Ensembl ID ENSG00000145191 Gene ID 8893 Accession 3261
Gene Symbol EIF2B5 Alias CLE;CACH;LVWM;VWM5;EIF-2B;EIF2Bepsilon Full Name eukaryotic translation initiation factor 2B subunit epsilon
Position 3 : 184135355 - 184145311 Length 9957 bases Strand Plus strand
Status Confidence Main interacting RNAsmRNARBP type Canonical_RBPs
Summary This gene encodes one of five subunits of eukaryotic translation initiation factor 2B (EIF2B), a GTP exchange factor for eukaryotic initiation factor 2 and an essential regulator for protein synthesis. Mutations in this gene and the genes encoding other EIF2B subunits have been associated with leukoencephalopathy with vanishing white matter. [provided by RefSeq, Nov 2009]

ENSG00000145191 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000145191 EIF2B5 0.42 4.20e-28 BRCA
ENSG00000145191 EIF2B5 1.36 2.34e-39 LUSC
ENSG00000145191 EIF2B5 0.31 1.24e-11 PRAD
ENSG00000145191 EIF2B5 0.68 1.82e-16 UCEC
ENSG00000145191 EIF2B5 0.36 8.77e-11 LUAD
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000145191 EIF2B5 cancer 20103664
ENSG00000145191 EIF2B5 Cancer 26208496
ENSG00000145191 EIF2B5 tumors 28961236
ENSG00000145191 EIF2B5 tumors 30380422
ENSG00000145191 EIF2B5 liver cancer 30538549
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000145191 EIF2B5 MESO 0.025 low
ENSG00000145191 EIF2B5 SARC 0.023 high
ENSG00000145191 EIF2B5 STAD 0.049 low
ENSG00000145191 EIF2B5 LUSC 0.0035 low
ENSG00000145191 EIF2B5 HNSC 0.031 high
ENSG00000145191 EIF2B5 READ 0.017 low
ENSG00000145191 EIF2B5 KIRP 0.00098 high
ENSG00000145191 EIF2B5 KICH 0.027 high
ENSG00000145191 EIF2B5 THYM 0.011 low
ENSG00000145191 EIF2B5 COAD 0.0018 high
ENSG00000145191 EIF2B5 UCS 0.047 low
ENSG00000145191 EIF2B5 OV 0.042 high
ENSG00000145191 EIF2B5 PRAD 0.0028 high
ENSG00000145191 EIF2B5 LAML 0.012 high
ENSG00000145191 EIF2B5 GBM 0.012 low
ENSG00000145191 EIF2B5 CESC 0.0028 low
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000145191 EIF2B5 LGG Amp 2.204055 0.065918 0.903023 0.037037
ENSG00000145191 EIF2B5 PCPG Del 2.602850 0.095567 0.639075 0.580247
ENSG00000145191 EIF2B5 KIRC Amp 1.404341 0.042058 0.388029 0.159091
ENSG00000145191 EIF2B5 UVM Del 0.709713 0.058192 0.806385 0.550000