00000498164
EIF2B5-221 ENST00000648599 2613 269aa ENSP00000497159
EIF2B5-228 ENST00000649688 2932 269aa ENSP00000497097
EIF2B5-224 ENST00000648882 2505 113aa ENSP00000497603
EIF2B5-207 ENST00000481054 3460 No protein -
EIF2B5-211 ENST00000492226 3790 No protein -
EIF2B5-222 ENST00000648630 2674 382aa ENSP00000497887
EIF2B5-202 ENST00000432982 597 92aa ENSP00000408198
EIF2B5-204 ENST00000468748 4425 No protein -
EIF2B5-219 ENST00000648256 2483 267aa ENSP00000497356
EIF2B5-230 ENST00000650244 696 41aa ENSP00000497227
EIF2B5-231 ENST00000650270 2389 546aa ENSP00000497711
EIF2B5-209 ENST00000491008 3298 No protein -
EIF2B5-214 ENST00000498831 597 No protein -
EIF2B5-217 ENST00000648145 2307 310aa ENSP00000497476
EIF2B5-218 ENST00000648189 2345 231aa ENSP00000497241
EIF2B5-208 ENST00000484154 3961 No protein -
EIF2B5-227 ENST00000649545 2164 230aa ENSP00000497598
EIF2B5-212 ENST00000492773 2254 141aa ENSP00000497833
EIF2B5-213 ENST00000493740 564 No protein -
EIF2B5-206 ENST00000479250 466 No protein -

Gene Model

Pathways

Pathway ID Pathway Name Source

Phenotypes

ensgID Trait pValue Pubmed ID

GWAS

ensgIDSNPChromosomePosition TraitPubmedIDOr or BEAT EFO ID

Protein-Protein Interaction (PPI)

Paralogs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id
ENSG00000145191homo_sapiensENSP0000035357536.061921.4602homo_sapiensENSP0000049716022.607513.4535
ENSG00000145191homo_sapiensENSP0000031592538.809519.5238homo_sapiensENSP0000049716022.607511.3731
ENSG00000145191homo_sapiensENSP0000031113039.166720.2778homo_sapiensENSP0000049716019.556210.1248

Orthologs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id
ENSG00000145191homo_sapiensENSP0000049716099.306598.8904nomascus_leucogenysENSNLEP0000000742299.306598.8904
ENSG00000145191homo_sapiensENSP0000049716099.722699.4452pan_paniscusENSPPAP0000001488699.722699.4452
ENSG00000145191homo_sapiensENSP0000049716099.306598.7517pongo_abeliiENSPPYP0000001604198.216797.668
ENSG00000145191homo_sapiensENSP0000049716099.861399.7226pan_troglodytesENSPTRP0000002697799.861399.7226
ENSG00000145191homo_sapiensENSP0000049716099.861399.5839gorilla_gorillaENSGGOP0000000727199.861399.5839
ENSG00000145191homo_sapiensENSP0000049716089.875282.8017ornithorhynchus_anatinusENSOANP0000000223090.629483.4965
ENSG00000145191homo_sapiensENSP0000049716089.459179.1956sarcophilus_harrisiiENSSHAP0000000089877.710868.7952
ENSG00000145191homo_sapiensENSP0000049716083.356575.5895notamacropus_eugeniiENSMEUP0000000231991.337482.8267
ENSG00000145191homo_sapiensENSP0000049716057.558955.8946choloepus_hoffmanniENSCHOP0000000246659.032757.3257
ENSG00000145191homo_sapiensENSP0000049716088.349584.3273dasypus_novemcinctusENSDNOP0000000580695.359391.018
ENSG00000145191homo_sapiensENSP0000049716046.463244.3828erinaceus_europaeusENSEEUP0000000437876.136472.7273
ENSG00000145191homo_sapiensENSP0000049716089.320484.3273echinops_telfairiENSETEP0000000388189.818784.7978
ENSG00000145191homo_sapiensENSP0000049716095.977893.4813callithrix_jacchusENSCJAP0000008509679.907677.8291
ENSG00000145191homo_sapiensENSP0000049716099.306598.3356cercocebus_atysENSCATP0000004124299.306598.3356
ENSG00000145191homo_sapiensENSP0000049716098.751798.0583macaca_fascicularisENSMFAP0000002847599.026498.331
ENSG00000145191homo_sapiensENSP0000049716099.029198.1969macaca_mulattaENSMMUP0000000863999.029198.1969
ENSG00000145191homo_sapiensENSP0000049716097.087495.9778macaca_nemestrinaENSMNEP0000002469897.765496.648
ENSG00000145191homo_sapiensENSP0000049716098.890498.1969papio_anubisENSPANP0000000224397.805297.1193
ENSG00000145191homo_sapiensENSP0000049716099.167898.1969mandrillus_leucophaeusENSMLEP0000000833999.167898.1969
ENSG00000145191homo_sapiensENSP0000049716086.823984.466tursiops_truncatusENSTTRP0000000289986.225983.8843
ENSG00000145191homo_sapiensENSP0000049716094.590891.1234vulpes_vulpesENSVVUP0000000976394.459890.9972
ENSG00000145191homo_sapiensENSP0000049716093.203987.9334mus_spretusMGP_SPRETEiJ_P004276993.723888.424
ENSG00000145191homo_sapiensENSP0000049716096.948792.5104equus_asinusENSEASP0000502152195.753491.3699
ENSG00000145191homo_sapiensENSP0000049716096.393993.4813capra_hircusENSCHIP0000003202895.994593.0939
ENSG00000145191homo_sapiensENSP0000049716094.868289.1817loxodonta_africanaENSLAFP0000001237695.397589.6792
ENSG00000145191homo_sapiensENSP0000049716096.116592.7878panthera_leoENSPLOP0000001581695.061791.7695
ENSG00000145191homo_sapiensENSP0000049716095.839191.2621ailuropoda_melanoleucaENSAMEP0000001827794.917690.3846
ENSG00000145191homo_sapiensENSP0000049716096.532693.62bos_indicus_hybridENSBIXP0000501719995.604492.7198
ENSG00000145191homo_sapiensENSP0000049716095.145690.846oryctolagus_cuniculusENSOCUP0000000391994.101589.8491
ENSG00000145191homo_sapiensENSP0000049716096.8192.6491equus_caballusENSECAP0000001651591.48187.5491
ENSG00000145191homo_sapiensENSP0000049716096.255293.2039canis_lupus_familiarisENSCAFP0084503580795.198992.1811
ENSG00000145191homo_sapiensENSP0000049716095.977892.5104panthera_pardusENSPPRP0000000760295.977892.5104
ENSG00000145191homo_sapiensENSP0000049716095.561791.8169marmota_marmota_marmotaENSMMMP0000000711695.694491.9444
ENSG00000145191homo_sapiensENSP0000049716096.255293.0652balaenoptera_musculusENSBMSP0001000938595.460892.2971
ENSG00000145191homo_sapiensENSP0000049716092.510487.5173cavia_porcellusENSCPOP0000002762891.244986.3201
ENSG00000145191homo_sapiensENSP0000049716096.255292.9265felis_catusENSFCAP0000000721195.198991.9067
ENSG00000145191homo_sapiensENSP0000049716095.839191.5395ursus_americanusENSUAMP0000000677595.972291.6667
ENSG00000145191homo_sapiensENSP0000049716089.736580.5825monodelphis_domesticaENSMODP0000000389090.237181.0321
ENSG00000145191homo_sapiensENSP0000049716096.393993.3426bison_bison_bisonENSBBBP0000002166696.527893.4722
ENSG00000145191homo_sapiensENSP0000049716095.977892.9265monodon_monocerosENSMMNP0001500579694.277991.2807
ENSG00000145191homo_sapiensENSP0000049716093.203989.8752sus_scrofaENSSSCP0000002243995.726592.3077
ENSG00000145191homo_sapiensENSP0000049716095.145692.0943microcebus_murinusENSMICP0000005118494.751491.7127
ENSG00000145191homo_sapiensENSP0000049716094.174889.3204octodon_degusENSODEP0000001730994.832489.9441
ENSG00000145191homo_sapiensENSP0000049716093.758789.7365jaculus_jaculusENSJJAP0000000274994.019589.9861
ENSG00000145191homo_sapiensENSP0000049716096.532693.4813ovis_aries_rambouilletENSOARP0002000550295.08292.0765
ENSG00000145191homo_sapiensENSP0000049716092.23387.5173ursus_maritimusENSUMAP0000000834291.471886.7951
ENSG00000145191homo_sapiensENSP0000049716093.065287.2399ochotona_princepsENSOPRP0000000510096.131890.1146
ENSG00000145191homo_sapiensENSP0000049716096.255293.0652delphinapterus_leucasENSDLEP0000001494695.592392.4242
ENSG00000145191homo_sapiensENSP0000049716096.255292.7878physeter_catodonENSPCTP0000503040794.550491.1444
ENSG00000145191homo_sapiensENSP0000049716093.203987.9334mus_caroliMGP_CAROLIEiJ_P004091593.854888.5475
ENSG00000145191homo_sapiensENSP0000049716093.203988.0721mus_musculusENSMUSP0000000332093.723888.5635
ENSG00000145191homo_sapiensENSP0000049716095.284390.43dipodomys_ordiiENSDORP0000002002595.152490.3047
ENSG00000145191homo_sapiensENSP0000049716096.116591.6782mustela_putorius_furoENSMPUP0000000240796.2591.8056
ENSG00000145191homo_sapiensENSP0000049716096.532694.0361aotus_nancymaaeENSANAP0000002596196.532694.0361
ENSG00000145191homo_sapiensENSP0000049716096.393993.4813saimiri_boliviensis_boliviensisENSSBOP0000002401896.393993.4813
ENSG00000145191homo_sapiensENSP0000049716080.998678.2247vicugna_pacosENSVPAP0000000036687.556284.5577
ENSG00000145191homo_sapiensENSP0000049716098.335697.2261chlorocebus_sabaeusENSCSAP0000000971098.472297.3611
ENSG00000145191homo_sapiensENSP0000049716074.063871.8447tupaia_belangeriENSTBEP0000000710283.437580.9375
ENSG00000145191homo_sapiensENSP0000049716094.313589.043mesocricetus_auratusENSMAUP0000002092094.972189.6648
ENSG00000145191homo_sapiensENSP0000049716096.532692.7878phocoena_sinusENSPSNP0000000368795.604491.8956
ENSG00000145191homo_sapiensENSP0000049716094.036190.1526camelus_dromedariusENSCDRP0000500383591.621687.8378
ENSG00000145191homo_sapiensENSP0000049716095.700492.7878carlito_syrichtaENSTSYP0000001142797.320294.3583
ENSG00000145191homo_sapiensENSP0000049716095.977892.3717panthera_tigris_altaicaENSPTIP0000001899995.844992.2438
ENSG00000145191homo_sapiensENSP0000049716093.758788.2108rattus_norvegicusENSRNOP0000000232194.413488.8268
ENSG00000145191homo_sapiensENSP0000049716096.255293.2039prolemur_simusENSPSMP0000003113195.068592.0548
ENSG00000145191homo_sapiensENSP0000049716093.6288.9043microtus_ochrogasterENSMOCP0000001839594.142389.4003
ENSG00000145191homo_sapiensENSP0000049716062.968161.0264sorex_araneusENSSARP0000000739265.988463.9535
ENSG00000145191homo_sapiensENSP0000049716094.174889.1817peromyscus_maniculatus_bairdiiENSPEMP0000000695294.700189.6792
ENSG00000145191homo_sapiensENSP0000049716093.203990.2913bos_mutusENSBMUP0000002731292.307789.4231
ENSG00000145191homo_sapiensENSP0000049716092.926587.656mus_spicilegusENSMSIP0000001251593.444988.1451
ENSG00000145191homo_sapiensENSP0000049716094.174889.5978cricetulus_griseus_chok1gshdENSCGRP0000100641094.700190.0976
ENSG00000145191homo_sapiensENSP0000049716095.839192.3717pteropus_vampyrusENSPVAP0000000457895.839192.3717
ENSG00000145191homo_sapiensENSP0000049716096.671393.2039myotis_lucifugusENSMLUP0000001230996.537493.0748
ENSG00000145191homo_sapiensENSP0000049716089.736580.5825vombatus_ursinusENSVURP0001003016988.873679.8077
ENSG00000145191homo_sapiensENSP0000049716096.671392.9265rhinolophus_ferrumequinumENSRFEP0001003087996.537492.7978
ENSG00000145191homo_sapiensENSP0000049716092.23388.3495neovison_visonENSNVIP0000001998195.959691.9192
ENSG00000145191homo_sapiensENSP0000049716096.532693.4813bos_taurusENSBTAP0000001516895.604492.5824
ENSG00000145191homo_sapiensENSP0000049716093.897490.43heterocephalus_glaber_femaleENSHGLP0000002430993.508390.0553
ENSG00000145191homo_sapiensENSP0000049716099.029198.1969rhinopithecus_bietiENSRBIP0000004033599.029198.1969
ENSG00000145191homo_sapiensENSP0000049716096.255293.2039canis_lupus_dingoENSCAFP0002000268996.255293.2039
ENSG00000145191homo_sapiensENSP0000049716095.006991.5395sciurus_vulgarisENSSVLP0000500568794.093490.6593
ENSG00000145191homo_sapiensENSP0000049716087.378677.9473phascolarctos_cinereusENSPCIP0000003461681.818272.987
ENSG00000145191homo_sapiensENSP0000049716083.217876.9764procavia_capensisENSPCAP0000000682290.771683.9637
ENSG00000145191homo_sapiensENSP0000049716093.203989.4591nannospalax_galiliENSNGAP0000002610393.723889.9582
ENSG00000145191homo_sapiensENSP0000049716096.393993.3426bos_grunniensENSBGRP0000000153496.527893.4722
ENSG00000145191homo_sapiensENSP0000049716094.452190.9847chinchilla_lanigeraENSCLAP0000001885593.93190.4828
ENSG00000145191homo_sapiensENSP0000049716095.977892.7878cervus_hanglu_yarkandensisENSCHYP0000001571695.448392.2759
ENSG00000145191homo_sapiensENSP0000049716096.255292.6491catagonus_wagneriENSCWAP0000001733794.550491.0082
ENSG00000145191homo_sapiensENSP0000049716095.700491.5395ictidomys_tridecemlineatusENSSTOP0000001568995.567991.4127
ENSG00000145191homo_sapiensENSP0000049716092.510488.6269otolemur_garnettiiENSOGAP0000001444195.558791.5473
ENSG00000145191homo_sapiensENSP0000049716095.700493.0652cebus_imitatorENSCCAP0000002175594.780292.1703
ENSG00000145191homo_sapiensENSP0000049716095.145691.2621urocitellus_parryiiENSUPAP0001000440795.145691.2621
ENSG00000145191homo_sapiensENSP0000049716096.255293.3426moschus_moschiferusENSMMSP0000000022994.679491.8145
ENSG00000145191homo_sapiensENSP0000049716099.167898.3356rhinopithecus_roxellanaENSRROP0000002755299.167898.3356
ENSG00000145191homo_sapiensENSP0000049716093.6289.1817mus_pahariMGP_PahariEiJ_P002829793.6289.1817
ENSG00000145191homo_sapiensENSP0000049716095.977893.3426propithecus_coquereliENSPCOP0000000354495.844993.2133
ENSG00000145191homo_sapiensENSP0000049716044.105424.1331caenorhabditis_elegansD2085.3.147.747726.1261
ENSG00000145191homo_sapiensENSP0000049716048.127629.681drosophila_melanogasterFBpp008921751.868531.988
ENSG00000145191homo_sapiensENSP0000049716026.074917.7531ciona_intestinalisENSCINP0000000009370.41247.9401
ENSG00000145191homo_sapiensENSP0000049716046.463231.2067ciona_intestinalisENSCINP0000000009159.502739.9645
ENSG00000145191homo_sapiensENSP0000049716058.807245.6311petromyzon_marinusENSPMAP0000000091868.608453.2362
ENSG00000145191homo_sapiensENSP0000049716051.178937.5867eptatretus_burgeriENSEBUP0000000313264.964847.7113
ENSG00000145191homo_sapiensENSP0000049716079.611664.6325callorhinchus_miliiENSCMIP0000003248180.055864.993
ENSG00000145191homo_sapiensENSP0000049716080.582567.5451latimeria_chalumnaeENSLACP0000001371380.919267.8273
ENSG00000145191homo_sapiensENSP0000049716079.750365.3259lepisosteus_oculatusENSLOCP0000000556579.310364.9655
ENSG00000145191homo_sapiensENSP0000049716068.099954.5076danio_rerioENSDARP0000009934280.889664.7446
ENSG00000145191homo_sapiensENSP0000049716077.808662.8294carassius_auratusENSCARP0000004052179.914564.5299
ENSG00000145191homo_sapiensENSP0000049716078.363462.8294carassius_auratusENSCARP0000010571278.146662.6556
ENSG00000145191homo_sapiensENSP0000049716079.195663.6616astyanax_mexicanusENSAMXP0000005422178.112262.7907
ENSG00000145191homo_sapiensENSP0000049716078.502162.9681ictalurus_punctatusENSIPUP0000000843179.943564.1243
ENSG00000145191homo_sapiensENSP0000049716079.47365.1872esox_luciusENSELUP0000005862179.69465.3686
ENSG00000145191homo_sapiensENSP0000049716077.669962.4133electrophorus_electricusENSEEEP0000000446778.103262.7615
ENSG00000145191homo_sapiensENSP0000049716078.779564.9099oncorhynchus_kisutchENSOKIP0000510880080.453366.2889
ENSG00000145191homo_sapiensENSP0000049716077.115163.5229oncorhynchus_mykissENSOMYP0000012344874.630961.4765
ENSG00000145191homo_sapiensENSP0000049716060.194246.4632salmo_salarENSSSAP0000010176361.473147.4504
ENSG00000145191homo_sapiensENSP0000049716079.750365.0485salmo_truttaENSSTUP0000007067579.092264.5117
ENSG00000145191homo_sapiensENSP0000049716078.224762.4133gadus_morhuaENSGMOP0000002535477.366361.7284
ENSG00000145191homo_sapiensENSP0000049716078.640865.0485fundulus_heteroclitusENSFHEP0000001606779.859266.0563
ENSG00000145191homo_sapiensENSP0000049716076.837763.939poecilia_reticulataENSPREP0000003216379.256165.9514
ENSG00000145191homo_sapiensENSP0000049716078.08664.9099xiphophorus_maculatusENSXMAP0000000031879.407666.0085
ENSG00000145191homo_sapiensENSP0000049716078.363464.7711oryzias_latipesENSORLP0000001501379.915166.0537
ENSG00000145191homo_sapiensENSP0000049716077.947365.3259cyclopterus_lumpusENSCLMP0000502247578.164165.5077
ENSG00000145191homo_sapiensENSP0000049716078.779565.4646oreochromis_niloticusENSONIP0000007938580.112866.5726
ENSG00000145191homo_sapiensENSP0000049716078.779565.0485haplochromis_burtoniENSHBUP0000003539280.339566.3366
ENSG00000145191homo_sapiensENSP0000049716078.779565.1872astatotilapia_callipteraENSACLP0000002860780.22666.3842
ENSG00000145191homo_sapiensENSP0000049716076.69962.4133sparus_aurataENSSAUP0001005673677.887363.3803
ENSG00000145191homo_sapiensENSP0000049716078.363464.9099lates_calcariferENSLCAP0001001291678.581465.0904
ENSG00000145191homo_sapiensENSP0000049716079.47365.6033xenopus_tropicalisENSXETP0000003127780.027966.0615
ENSG00000145191homo_sapiensENSP0000049716085.575674.3412chrysemys_picta_belliiENSCPBP0000002169287.02475.5994
ENSG00000145191homo_sapiensENSP0000049716084.188671.5673sphenodon_punctatusENSSPUP0000001734385.252872.4719
ENSG00000145191homo_sapiensENSP0000049716085.159572.5381crocodylus_porosusENSCPRP0000501677184.109671.6438
ENSG00000145191homo_sapiensENSP0000049716066.990354.6463laticauda_laticaudataENSLLTP0000001914274.652260.8964
ENSG00000145191homo_sapiensENSP0000049716078.363465.4646notechis_scutatusENSNSUP0000001199781.412168.0115
ENSG00000145191homo_sapiensENSP0000049716075.173462.4133pseudonaja_textilisENSPTXP0000002444678.664765.312
ENSG00000145191homo_sapiensENSP0000049716084.604772.3994anas_platyrhynchos_platyrhynchosENSAPLP0000000505486.158273.7288
ENSG00000145191homo_sapiensENSP0000049716081.414768.6546gallus_gallusENSGALP0001002541782.676169.7183
ENSG00000145191homo_sapiensENSP0000049716083.079170.4577meleagris_gallopavoENSMGAP0000002464182.620770.069
ENSG00000145191homo_sapiensENSP0000049716078.640866.9903serinus_canariaENSSCAP0000001966986.963274.0798
ENSG00000145191homo_sapiensENSP0000049716083.911271.9834parus_majorENSPMJP0000000167185.572873.4088
ENSG00000145191homo_sapiensENSP0000049716073.092961.0264anolis_carolinensisENSACAP0000001056579.969766.7678
ENSG00000145191homo_sapiensENSP0000049716078.502165.0485neolamprologus_brichardiENSNBRP0000002260479.943566.2429
ENSG00000145191homo_sapiensENSP0000049716080.721266.4355naja_najaENSNNAP0000000887670.716958.2017
ENSG00000145191homo_sapiensENSP0000049716084.049971.706podarcis_muralisENSPMRP0000002971285.112472.6124
ENSG00000145191homo_sapiensENSP0000049716078.502167.2677geospiza_fortisENSGFOP0000001954386.809874.3865
ENSG00000145191homo_sapiensENSP0000049716084.049971.8447taeniopygia_guttataENSTGUP0000001042685.714373.2673
ENSG00000145191homo_sapiensENSP0000049716080.027766.8516erpetoichthys_calabaricusENSECRP0000000601280.925767.6017
ENSG00000145191homo_sapiensENSP0000049716078.363464.6325kryptolebias_marmoratusENSKMAP0000002695079.689765.7264
ENSG00000145191homo_sapiensENSP0000049716083.633870.0416salvator_merianaeENSSMRP0000002551084.217970.5307
ENSG00000145191homo_sapiensENSP0000049716076.144262.9681oryzias_javanicusENSOJAP0000001049576.783263.4965
ENSG00000145191homo_sapiensENSP0000049716079.056965.4646amphilophus_citrinellusENSACIP0000000877180.394966.5726
ENSG00000145191homo_sapiensENSP0000049716079.195665.8807dicentrarchus_labraxENSDLAP0000505294178.976565.6985
ENSG00000145191homo_sapiensENSP0000049716078.640865.0485amphiprion_perculaENSAPEP0000002900780.084766.2429
ENSG00000145191homo_sapiensENSP0000049716078.363465.0485oryzias_sinensisENSOSIP0000001097779.915166.3366
ENSG00000145191homo_sapiensENSP0000049716085.298274.2025pelodiscus_sinensisENSPSIP0000001575786.255375.0351
ENSG00000145191homo_sapiensENSP0000049716085.575674.2025gopherus_evgoodeiENSGEVP0000500571487.393875.779
ENSG00000145191homo_sapiensENSP0000049716085.85374.3412chelonoidis_abingdoniiENSCABP0000001716087.306175.5994
ENSG00000145191homo_sapiensENSP0000049716078.640865.1872seriola_dumeriliENSSDUP0000000115080.084766.3842
ENSG00000145191homo_sapiensENSP0000049716077.947364.6325cottoperca_gobioENSCGOP0000001729179.266665.7264
ENSG00000145191homo_sapiensENSP0000049716079.195667.2677struthio_camelus_australisENSSCUP0000001930987.442674.2726
ENSG00000145191homo_sapiensENSP0000049716084.604772.2607anser_brachyrhynchusENSABRP0000000537286.158273.5876
ENSG00000145191homo_sapiensENSP0000049716078.08664.4938gasterosteus_aculeatusENSGACP0000001868377.762464.2265
ENSG00000145191homo_sapiensENSP0000049716071.567356.3107cynoglossus_semilaevisENSCSEP0000001486375.659859.5308
ENSG00000145191homo_sapiensENSP0000049716077.669964.0777poecilia_formosaENSPFOP0000001613178.984565.1622
ENSG00000145191homo_sapiensENSP0000049716078.08663.939myripristis_murdjanENSMMDP0000504626577.8763.7621
ENSG00000145191homo_sapiensENSP0000049716077.115163.1068sander_luciopercaENSSLUP0000003023975.956362.1585
ENSG00000145191homo_sapiensENSP0000049716084.049971.8447strigops_habroptilaENSSHBP0000502062985.593273.1638
ENSG00000145191homo_sapiensENSP0000049716078.640865.1872amphiprion_ocellarisENSAOCP0000002783180.084766.3842
ENSG00000145191homo_sapiensENSP0000049716085.575674.3412terrapene_carolina_triunguisENSTMTP0000001656687.02475.5994
ENSG00000145191homo_sapiensENSP0000049716069.070757.0042hucho_huchoENSHHUP0000005708281.505767.2668
ENSG00000145191homo_sapiensENSP0000049716077.808663.2455betta_splendensENSBSLP0000002966778.242763.5983
ENSG00000145191homo_sapiensENSP0000049716080.166463.939pygocentrus_nattereriENSPNAP0000002214679.286763.2373
ENSG00000145191homo_sapiensENSP0000049716078.918264.9099anabas_testudineusENSATEP0000000985378.052164.1975
ENSG00000145191homo_sapiensENSP0000049716057.142938.2802ciona_savignyiENSCSAVP0000001700158.773239.3723
ENSG00000145191homo_sapiensENSP0000049716049.79228.1553saccharomyces_cerevisiaeYDR211W50.421328.5112
ENSG00000145191homo_sapiensENSP0000049716078.779565.3259seriola_lalandi_dorsalisENSSLDP0000000240880.22666.5254
ENSG00000145191homo_sapiensENSP0000049716078.363464.6325labrus_bergyltaENSLBEP0000000390779.689765.7264
ENSG00000145191homo_sapiensENSP0000049716075.589561.9972labrus_bergyltaENSLBEP0000000457977.968563.9485
ENSG00000145191homo_sapiensENSP0000049716078.918265.0485pundamilia_nyerereiENSPNYP0000002356480.367266.2429
ENSG00000145191homo_sapiensENSP0000049716078.502164.7711mastacembelus_armatusENSMAMP0000002474178.284964.592
ENSG00000145191homo_sapiensENSP0000049716078.779564.6325stegastes_partitusENSSPAP0000003053480.22665.8192
ENSG00000145191homo_sapiensENSP0000049716077.253863.3842oncorhynchus_tshawytschaENSOTSP0000507183474.664961.2601
ENSG00000145191homo_sapiensENSP0000049716079.611665.4646acanthochromis_polyacanthusENSAPOP0000002974876.943763.2708
ENSG00000145191homo_sapiensENSP0000049716084.327371.8447aquila_chrysaetos_chrysaetosENSACCP0002000561985.875773.1638
ENSG00000145191homo_sapiensENSP0000049716078.224763.939nothobranchius_furzeriENSNFUP0001501867379.436664.9296
ENSG00000145191homo_sapiensENSP0000049716076.421662.4133denticeps_clupeoidesENSDCDP0000003869777.496563.2911
ENSG00000145191homo_sapiensENSP0000049716079.056965.3259larimichthys_croceaENSLCRP0000501352379.720365.8741
ENSG00000145191homo_sapiensENSP0000049716078.502167.2677ficedula_albicollisENSFALP0000000826586.809874.3865
ENSG00000145191homo_sapiensENSP0000049716076.976462.6907hippocampus_comesENSHCOP0000001265378.947464.2959
ENSG00000145191homo_sapiensENSP0000049716078.779567.129coturnix_japonicaENSCJPP0000501675087.116674.2331
ENSG00000145191homo_sapiensENSP0000049716077.531263.8003poecilia_latipinnaENSPLAP0000000310878.843464.8801
ENSG00000145191homo_sapiensENSP0000049716077.531263.8003poecilia_latipinnaENSPLAP0000001384578.843464.8801
ENSG00000145191homo_sapiensENSP0000049716068.793355.3398sinocyclocheilus_grahamiENSSGRP0000001073671.060257.1633
ENSG00000145191homo_sapiensENSP0000049716060.055547.1567sinocyclocheilus_grahamiENSSGRP0000010703078.44261.5942
ENSG00000145191homo_sapiensENSP0000049716078.779565.1872maylandia_zebraENSMZEP0000501589580.22666.3842
ENSG00000145191homo_sapiensENSP0000049716076.69961.8585tetraodon_nigroviridisENSTNIP0000001074878.774963.5328
ENSG00000145191homo_sapiensENSP0000049716077.669964.3551paramormyrops_kingsleyaeENSPKIP0000002107878.541465.0771
ENSG00000145191homo_sapiensENSP0000049716079.195666.2968scleropages_formosusENSSFOP0001506976976.850664.3338
ENSG00000145191homo_sapiensENSP0000049716079.195666.5742leptobrachium_leishanenseENSLLEP0000000864576.336964.1711
ENSG00000145191homo_sapiensENSP0000049716076.560362.8294scophthalmus_maximusENSSMAP0000004648477.310963.4454
ENSG00000145191homo_sapiensENSP0000049716077.947364.0777oryzias_melastigmaENSOMEP0000002908779.490865.3465

Gene Ontology

Go ID Go term No. evidence Entries Species Category
GO:0001541involved_in ovarian follicle development1IMPHomo_sapiens(9606)Process
GO:0003743contributes_to translation initiation factor activity2IDA,NASHomo_sapiens(9606)Function
GO:0005085enables guanyl-nucleotide exchange factor activity4IBA,IDA,IMP,ISSHomo_sapiens(9606)Function
GO:0005515enables protein binding1IPIHomo_sapiens(9606)Function
GO:0005634NOT located_in nucleus2IDA,ISSHomo_sapiens(9606)Component
GO:0005737located_in cytoplasm1IDAHomo_sapiens(9606)Component
GO:0005829located_in cytosol2IDA,TASHomo_sapiens(9606)Component
GO:0005851part_of eukaryotic translation initiation factor 2B complex2IBA,IDAHomo_sapiens(9606)Component
GO:0006413involved_in translational initiation1IDAHomo_sapiens(9606)Process
GO:0009408involved_in response to heat3IMP,ISS,TASHomo_sapiens(9606)Process
GO:0009749involved_in response to glucose1ISSHomo_sapiens(9606)Process
GO:0014002involved_in astrocyte development1IMPHomo_sapiens(9606)Process
GO:0014003involved_in oligodendrocyte development1IMPHomo_sapiens(9606)Process
GO:0021766involved_in hippocampus development1IEAHomo_sapiens(9606)Process
GO:0031369enables translation initiation factor binding2IBA,ISSHomo_sapiens(9606)Function
GO:0034976involved_in response to endoplasmic reticulum stress1IMPHomo_sapiens(9606)Process
GO:0042552involved_in myelination1IMPHomo_sapiens(9606)Process
GO:0043065involved_in positive regulation of apoptotic process1IEAHomo_sapiens(9606)Process
GO:0043434involved_in response to peptide hormone1ISSHomo_sapiens(9606)Process
GO:0045948involved_in positive regulation of translational initiation1ISSHomo_sapiens(9606)Process
GO:0048708involved_in astrocyte differentiation1IMPHomo_sapiens(9606)Process
GO:0050852involved_in T cell receptor signaling pathway1IDAHomo_sapiens(9606)Process

Expression